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| 1 | 植物免疫研究与抗病虫绿色防控:进展、机遇与挑战显示文摘植物免疫学是研究植物与病原生物互作的学科.同动物一样,植物也具有强大的先天免疫系统,其本质是通过对病毒、细菌、真菌、卵菌、线虫、昆虫、寄生植物等病原生物的识别激活防卫反应,拒阻病原生物的侵害;而病原生物则能够逃避或抑制宿主植物的识别和防卫反应,在植物上引起病虫害.20年来,我国植物免疫研究取得巨大进步,与国际同行相比,在多个研究方向实现了并跑,在少数方向实现了领跑,为农作物病虫害绿色防控提供了理论支撑和新的技术手段. | 张杰 董莎萌 王伟 赵建华 陈学伟 郭惠珊 何光存 何祖华 康振生 李毅 彭友良 王国梁 周雪平 王源超 周俭民 | 2019 | 中国科学:生命科学2019，49，11： | 43 |
| 2 | A cyclic nucleotide-gated channel mediates cytoplasmic calcium elevation and disease resistance in rice显示文摘The transient elevation of cytoplasmic calcium is essential for pathogen-associated molecular pattern(PAMP)-triggered immunity(PTI).However,the calcium channels responsible for this process have remained unknown.Here,we show that rice CDSI(CELL DEATH and SUSCEPTIBLE to BLAST 1)encoding OsCNGC9;a cyclic nucleotide-gated channel protein,positively regulates the resistance to rice blast disease.We show that OsCNGC9 mediates PAMP-induced Ca2+influx and that this event is critical for PAMPs-triggered ROS burst and induction of PTI-related defense gene expression.We further show that a PTI related receptor-lih cytoplasmic kinase OsRLCK185 physically interacts with and phosphorylates OsCNGC9 to activate its channel activity.Our results suggest a signaling cascade linking pattern recognition to calcium channel activation,which is required for initiation of PTI and disease resistance in rice. | Jiachang Wang Xi Liu An Zhang Yulong Ren Fuqing Wu Gang Wang Yang Xu Cailin Lei Shanshan Zhu Tian Pan Yongfei Wang Huan Zhang Fan Wang Yan-Qiu Tan Yupeng Wang Xin Jin Sheng Luo Chunlei Zhou Xiao Zhang Jinling Liu Shuai Wang Lingzhi Meng Yihua Wang Xi Chen Qibing Lin Xin Zhang Xiuping Guo Zhijun Cheng Jiulin Wang Yunlu Tian Shijia Liu Ling Jiang Chuanyin Wu Ertao Wang Jian-Min Zhou Yong-Fei Wang Haiyang Wang Jianmin Wan | 2019 | Cell Research2019，29，10： | 13 |
| 3 | Plant Immune Mechanisms:From Reductionistic to Holistic Points of View显示文摘After three decades of the amazing progress made on molecular studies of plant-microbe interactions(MPMI),we have begun to ask ourselves'what are the major questions still remaining?'as if the puzzle has only a few pieces missing.Such an exercise has ultimately led to the realization that we still have many more questions than answers.Therefore,it would be an impossible task for us to project a coherent'big picture'of the MPMI field in a single review.Instead,we provide our opinions on where we would like to go in our research as an invitation to the community to join us in this exploration of new MPMI frontiers. | Jie Zhang Gitta Coaker Jian-Min Zhou Xinnian Dong | 2020 | Molecular Plant2020，13，10： | 13 |
| 4 | Plant immune signaling: Advancing on two frontiers显示文摘Plants have evolved multiple defense strategies to cope with pathogens, among which plant immune signaling that relies on cell-surface localized and intracellular receptors takes fundamental roles. Exciting breakthroughs were made recently on the signaling mechanisms of pattern recognition receptors(PRRs) and intracellular nucleotide-binding site(NBS) and leucine-rich repeat(LRR)domain receptors(NLRs). This review summarizes the current view of PRRs activation, emphasizing the most recent discoveries about PRRs’ dynamic regulation and signaling mechanisms directly leading to downstream molecular events including mitogen-activated protein kinase(MAPK) activation and calcium(Ca2+) burst. Plants also have evolved intracellular NLRs to perceive the presence of specific pathogen effectors and trigger more robust immune responses. We also discuss the current understanding of the mechanisms of NLR activation, which has been greatly advanced by recent breakthroughs including structures of the first full-length plant NLR complex, findings of NLR sensor-helper pairs and novel biochemical activity of Toll/interleukin-1 receptor(TIR) domain. | Wei Wang Baomin Feng Jian-Min Zhou Dingzhong Tang | 2020 | Journal of Integrative Plant Biology2020，62，1： | 11 |
| 5 | 蛋白磷酸化修饰在植物-病原微生物互作中的作用研究进展显示文摘蛋白磷酸化修饰是植物细胞信号调控的普遍机制。植物-病原微生物互作过程中,关键调控蛋白的磷酸化状态影响免疫信号的激活。多种病原微生物通过干扰宿主蛋白的磷酸化状态攻击免疫系统,以提高致病性。该文对植物免疫调控过程中关键元件的磷酸化修饰及其在免疫信号中的调控作用进行了综述。研究植物-病原菌互作过程中关键蛋白的磷酸化修饰,有助于深入探讨植物-病原微生物互作的分子机理。该文将为寻找广谱抗病的新途径提供理论依据。 | 刘雅琼 侯岁稳 | 2019 | 植物学报2019，0，2： | 8 |
| 6 | Control of grain size by G protein signaling in rice显示文摘Heterotrimeric G proteins are involved in multiple cellular processes in eukaryotes by sensing and transducing various signals. G protein signaling in plants is quite different from that in animals, and the mechanisms of plant G protein signaling are still largely unknown. Several recent studies have provided new insights into the mechanisms of G protein signaling in rice grain size and yield control. In this review,we summarize recent advances on the function of G proteins in rice grain size control and discuss the potential genetic and molecular mechanisms of plant G protein signaling. | Ran Xu Na Li Yunhai Li | 2019 | Journal of Integrative Plant Biology2019，61，5： | 5 |
| 7 | 固醇合成途径关键基因SMT2、SMT3在植物免疫中的功能研究显示文摘植物固醇是细胞膜和膜筏的重要组分,与膜的稳定性密切相关。SMT2 (sterol methyltransferase 2)和SMT3 (sterol methyltransferase 3)是植物固醇合成途径中的关键基因,已有研究表明SMT2和SMT3基因在植物的生长发育中发挥重要作用。为探究SMT2和SMT3基因在植物免疫中的功能,采用细胞生物学、植物生理学等手段,分析smt2、smt3突变体在flg22诱导的防御反应中的作用。研究结果显示:与野生型相比,flg22诱导的smt2、smt3突变体产生的活性氧显著增加(高达50%);此外,flg22诱导smt2、smt3突变体中胼胝质沉积显著减少,减少量约为野生型的30%-40%。更为重要的是,flg22处理可以抑制野生型植株根的生长,而在smt2、smt3突变体中这种抑制作用相对减弱。以上这些结果表明,固醇在flg22诱导的植物免疫过程中起到了重要的作用,这一研究结果将为深入理解植物天然免疫的机制提供了新的依据。 | 钱虹萍 林金星 崔亚宁 | 2021 | 电子显微学报2021，40，2： | 2 |
| 8 | 植物模式识别受体FLS2的研究进展显示文摘植物通过模式识别受体识别病原微生物保守的分子,开启第一层次免疫屏障,以此实现对各种微生物的非寄主抗性和产生基础防御。第一个被鉴定的植物模式识别受体是识别细菌鞭毛蛋白的拟南芥FLS2,围绕FLS2的大量研究为其他模式识别受体的研究提供了范例,促进了植物免疫理论的建立和发展。通过介绍FLS2的发现过程、命名过程的插曲、结构与功能、激活步骤与相关元件、调控的分子机制、FLS2与病原微生物效应因子的相互作用以及FLS2在被子植物中的系统发生关系,对FLS2研究中显现的蛋白污染和C末端标签问题进行了分析,并介绍了依靠遗传转化植物模式识别受体基因,培育广谱耐久抗病植物的前景。 | 肖红菊 程强 | 2020 | 南京林业大学学报(自然科学版)2020，44，2： | 2 |
| 9 | BAK1-mediated phosphorylation of canonical G protein alpha during flagellin signaling in Arabidopsis显示文摘Heterotrimeric G proteins consisting of Gα,Gβand Gγare conserved signaling hubs in eukaryotes.Without analogs to canonical animal G protein-coupled receptors,plant cells are thought to use RGS1 and a yet unknown mechanism to regulate the activity of Gα.Meanwhile,the exact role of canonical Gαin plant innate immunity remains controversial.Here,we report multiple immune deficiencies in the null allele of Arabidopsis Gα(GPA1)in response to bacterial flg22 elicitor,clarifying a positive regulatory role of GPA1 in flg22 signaling.We also detect overall increased phosphorylation of GPA1 but reduced phosphorylation at Thr^19 upon flg22 elicitation.Interestingly,flg22 could not induce phosphorylation of GPA1 T19 Aand GPA1 T19D,suggesting that the dynamic Thr^19 phosphorylation is required for GPA1 to respond to flg22.Moreover,flg22-induced GPA1 phosphorylation is largely abolished in the absence of BAK1 in vivo,and BAK1 could phosphorylate GPA1 but not GPA1^T19A in vitro at the phosphorylation sites identified in vivo,suggesting BAK1 is likely the kinase for GPA1 phosphorylation in response to flg22.Furthermore,the T19A mutation could promote flg22-induced association,rather than dissociation,between GPA1 and RGS1.Taken together,our findings shed new insights into the function and regulation of GPA1 in Arabidopsis defense signaling. | Jiao Xue Ben-Qiang Gong Xinran Yao Xiangjuan Huang Jian-Feng Li | 2020 | Journal of Integrative Plant Biology2020，62，5： | 2 |
| 10 | 模式识别受体的胞内转运及其在植物免疫中的作用显示文摘植物利用细胞表面模式识别受体(PRRs)来感知病原相关分子模式(PAMPs),进而触发自身的免疫反应(PTI)。在植物免疫过程中,PRRs在细胞内的正确定位对其生理功能的发挥至关重要。PRRs蛋白可以在内质网(ER)上合成,并通过胞吐被分泌到质膜(PM)上。此外,PRRs蛋白也可以通过胞吞进行胞内循环或降解。细胞可以通过胞内转运降解PRRs蛋白以终止信号转导,也可以通过形成胞内体进行信号传递。该文概述了PRRs蛋白及其配体的研究进展以及PRRs蛋白的胞内转运在植物免疫中的重要作用。 | 崔亚宁 钱虹萍 赵艳霞 李晓娟 | 2020 | 植物学报2020，55，3： | 1 |
| 11 | 鸟苷酸结合蛋白4在多种肿瘤中的作用及分子机制研究进展显示文摘恶性肿瘤是严重影响人类健康的一大顽疾,其发病率和死亡率在全球逐年增长。近年来,靶向基因治疗肿瘤的研究已取得较大突破。其中,鸟苷酸结合蛋白4(GTPBP4)是最新发现的一种肿瘤相关基因,定位于细胞核,可表达为具有GTP水解酶活性的蛋白质,并与细胞生物核糖体合成、细胞增殖等生物学过程息息相关。研究发现GTPBP4过表达的恶性肿瘤患者往往预后较差,沉默GTPBP4基因则可降低肿瘤细胞的侵袭、迁移及增殖等能力。本文主要对GTPBP4在多种肿瘤发生、发展过程中的功能及分子机制作一综述,以期为进一步研究和运用GTPBP4靶向治疗肿瘤提供理论参考。 | 张枝倩 王娟 王伟 | 2020 | 浙江医学2020，42，12： | 0 |
| 12 | 植物异三聚体G蛋白研究进展显示文摘植物细胞中的异三聚体G蛋白信号转导系统包括异三聚体G蛋白、G蛋白偶联受体、类受体激酶、G蛋白信号调节因子等,这些信号转导组分在感受物理及化学刺激、启动细胞内信号级联反应、调控细胞内代谢和基因表达过程中发挥重要作用.异三聚体G蛋白参与调控植物生长发育(如胚胎形成、营养器官生长、有性生殖等)、植物对生物及非生物胁迫的响应、根瘤形成等过程.因此,异三聚体G蛋白信号系统组分参与调控多种农作物的农艺性状,并最终影响农产品的产量和品质.对植物异三聚体G蛋白的结构、活化机制和生理功能等方面近年来取得的研究进展进行了回顾和总结. | 尚忠林 康二芳 李雨珂 付玉 | 2024 | 河北师范大学学报(自然科学版)2024，48，1： | 0 |
| 13 | AtRGS1胞吞动态调控G蛋白参与拟南芥生长发育和抗性反应显示文摘异源三聚体G蛋白由Gα、Gβ和Gγ 3个亚基组成,是普遍存在于真核细胞中的跨膜信号转导因子。植物细胞通过定位于细胞质膜的G蛋白信号调节子RGS蛋白(regulator of G protein signaling),调控异源三聚体G蛋白的活性,进而参与生长发育、激素和糖信号转导以及抗病反应等多个重要生物学过程。膜蛋白可通过胞吞循环调控其在细胞质膜上的数量,以响应外界环境因子和自身发育信号。近年来,研究表明多种外界信号诱导拟南芥AtRGS1蛋白的胞吞,进而促进其与Gα亚基的解离,游离的Gα-GTP、Gβγ亚基和定位于内含体的AtRGS1蛋白均可能调控下游信号转导,进而影响相应生物学过程。本文综述了AtRGS1通过胞吞作用调控G蛋白参与的生长发育和抗性反应的分子细胞学机制研究进展,以期为深入理解G蛋白信号调节子影响植物发育进程和抗性反应的作用机制提供理论参考,为植物膜蛋白胞吞调控信号转导提供新的视角。 | 古盼 齐学影 李莉 张曦 单晓昳 | 2022 | 生物技术通报2022，38，6： | 0 |
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