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| 1 | Using Statistical Downscaling to Quantify the GCM-Related Uncertainty in Regional Climate Change Scenarios: A Case Study of Swedish Precipitation显示文摘有在地区性的气候变化情形的不确定性的很多来源。当统计 downscaling 被用来获得地区性的气候变化情形时,不确定性可以在使用的模型,统计模型的技巧,和强迫的情形用于世界气候模型的世界气候从不确定性发源。与世界气候模型联系的不确定性能被基于一套不同世界气候模型在预言者并且在 downscaled 气候变化情形检验差别评估。什么时候标准化了象 CoupledModel Intercomparison 工程(CMIP2 ) 的第二个阶段那样的世界气候模型模拟,被使用,在 downscaled 变量的差别主要在模仿的气候在气候模型和自然可变性反映差别。Itis 建议估计的传播能作为与世界气候模型联系的不确定性的一项措施被拿。建议方法在瑞典在地区性的降水变化情形被用于评价 ofglobal-climate-model-related 不确定性。尽管在降水的变化的可观的传播存在,基于在整个瑞典的年度降水有全面增加的 17 世界气候模型表演源于统计 downscaling。一般增加能被归因于增加的 large-scaleprecipitation 和提高的偏午。估计的不确定性将近独立于区域。然而,有季节的依赖。为冬季的估计显示出信心的高水平,当为夏天的估计最不出现时。 | Deliang CHEN Christine ACHBERGER Jouni R■IS■NEN Cecilia HELLSTRM | 2006 | Advances in Atmospheric Sciences2006，23，1： | 9 |
| 2 | Overexpression of HSP27 and HSP70 is associated with decreased survival among patients with esophageal adenocarcinoma显示文摘BACKGROUND Overexpression of heat shock proteins(HSPs) is associated with several malignancies and contributes to the development, progression, and metastasis of cancer, in addition to the inhibition of cellular death. In recent years, there has been active research into using HSP inhibitors in several malignancies. Due to the poor prognosis of esophageal adenocarcinoma(EAC), it would be valuable to find new biomarkers for the development of cancer treatments.AIM To evaluate the expressions of HSP27 and HSP70 and their effect on survival in EAC.METHODS Immunohistochemical analyses and evaluations of HSP27 and HSP70 expression were performed on all available samples from 93 patients diagnosed with EACbetween 1990 and 2007 at two university hospitals. Fifteen cases with Barrett's metaplasia and 5 control cases from the same patient population were included in the analysis. HSP expression was quantitatively assessed and classified as high or low. Kaplan-Meier analyses and Cox regression models adjusting for age and sex as well as tumor site, stage, and grade were used to evaluate the effect on survival.RESULTS Tumor stage and surgical treatment were the main prognostic factors. High HSP27 expression in cancer cases was a strong negative predictive factor, with a mean survival of 23 mo compared to the 49 mo in cases with a low expression(P= 0.018). The results were similar for HSP70, with a poorer survival of 17 mo in cases with high HSP70 expression, in contrast to 40 mo(P = 0.006) in cases with a low expression. A Cox regression survival analysis was performed, adjusting for possible confounding factors, and higher HSP27 and HSP70 expressions remained an independent negative prognostic factor. The HSPs' correlation with survival was not affected by cancer treatments. When the analysis was adjusted for all factors, the odds ratios for HSP27 and HSP70 were 3.3(CI: 1.6–6.6, P =0.001) and 2.2(CI: 1.2–3.9, P = 0.02), respectively.CONCLUSION HSP27 and HSP70 overexpression is associated with poor survival in EAC, which is, to the best of our knowledge, reported for the first time. | Henna K S?derstr?m Juha T Kauppi Niku Oksala Timo Paavonen Leena Krogerus Jari R?s?nen Tuomo Rantanen | 2019 | World Journal of Clinical Cases2019，7，3： | 7 |
| 3 | 冷战和环境:芬兰在波罗的海地区国际环境政治方面的角色显示文摘1974年在赫尔辛基签署的关于《波罗的海区域海洋环境保护公约》可能是在波罗的海地区最重要的环境保护协议。本篇文章是首次运用原始档案资料第一次探究本公约的历史,也称之为《赫尔辛基公约》。这些原始资料主要出自芬兰外交部的档案。我们从国际政治角度研究了《赫尔辛基公约》整个签署的过程中芬兰的作用。本研究主要集中在芬兰、瑞典和苏联从20世纪60年代末到1974年的国家政党。我们表明,冷战政治从若干方面影响《赫尔辛基公约》的谈判和内容。我们也认为苏联利用新出现的国际环境问题作为一种新的强权政治的工具。 | Tuomas Rsnen Simo Laakkonen 翟伟康 | 2007 | AMBIO-人类环境杂志2007，36，2： | 4 |
| 4 | Cost-utility of molecular adsorbent recirculating system treatment in acute liver failure显示文摘AIM:To determine the short-term cost-utility of mo-lecular adsorbent recirculating system(MARS) treatment in acute liver failure(ALF).METHODS:A controlled retrospective study was conducted with 90 ALF patients treated with MARS from 2001 to 2005.Comparisons were made with a historical control group of 17 ALF patients treated from 2000 to 2001 in the same intensive care unit(ICU) specializing in liver diseases.The 3-year outcomes and number of liver transplantations were recorded.All direct liver disease-related medical expenses from 6 mo before to 3 years after ICU treatment were determined for 31 MARS patients and 16 control patients.The health-related quality of life(HRQoL) before MARS treatment was estimated by a panel of ICU doctors and after MARS using a mailed 15D(15-dimensional generic healthrelated quality of life instrument) questionnaire.The HRQoL,cost,and survival data were combined and the incremental cost/quality-adjusted life years(QALYs) was calculated.RESULTS:In surviving ALF patients,the health-related quality of life after treatmeant was generally high and comparable to the age-and gender-matched general Finnish population.Compared to the controls,the average cost per QALY was considerably lower in the MARS group(64 732€ vs 133 858€) within a timeframe of 3.5 years.The incremental cost of standard medical treatment alone compared to MARS was 10 928€,and the incremental number of QALYs gained by MARS was 0.66.CONCLUSION:MARS treatment combined with standard medical treatment for ALF in an ICU setting is more cost-effective than standard medical treatment alone. | Taru Kantola Suvi Mklin Anna-Maria Koivusalo Pirjo Rsnen Anne Rissanen Risto Roine Harri Sintonen Krister Hckerstedt Helena Isoniemi | 2010 | World Journal of Gastroenterology2010，16，18： | 3 |
| 5 | Obesity and nosocomial infections 显示文摘 | Huttunen R Karppelin M Syrj ?? nen J | 2013 | J Hosp Infect2013，85，1： | 1 |
| 6 | Data-based method for creating electricity use load profiles using large amount of customer-specific hourly measured electricity use data显示文摘 | Teemu R?s?nen Dimitrios Voukantsis Harri Niska Kostas Karatzas Mikko Kolehmainen | 2010 | Applied Energy2010，，11： | 1 |
| 7 | Early selective-attention effect on evoked potential reinterpreted显示文摘 | N??t?nen R Gaillard AW Mantysalo S | 1978 | Acta Psychologica1978，42，4： | 1 |
| 8 | 高速新概念成形——低定量双层箱纸板,变不可能为可能显示文摘介绍了一种全新的、已获专利保护的、用单台混合成形单元生产容器用轻量双层箱纸板的成本效益型的概念。新概念将三个独特的部件和技术结合为一体:新型ValFloPro双层流浆箱、VacuBalence真空辅助成形板和ValFormer靴刮刀混合成形器技术。这个具备分层技术的混合成形新概念将纸机运行速度提高到1400m/min,是生产一流质量轻量箱纸板的一种切实可行的替代方案。 | Teuvo Virkkunen Hannu Turpeinen Kari Risnen Hannu Partanen | 2010 | 中华纸业2010，，16： | 1 |
| 9 | Long-distance signaling in nodulation directed by a CLAVATAI-like receptor kinase显示文摘 | Searle I R Nen A E Laniya T S | 2003 | Science2003，299，： | 1 |
| 10 | Human fetal cardiac function during the first trimester of pregnancy显示文摘 | M?kikallio K Jouppila P R?s?nen J | | 0，，03： | 1 |
| 11 | Temperature and soil organic matter decomposition rates-synthesis of current knowledge and a way forward显示文摘 | Conant RT Ryan MG Agren GI Birge HE Davidson EA Eliasson PE Evans SE Frey SD Giardina CP Hopkins FM Hyvǒnen R Kirschbaum MUF Lavallee JM Leifeld J Parton WJ Megan Steinweg J Wallenstein MD Martin Wetterstedt JA Bradford MA | | 0，，： | 1 |
| 12 | The mismatch negativity (MMN) in basic research of central auditory processing: a review显示文摘 | N??t?nen R Paavilainen P Rinne T | 2007 | Clin Neuroph2007，118，12： | 1 |
| 13 | European climate in the late twenty-first century: regional simulations with two driving global models and two forcing scenarios显示文摘 | J. R?is?nen U. Hansson A. Ullerstig R. D?scher L. P. Graham C. Jones H. E. M. Meier P. Samuelsson U. Willén | 2004 | Climate Dynamics2004，，1： | 1 |
| 14 | Body size at birth predicts hypothalamic-pituitary-adrenal axis response to psychosocial stress at age 60 to 70 years 显示文摘 | Kajantie E Feldt K R?ikk?nen K | 2007 | J Chn Endocrinol Metab2007，92，11： | 1 |
| 15 | Surgical or Nonoperative Treatment for Lumbar Spinal Stenosis?: A Randomized Controlled Trial显示文摘 | Antti Malmivaara P?r Sl?tis Markku Heli?vaara P?ivi Sainio Heikki Kinnunen Jyrki Kankare Nina Dalin-Hirvonen Seppo Seitsalo Arto Herno Pirkko Kortekangas Timo Niinim?ki Hannu R?nty Kaj Tallroth Veli Turunen Paul Knekt Tommi H?rk?nen Heikki Hurri | 2007 | Spine2007，，1： | 1 |
| 16 | Mismatch negativity(MMN):perspectives for application显示文摘 | NTNEN R | 2000 | Int J Psychophysiol2000，37，： | 1 |
| 17 | The effect of platelet-derived growth factor ligands in rat cardiac allograft vasculopathy and fibrosis显示文摘 | Tuuminen R Nyknen A Kernen MA | 2006 | Transplant Proc2006，38，10： | 1 |
| 18 | Methylation-specific PCR:A novel PCR assay for methylation status of CpG islands显示文摘 | HERMAN J G GRAFF J R MYH(A)NEN S | 1996 | Proc Nat Acad Sci U S A1996，93，18： | 1 |
| 19 | Analysing temperature response of decomposition of organic matter显示文摘 | Hyv(o)nen R (A)gren G I Dalias P | 2005 | Global Change Biology2005，11，： | 1 |
| 20 | The pH measurement of concrete and smoothing mortar using a concrete powder suspension显示文摘 | R(A)S(A)NEN V PENTTALA V | | 0，，05： | 1 |
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