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| 1 | 阿司匹林或利伐沙班对髋膝关节置换术后VTE的预防效果显示文摘静脉血栓栓塞(venous thromboembolism,VTE)是全髋关节置换(total hip arthroplasty,THA)或全膝关节置换(total knee arthroplasty,TKA)常见的术后并发症。诸多临床试验研究和Meta分析结果表明,阿司匹林在预防THA或TKA术后VTE(近端深静脉血栓形成或肺栓塞)方面可能是有效的,但缺乏与直接口服抗凝剂在出院后预防效果方面的比较。 | Anderson DR Dunbar M Murnaghan J 李炳林 章莹 | 2018 | 中国骨科临床与基础研究杂志2018，10，2： | 8 |
| 2 | 脂质组学改善传统危险因素预测的2型糖尿病患者的心血管事件显示文摘临床脂质测定并未显示出糖尿病或心血管病相关的脂质代谢改变的复杂性。脂质组学则能够评估可作为疾病风险潜在标志物的数百种脂质种类。方法:纳入来自糖尿病治疗和血管保护行动。 | 刘莉 叶鹏 Alshehry ZH Mundra PA Barlow CK Mellett NA Wong G McConville MJ Simes J Tonkin AM Sullivan DR Barnes EH Nestel PJ Kingwell BA Marre M Neal B Poulter NR Rodgers A Williams B Zoungas S Hillis GS Chalmers J Woodward M Meikle PJ | 2016 | 中华高血压杂志2016，24，10： | 3 |
| 3 | WONCA研究论文摘要汇编——有流产史女性患心血管疾病的风险:女性健康行动显示文摘目的与流产/死产相关的新陈代谢、激素和凝血机制的变化可导致心血管疾病(CVD)。本研究评价了有流产史女性与CVD的相关性。方法 1993—1998年,将77 701名绝经后妇女纳入研究。收集基线信息,包括既往史、社会人口学和CVD风险因素。对有1次或≥2次流产、≥1次死胎与发生CVD的关系行多元Logistic回归分析。结果 77 701名妇女中有23 538名(30.3%)报告有流产史,1 670名(2.2%)有死胎史,1 673名(2.2%)既有流产史又有死胎史。与无死胎史者相比,≥1次死胎史者患冠心病(CHD)的风险升高〔OR=1.27,95%CI(1.07,1.51)〕;与无流产史者相比,有1次流产史、≥2次流产史者患CHD的风险升高〔OR=1.19,95%CI(1.08,1.32);OR=1.18,95%CI(1.04,1.34)〕。缺血性卒中者与死产或流产史者患CHD的风险比间无显著差异。结论流产史与CHD相关,但与缺血性卒中无关。有≥1次死产或有≥1次流产史妇女患CVD的风险增加,应该列为密切观察或行早期干预的对象;流产导致CVD风险增加的病理生理学机制还需行进一步研究。 | Parker DR Lu B Sands-Lincoln M 周淑新 | 2014 | 中国全科医学2014，17，32： | 2 |
| 4 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 5 | Significance of an additional unenhanced scan in computed tomography angiography of patients with suspected acute aortic syndrome显示文摘AIM To assess potential benefits of an additional unenhanced acquisition in computed tomography angiography(CTA) in patients with suspected acute aortic syndrome(AAS).METHODS A total of 103 aortic CTA(non-electrocardiography-gated, 128 slices) performed due to suspected AAS were retrospectively evaluated for acute aortic dissection(AAD), intramural hematoma(IMH), or penetrating aortic ulcer(PAU). Spiral CTA protocol consisted of an unenhanced acquisition and an arterial phase. If AAS was detected, a venous phase(delay, 90 s) was added. Images were evaluated for the presence and extent of AAD, IMH, PAU, and related complications. The diagnostic benefit of the unenhanced acquisition was evaluated concerning detection of IMH.RESULTS Fifty-six(30% women; mean age, 67 years; median, 68 years) of the screened individuals had AAD or IMH. A triphasic CT scan was conducted in 76.8%(n =43). 56% of the detected AAD were classified as Stanford type A, 44% as Stanford type B. 53.8% of the detected IMH were classified as Stanford type A, 46.2% as Stanford type B. There was no significant difference in the involvement of the ascending aorta between AAD and IMH(P = 1.0) or in the average age between AAD and IMH(P = 0.548), between Stanford type A and Stanford type B in general(P = 0.650) and between Stanford type A and Stanford type B within the entities of AAD and IMH(AAD: P = 0.785; IMH: P = 0.146). Only the unenhanced acquisitions showed a significant density difference between the adjacent lumen and the IMH(P = 0.035). Subadventitial hematoma involving the pulmonary trunk was present in 5 patients(16%) with Stanford A AAD. The difference between the median radiation exposure of a triphasic(2737 mGy*cm) compared to a biphasic CT scan(2135 mGy*cm) was not significant(P = 0.135).CONCLUSION IMH is a common and difficult to detect entity of AAS. An additional unenhanced acquisition within an aortic CTA protocol facilitates the detection of IMH. | Nikolaos Panagiotopoulos Felix Drüschler Martin Simon Florian M Vogt Sebastian Wolfrum Steffen Desch Doreen Richardt Jorg Barkhausen Peter Hunold | 2018 | World Journal of Radiology2018，10，11： | 2 |
| 6 | Autountibodies to GPI in cheumatoid arthritis:linkage between an antmal mode and luman disease显示文摘 | Schaller M Burton DR Ditzel HJ | 2001 | Nat lmmunol2001，2，： | 1 |
| 7 | MMP-2 and MMP-9 secretion by rpe is stimulated by angiogenic molecules found in choroidal neovascular membranes 显示文摘 | Hoffmann S He S Ehren M Ryan S J Wiedemann P Hinton DR | 2006 | Retina2006，26，4： | 1 |
| 8 | Linear accuracyand reliability of cone beam CT derived 3-dimensional ima-ges constructed using an orthodontic volumetric renderingprogram显示文摘 | Periago DR Scarfe WC Moshiri M | 2008 | Angle Orthod2008，78，3： | 1 |
| 9 | Excluding pulmonary embolism at the bedside without diagnostic imaging: management of patients with suspected pulmonary embolism presenting to the emergency department by using a simple clinical model and D - Dimer显示文摘 | Wells PS Anderson DR Rodger M | 2001 | Ann Intern Med2001，135，2： | 1 |
| 10 | Effect of graded doses of ionizing radiation on the human testis显示文摘 | Rowley M J Leach DR Warner GA | 1974 | Radiat Res1974，59，3： | 1 |
| 11 | Constitutive activation of phosphatidylinositol 3-kinase by a natureally occurring mutant epidermal growth factor receptor显示文摘 | Moscatello DK Holgado-Madruga M Emlet DR | 1998 | J Biol Chem1998，273，1： | 1 |
| 12 | Th1 and Th2 eytokine dysregulation in human infectious,neoplastic,and inflammatory diseases显示文摘 | Lucy DR Clerici M Shearer GM | 1996 | Clin Microbiol Rev1996，9，4： | 1 |
| 13 | Interleukin 18 in the heart 显示文摘 | Wang M Markel TA Meldrum DR | 2008 | Shock2008，30，1： | 1 |
| 14 | Coronary artery calcification and myocardial perfusion in asymptomatic adults显示文摘 | Wang L Jerosch- Herold M Jacobs DR | 2006 | J Am Coll Cardiol2006，48，： | 1 |
| 15 | The hedgehog pathway as a therapeutic target for treatment of breast cancer显示文摘 | Barginear MF Leung M Budman DR | 2009 | Breast Cancer Res Treat2009，116，2： | 1 |
| 16 | Derivation of a simple clinical model to categorize patientsprobability of pulmonary embolism:increasing the models utility with the simpliRED D-dimer显示文摘 | Wells PS Anderson DR Rodger M | 2000 | Thromb Haemost2000，83，3： | 1 |
| 17 | Effect of handwashing on child health: a randomised controlled trial显示文摘 | Luby SP Agboatwalla M Feikin DR | 2005 | Lancet2005，366，9481： | 1 |
| 18 | Autoantibodies to GPIin rheumatoid arthritis:linkage between an animal model and human disease显示文摘 | Burton DR Ditzel HJ | 2001 | Nat Immunol2001，2，8： | 1 |
| 19 | A multicentre study of Shigella diarrhoea in six Asian countries:disease burden, clinical manifestations, and microbiology 显示文摘 | Seidlein L Kim DR Ali M at el | | Plos Med0，3，： | 1 |
| 20 | Comparion of exhaled nitric oxide,serum eosinopilic cationic protein,and soluble interleukin-2 receptor in exacerbations of pediatric asthma显示文摘 | Lanz M J Leung DY McCormick DR | 1997 | Pediatric Pulmonology1997，24，： | 1 |
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