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| 1 | A review on phospholipids and their main applications in drug delivery systems显示文摘Phospholipids have the characteristics of excellent biocompatibility and a especial amphiphilicity.These unique properties make phospholipids most appropriate to be employed as important pharmaceutical excipients and they have a very wide range of applications in drug delivery systems.The aim of this review is to summarize phospholipids and some of their related applications in drug delivery systems,and highlight the relationship between the properties and applications,and the effect of the species of phospholipids on the efficiency of drug delivery.We refer to some relevant literatures,starting from the structures,main sources and properties of phospholipids to introduce their applications in drug delivery systems.The present article focuses on introducing five types of carriers based on phospholipids,including liposomes,intravenous lipid emulsions,micelles,drug-phospholipids complexes and cochleates. | Jing Li Xuling Wang Ting Zhang Chunling Wang Zhenjun Huang Xiang Luo Yihui Deng | 2015 | Asian Journal of Pharmaceutical Sciences2015，10，2： | 23 |
| 2 | Pickering emulsions stabilized by colloidal surfactants:Role of solid particles显示文摘Pickering emulsions are emulsions stabilized by colloidal surfactants,i.e.solid particles.Compared with traditional molecular suffactant-stabilized emulsions,Pickering emulsions show many advantages,such as high resistance to coalescence,long-term stability,good biocompatibility and tunable properties.In recent years,Pickering emulsions are widely applied in scientific researches and industrial applications.In this review,we focus on the influences of particle properties on Pickering emulsions,including particle amphiphilicity,concentration,size and shape,and summarize the strategies developed for the preparation of amphiphilic Janus particles.The applications of Pickering emulsions in food industry,cosmetic industry,material science,drug delivery,biomedical research and vaccine adjuvant will also be covered.Pickering emulsions are a unique system for multi-disciplinary studies and will become more and more important in the future. | Zhu Sun Xiaoxiao Yan Yao Xiao Lingjie Hu Max Eggersdorfer Dong Chen Zhenzhong Yang David AWeitz | 2022 | Particuology2022，20，5： | 6 |
| 3 | High Performance of PVA Nanocomposite Reinforced by Janus-like Asymmetrically Oxidized Graphene:Synergetic Effect of H-bonding Interaction and Interfacial Crystallization显示文摘Macromolecule nanocrystal network and strong interfacial interaction are always beneficial to enhance the mechanical property of polymer-based nanocomposites.Poly(vinyl alcohol)(PVA),a typical biocompatible semicrystalline polymer,is an ideal candidate for preparing high performance polymer-based nanocomposites.However,the rich hydrogen bonds between PVA matrix and graphene oxide(GO)can disrupt the formation of PVA nanocrystal network.Thus,it remains a great challenge to achieve both strong and tough PVA-GO nanocomposites.Herein,by introducing a novel Janus-like amphiphilic graphene oxide(JGO),both hydrogen bonding and interfacial crystallization have been constructed between JGO sheets and PVA matrix.Benefiting from amphiphilic interfacial interaction and the enhanced crystal network,both PVA-JGO dried films and their swollen hydrogel films show superior mechanical properties than those of traditional PVA-GO nanocomposites.PVA-JGO dried films exhibit a 264%improvement of toughness at a JGO loading of 1 wt%.Meanwhile,the corresponding PVA-JGO swollen hydrogel films display simultaneous improvement of nearly 8 times increase of tensile strength and 20 times increase of toughness compared to traditional PVA-GO nanocomposite.This work indicates multiple interfacial interactions and macromolecule crystal networks can be concurrent in PVA nanocomposites by innovative modification of nanofillers,providing a new strategy to construct PVA nanocomposites with high strength and high toughness.The integration of outstanding mechanical and swelling resistance properties on PVA-JGO nanocomposite films render their promising applications,such as packaging and toughening hydrogel materials. | Ning Zhang Bin Zhang Yong Pang Hong-Sheng Yang Lu Zong Yong-Xin Duan Jian-Ming Zhang | 2022 | Chinese Journal of Polymer Science2022，40，4： | 1 |
| 4 | Toward a Two-Dimensional Supramolecular Organic Framework with High Degree of Internal Order via Amphiphilic Modification显示文摘Solution-phase self-assembly of two-dimensional(2D)networks with a high degree of internal order and long-range periodicity is a great challenge.Herein,we report a rational design to improve 2D self-assembly in water through amphiphilic modification of the building block.An amphiphilic tritopic molecule(1)is designed and synthesized by introducing three hydrophilic oligo(ethylene glycol)moieties and three hydrophobic hexyl chains.The assembly of 1 and cucurbit[8]uril(CB[8])leads to the formation of a Janus 2D supramolecular organic framework(SOF),which further creates unique bilayer supramolecular networks and exhibits an unprecedentedly high degree of internal order and long-range periodicity.In contrast,the assembly of a nonamphiphilic analog(2)with CB[8]only generates a 2D SOF with a lower degree of internal order,suggesting that the inherent amphiphilicity of 1 plays a crucial role in improving its 2D self-assembly in aqueous phase. | Zhi-Jian Yin Shu-Yan Jiang Na Liu Qiao-Yan Qi Zong-Quan Wu Tian-Guang Zhan Xin Zhao | 2022 | CCS Chemistry2022，4，1： | 0 |
| 5 | Thermodynamic Dual Descriptor显示文摘A new definition of the dual descriptor,namely,thethermodynamic dual descriptor,is developed within the grand canonicalpotential formalism.This new definition is formulated to describe the same △f_r(r)=β/2C[f^+(r)-f^-(r)](C>0) physical phenomenon as the original definition proposed by Morell,Grand,and Toro-Labbé(J.Phys.Chem.A2005,109,205),which is characterized by a second-order response of the electron density towards an electron flux.To formulate the new definition,we performed two successive partial derivatives of the average electron density,one with respect to the average number of electrons,and the other with respect to the chemical potential of the electron reservoir.When the derivative is expressed in terms of the three-state ensemble model,in the regime of low temperatures up to temperatures of chemical interest,one finds that the thermodynamic dual descriptor can be expressed as?f_T(r)=(β/2)C[f^+(r)-f^-(r)],whereβ=1/k_BT,Cis a global quantity that depends on the temperature and global electronic properties of the molecule(the first ionization potential and the electron affinity),C=1 for systems with zero fractional charge,and C=C_ω>0(albeit very close to zero)for systems with nonzero fractional charge,,and f^+(r)and f^-(r)are the nucleophilic and electrophilic Fukui functions,respectively.The quantity within the square brackets is the original definition of the dual descriptor.As the local terms(the ones containing regioselectivity information)are equal to those of the dual descriptor,?f_T(r)has the same regioselectivity information,multiplied by the global quantity(β/2)C.This implies that the regioselectivity information contained in the original dual descriptor is preserved at all temperatures different from zero,and for any value of C>0.One of the most important features of this new definition is that it avoidsthe undesired Dirac delta behavior observed when the second order partial derivative of the average density is taken with respect to the average number of electrons,using the exact density dependence of the average number of electrons. | FRANCO-PéREZ Marco GáZQUEZ José L. AYERS Paul W. VELA Alberto | 2018 | 物理化学学报2018，34，6： | 0 |
| 6 | P-glycoprotein(ABCB1)-weak dipolar interactions provide the key to understanding allocrite recognition,binding,and transport显示文摘P-glycoprotein(ABCB1)is the first discovered mammalian member of the large family of ATP binding cassette(ABC)transporters.It facilitates the movement of compounds(called allocrites)across membranes,using the energy of ATP binding and hydrolysis.Here,we review the thermodynamics of allocrite binding and the kinetics of ATP hydrolysis by ABCB1.In combination with our previous molecular dynamics simulations,these data lead to a new model for allocrite transport by ABCB1.In contrast to previous models,we take into account that the transporter was evolutionarily optimized to operate within a membrane,which dictates the nature of interactions.Hydrophobic interactions drive lipid-water partitioning of allocrites,the transport process’s first step.Weak dipolar interactions(including hydrogen bonding,π-π stacking,and π-cation interactions)drive allocrite recognition,binding,and transport by ABCB1 within the membrane.Increasing the lateral membrane packing density reduces allocrite partitioning but enhances dipolar interactions between allocrites and ABCB1.Allocrite flopping(or reorientation of the polar part towards the extracellular aqueous phase)occurs after hydrolysis of one ATP molecule and opening of ABCB1 at the extracellular side.Rebinding of ATP re-closes the transporter at the extracellular side and expels the potentially remaining allocrite into the membrane.The high sensitivity of the steady-state ATP hydrolysis rate to the nature and number of dipolar interactions,as well as to the dielectric constant of the membrane,points to a flopping process,which occurs to a large extent at the membrane-transporter interface.The proposed unidirectional ABCB1 transport cycle,driven by weak dipolar interactions,is consistent with membrane biophysics. | Anna Seelig Xiaochun Li-Blatter | 2023 | Cancer Drug Resistance2023，6，1： | 0 |
| 7 | Rapid Self-healing and Strong Adhesive Elastomer via Supramolecular Aggregates from Core-shell Micelles of Silicon Hydroxyl-functionalized cis-Polybutadiene显示文摘Liquid trimethoxy silane-functionalized cis-polybutadiene(cis-PB-Si(OMe)3),possessing number-average molecular weights of cis-PB segments(Mn,PB)ranging from 1800 g/mol to 5400 g/mol,with cis-1,4 content of ca.80%and high functionality(>96%)could be synthesized by coordination copolymerization of living cis-PB chain ends with ethenyltrimethoxy-silane with neodymium-based catalytic system.The silicon hydroxyl-functionalized cis-polybutadiene(cis-PB-Si(OH)_(3))-based micelles in water have been achieved by in situ hydrolysis of cis-PB-Si(OMe)_(3)in hexane/water mixture(pH=6.8)at 70℃and by sequential removal of residue hexane.The size of the above micelles with soft elastic cis-PB cores could be remarkably enlarged by loading SiO_(2)nanoparticles on their surfaces via hydrogen bonding interaction.Giant supramolecular long chain aggregates or networks formed by hydrogen bonding interaction and possible O—Si—O chemical bonds between cis-PB-Si(OH)3-based micellar surfaces had relatively large size and thus precipitated from water after several months of storage,leading to production of cis-PB-Si(OH)_(3)solid elastomer with extremely low T_(g)at−107.0℃.The left cis-PB-Si(OH)_(3)-based micelles in water with relatively small size gradually formed the water-insoluble cis-PB-Si(OH)_(3)-based supramolecular aggregates or networks.The cis-PB-Si(OH)_(3)-based supramolecular elastomer exhibited excellent self-healing property within 60 s at 25℃.The elastomer(20 mg)in a joint of 25 mm×30 mm(2.7 mg/cm^(2))provided very strong adhesion for two pieces of glass and the bound glass keep unchanged at room temperature for 98 h even hung with 100 g of steel column below.The cis-PB-Si(OH)3-based supramolecular elastomer would have potential applications in adhesives,self-healing materials,damping materials and elastic materials. | Ying-Ying Zheng Han Zhu Yi Tan Feng-Yi-Qi Liu Yi-Xian Wu | 2023 | Chinese Journal of Polymer Science2023，41，1： | 0 |
| 8 | Spatiotemporal Visualization of Cell Membrane with Amphiphilic Aggregation-Induced Emission-Active Sensor显示文摘High-fidelity spatiotemporal monitoring of the cell membrane is critically important.However,commercial fluorescence probes are stalked by the aggregation-caused quenching(ACQ)effect,and the reported aggregation-induced emission(AIE)-active probes are always limited by nonspecific aggregations in the biological environment.Herein,we report the rational molecular design of a stateof-the-art amphiphilic AIE luminogen(AIEgen),membrane tracker QMC12,using a core quinolinemalononitrile(QM)structure to suppress the ACQ effect,incorporate a positively charged pyridinium to regulate dispersity and strengthen the binding affinity to the negatively charged cell membrane,and extend the alky chain to improve the anchoring ability to the cell membrane.The membrane tracker QMC12,which disperses well in both hydrophilic and lipophilic environments,not only achieves minimal background interference and high signal-to-noise(S/N)ratio in the“ultrafast”visualization of the cell membrane,but also endows a“wash-free”characteristic.Furthermore,it realizes a spatial three dimensional(3D)view in a multicellular spheroid model and morphology changes over time.Moreover,QMC12 avoids false staining and signal loss and unprecedentedly achieves the direct observation of the cell membrane’s microstructure,which could elucidate spatiotemporal 3D model studies of the intercellular information exchange. | Youheng Zhang Qi Wang Zhirong Zhu Weijun Zhao Chenxu Yan Zhenxing Liu Ming Liu Xiaolei Zhao He Tian Wei-Hong Zhu | 2022 | CCS Chemistry2022，4，5： | 0 |
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