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| 1 | 中药材上农药应用现状及其炮制加工过程对农药残留的影响显示文摘中医药是我国独特的医药资源,中药材作为中医药的重要组成部分,其质量安全广受关注。在中药材病虫草害防治过程中,由于农药不规范使用导致的农药残留问题直接影响着中药材产品质量安全甚至出口贸易。本文对我国中药材上农药登记情况及残留限量(maximum residue limit,MRL)标准进行了概述,并重点归纳了炮制加工过程对中药材中农药残留的影响,同时就中药材上农药使用和管理等方面的相关问题进行了讨论,提出了降低农药残留污染的相关措施。旨在明确中药材从采收到入口全过程中农药残留的变化规律,以期为加强对中药材中农药残留的控制,降低农药残留污染风险以及为我国中药材上农药使用和管理提供参考。 | 郭璐瑶 董丰收 李远播 徐军 刘新刚 吴小虎 郑永权 | 2021 | 农药学学报2021，23，4： | 17 |
| 2 | 中药材中常见农药残留及其研究进展显示文摘中药材是我国传统的宝贵资源,因其天然、疗效确切的特点备受国内外青睐。在中药材种植和生长过程中常需要使用大量农药来预防和治理中药材中各类病虫害,以达到提高中药材产量、保证中药材质量的目的。作为一类用于防治病虫害及调节植物生长的化学药剂,大部分农药可通过内吸、胃毒、触杀、熏蒸等多种方式起到很好的除虫害效果,特别是内吸性农药,能够通过进入中药材体内从而杀灭隐藏害虫,虽然防虫效果良好,但残留在中药材中的内吸性农药也难以通过简单清洗去除,为中药材的安全埋下了较大的隐患。同时,若过量或不规范使用农药都将导致中药材中出现严重的农药残留问题,这不仅会影响中药材的质量和药效,危害人类健康,同时也影响了中药行业的国际化发展。当前中药材中的农药残留问题已经成为影响国内中药材行业发展的瓶颈,同样也阻碍着中药材的出口贸易。因此,研究对中药材中的农药残留如何进行快速、灵敏、精准检测和脱除具有重要意义。该文综述了近年来中药材中常见农药残留的特点、危害以及检测方法和脱除技术,并对其检测和脱除技术的发展进行展望,旨在为中药材中农药残留检测技术和质量控制提供参考,有效保证中药材质量安全,并进一步促进中药产业健康发展。 | 任理雪 邓高琼 龙婉君 陈亨业 郭兰萍 杨健 付海燕 | 2022 | 中国中药杂志2022，47，11： | 14 |
| 3 | 基于网络药理学和分子对接技术的化湿败毒方抗新型冠状病毒肺炎(COVID-19)的潜在机制研究显示文摘目的:通过网络药理学研究化湿败毒方抗COVID-19的潜在作用机理并辅以分子对接验证。方法:基于TCMSP、GeneCard、String等数据库以及Cytoscape、AutoDockVina等软件,构建网络关系,通过分子对接计算活性成分与靶点蛋白的结合能力,进行生物功能富集分析。结果:与3CL水解酶(3CLpro)和血管紧张素转换酶2(ACE2)受体强亲和力的成分有槲皮素、黄芩素、黄芪甲苷、汉黄芩素等成分;筛选得到的25个活性成分与IL-6、IL-1β、NOS2、CCL2等靶点都有较强的亲和力。生物功能富集分析主要聚焦于Th17、Th1和Th2细胞分化、NF-κB、MAPK、TNF、IL-17等信号通路。结论:化湿败毒方活性成分可抑制SARS-CoV-2病毒的侵染与复制,调节RAS系统平衡、3抑制过激的免疫炎症反应,阻止炎症风暴出现来抗COVID-19。 | 宋红新 王汉 马旭冉 王敦方 王彦礼 邹迪新 苗金雪 杨伟鹏 | 2020 | 海南医学院学报2020，26，23： | 9 |
| 4 | Isochlorogenic acid(ICGA): natural medicine with potentials in pharmaceutical developments显示文摘Natural products have attracted a great deal of attention as significant resources in traditional Chinese medicine(TCM)and in chemical medicine, as well as in cosmetic ingredients, nutraceuticals and food products. Isochlorogenic acid(ICGA), which has medicinal value, has been discovered in various plants. As a widespread natural medicine, ICGA should be the subject of further research and development. However, there have been no systematic analyses of ICGA. According to our investigation, ICGA was initially isolated from green coffee extracts by Barnes et al. in 1950. To date, it has been discovered in a variety of tea, vegetables, medicinal diet and TCM materials. ICGA is used as a chemical marker for the quality control of these TCM materials. The metabolic process of ICGA has been studied in detail, conforming to be linear dynamics. Thus, the clear pharmacokinetics of ICGA offers a solid foundation for its research and development. ICGA has multiple biological and pharmacological effects, and studies have mainly focused on its antioxidant, anti-inflammatory, antimicrobial, hypoglycemic, neuroprotective, and cardiovascular protective effects, and hepatoprotective properties. The mechanisms underlying these effects are summarized in this review to provide scientific support and inspiration for the future research and development of ICGA and ICGA-rich natural products. | WANG Hao-Nan SHEN Zheng LIU Qing HOU Xiao-Ying CAO Yan LIU Da-Hui JIANG Hong DU Hong-Zhi | 2020 | Chinese Journal of Natural Medicines2020，18，11： | 9 |
| 5 | Natural products as LSD1 inhibitors for cancer therapy显示文摘Natural products generally fall into the biologically relevant chemical space and always possess novel biological activities, thus making them a rich source of lead compounds for new drug discovery. With the recent technological advances, natural product-based drug discovery is now reaching a new era. Natural products have also shown promise in epigenetic drug discovery, some of them have advanced into clinical trials or are presently being used in clinic. The histone lysine specific demethylase1(LSD1), an important class of histone demethylases, has fundamental roles in the development of various pathological conditions. Targeting LSD1 has been recognized as a promising therapeutic option for cancer treatment. Notably, some natural products with different chemotypes including protoberberine alkaloids, flavones, polyphenols, and cyclic peptides have shown effectiveness against LSD1. These natural products provide novel scaffolds for developing new LSD1 inhibitors. In this review, we mainly discuss the identification of natural LSD1 inhibitors, analysis of the co-crystal structures of LSD1/natural product complex, antitumor activity and their modes of action. We also briefly discuss the challenges faced in this field. We believe this review will provide a landscape of natural LSD1 inhibitors. | Yuan Fang Chao Yang Zhiqiang Yu Xiaochuan Li Qingchun Mu Guochao Liao Bin Yu | 2021 | Acta Pharmaceutica Sinica B2021，11，3： | 6 |
| 6 | Traditional Chinese medicine for combating COVID-19显示文摘COVID-19 is an emerging,rapidly evolving pandemic caused by severe acute respiratory syndrome coronavirus 2(SARS-CoV-2).Due to its distinctive features in etiology,epidemiology and pathology,this infectious disease poses considerable diagnostic and therapeutic challenge[1].Patients with COVID-19 mainly receive supportive care and symptom management. | Kaixian Chen Hongzhuan Chen | 2020 | Frontiers of Medicine2020，14，5： | 5 |
| 7 | 氯喹药理特点及用于新型冠状病毒肺炎治疗的建议显示文摘2019年底,我国湖北省武汉市出现了新型冠状病毒肺炎疫情,随后在全国扩散并成为全球大流行。由于尚无针对新型冠状病毒的特效治疗药物和疫苗,我国新型冠状病毒感染救治临床专家团队在救治新型冠状病毒感染患者的同时,积极研究和筛选有效抗病毒治疗药物,发现一种古老的抗疟药--氯喹有一定抗新型冠状病毒效果,随后纳入我国新型冠状病毒肺炎诊疗方案。目前,临床应用的是氯喹衍生物磷酸氯喹和硫酸羟氯喹,这两种药物虽药理机制相近,但其治疗对象、疗效和不良反应均存在一定差异。本文拟通过对氯喹类药物已有研究和在疟疾临床治疗中的经验总结,为我国临床专家更科学合理地使用氯喹类药物进行新型冠状病毒肺炎治疗提供参考。 | 高琪 | 2020 | 中国血吸虫病防治杂志2020，32，2： | 4 |
| 8 | Recent insights for the emerging COVID-19:Drug discovery,therapeutic options and vaccine development显示文摘SARS-CoV-2 has been marked as a highly pathogenic coronavirus of COVID-19 disease into the human population,causing over 5.5 million confirmed cases worldwide.As COVID-19 has posed a global threat with significant human casualties and severe economic losses,there is a pressing demand to further understand the current situation and develop rational strategies to contain the drastic spread of the virus.Although there are no specific antiviral therapies that have proven effective in randomized clinical trials,currently,the rapid detection technology along with several promising therapeutics for COVID-19 have mitigated its drastic transmission.Besides,global institutions and corporations have commenced to parse out effective vaccines for the prevention of COVID-19.Herein,the present review will give exhaustive details of extensive researches concerning the drug discovery and therapeutic options for COVID-19 as well as some insightful discussions of the status of COVID-19. | Yuefei Zhu Jia Li Zhiqing Pang | 2021 | Asian Journal of Pharmaceutical Sciences2021，16，1： | 4 |
| 9 | 抗病毒药物治疗COVID-19的研究进展:临床试验的系统综述显示文摘目的:探讨抗病毒药物治疗新型冠状病毒肺炎(coronavirus disease 2019,COVID-19)的有效性和安全性。方法:计算机检索PubMed、Embase、medRxiv、中国知网、中国临床试验注册中心、Clinical trials.gov等数据库截止至2020年4月29日有关新型冠状病毒肺炎抗病毒治疗的临床试验,对试验结果进行系统综述。结果:共纳入20项研究,随机对照研究8项,非随机对照研究3项,回顾性队列研究3项,回顾性病例系列研究4项,观察性研究2项,合计2299例患者。评价的药物包括瑞德西韦、洛匹那韦/利托那韦、羟氯喹、法匹拉韦、阿比多尔、达诺瑞韦、疏风解毒胶囊和连花清瘟胶囊(颗粒)。所评价的抗病毒药物均未在临床试验中展现出对COVID-19的优越疗效。中成药疏风解毒胶囊和连花清瘟胶囊(颗粒)能明显改善轻型和普通型患者临床症状,提高治疗效果。安全性方面,需要特别关注洛匹那韦/利托那韦的胃肠道不良反应和瑞德西韦的严重不良反应。结论:目前暂无特效药,重型患者早期可试用瑞德西韦或采用2种以上抗病毒药物联合治疗,轻型和普通型患者可加用中成药辅助治疗。需要更高质量,大样本随机对照试验进一步验证瑞德西韦、羟氯喹、法匹拉韦等药物的疗效。 | 吴燕子 周强 薛源 周国华 黄晓晖 | 2020 | 中国医院药学杂志2020，40，20： | 3 |
| 10 | 新型冠状病毒疫情下武汉雷神山医院药品供应保障实践与思考显示文摘目的:分享新型冠状病毒肺炎(COVID-19)疫情下武汉雷神山医院药品供应保障的实践与经验,为医疗机构应对突发重大公共卫生事件提供参考。方法:从药房区域划分、药品供应与调剂、药品保管、消毒制剂管理,人员培训以及特殊管理药品信息化调剂等方面总结雷神山医院药学部门在COVID-19疫情下的药品供应保障情况。结果:根据防控要求对药库进行区域划分,不同区域执行有区别的消毒管理;对上岗人员进行防控知识培训,截止雷神山医院闭院,药学部门'0'感染;保障药品持续供应,并做好药品的保管工作,根据病区药物治疗情况积极调整药品供应目录,满足病区用药需求;提供消毒制剂的供应,并指导使用和储存;创新特殊管理药品无纸化调剂方式,减少人员接触。结论:雷神山医院药品供应保障工作是专业性极强、涉及范围极广的复杂性工作,雷神山医院药学部门在做好自身防控的情况下积极调整、创造、创新,制定出了一系列适合疫情防控的药品供应保障策略,并充分发挥药学人员的职责打赢了这场疫情防控战。 | 钟建勋 王涛 林红 罗国庆 张世应 曾晖 雷云 卢凯 朱玉立 庞丽艳 刘亮 汪辰龙 程虹 | 2020 | 中国药师2020，23，11： | 2 |
| 11 | Classic mechanisms and experimental models for the anti-inflammatory effect of traditional Chinese medicine显示文摘Inflammation is a common disease involved in the pathogenesis,complications,and sequelae of a large number of related diseases,and therefore considerable research has been directed toward developing anti-inflammatory drugs for the prevention and treatment of these diseases.Traditional Chinese medicine(TCM)has been used to treat inflammatory and related diseases since ancient times.According to the re-view of abundant modern scientific researches,it is suggested that TCM exhibit anti-inflammatory effects at different levels,and via multiple pathways with various targets,and recently a series of in vitro and in vivo anti-inflammatory models have been developed for anti-inflammation research in TCM.Currently,the reported classic mechanisms of TCM and experimental models of its anti-inflammatory effects pro-vide reference points and guidance for further research and development of TCM.Importantly,the research clearly confirms that TCM is now and will continue to be an effective form of treatment for many types of inflammation and inflammation-related diseases. | Du Hongzhi Hou Xiaoying Guo Yujie Chen Le Miao Yuhuan Liu Dahui Huang Luqi | 2022 | Animal Models and Experimental Medicine2022，5，2： | 2 |
| 12 | 清肺排毒汤及其主要方剂治疗新型冠状病毒肺炎疗效解析显示文摘新型冠状病毒肺炎(COVID-19)是一种严重呼吸系统传染性疾病,爆发以来引起世界各国广泛的关注与讨论。从中医角度来看COVID-19属于“疫病”范畴,中医在防治“疫病”方面历史悠久,有很多宝贵经验且疗效稳定。根据中西医临床治疗及疗效观察,中医药管理局临床推荐用药“清肺排毒汤”可有效提高COVID-19治愈率。相关临床研究表明,中西医结合综合治疗可提高患者治愈率和缩短住院时间,且中医在改善患者症状和生活质量方面优于西药。鉴于“清肺排毒汤”在COVID-19的治疗中发挥着关键作用,旨在对清肺排毒汤治疗COVID-19的药效作用有更全面的认识,从清肺排毒汤的4个主要组成方剂麻杏石甘汤、射干麻黄汤、五苓散、小柴胡汤出发,探讨其抗COVID-19的中医学理论及现代药理学作用,为临床用药及基础研究提供参考。 | 杜文琪 梅鑫鑫 李晋 | 2022 | 中华中医药学刊2022，40，9： | 2 |
| 13 | 中医药治疗新型冠状病毒肺炎的优势显示文摘自古以来,中医药在疫病的防治方面已积累数千年的经验。新型冠状病毒肺炎的治疗尚无特效药出现,但中西医单独或联合应用均有效果。新型冠状病毒肺炎特点:(1)发病迅速、传播很快、传染性极强;(2)患者具相同主症,发热、咳嗽、然后气喘,且病势发展迅猛;(3)发病季节在大雪、冬至之后。新型冠状病毒肺炎归属于中医'疫病'范畴。对于预防疫病,中医药主要目的有两方面:一方面是祛避邪气;另一方面,也是一个重要方面,即适当借助食物或药物以提高机体正气,提高抵抗力。此外,在防治新型冠状病毒中融会贯通中医特色理论体系辨证论治和整体恒动观,按照疫病不同分类和不同分期给予不同的防治举措,充分发挥中医药的独有特色及优势,且全程发挥作用。 | 韦平原 韦超河 郭超 刘美珍 | 2021 | 临床合理用药杂志2021，14，16： | 1 |
| 14 | 新型冠状病毒肺炎流行期间隔离人群中医预防性用药效果评价显示文摘目的:调查新型冠状病毒肺炎(Corona Virus Disease 2019,COVID-19)流行期间,在隔离人群中预防性使用中药的有效性及安全性。方法:选取甘肃省COVID-19流行期间隔离人员作为研究对象,采用自编基本资料、中医预防性用药情况、中医预防性用药疗效及副作用统计调查问卷进行调查。结果:共计收回有效调查问卷2104份,参与问卷的2104个隔离人员中,中医预防性用药后,没有转为确诊病例者、核酸阴性转阳性率为0;参与问卷的2104个隔离人员中出现类似新冠感染症状者205例,中医预防性用药后201例呼吸道症状改善,客观有效率达98.05%;不同中药方剂在预防性使用时均未出现严重副作用。结论:COVID-19流行期间隔离人员中医预防性用药安全有效。 | 张尚祖 张利英 陈琰 王鑫 张录梅 雍文兴 张志明 刘永琦 | 2022 | 西部中医药2022，35，12： | 1 |
| 15 | 5种清感饮系列制剂同时多成分表征与鉴定显示文摘[目的]分析清感饮系列制剂(春饮、夏饮、秋饮、冬饮与童饮)中化学成分,进行多成分同步表征。[方法]利用超高效液相色谱/离子淌度-四极杆-飞行时间质谱数据非依赖高分辨MSE采集技术(UHPLC/IM-QTOF-HDMS^(E)),在相同色谱-质谱条件下对清感饮系列制剂及其组方各单味药的色谱图进行比对分析,对复方中色谱峰进行单味药归属,并结合高分辨质谱数据和对照品信息,构建基于UNIFITM软件调用自建数据库的自动峰注解流程实现中药成分的智能化、高效鉴定。[结果]从清感饮5种制剂中共鉴定177种化学成分,包括73种黄酮类,32种有机酸类,18种单萜类,15种苯乙醇苷类,13种木脂素类,10种三萜皂苷类,6种醌类,5种糖类,3种生物碱类及2种二苯乙烯类化合物。[结论]本实验所建立的UHPLC/IM-QTOF-HDMS^(E)技术适合于鉴定中药复方清感饮系列制剂主要化学成分,为阐明该复方药效物质基础提供了科学依据。 | 孙梦晓 丁辉 王跃飞 高秀梅 李雪 杨文志 | 2022 | 天津中医药2022，39，6： | 1 |
| 16 | 新型冠状病毒肺炎的多层螺旋CT影像学特点及诊断价值分析显示文摘目的:新型冠状病毒肺炎(新冠肺炎)多层螺旋CT影像学特点及诊断价值探讨。方法:以随机样本抽样法,抽取40例(2020年2月-7月)疑似新冠病毒肺炎患者,均进行多层螺旋CT(MSCT),分析其影像学特征、检出率。结果:40例疑似新冠肺炎患者多层螺旋CT影像学特征病变密度多表现为单纯GGO(47.50%)、GGO伴细小网格影(42.50%);病变形状多表现为斑片状(45.00%);病灶特点多表现为单纯磨玻璃密度影(60.00%);病灶特点多表现为单纯磨玻璃密度影(60.00%)。40例疑似新冠肺炎患者,检出10例,检出率为25.00%(10/40)。结论:MSCT对疑似新冠肺炎检出率较高,具有推广意义。 | 潘姗姗 徐大强 | 2021 | 影像技术2021，33，2： | 1 |
| 17 | Traditional medicine is the valuable resource for global health显示文摘The dramatic changes brought about by the Coronavirus Disease 2019(COVID-19)pandemic have prompted us to reassess the current global healthcare system.As we seek to identify solutions and formulate a vaccine,it is also an opportune time to consider resources that are already accessible,namely traditional medicine with a long history in dealing with contagious diseases.In this respect,Chinese medicine,with its millennia-old un-interrupted history of country-wide practice offers valuable tools. | Anlong Xu | 2021 | Journal of Traditional Chinese Medical Sciences2021，8，1： | 1 |
| 18 | 中医药抗肾小管病变防治新型冠状病毒感染相关肾病近况显示文摘新型冠状病毒(SARS-COV-2)感染相关肾病(COVAN)是SARS-COV-2通过血管紧张素转换酶Ⅱ(ACE2)靶向损伤肺外受累重要器官肾脏所致,以肾小管损伤为主要表现,是SARS-COV-2感染重要的并发症,也是患者预后不良的独立危险因素。防止SARS-COV-2靶向损伤肾小管是SARS-COV-2感染进程中预防肾损伤发生、发展的关键环节,在疾病早期就应该重视肾小管病变。中医药凭借多成分、多通路的特点在SARS-COV-2感染早期介入,可有效预防急性肾损伤(AKI)的发生,防止AKI向慢性肾脏病(CKD)发展,对于SARS-COV-2感染患者的远期肾脏转归有重要意义。 | 李娜 雷根平 王婷 董盛 | 2023 | 中国中医急症2023，32，10： | 0 |
| 19 | 中药的抗炎作用及分子机制显示文摘Traditional Chinese medicines(TCMs)are great treasures in pharmacological history with records of more than 3000 years.From ancient times to the present,TCMs of clearing heat,eliminating dampness,unblocking collaterals and removing toxins have been used in clinic to treat many infectious diseases and noninfectious chronic diseases,whose pathogenesis may involve inflammation induced by different causes. | 李林 徐淑君 | 2020 | 生物化学与生物物理进展2020，47，8： | 0 |
| 20 | “诺如病毒”致病中医防治探析显示文摘诺如病毒是属于杯状病毒科诺瓦克病毒属的非包膜单链RNA病毒,1968年首次在美国俄亥俄州诺瓦克爆发,因此命名为“诺沃克病毒”。诺如病毒是全世界急性胃肠道疾病的常见病因,常表现为恶心、呕吐和腹泻等症状,严重威胁全球卫生安全并造成了巨大的医疗经济负担。目前尚缺乏诺如病毒有效疫苗,西医常给予对症治疗亦缺乏特效药物,中医药在治疗急性传染病方面积累了大量有效经验,运用中医药整体观念、辨证论治特色势必推动“诺如病毒”防治取得突破性进展。 | 张宏伟 李龙 | 2022 | 甘肃科技2022，38，9： | 0 |
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