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| 1 | 韩明士:《官宦与绅士:两宋江西抚州的精英》 | 周鑫 | 2006 | 中国社会历史评论2006，，1： | 31 |
| 2 | Precise Modifications of Both Exogenous and Endogenous Genes in Rice by Prime Editing显示文摘Dear Editor,Harnessing genetic diversity and the introduction of elite alleles from wild relatives or landraces into commercial cultivars has been a major goal in crop breeding programs.Precise modification of the plant genome through clustered regularly interspaced short palindromic repeat(CRISPR)/CRISPR-associated protein(Cas)(CRISPR/Cas)-mediated homology-directed repair(HDR)offers a great promise to introduce elite alleles from wild relatives or landraces into commercialized cultivars in the short term. | Huiyuan Li Jingying Li Jilin Chen Lei Yan Lanqin Xia | 2020 | Molecular Plant2020，13，5： | 30 |
| 3 | The Ghd7 transcription factor represses ARE1 expression to enhance nitrogen utilization and grain yield in rice显示文摘The genetic improvement of nitrogen use efficiency(NUE)of crops is vital for grain productivity and sustainable agriculture.However,the regulatory mechanism of NUE remains largely elusive.Here,we report that the rice Grain number,plant height,and heading date7(Ghd7)gene genetically acts upstream of ABC1 REPRESSOR1(ARE1),a negative regulator of NUE,to positively regulate nitrogen utilization.As a transcriptional repressor,Ghd7 directly binds to two Evening Element-like motifs in the promoter and intron 1 of ARE1,likely in a cooperative manner,to repress its expression.Ghd7 and ARE1 display diurnal expression patterns in an inverse oscillation manner,mirroring a regulatory scheme based on these two loci.Analysis of a panel of 2656 rice varieties suggests that the elite alleles of Ghd7 and ARE1 have undergone diversifying selection during breeding.Moreover,the allelic distribution of Ghd7 and ARE1 is associated with the soil nitrogen deposition rate in East Asia and South Asia.Remarkably,the combination of the Ghd7 and ARE1 elite alleles substantially improves NUE and yield performance under nitrogen-limiting conditions.Collectively,these results define a Ghd7–ARE1-based regulatory mechanism of nitrogen utilization,providing useful targets for genetic improvement of rice NUE. | Qing Wang Qingmei Su Jinqiang Nian Jian Zhang Meng Guo Guojun Dong Jiang Hu Rongsheng Wang Changshuo Wei Guanwen Li Wan Wang Hui-Shan Guo Shaoyang Lin Wenfeng Qian XianzhiXie Qian Qian Fan Chen Jianru Zuo | 2021 | Molecular Plant2021，14，6： | 10 |
| 4 | Von Clauss法与PT衍生法测定纤维蛋白原在全自动血凝仪的应用比较显示文摘目的:比较ACL ELITE PRO全自动血凝分析仪上Von Clauss法与PT衍生法(PT-der法)测定纤维蛋白原(FIB)的准确性及其临床应用价值。方法:用Von Clauss法与PT衍生法分别对新鲜混合血浆,20份正常质控品,301例临床样本和15例D-D二聚体阳性标本进行检测。结果:两种方法测定FIB的重复性良好;对20份正常质控品的测定结果差异无统计学意义(P>0.05);对临床样本按PT-der法检测结果分阶段做分析,FIB在1.51~3.50 g/L时,两种方法测定结果相近,差异无统计学意义(P>0.05),FIB>3.50 g/L时,PT-der法结果偏高,差异有统计学意义(P<0.05);15例D-D二聚体阳性标本用PT-der法测定结果明显高于Von Clauss法,差异有统计学意义(P<0.05)。结论:在ACLELITE PRO全自动血凝分析仪上,当PT-der法测出的FIB值在1.51~3.50 g/L时,直接报告结果,当PT-der法测出的FIB值>3.50 g/L时,以Von Clauss法复查的结果发出报告,两者结合应用可确保工作质量,提高实际工作效益。 | 彭裕辉 方裕森 许镒洧 罗育豪 林雪琼 | 2011 | 中国医药导报2011，8，12： | 9 |
| 5 | High-Efficiency Reduction of Rice Amylose Content via CRISPR/Cas9-Mediated Base Editing显示文摘Rice is a staple food for more than half of the human population.It has been estimated that by 2030,rice production must increase by 40%to meet the growing demand(Khush,2005).In addition,with the improvement of people's living standards,the demand for elite rice with better eating and cooking quality(ECQ)is increasing.ECQ is determined by several factors,including amylose content(AC),gel consistency(GC),gelatinization temperature(GT)and viscosity,where AC is the predominant factor(Juliano,1998). | Li He Li Xiufeng Xu Yang Liu Hualong He Mingliang Tian Xiaojie Wang Zhenyu Wu Xiuju Bu Qingyun Yang Jie | 2020 | Rice science2020，27，6： | 7 |
| 6 | GE公司Discovery Elite PET/CT常见故障的维修、分析及保养显示文摘当前,PET/CT的高效已经过大量的临床案例证明,现已跻身于最高端的医学成像设备之列。它结合了传统CT和PET的优势,弥补了单一设备成像的不足,极大地提高了相应医学检查的效率,节省了时间及技术成本。目前,GE公司最先进的Discovery Elite型号PET/CT具有采集用时短、分辨率高、分析精准的优点。但是也存在一定的故障比例。本文主要是对常见的故障进行分析,并提出相应的维修及保养措施,以期对该设备的维修保养工作提供技术支持。 | 张鹏 | 2018 | 中国医疗器械信息2018，24，10： | 7 |
| 7 | Development of nutritious rice with high zinc/selenium and low cadmium in grains through QTL pyramiding显示文摘Enriching zinc(Zn) and selenium(Se) levels,while reducing cadmium(Cd) concentration in rice grains is of great benefit for human diet and health.Large natural variations in grain Zn, Se, and Cd concentrations in different rice accessions enable Zn/Sebiofortification and Cd-minimization through molecular breeding. Here, we report the development of new elite varieties by pyramiding major quantitative trait loci(QTLs) that significantly contribute to high Zn/Se and low Cd accumulation in grains. A chromosome segment substitution line CSSLGCC7 with the PA64s-derived GCC7 allele in the 93-11 background, exhibited steadily higher Mn and lower Cd concentrations in grains than those of 93-11. This elite chromosome segment substitution line(CSSL) was used as the core breeding material to cross with CSSLs harboring other major QTLs for essential mineral elements, especially CSSLGZC6 for grain Zn concentration and CSSLGSC5 for grain Se concentration. The CSSLGCC7+GZC6 and CSSLGCC7+GSC5 exhibited lower Cd concentration with higher Zn and Se concentrations in grains, respectively. Our study thus provides elite materials for rice breeding targeting high Zn/Se and low Cd concentrations in grains. | Chaolei Liu Shilin Ding Anpeng Zhang Kai Hong Hongzhen Jiang Shenglong Yang Banpu Ruan Bin Zhang Guojun Dong Longbiao Guo Dali Zeng Qian Qian Zhenyu Gao | 2020 | Journal of Integrative Plant Biology2020，62，3： | 7 |
| 8 | GE 16排螺旋CT典型故障案例分析显示文摘16排螺旋CT具有高速、精准及低消耗的特征,型号为bright speed elite select的16排CT光速为3.5 M,在全新MERI平台的基础上,使图像精度、扫描速度以及扫描剂量方面更加完美[1-3]。目前,在国内各级医院中有较多用户,将3例特殊故障维修实例进行总结,以供同行参考。1故障案例一(1)故障现象。高压系统报错"80-1403"[4]。(2)故障分析。 | 徐勇 | 2015 | 中国医学装备2015，12，11： | 7 |
| 9 | Pyramiding favorable alleles in an elite wheatvariety in one generation by CRISPR-Cas9-mediated multiplex gene editing显示文摘Dear Editor,Common wheat(Triticum aestivum,2n=6x=42,AABBDD)is amajor staple crop consumed by more than 30%of the world’spopulation.It is the main source of cereal-based processed prod-ucts,such as bread,cookies,pasta,and noodles.Althoughwheat production increased by 10-fold following the Green revo-lution and maker-assisted breeding over the past decades,it isstill facing unprecedented challenges in the context of globalclimate changes,growing world population,decreased farm-lands,as well as water shortages in arid and semi-arid lands.Meanwhile,the functional redundancy of genes in hexaploidywheat makes a forward genetics approach to select a desiredphenotype,especially for pyramiding of several agronomicallyimportant traits in a modern variety,very time-consuming and in some cases,impossible because of gene linkage or genedrag. | Jinman Luo Shaoya Li Jiajing Xu Lei Yan Youzhi Ma Lanqin Xia | 2021 | Molecular Plant2021，14，6： | 6 |
| 10 | Modeling and simulation of recurrent phenotypic and genomic selections in plant breeding under the presence of epistasis显示文摘Recurrent selection is an important breeding method for population improvement and selecting elite inbreds or fixed lines from the improved germplasm.Recently,a computer simulation tool called QuMARS has been developed,which allows the simulation and optimization of various recurrent selection strategies.Our major objective in this study was to use the QuMARS tool to compare phenotypic recurrent,marker-assisted recurrent,and genomic selections(abbreviated respectively as PS,MARS and GS)for both short-and long-termbreeding procedures.ForMARS,twomarker selection models were considered,i.e.,stepwise(Rstep)and forward regressions(Forward).For GS,three prediction models were considered,i.e.,genomic best linear unbiased predictors(GBLUP),ridge regression(Ridge),and regression by Moore-Penrose general inverse(InverseMP).To generate genotypes and phenotypes for a given individual during simulation,one additive and two epistasis genetic models were considered with three levels of heritability.Results demonstrated that selection responses from GBLUP-based GS and MARS(Forward)were consistently greater than those from PS under the additive model,particularly in early selection cycles.In contrast,selection response from PS was consistently superior over MARS and GS under epistatic models.For the two epistasis models,total genetic variance and the additive variance component were increased in some cases after selection.Through simulation,we concluded that GS and PS were effective recurrent selection methods for improved breeding of targeted traits controlled by additive and epistatic quantitative trait loci(QTL).QuMARS provides an opportunity for breeders to compare,optimize and integrate new technology into their conventional breeding programs. | Mohsin Ali Luyan Zhang Ian DeLacy Vivi Arief Mark Dieters Wolfgang H.Pfeiffer Jiankang Wang Huihui Li | 2020 | The Crop Journal2020，8，5： | 4 |
| 11 | Genetic basis of high aroma and stress toleranee in the oolong tea cultivar genome显示文摘Tea plants(Camellia sinensis)are commercially cultivated in>60 countries,and their fresh leaves are processed into tea,which is the most widely consumed beverage in the world.Although several chromosome-level tea plant genomes have been published,they collapsed the two haplotypes and ignored a large number of allelic variations that may underlie important biological functions in this species.Here,we present a phased chromosome-scale assembly for an elite oolong tea cultivar,'Huangdan',that is well known for its high levels of aroma.Based on the two sets of haplotype genome data,we identi fi ed numerous genetic variations and a substantial proportion of allelic imbalance related to important traits,including aroma-and stress-related alleles.Comparative genomics revealed extensive structural variations as well as expansion of some gene families,such as terpene synthases(TPSs),that likely contribute to the high-aroma characteristics of the backbone parent,underlying the molecular basis for the biosynthesis of aroma-related chemicals in oolong tea.Our results uncovered the genetic basis of special features of this oolong tea cultivar,providing fundamental genomic resources to study evolution and domestication for the economically important tea crop. | Pengjie Wang Jiaxin Yu Shan Jin Shuai Chen Chuan Yue Wenling Wang Shuilian Gao Hongli Cao Yucheng Zheng Mengya Gu Xuejin Chen Yun Sun Yuqiong Guo Jiangfan Yang Xingtan Zhang Naixing Ye | 2021 | Horticulture Research2021，8，1： | 4 |
| 12 | Risk management strategies for the 2022 Olympic Winter Games:The Beijing scheme显示文摘As the first international sporting event scheduled since the outbreak of the novel coronavirus disease 2019(COVID-19)pandemic,the Beijing XXIV Olympic Winter Games were officially held in China between the 4th and 20th of February 2022.1 According to the International Olympic Committee(IOC),there were approximately 2900 elite athletes from 91 National Olympic Committees competing in 109 events during the 16 days of the Games.2 In fact,under the conditions of a global pandemic,mass gatherings during large-scale sporting events represent a conducive environment for viral transmission given the close,prolonged,and frequent interactions between participants;this includes an increased risk of transmission of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2). | Jie Liu Jing Lou Yong Wang Jinjun Zhang | 2022 | Journal of Sport and Health Science2022，11，5： | 4 |
| 13 | Short-and long-term challenges in crop breeding显示文摘Agriculture provides the primary energy source and nutrients for humans,and is the key factor determining worldwide population and its basic health status.In the history of agriculture,desirable traits beneficial for farming rather than natural growth have been artificially selected through breeding of new elite varieties.Each successful step in crop breeding,e.g.wild plant domestication,crop introduction and the'Green Revolution',led to a period of rapid population growth.In the last seven decades after the Second World War,the world population has grown from 2.5 to7 billion.Driven by rapid advances in science and technology,the rate of generating crop varieties is accelerating.T aking China as an example,the annual production of its major staple crop,rice,has increased from~57 million tons in 1950 to more than 200 million tons at present.More importantly,in the past two decades。 | Hong Yu Jiayang Li | 2021 | National Science Review2021，8，2： | 3 |
| 14 | A New PCR/LDR-Based Multiplex Functional Molecular Marker for Marker-Assisted Breeding in Rice显示文摘Marker-assisted selection or marker-aided selection(MAS)provides an effective complementary approach for conventional rice breeding with precise and speedy mobilization of target genes into elite genetic backgrounds.The targeted genes,however,may not be selected in the course of MAS due to the occasional recombination between the marker and the target gene/QTL during the many cycles of meiosis involved in breeding programs.This leads to failure in the selection of target traits(Gopalakrishnan et al,2008). | Chu Huangwei Tu Rongjian Niu Fuan Zhou Jihua Sun Bin Luo Zhongyong Cheng Can Cao Liming | 2021 | Rice science2021，28，1： | 3 |
| 15 | Philips Brilliance iCT Elite冠状动脉CTA低剂量扫描的研究与探讨显示文摘目的 :评价冠状动脉CT血管成像(CT angiography,CTA)低剂量扫描结合i Dose重建与常规剂量扫描结合滤波反投影(filtered back-projection,FBP)重建图像的图像质量,探讨Philips Brilliance i CT Elite冠状动脉成像中降低k Vp对减低辐射剂量的影响程度。方法:筛选73例行门控轴位扫描的患者,分为A、B、C、D 4组。其中A组采用常规剂量120 k Vp,B、C、D组均采用100 k Vp,应用软件i Dose4分别降噪,观察降低剂量的效果。结果 :应用Philips Brilliance i CT Elite的i Dose4迭代重建可以显著改善图像的质量,在CT剂量指数(CT dose index,CTDI)较常规剂量降低50%的条件下仍可以得到与常规剂量FBP重建相当甚至更好的图像,在非选择性人群中,其冠状动脉CTA辐射剂量降至55%是可行的。结论 :通过降低k Vp可以显著降低冠状动脉成像扫描的辐射剂量。 | 胡安宁 辛小燕 朱斌 | 2016 | 医疗卫生装备2016，37，5： | 3 |
| 16 | ELITE PRO血凝仪2种测定纤维蛋白原方法结果的比较显示文摘目的:研究贝克曼库尔特ACL ELITE PRO全自动血凝仪,简称ELITE PRO。用凝血酶原时间(Prothrombin time,PT)衍算法(PT-Fib)测定纤维蛋白原(Fibrinogen,Fib)含量的精密度及其与凝血酶法(Clauss法)检测结果的相关性。方法:用Clauss法及PT-Fib法同时测定232例标本的Fib含量,对其结果的相关性进行分析,得出PT-Fib法测定Fib在ELITE PRO上的可信范围。结果:PT-Fib法检测结果精密度高,当Fib含量在1.5~4.5 g/L时,PT-Fib法与Clauss法的结果接近,两者测定结果正相关;当Fib<1.5 g/L或>4.5 g/L时,PT-Fib法的结果高于Clauss法。结论:当PT-Fib法测定的Fib含量在1.5~4.5 g/L时结果可靠,可直接用于临床报告;当PT-Fib法测定的Fib结果<1.5 g/L或>4.5 g/L时结果不稳定,应用Clauss法进一步复查。2种方法结合使用既可保证Fib检测速度的迅速、结果的准确,也可达到节约试剂的目的。 | 徐承来 周彦 刘小林 | 2012 | 重庆医科大学学报2012，37，9： | 3 |
| 17 | Manipulation of genetic recombination by editing the transcriptional regulatory regions of a meiotic gene in hybrid rice显示文摘Dear Editor,Genetic breeding involves the recombination and selection of various valuable genes.Meiotic crossover(CO)promotes the generation of new allelic combinations on chromosomes,which is essential for breeding elite varieties(Wijnker and de Jong,2008).An increase in CO promotes genetic diversity,whereas a decrease can rapidly stabilize excellent traits(Mercier et al.,2015).Furthermore,the complete elimination of CO facilitates heterotic fixation during apomixis(Wang et al.,2019). | Xin Wei Qing Liu Tingting Sun Xiaozhen Jiao Chaolei Liu Yufeng Hua Xi Chen Kejian Wang | 2023 | Plant Communications2023，4，2： | 2 |
| 18 | 集聚纺纱系统成纱原理及装置分析显示文摘本文详细介绍了COM4、EliTe和Air-Com-Tex700集聚纺纱系统的纺纱原理,并对各种集聚纺纱系统存在的问题及不足进行了分析。 | 王秀燕 李梅 | 2006 | 天津纺织科技2006，44，3： | 2 |
| 19 | Auxin regulation and MdPIN expression during adventitious root initiation in apple cuttings显示文摘Adventitious root(AR)formation is critical for the efficient propagation of elite horticultural and forestry crops.Despite decades of research,the cellular processes and molecular mechanisms underlying AR induction in woody plants remain obscure.We examined the details of AR formation in apple(Malus domestica)M.9 rootstock,the most widely used dwarf rootstock for intensive production,and investigated the role of polar auxin transport in postembryonic organogenesis.AR formation begins with a series of founder cell divisions and elongation of the interfascicular cambium adjacent to vascular tissues.This process is associated with a relatively high indole acetic acid(IAA)content and hydrolysis of starch grains.Exogenous auxin treatment promoted this cell division,as well as the proliferation and reorganization of the endoplasmic reticulum and Golgi membrane.In contrast,treatment with the auxin transport inhibitor N-1-naphthylphthalamic acid(NPA)inhibited cell division in the basal region of the cuttings and resulted in abnormal cell divisions during the early stage of AR formation.In addition,PIN-FORMED(PIN)transcripts were differentially expressed throughout the whole AR development process.We also detected upregulation of MdPIN8 and MdPIN10 during induction;upregulation of MdPIN4,MdPIN5,and MdPIN8 during extension;and upregulation of all MdPINs during AR initiation.This research provides an improved understanding of the cellular and molecular underpinnings of the AR process in woody plants. | Ling Guan Yingjun Li Kaihui Huang Zong-Ming(Max)Cheng | 2020 | Horticulture Research2020，7，1： | 2 |
| 20 | 《聊斋志异》的“难题求婚型”叙事模式显示文摘文化在自身的发展中出现了分流现象,有些主要属于上层知识阶层,有些则更多属于没有受过教育的下层人民.在文化史上,前者被称为大传统(greattradition)或精英文化(elite cultuye re),后者被称为小传统(littletradition) | 安国梁 | 1994 | 十堰职业技术学院学报1994，0，2： | 2 |
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