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| 1 | A MXene-Based Bionic Cascaded-Enzyme Nanoreactor for Tumor Phototherapy/Enzyme Dynamic Therapy and Hypoxia-Activated Chemotherapy显示文摘The enzyme-mediated elevation of reactive oxygen species(ROS)at the tumor sites has become an emerging strategy for regulating intracellular redox status for anticancer treatment.Herein,we proposed a camouflaged bionic cascaded-enzyme nanoreactor based on Ti_(3)C_(2)nanosheets for combined tumor enzyme dynamic therapy(EDT),phototherapy and deoxygenation-activated chemotherapy.Briefly,glucose oxidase(GOX)and chloroperoxidase(CPO)were chemically conjugated onto Ti_(3)C_(2)nanosheets,where the deoxygenation-activated drug tirapazamine(TPZ)was also loaded,and the Ti_(3)C_(2)-GOX-CPO/TPZ(TGCT)was embedded into nanosized cancer cell-derived membrane vesicles with high-expressed CD47(m_eTGCT).Due to biomimetic membrane camouflage and CD47 overexpression,m_eTGCT exhibited superior immune escape and homologous targeting capacities,which could effectively enhance the tumor preferential targeting and internalization.Once internalized into tumor cells,the cascade reaction of GOX and CPO could generate HClO for efficient EDT.Simultaneously,additional laser irradiation could accelerate the enzymic-catalytic reaction rate and increase the generation of singlet oxygen(~1O_(2)).Furthermore,local hypoxia environment with the oxygen depletion by EDT would activate deoxygenation-sensitive prodrug for additional chemotherapy.Consequently,m_eTGCT exhibits amplified synergistic therapeutic effects of tumor phototherapy,EDT and chemotherapy for efficient tumor inhibition.This intelligent cascaded-enzyme nanoreactor provides a promising approach to achieve concurrent and significant antitumor therapy. | Xiaoge Zhang Lili Cheng Yao Lu Junjie Tang Qijun Lv Xiaomei Chen You Chen Jie Liu | 2022 | Nano-Micro Letters2022，14，2： | 1 |
| 2 | Multifunctional inorganic nanomaterials for cancer photoimmunotherapy显示文摘Phototherapy and immunotherapy in combination is regarded as the ideal ther-apeutic modality to treat both primary and metastatic tumors.Immunother-apy uses different immunological approaches to stimulate the immune system to identify tumor cells for targeted elimination.Phototherapy destroys the pri-mary tumors by light irradiation,which induces a series of immune responses through triggering immunogenic cancer cell death.Therefore,when integrat-ing immunotherapy with phototherapy,a novel anti-cancer strategy called pho-toimmunotherapy(PIT)is emerging.This synergistic treatment modality can not only enhance the effectiveness of both therapies but also overcome their inherent limitations,opening a new era for the current anti-cancer therapy.Recently,the advancement of nanomaterials affords a platform for PIT.From all these nanomaterials,inorganic nanomaterials stand out as idealmediators in PIT due to their unique physiochemical properties.Inorganic nanomaterials can not only serve as carriers to transport immunomodulatory agents in immunotherapy owing to their excellent drug-loading capacity but also function as photother-mal agents or photosensitizers in phototherapy because of their great optical characteristics.In this review,the recent advances of multifunctional inorganic nanomaterial-mediated drug delivery and their contributions to cancer PIT will be highlighted. | Lu Tang Aining Zhang Ziyao Zhang Qingqing Zhao Jing Li Yijun Mei Yue Yin Wei Wang | 2022 | Cancer Communications2022，42，2： | 1 |
| 3 | 近红外光在现代医学中的应用和研究进展显示文摘近红外光对活体组织具有更好的穿透深度和生物相容性,最大限度地减少了组织中照射的散射和衰减,近年来已用于体内成像、3D图像可视化、光热疗法、药物释放和体内光遗传学等多个方面,在生物医学领域有着非常广阔的前景。目前近红外在临床医学中的应用愈发广泛,包括与多种分子成像方式结合,使用纳米探针,发挥光声成像作用;开发不同性能的光热剂,通过光能和热能的转化,实现近红外光疗法;结合3D打印这一新兴技术,个性化定制支架或植入物,利用近红外光的时空可调性,使得诊断与治疗同时进行,实现精准化医疗。 | 裴雅楠 郭婷婷 崔超强 何进伟 周栋 | 2023 | 分子影像学杂志2023，46，4： | 1 |
| 4 | Photoacoustic and magnetic resonance imaging-based gene and photothermal therapy using mesoporous nanoagents显示文摘The integration of photothermal therapy(PTT)with gene therapy(GT)in a single nanoscale platform demonstrates great potential in cancer therapy.Porous iron oxide nanoagents(PIONs)are widely used as magnetic nanoagents in the drug delivery field and also serve as a photothermal nanoagent for photothermal therapy.However,the therapeutic efficacy of PIONs-mediated GT has not been studied.The long noncoding RNA(lncRNA)CRYBG3(LNC CRYBG3),a lncRNA induced by heavy ion irradiation in lung cancer cells,has been reported to directly bind to globular actin(G-actin)and cause degradation of cytoskeleton and blocking of cytokinesis,thus indicating its potential for use in GT by simulating the effect of heavy ion irradiation and functioning as an antitumor drug.In the present study,we investigated the possibility of combining PIONs-mediated PTT and LNC CRYBG3-mediated GT to destroy non-small cell lung cancer(NSCLC)cells both in vitro and in vivo.The combination therapy showed a high cancer cell killing efficacy,and the cure rate was better than that achieved using PTT or GT alone.Moreover,as a type of magnetic nanoagent,PIONs can be used for magnetic resonance imaging(MRI)and photoacoustic imaging(PAI)both in vitro and in vivo.These findings indicate that the new combination therapy has high potential for cancer treatment. | Hao Huang Guotao Yuan Ying Xu Yuan Gao Qiulian Mao Yin Zhang Lu Bai Weijie Li Anqing Wu Wentao Hu Yue Pan Guangming Zhou | 2022 | Bioactive Materials2022，7，3： | 0 |
| 5 | 光动力疗法诱导的免疫原性细胞死亡的研究进展显示文摘光动力疗法(PDT)已被证明可以诱导免疫原性细胞死亡(ICD).但是由于PDT本身的局限性以及肿瘤部位的免疫原性差和免疫抑制环境的原因,单独的PDT在癌症免疫治疗中难以获得强大而持久的适应性抗肿瘤功效,往往需要采用不同的策略来提高肿瘤的免疫应答效果.因此,文章简述了光动力学机理、ICD原理,以及对PDT诱导的ICD的各种不同策略进行了总结和讨论,策略包括增加氧气(O_(2))和靶向性提高PDT效果,PDT联合光热疗法(PTT)和化疗等治疗方式,PDT结合免疫检查点以及免疫佐剂抑制来提高ICD效应,以此为研究人员提供更多的癌症免疫治疗方面的参考. | 钟蒙 杨红 | 2021 | 上海师范大学学报(自然科学版)2021，50，6： | 0 |
| 6 | Aggregation-induced emission luminogens for highly effective microwave dynamic therapy显示文摘Aggregation-induced emission luminogens(AIEgens)exhibit efficient cytotoxic reactive oxygen species(ROS)generation capability and unique light-up features in the aggregated state,which have been well explored in image-guided photodynamic therapy(PDT).However,the limited penetration depth of light in tissue severely hinders AIEgens as a candidate for primary or adjunctive therapy for clinical applications.Coincidentally,microwaves(MWs)show a distinct advantage for deeper penetration depth in tissues than light.Herein,for the first time,we report AIEgen-mediated microwave dynamic therapy(MWDT)for cancer treatment.We found that two AIEgens(TPEPy-I and TPEPy-PF6)served as a new type of microwave(MW)sensitizers to produce ROS,including singlet oxygen(1O2),resulting in efficient destructions of cancer cells.The results of 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide(MTT)and live/dead assays reveal that the two AIEgens when activated by MW irradiation can effectively kill cancer cells with average IC-50 values of 2.73 and 3.22μM,respectively.Overall,the ability of the two AIEgens to be activated by MW not only overcomes the limitations of conventional PDT,but also helps to improve existing MW ablation therapy by reducing the MW dose required to achieve the same therapeutic outcome,thus reducing the occurrence of side-effects of MW radiation. | Nil Kanatha Pandey Wei Xiong Lingyun Wang Wei Chen Brian Bui Jian Yang Eric Amador Mingli Chen Christina Xing Aseem Atul Athavale Yaowu Hao Wirya Feizi Lloyd Lumata | 2022 | Bioactive Materials2022，7，1： | 0 |
| 7 | Therapeutic sponge prevents postoperative breast cancer recurrence by sustainably dissociating into CD44-targeted nanoplatform显示文摘Locoregional recurrence and distant metastasis of breast cancer still pose a significant risk for patients’survival.To address the clinical challenge,functional absorbable sponges(HA-SH/PP-Dox/Lap/COL I(HCNPs))were constructed by biomimetic extracellular matrix of collagen I/hyaluronic acid complex conjugated with doxorubicin/lapatinib(Dox/Lap)-loaded nanoparticles.The HCNPs sponge exhibited excellent clotting ability and blood absorption rate.Worthily,Dox/Lap-loaded nanoparticles were synchronously endowed with a large number of oligo hyaluronic acid segments after degradation,which thus enhanced the ability of targeting into CD44-overexpressed tumor cells.The implantable HCNPs sponge in resected cavity of postoperative 4T1 models inhibited the spread of scattered tumor cells by absorbing the inevitable bleeding.More importantly,CD44 targeted nanoparticle with suitable Dox/Lap proportion continuously released from sponge to kill tumor cells of surrounding HCNPs and those remaining at surgical margin,thus prevented local recurrence as well as distant metastasis.Therefore,the functional HCNPs sponge might provide a safer and more effective strategy for postoperative treatment of cancer. | Junhui Sui Mingda Zhao Zhihao Guo Jiafeng Li Jie Chen Hongli Chen Jie Liang Yong Sun Xingdong Zhang Yujiang Fan | 2024 | Nano Research2024，17，3： | 0 |
| 8 | 多功能无机纳米材料应用于癌症光免疫治疗的研究进展显示文摘光疗和免疫治疗相结合被认为是治疗原发性和转移性肿瘤的理想方式。免疫治疗使用不同的免疫方法刺激免疫系统,以识别肿瘤细胞进行靶向清除。光疗通过光照射破坏原发肿瘤,通过引起免疫原性癌细胞死亡引发一系列免疫反应。因此,将免疫治疗与光疗相结合,便产生了一种新的抗癌方法——光免疫疗法(photoimmunotherapy,PIT)。这种协同治疗方式不仅提高了两种治疗方法的有效性,还克服了它们固有的局限性,为当前的抗癌治疗开辟了一个新时代。最近,纳米材料的进步为PIT的发展提供了平台。在各种纳米材料中,无机纳米材料因其独特的理化性质成为理想的PIT介质。无机纳米材料不仅具有良好的载药能力,可作为免疫治疗中免疫调节剂的载体;其还具有良好的光学特性,可作为光疗中的光热剂或光敏剂。本文介绍了多功能无机纳米材料介导药物输送及其在肿瘤PIT中应用的最新研究进展。 | 唐璐 张爱宁 张子瑶 赵青青 李菁 梅逸君 尹悦 王伟 | 2022 | 癌症2022，41，9： | 0 |
| 9 | 二维黑磷及其在口腔医学领域的研究应用进展显示文摘二维黑磷具备独特的层状结构和出色的光学性能、良好的生物相容性和高生物降解性。近年研究显示,二维黑磷在生物医学领域具有稳定的载药和光控调节缓释药物功能、优异的抗菌活性和促血管和神经再生能力,因此在口腔医学中具有广阔的应用前景。本文就二维黑磷的生物学特性及其在口腔医学领域的研究应用进展进行综述,以期为二维黑磷的进一步研究和应用提供新思路。 | 许桐 华咏梅 曾德良 廖崇珊 | 2022 | 中华口腔医学杂志2022，57，2： | 0 |
| 10 | Photoactivatable nanogenerators of reactive species for cancer therapy显示文摘In recent years,reactive species-based cancer therapies have attracted tremendous attention due to their simplicity,controllability,and effectiveness.Herein,we overviewed the state-of-art advance for photo-controlled generation of highly reactive radical species with nanomaterials for cancer therapy.First,we summarized the most widely explored reactive species,such as singlet oxygen,superoxide radical anion(O2●-),nitric oxide(●NO),carbon monoxide,alkyl radicals,and their corresponding secondary reactive species generated by interaction with other biological molecules.Then,we discussed the generating mechanisms of these highly reactive species stimulated by light irradiation,followed by their anticancer effect,and the synergetic principles with other therapeutic modalities.This review might unveil the advantages of reactive species-based therapeutic methodology and encourage the pre-clinical exploration of reactive species-mediated cancer treatments. | Xiaohua Zheng Yilan Jin Xiao Liu Tianqing Liu Weiqi Wang Haijun Yu | 2021 | Bioactive Materials2021，6，12： | 0 |
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