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| 1 | Genetic diversity of pepper(Capsicum spp.) germplasm resources in China reflects selection for cultivar types and spatial distribution显示文摘Pepper(Capsicum spp.) is an important vegetable crop in the world. Now the pepper in China contributes one-third of the world's peppers production. Genetic diversity of the pepper germplasm of China is expected interesting to know. To explore the structure of genetic diversity in Chinese pepper germplasm resources and possible relationship with cultivar types or geographic origin, we sampled and compared 372 Gen Bank pepper accessions(local cultivars and landraces) from 31 provinces, autonomous regions and municipalities of China and 31 additional accessions from other countries. These accessions were genotyped using 28 simple sequence repeat(SSR) markers spanning the entire pepper genome. We then investigated the genetic structure of the sampled collection using model-based analysis in STRUCTURE v2.3.4 and examined genetic relationships by the unweighted pair-group method of mathematical averages(UPGMA) in MEGA. In addition to geographic origin, we evaluated eight plant and fruit traits. In total, 363 alleles were amplified using the 28 SSR primers. Gene diversity, polymorphism information content and heterozygosity of the 28 SSR loci were estimated as 0.09–0.92, 0.08–0.92 and 0.01–0.34, respectively. The UPGMA cluster analysis clearly distinguished Capsicum annuum L. from other cultivated pepper species. Population structure analysis of the 368 C. annuum accessions uncovered three genetic groups which also corresponded to distinct cultivar types with respect to the plant and fruit descriptors. The genetic structure was also related to the geographic origin of the landraces. Overall results indicate that genetic diversity of Chinese pepper landraces were structured by migration of genotypes followed by human selection for cultivar types in agreement with consumption modes and adaptation to the highly diversified agro-climatic conditions. | ZHANG Xiao-min ZHANG Zheng-hai GU Xiao-zhen MAO Sheng-li LI Xi-xiang Joel Chadceuf Al ain Palloix WANG Li-hao ZHANG Bao-xi | 2016 | Journal of Integrative Agriculture2016，15，9： | 6 |
| 2 | Preoperative Serum C-Reactive Protein Levels and Early Breast Cancer by BMI and Menopausal Status显示文摘 | Tingting Hong Aining Liu Dongyan Cai Ying Zhang Dong Hua Xiaosheng Hang Xiaohong Wu | 2013 | Cancer Investigation2013，，4： | 1 |
| 3 | Genetic variations in CD14 promoter and acute lymphoblastic leukemia susceptibility in a Chinese population显示文摘 | Yu Xiao Zhang Chun Sun Aining | 2011 | DNA Cell Biol2011，30，10： | 1 |
| 4 | The short isoform of the long‐type PML ‐ RARA fusion gene in acute promyelocytic leukaemia lacks sensitivity to all‐trans‐retinoic acid显示文摘 | Yanhong Tan Sicheng Bian Zhifang Xu Xiuhua Chen Xiling Qi Fanggang Ren Li Li Haixiu Guo Aining Xu Linlin Zhang Hongwei Wang | 2013 | Br J Haematol2013，，1： | 1 |
| 5 | Multifunctional inorganic nanomaterials for cancer photoimmunotherapy显示文摘Phototherapy and immunotherapy in combination is regarded as the ideal ther-apeutic modality to treat both primary and metastatic tumors.Immunother-apy uses different immunological approaches to stimulate the immune system to identify tumor cells for targeted elimination.Phototherapy destroys the pri-mary tumors by light irradiation,which induces a series of immune responses through triggering immunogenic cancer cell death.Therefore,when integrat-ing immunotherapy with phototherapy,a novel anti-cancer strategy called pho-toimmunotherapy(PIT)is emerging.This synergistic treatment modality can not only enhance the effectiveness of both therapies but also overcome their inherent limitations,opening a new era for the current anti-cancer therapy.Recently,the advancement of nanomaterials affords a platform for PIT.From all these nanomaterials,inorganic nanomaterials stand out as idealmediators in PIT due to their unique physiochemical properties.Inorganic nanomaterials can not only serve as carriers to transport immunomodulatory agents in immunotherapy owing to their excellent drug-loading capacity but also function as photother-mal agents or photosensitizers in phototherapy because of their great optical characteristics.In this review,the recent advances of multifunctional inorganic nanomaterial-mediated drug delivery and their contributions to cancer PIT will be highlighted. | Lu Tang Aining Zhang Ziyao Zhang Qingqing Zhao Jing Li Yijun Mei Yue Yin Wei Wang | 2022 | Cancer Communications2022，42，2： | 1 |
| 6 | To Guarantee Lawyers' Right to Practice is to Protect Human Rights——An analytical review of the new Law on Lawyers显示文摘Power balance is a systematic frame- work that facilitates the forming and existence of rule of law and is also a direct precondition for the forming and existence of rule of law.It is designed for restriction of the State power, and it is also for those who have the adminis- trative power to use their power for safe- guarding the social justice.The lawyers' right to practice is an important part of social balance mechanism and is also an interna- tionally accepted form.The essence is an extension and an indispensable part of citi- zens' rights.Therefore,to guarantee lawyers' right to practice is to safeguard human rights. | ZHANG AINING | 2008 | The Journal of Human Rights2008，7，2： | 0 |
| 7 | A systematic survey of LU domain-containing proteins reveals a novel human gene,LY6A,which encodes the candidate ortholog of mouse Ly-6A/Sca-1 and is aberrantly expressed in pituitary tumors显示文摘The Ly-6 and uPAR(LU)domain-containing proteins represent a large family of cell-surface markers.In particular,mouse Ly-6A/Sca-1 is a widely used marker for various stem cells;however,its human ortholog is missing.In this study,based on a systematic survey and comparative genomic study of mouse and human LU domain-containing proteins,we identified a previously unannotated human gene encoding the candidate ortholog of mouse Ly-6A/Sca-1.This gene,hereby named LY6A,reversely overlaps with a lncRNA gene in the majority of exonic sequences.We found that LY6A is aberrantly expressed in pituitary tumors,but not in normal pituitary tissues,and may contribute to tumorigenesis.Similar to mouse Ly-6A/Sca-1,human LY6A is also upregulated by interferon,suggesting a conserved transcriptional regulatory mechanism between humans and mice.We cloned the full-length LY6A cDNA,whose encoded protein sequence,domain architecture,and exon‒intron structures are all well conserved with mouse Ly-6A/Sca-1.Ectopic expression of the LY6A protein in cells demonstrates that it acts the same as mouse Ly-6A/Sca-1 in their processing and glycosylphosphatidylinositol anchoring to the cell membrane.Collectively,these studies unveil a novel human gene encoding a candidate biomarker and provide an interesting model gene for studying gene regulatory and evolutionary mechanisms. | Dan Liu Chunhui Xu Yanting Liu Wen Ouyang Shaojian Lin Aining Xu Yuanliang Zhang Yinyin Xie Qiuhua Huang Weili Zhao Zhu Chen Lan Wang Saijuan Chen Jinyan Huang Zhe Bao Wu Xiaojian Sun | 2023 | Frontiers of Medicine2023，17，3： | 0 |
| 8 | Genotoxicity evaluation of surface waters located in urban area of Xi'an City using Vicia faba bioassays显示文摘 | Yongjun LIU Aining ZHANG Xiaoyan MA Xiaochang WANG | 2013 | Frontiers of Environmental Science & Engineering2013，7，6： | 0 |
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