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| 1 | Cancer incidence and mortality in China in 2013:an analysis based on urbanization level显示文摘Objective: To explore the cancer patterns in areas with different urbanization rates(URR) in China with data from 255 population-based cancer registries in 2013, collected by the National Central Cancer Registry(NCCR).Methods: There were 347 cancer registries submitted cancer incidence and deaths occurred in 2013 to NCCR.All those data were checked and evaluated based on the NCCR criteria of data quality, and qualified data from 255 registries were used for this analysis. According to the proportion of non-agricultural population, we divided cities/counties into 3 levels: high level, with URR equal to 70% and higher; median level, with URR between 30%and 70%; and low level, with URR equal to 30% and less. Cancer incidences and mortalities were calculated,stratified by gender and age groups in different areas. The national population of Fifth Census in 2000 and Segi's population were applied for age-standardized rates.Results: Qualified 255 cancer registries covered 226,494,490 populations. The percentage of cases morphologically verified(MV%) and death certificate-only cases(DCO%) were 68.04% and 1.74%, respectively,and the mortality to incidence rate ratio(M/I) was 0.62. A total of 644,487 new cancer cases and 399,275 cancer deaths from the 255 cancer registries were submitted to NCCR in 2013. The incidence rate was 284.55/100,000(314.06/100,000 in males, 254.19/100,000 in females), and the age-standardized incidence rates by Chinese standard population(ASIRC) and by world standard population(ASIRW) were 190.10/100,000 and 186.24/100,000 with the cumulative incidence rate(0–74 age years old) of 21.60%. The cancer mortality was 176.28/100,000(219.03/100,000 in males, 132.30/100,000 in females), and the age-standardized mortality rates by Chinese standard population(ASMRC) and by world standard population(ASMRW) were 110.91/100,000 and 109.92/100,000, and the cumulative mortality rate(0–74 age years old) was 12.43%. Low urbanization areas were high in crude cancer incidence and mortality rates, middle urbanization areas came next to it followed by high urbanization areas. After adjusted by age, there was a U-shaped association between age-standardized incidence(ASIRC and ASIRW) and the urbanized ratio with the middle urbanization areas having the lowest ASIRC and ASIRW. Unlike with the agestandardized incidence, the sort order of age-standardized mortality(ASMRC and ASMRW) among three urbanization areas was reversed completely from the crude mortality. Lung cancer was the most common cancer in all areas of 255 cancer registries, followed by stomach cancer, liver cancer, colorectal cancer and esophageal cancer with new cases of 130,700, 76,200, 63,800, 60,900 and 50,200 respectively. Lung cancer was also the leading cause of cancer death in all areas of 255 cancer registries for both males and females with the number of deaths of 72,200 and 34,100, respectively. Other cancer types with high mortality in males were liver cancer, stomach cancer,esophageal cancer and colorectal cancer. In females, stomach cancer was the second cause of cancer death, followed by liver cancer, colorectal cancer and breast cancer.Conclusions: Along with the development of socioeconomics associated with urbanization, as well as the agingpopulation, the incidence and mortality keep increasing in China. Cancer burden and patterns are different in each urbanization level. Cancer control strategies should be implemented referring to local urbanization status. | Wanqing Chen Rongshou Zheng Siwei Zhang Hongmei Zeng Tingting Zuo Changfa Xia Zhixun Yang Jie He | 2017 | Chinese Journal of Cancer Research2017，29，1： | 305 |
| 2 | Effect of early enteral nutrition on postoperative nutritional status and immune function in elderly patients with esophageal cancer or cardiac cancer显示文摘Objective: To explore the effect of early enteral nutrition (EN) on postoperative nutritional status, intestinal permeability, and immune function in elderly patients with esophageal cancer or cardiac cancer. Methods: A total of 96 patients with esophageal cancer or cardiac cancer who underwent surgical treatment in our hospital from June 2007 to December 2010 were enrolled in this study. They were divided into EN group (n=50) and parenteral nutrition (PN) group (n=46) based on the nutrition support modes. The body weight, time to first flatus/defecation, average hospital stay, complications and mortality after the surgery as well as the liver function indicators were recorded and analyzed. Peripheral blood samples were collected on the days 1, 4 and 7 after surgery. The plasma diamine oxidase (DAO) activity and D-lactate level were determined to assess the intestinal permeability. The plasma endotoxin levels were determined using dynamic turbidimetric assay to assess the protective effect of EN on intestinal mucosal barrier. The postoperative blood levels of inflammatory cytokines and immunoglobulins were determined using enzyme- linked immunosorbent assay (ELISA). Results: After the surgery, the time to first flatus/defecation, average hospital stay, and complications were significantly less in the EN group than those in the PN group (P<0.05), whereas the EN group had significantly higher albumin levels than the PN group (P<0.05). On the 7th postoperative day, the DAO activity, D-lactate level and endotoxin contents were significantly lower in the EN group than those in the PN group (all P<0.05). In addition, the EN group had significantly higher IgA, IgG, IgM, and CD4 levels than the PN group (P<0.05) but significantly lower IL-2, IL-6, and TNF-α levels (P<0.05). Conclusions: In elderly patients with esophageal cancer or cardiac cancer, early EN after surgery can effectively improve the nutritional status, protect intestinal mucosal barrier (by reducing plasma endoxins), and enhance the immune | Guiping Yu Guoqiang Chen Bin Huang Wenlong Shao Guangqiao Zeng | 2013 | Chinese Journal of Cancer Research2013，25，3： | 67 |
| 3 | 乳腺癌术后康复的研究进展显示文摘近年来,我国乳腺癌发病率呈明显上升的趋势。当前的治疗是以外科切除为主的综合治疗,对于乳腺癌术后的多种并发症,如乳腺癌术后上肢淋巴水肿、上肢功能障碍等,均需要妥善的治疗以保证良好的康复效果。然而,鉴于乳腺癌对患者生理和心理产生的严重影响,心理康复、通过评估患者生活质量来指导临床工作越发重要。本文从乳腺癌上肢淋巴水肿、上肢功能障碍、心理康复及术后生活质量评估方面进行综述,为探讨乳腺癌术后康复提供依据。 | 周扬 张晟 | 2014 | 中国全科医学2014，17，18： | 41 |
| 4 | 1989~2014年中国胃癌发病率与统计年鉴指标的相关性分析显示文摘目的:分析中国胃癌发病率30年来的变化趋势,找到影响胃癌发病率的最主要原因,为中国胃癌的防治提供有用的指导意见。方法:收集各影响因素的历年变化趋势数据,采用双变量相关的统计学方法,与当年胃癌的发病率进行相关性分析,求出Spearman等级相关系数r_s,并对有统计学意义的影响因素按照r_s绝对值的大小进行排序。结果:农村胃癌的发病率总体呈下降趋势,而城市胃癌的发病率一直趋于平稳,且远低于农村的水平,但从2009年开始小幅上升,使得城乡胃癌发病率水平基本接近。与城乡胃癌发病率负相关的有:新鲜瓜果消费量、可支配收入、电冰箱拥有量、老龄化水平;仅与城市胃癌发病率负相关的有:城市人口比例;仅与农村胃癌发病率正相关的有:高盐腌渍食物消费量、工业废水化学需氧量排放量、工业废水氨氮排放量、农村人口比例。结论:我国近30年来胃癌发病率呈逐渐下降趋势,其主要原因在于社会经济的发展和生活方式的改变。 | 韩川 吴琼 倪阵 袁挺 张剑 刘洁 孙妮娜 石淼 刘彩芳 时永全 | 2019 | 肿瘤预防与治疗2019，32，5： | 20 |
| 5 | 太极拳联合肌内效贴对乳腺癌术后患者上肢功能及生活质量的影响显示文摘目的 观察太极拳联合肌内效贴对乳腺癌改良根治术后患者上肢水肿的影响。 方法 选取乳腺癌改良根治术后出现上肢淋巴水肿患者57例,采用随机数字表法将其分为观察组及对照组。2组患者术后均给予常规康复训练,观察组同时辅以太极拳及肌内效贴治疗。于治疗前、治疗8d、24d及40d时检测2组患者上肢周径,同时采用Constant-Murley肩关节功能评分及生活质量评价量表(SF-36)对2组患者上肢功能及生活质量进行评定。 结果 2组患者淋巴水肿程度、上肢Constant-Murley评分及SF-36评分均较治疗前明显改善(P〈0.05),在治疗24d及40d时观察组患者淋巴水肿缓解情况(特别是中度水肿患者)明显优于对照组(P〈0.05)。随着治疗时间延长,观察组患者Constant-Murley评分各项指标亦显著优于对照组(P〈0.05)。在治疗40d时发现观察组生活质量评定(SF-36)在身体角色(RP)、社会功能(SF)、情绪角色(RE)、活力(VT)、心理卫生(MH)等方面均明显优于对照组(P〈0.05)。 结论 太极拳锻炼联合肌内效贴干预能明显减轻乳腺癌患者术后淋巴水肿,改善上肢功能,提高生活质量,该联合疗法值得临床推广、应用。 | 吕峰 孔舒欣 梁栋 于洋 李翠 张斌 | 2018 | 中华物理医学与康复杂志2018，40，6： | 19 |
| 6 | 宫颈癌的手术-病理分期和评分系统的建立和验证显示文摘目的:世界范围内大多数宫颈癌患者接受手术治疗,但目前国际妇产科联合会(FIGO)分期系统未考虑手术-病理资料。本文提出了一个更综合全面且对预后有指导价值的手术-病理分期和评分系统。方法:4220例宫颈癌队列(1)用于筛选手术-病理危险因素,构建手术-病理分期和评分系统,采用1104例宫颈癌的前瞻性研究队列(2)进行验证。结果:宫颈癌队列(1)的筛选研究中,7个独立危险因素与预后相关:淋巴结转移、宫旁浸润、病理类型、组织学分级、肿块大小、间质浸润和脉管浸润。通过纳入淋巴结转移、间质浸润和脉管浸润的附加衡量标准,FIGO分期系统被修订和扩展成为一个手术-病理分期系统。根据数量和转移部位,淋巴结转移被分为3个亚组。加入7个预后危险因素提高了评分系统实践的可行性。评分系统将患者划分为3个级别:零分、低分和高分,分别对应0分、1~3分和≥4分(P=1.08E-45;P=6.15E-55)。队列(2)的验证研究中,随着评分系统分数的升高,患者的5年总生存率和无瘤生存率减低(P=9.04E-15;P=3.23E-16)。手术-病理分期和评分系统比FIGO分期有更好的同质性和辨识力。结论:手术-病理分期和评分系统改进了对肿瘤严重程度和病灶侵袭程度的性状描述,可更精确地预测预后并指导术后治疗。 | 李双 李雄 张媛 周航 唐方徐 贾瑶 胡婷 孙海英 杨茹 陈亦乐 程晓东 吕卫国 吴丽 周金 王少帅 黄科程 王琳 姚远 杨其峰 杨兴升 张庆华 韩晓兵 林仲秋 邢辉 曲芃芃 蔡红兵 宋晓婕 田晓予 沈健 奚玲 李科珍 邓东锐 汪辉 王常玉 吴明富 朱涛 陈刚 高庆蕾 王世宣 胡俊波 孔北华 谢幸 马丁 | 2016 | 现代妇产科进展2016，25，11： | 18 |
| 7 | 中医对胰腺癌的认识及中医药干预胰腺癌刍议显示文摘胰腺癌是一种死亡率极高的恶性肿瘤,目前手术,放、化疗治疗尚不能取得理想的临床疗效。作者联系中医典籍相关记载,总结中医关于胰腺癌的病因病机、诊疗等方面的认识,并结合中医药治疗胰腺癌的现代研究成果,探究中医药治疗胰腺癌的可行性,为临床治疗胰腺癌拓展新的思路。 | 吴四智 史玉聪 陈孝银 | 2019 | 辽宁中医杂志2019，46，3： | 15 |
| 8 | 2002-2012年上海市杨浦区女性人群乳腺癌的发病和生存情况分析显示文摘目的阐明上海市杨浦区2002-2012年期间乳腺癌发病率和生存率。方法整理2002年1月-2012年12月户籍居民乳腺癌发病和死亡资料,应用年平均变化百分比(annual percent change,APC)模型分析发病率和死亡率的时间变化趋势,应用Kaplan-Meier模型和Log-rank检验进行生存分析。采用2000年人口普查的女性年龄构成进行标化。结果在此期间乳腺癌总新发病人4 021例,其中男性30例,女性3 991例,女性乳腺癌占同期女性新发恶性肿瘤的16.09%,位列第1位。女性乳腺癌粗发病率为68.63/10万,标化发病率为40.18/10万。女性乳腺癌的粗发病率(APC=3.50,P〈0.001)和标化发病率(APC=2.91,P〈0.001)逐年增长。40岁以后女性乳腺癌发病率迅速增加。因乳腺癌死亡1 422例,其中男性21例,女性1 401例。女性乳腺癌年均粗死亡率为24.09/10万,标化死亡率为11.04/10万。50岁之后死亡率上升。女性乳腺癌患者的5年生存率为80.93%,其中手术治疗组5年生存率为85.40%,高于非手术组71.81%(U=8.12,P〈0.001)。结论乳腺癌是城市女性人群的主要恶性肿瘤,手术治疗是影响患者生存的一个重要因素。 | 韩雪 谢梦 赵佳 丁一波 殷建华 张宏伟 曹广文 马立业 | 2015 | 中华疾病控制杂志2015，19，7： | 14 |
| 9 | 肺癌患者血清microRNA-21表达临床意义探讨显示文摘目的:探讨miRNA-21在肺癌患者血清中的表达及其在肺癌早期诊断的应用价值。方法:收集中山大学孙逸仙纪念医院2011-06-09-2012-10-06收治的90例肺癌患者、40例肺部良性疾病患者和90名健康体检人群作为研究对象,采用Taqman探针实时定量PCR对miRNA-21血清含量进行半定量测定,并依据肺癌患者和两对照组血清miRNA-21相对表达量,利用ROC曲线评价其在肺癌诊断上的灵敏度和特异度。结果:健康组、良性病变组和肺癌组miRNA-21血清平均表达量分别为0.70±0.49、1.38±0.67和1.86±0.85。肺癌患者miRNA-21血清水平显著高于健康对照组和良性肺部疾病组(LSD-t=10.918,P<0.001;LSD-t=3.523,P<0.001),其相对表达量与患者年龄(u=940.000,P=0.626)、性别(u=801.000,P=0.243)、病理类型(χ2=4.109,P=0.128)和临床分期(u=777.000,P=0.085)无关。ROC曲线下面积为0.808(0.750~0.866),当临界值取1.32时,其灵敏度为0.711,特异度为0.823。结论:肺癌患者血清miRNA-21水平显著升高,提示可能是肺癌诊断的潜在肿瘤标志之一。 | 胡俊庭 鲍蕴文 白艳 吴博 | 2014 | 中华肿瘤防治杂志2014，21，1： | 14 |
| 10 | 基于医护视角的老年肺癌患者围术期需求认知的质性研究显示文摘目的 通过医护的视角探讨老年肺癌手术患者围术期需求的认知情况,为改进老年肺癌患者围术期护理措施提供依据.方法 2016年6 —9月,采用目的抽样法选取17名医生和护士进行面对面半结构式访谈,现场录音,借助NVivo 8.0软件,根据Colaizzi 的7步分析法对资料进行分析,提炼主题.结果 基于医护视角的老年肺癌患者围术期需求的认知可归纳为4个主题:对患者社会支持系统的迫切需求;对围术期进行营养筛查的需求;自我照护与协助的需求;提升医患沟通能力的需求.结论 护理管理者应重视从医护人员的视角出发,满足老年肺癌患者围术期的需求,针对需求提出相应的干预措施,以提高老年肺癌患者围术期的护理质量. | 严晓霞 侯黎莉 丁君蓉 商丽艳 | 2018 | 中华现代护理杂志2018，24，8： | 13 |
| 11 | Expression of Rab25 correlates with the invasion and metastasis of gastric cancer显示文摘The objective of this study was to determine the expression of the important vesicle trafficking- regulating factor Rab25 in human gastric cancer tissues, to analyze the correlation between Rab25 protein expression with gastric cancer occurrence and development, and to discuss the correlation of Rab25 protein expression with gastric cancer cell metastasis. The overall aim was to provide experimental evidence that can be used to design future biological treatments of human gastric cancer. Human gastric cancer tissue and the adjacent normal gastric tissue were surgically removed, and immunohistochemistry and Western blotting were used to detect Rab25 protein expression. The correlation between Rab25 protein expression with the development and pathological characteristics of gastric cancer was analyzed. Using RNAi, Rab25 expression was reduced in the gastric cancer cell line MGC80-3, and the changes in MGC80-3 cell invasiveness were then monitored. Immunohistochemistry showed that the Rab25 protein expression rates were 78.21% and 23.08% in gastric carcinoma and the adjacent normal gastric tissue, respectively. Immunohistochemistry and Western blot results showed that Rab25 protein expression in gastric cancer was significantly higher than in adjacent normal gastric tissues (P<0.01). Less differentiated gastric cancer cells had higher expression of Rab25 protein (P<0.01). Gastric carcinomas from patients with a late pathological stage (III-IV) had significantly higher Rab25 protein expression than early stage (I-II) patients (P<0.01). Gastric carcinomas from patients with lymph node metastasis had significantly higher Rab25 protein expression than lymph node metastasis- free patients (P<0.01). Gastric carcinomas from patients with distant metastases had significantly higher Rab25 protein expression than the distant metastasis-negative patients (P<0.01). Rab25 protein expression in gastric cancer was not affected by the patients , sex, age, or tumor size (P>0.05). MGC80-3 cells transfected with Rab25 siRNA had significantly lower Rab25 protein expression (P<0.01) and a significantly lower number of cells that passed through a Transwell chamber compared with non-transfected controls and the transfected control group (P<0.01). Rab25 protein expression is associated with the development of gastric cancer. siRNA knockdown of Rab25 protein expression in MGC80-3 gastric cancer cells reduced MGC80-3 cell invasiveness and provided experimental evidence for potential future biological treatment strategies of human gastric cancer. | Chuanwu Cao Chenhui Lu Jichong Xu Jiaxing Zhang Jun Zhang Maoquan Li | 2013 | Chinese Journal of Cancer Research2013，25，2： | 12 |
| 12 | Updated experiences with minimally invasive Mc Keown esophagectomy for esophageal cancer显示文摘AIM: To update our experiences with minimally invasive Mc Keown esophagectomy for esophageal cancer.METHODS: we retrospectively reviewed the medical records of 445 consecutive patients who underwent minimally invasive Mc Keown esophagectomy between January 2009 and July 2015 at the Cancer Hospital of Chinese Academy of Medical Sciences and used 103 patients who underwent open Mc Keown esophagectomy in the same period as controls. Among 375 patients who underwent total minimally invasive Mc Keown esophagectomy, 180 in the early period were chosen for the study of learning curve of total minimally invasive Mc Keown esophagectomy. These 180 minimally invasive Mc Keown esophagectomies performed by five surgeons were divided into three groups according to time sequence as group 1(n = 60), group 2(n = 60) and group 3(n = 60).RESULTS: Patients who underwent total minimally invasive Mc Keown esophagectomy had significantly less intraoperative blood loss than patients who underwent hybrid minimally invasive Mc Keown esophagectomy or open Mc Keown esophagectomy(100 ml vs 300 ml vs 200 ml, P = 0.001). However, there were no significant differences in operation time, number of harvested lymph nodes, or postoperative morbidity includingincidence of pulmonary complication and anastomotic leak between total minimally invasive Mc Keown esophagectomy, hybrid minimally invasive Mc Keown esophagectomy and open Mc Keown esophagectomy groups. There were no significant differences in 5-year survival between these three groups(60.5% vs 47.9% vs 35.6%, P = 0.735). Patients in group 1 had significantly longer duration of operation than those in groups 2 and 3. There were no significant differences in intraoperative blood loss, number of harvested lymph nodes, or postoperative morbidity including incidence of pulmonary complication and anastomotic leak between groups 1, 2 and 3.CONCLUSION: Total minimally invasive Mc Keown esophagectomy was associated with reduced intraoperative blood loss and comparable short term and long term survival compared with hybrid minimally invasive Mc Keown esophagectomy or open Mckeown esophagectomy. At least 12 cases are needed to master total minimally invasive Mc Keown esophagectomy in a high volume center. | Ju-wei Mu Shu-geng gao Qi Xue You-Sheng Mao Da-li wang Jun Zhao Yu-Shun gao Jin-feng Huang Jie He | 2015 | World Journal of Gastroenterology2015，21，45： | 10 |
| 13 | Anti-EGFR and anti-VEGF agents:Important targeted therapies of colorectal liver metastases显示文摘Colorectal liver metastasis(CLM)is common worldwide.Targeted therapies with monoclonal antibodies have been proven effective in numerous clinical trials,and are now becoming standards for patients with CLM.Thedevelopment and application of anti-epidermal growth factor receptor(anti-EGFR)and anti-vascular endothelial growth factor(anti-VEGF)antibodies represents significant advances in the treatment of this disease.However,new findings continue to emerge casting doubt on the efficacy of this approach.The Kirsten ratsarcoma viral oncogene(KRAS)has been proven to be a crucial predictor of the success of anti-EGFR treatment in CLM.Whereas a recent study summarizedseveral randomized controlled trials,and showed thatpatients with the KRAS G13D mutation significantlybenefited from the addition of cetuximab in terms of progress-free survival(PFS,4.0 mo vs 1.9 mo,HR=0.51,P=0.004)and overall survival(OS,7.6 mo vs5.7 mo,HR=0.50,P=0.005).Some other studiesalso reported that the KRAS G13D mutation might notbe absolutely predictive of non-responsiveness to antiEGFR therapy.At the same time,'new'RAS mutations,including mutations in neuroblastoma RAS viral(vras)oncogene homolog(NRAS)and exons 3 and 4 of KRAS,have been suggested to be predictors of a poor treatment response.This finding was first reported by the update of the PRIME trial.The update showed that for patients with non-mutated KRAS exon 2 but other RAS mutations,panitumumab-fluorouracil,leucovorin,and oxaliplatin(FOLFOX)4 treatment led to inferior PFS(HR=1.28,95%CI:0.79-2.07)and OS(HR=1.29,95%CI:0.79-2.10),which was consistent with the findings in patients with KRAS mutations in exon 2.Then,the update of the PEAK trial and the FIRE-Ⅲtrial also supported this finding,which would reduce candidates for anti-EGFR therapy but enhance the efficacy.In firstline targeted combination therapy,the regimens of cetuximab plus FOLFOX was called into question because of the inferior prognosis in the COIN trial and the NORDIC-Ⅶtrial.Also,bevacizumab plus oxaliplatin-based chemotherapy was questioned because of the NO16966trial.By the update and further analysis of the COIN trial and the NORDIC-Ⅶtrial,cetuximab plus FOLFOX was reported to be reliable again.But bevacizumab plus oxaliplatin-based chemotherapy was still controversial.In addition,some trials have reported that bevacizumab is not suitable for conversion therapy.The results of the FIRE-Ⅲtrial showed that cetuximab led to a significant advantage over bevacizumab in response rate(72%vs 63%,P=0.017)for evaluable population.With the balanced allocation of second-line treatment,the FIRE-Ⅲtrial was expected to provide evidence for selecting following regimens after first-line progression.There is still no strong evidence for the efficacy of targeted therapy as a preoperative treatment for resectable CLM or postoperative treatment for resected CLM,although the combined regimen is often administered based on experience.Combination therapy with more than one targeted agent has been proven to provide no benefit,and even was reported to be harmful as first-line treatment by four large clinical trials.However,recent studies reported positive results of erlotinib plus bevacizumab for maintenance treatment.The mechanism of antagonism between different targeted agents deserves further study,and may also provide greater understanding of the development of resistance to targeted agents. | Qing-Yang Feng Ye Wei Jing-Wen Chen Wen-Ju Chang Le-Chi Ye De-Xiang Zhu Jian-Min Xu | 2014 | World Journal of Gastroenterology2014，20，15： | 10 |
| 14 | 2011年石河子市恶性肿瘤发病和死亡流行特征显示文摘目的随着我国经济发展和居民生活行为模式的转变,恶性肿瘤发病率和死亡率有升高的趋势。了解2011年石河子市肿瘤发病与死亡的流行特征,为肿瘤的预防控制提供科学依据。方法根据石河子市肿瘤登记处2011年登记的恶性肿瘤发病及死亡资料,统计和分析肿瘤粗发病率、粗死亡率、年龄别发病率、年龄别死亡率、中标率及世标率指标。结果 2011年石河子市肿瘤新发病例1 151例,死亡病例516例。肿瘤发病率为199.77/10万(男225.37/10万,女173.88/10万),中标率和世标率分别为88.00/10万和117.21/10万;肿瘤死亡率为89.56/10万(男106.30/10万,女72.62/10万),中标率和世标率分别为44.52/10万和57.25/10万。男性肿瘤发病率和死亡率均高于女性,且随着年龄的增长而升高。乳腺癌、肺癌、胃癌和肝癌等是石河子常见的恶性肿瘤;肺癌、乳腺癌和结直肠癌是石河子主要的肿瘤死因。结论石河子市肿瘤发病率较高,男性肿瘤发病率与死亡率均高于女性,应加强肿瘤综合防控措施,有效降低石河子市肿瘤流行水平。 | 张学飞 姜新华 庞丽娟 陈云召 贾丽萍 李述刚 | 2015 | 中华肿瘤防治杂志2015，22，20： | 8 |
| 15 | 我国乳腺癌预防若干问题的思考显示文摘乳腺癌已是中国公共卫生的重大问题,是中国女性发病率最高的恶性肿瘤,预计未来10~20年的发病率仍会处于上升趋势[1-3]。基于中国有6.8亿女性人口(高于美国和欧盟女性人口总和)[4-5],中国女性乳腺癌的发病特征、社会、文化、经济、医疗体系、医疗资源、医疗保险等情况显著不同于美欧国家[6],显然不宜照搬美欧乳腺癌预防模式,我国乳腺癌的预防面临着巨大的挑战。 | 瞿亚军 吕青 | 2020 | 中国普外基础与临床杂志2020，27，11： | 8 |
| 16 | Sox4表达抑制对宣威地区女性肺癌细胞凋亡影响及其机制的探讨显示文摘目的:研究靶向抑制sox4基因的表达对宣威地区女性肺癌细胞凋亡的影响,并初步探讨其作用机制。方法:构建靶向抑制转录因子sox4的shRNA重组载体pGFP-V-RS-sox4shRNA并转染宣威地区女性肺癌细胞XWLC-05,以转染pGFP-V-RS-scramshRNA的XWLC-05细胞及亲本XWLC-05细胞作为对照,研究sox4表达抑制对Caspase-3表达、细胞形态、细胞周期和凋亡率等凋亡指标的影响。使用Caspase-3抑制剂z-VAD-FMK处理转染细胞,检测上述细胞凋亡指标。结果:成功构建了能高效抑制sox4基因表达的pGFP-V-RS-A-sox4shRNA重组载体;转染后48及72h,实验组细胞sox4mRNA表达水平分别为0.09±0.018及0.44±0.06,比转染后24h降低了88%和40%,与同一时段中的阴性对照及空白对照组相比表达水平明显降低(P<0.05),其中以转染后48h的抑制最为明显,而Caspase-3mRNA表达与阴性对照及空白对照组相比均明显升高(P<0.05),以48h升高最明显;空白对照组与阴性对照组间比较,转染48及72h后sox4mRNA(P=0.071;P=0.063)和Caspase-3mRNA(P=0.103;P=0.229)的表达水平差异无统计学意义;抑制sox4基因的表达后细胞出现典型的凋亡形态学改变;流式细胞术(FCM)检测显示,转染干扰质粒后48h,细胞出现明显的亚二倍体峰,实验组细胞的凋亡率平均为(34.8±3.37)%,显著高于阴性对照组(0.45±0.05)%及空白对照组(0.44±0.06)%,P均为0.000。经z-VAD-FMK阻断Caspase-3酶活性后,实验组细胞中活化的Caspase-3(13.6±1.76)%显著低于阴性对照组(50.5±6.15)%,差异有统计学意义,P=0.000;实验组细胞的凋亡率(10.8±1.05)%也明显低于阴性对照组细胞(38.3±3.16)%,P=0.000。结论:抑制sox4的表达可促进宣威地区女性肺癌细胞凋亡;转录因子sox4可能通过抑制Caspase-3依赖的凋亡途径而促进宣威地区女性肺癌的发生发展。 | 周永春 陈艳 王熙才 黄尤光 金从国 姚乾 杨世华 刘馨 黄云超 | 2013 | 中华肿瘤防治杂志2013，20，8： | 8 |
| 17 | 乳腺肿瘤超声造影无灌注区的病理基础探讨显示文摘目的:探讨乳腺肿瘤超声造影无灌注区的临床意义及其发生的病理基础。方法:回顾性分析120例乳腺肿瘤的超声造影动态图像,仔细观察这些图像中是否出现无灌注区,并进一步分析无灌注区的面积和部位等相应参数,研究其与肿块大小及病理结果中出现的特征性表现(坏死、出血、钙化和黏液样变)的相关性。结果:120例乳腺肿瘤超声造影图像中,93例出现无灌注区,在良恶性之间存在统计学差异(P=0.000,r=0.442),出现无灌注区与坏死之间有统计学差异(P=0.000,r=0.336)。但是无灌注区面积及部位与肿瘤大小,肿瘤良恶性及各种病理改变之间均无统计学意义(P>0.05)。结论:超声造影无灌注区的出现有助于乳腺癌的诊断、坏死等病理变化为其提供病理基础。有关无灌注区发生发展深入的病理基础尚有待于进一步的大样本研究。 | 贾宛儒 费晓春 唐蕾 丛阳 陈曼 | 2015 | 中国医学计算机成像杂志2015，21，2： | 7 |
| 18 | 卵巢癌患者PTEN蛋白表达及其与预后的关系显示文摘目的探讨卵巢癌患者磷酸酶及张力蛋白同源物(phosphatase and tensin homolog,PTEN)蛋白表达及其与预后的关系。方法选取2013年8月至2018年6月间西安市中医医院收治的59例卵巢癌患者及40例卵巢交界性肿瘤,分别纳入卵巢癌组与交界组。采用免疫组化法检测两组患者病理组织PTEN蛋白表达情况,同时随访调查患者的预后并进行影响因素分析。结果卵巢癌组的PTEN表达阳性率为40. 7%,显著低于交界组的90. 0%,差异有统计学意义(P <0. 05)。PTEN阳性患者的总生存时间与无进展生存时间都显著高于PTEN阴性患者,差异均有统计学意义(均P <0. 05)。PTEN表达阳性与卵巢癌组患者总生存时间和无进展生存时间呈现显著相关性,差异均有统计学意义(均P <0. 05);多因素Logistic回归方法显示,PTEN表达阴性、临床分期、分化程度和淋巴结转移为影响卵巢癌患者总生存时间的相关因素,差异均有统计学意义(均P <0. 05)。结论卵巢癌患者PTEN蛋白呈现低表达状况,PTEN蛋白较低表达患者预后较差,PTEN蛋白低是影响患者预后的重要因素。 | 苗芸 刘静 申月玲 | 2019 | 中国肿瘤临床与康复2019，0，9： | 6 |
| 19 | Diagnosis and management of acute complications in patients with colon cancer:bleeding,obstruction,and perforation显示文摘Among the colorectal cancers, the incidence of colon cancer has obviously increased. As a result, the actual incidence of colon cancer has exceeded that of rectal cancer, which dramatically changed the longexisting epidemiological profile. The acute complications of colon cancer include bleeding, obstruction, and perforation, which were among the common acute abdominal surgical conditions. The rapid and accurate diagnosis of these acute complications was very important, and laparoscopic techniques can be applied in abdominal surgery for management of the complications. | Xue-Fei Yang Kai Pan | 2014 | Chinese Journal of Cancer Research2014，26，3： | 6 |
| 20 | 基于自我效能干预方案对肝癌介入患者生活质量的影响显示文摘目的探讨基于自我效能干预方案对肝癌介入患者生活质量的影响。方法选取接受肝癌介入治疗的患者86例,按照随机数字表法将患者随机分为试验组与对照组,每组各43例,其中对照组患者接受常规护理,试验组患者在常规护理的基础上进行自我效能干预,比较两组患者疲乏、疼痛和生命质量评分的差异。结果干预后,两组患者的疲乏程度比较,差异有统计学意义(P﹤0.05);干预后,试验组患者疼痛程度与对照组比较,差异有统计学意义(P﹤0.05);干预后,试验组患者角色功能、情绪功能、认知功能、社会功能、躯体功能和总体生活质量评分均高于对照组(P﹤0.05)。结论自我效能干预可以大大减轻肝癌介入患者疲乏和疼痛程度,增强患者角色、情绪、认知、社会、躯体功能,进而提高患者生活质量。 | 曾蓉 先升萍 | 2016 | 癌症进展2016，14，12： | 6 |
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