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| 1 | Effect of hepatitis C virus infection on expression of several cancer-associated gene products in hepatocellular carcinoma显示文摘NTRODUCTIONOurpreviousstudiesbyseroepidemiological,molecularepidemiologicalandimmunopathologicalmethodshaverevealedthathepa... | YANG Jian Min, WANG Rong Quan, BU Bao Guo, ZHOU Zi Cheng, FANG Dian Chun and LUO Yuan Hui | 1999 | World Journal of Gastroenterology1999，5，1： | 42 |
| 2 | Expression of insulin-like growth factor Ⅱ and its receptor in liver cells of chronic liver diseases显示文摘ExpressionofinsulinlikegrowthfactorⅡanditsreceptorinlivercelsofchronicliverdiseasesYANGDongHua1,XIUChong1,YANGBo1,GUJianR... | YANG Dong Hua 1, XIU Chong 1, YANG Bo 1, GU Jian Ren 2, QIAN Lian Fang 2 and QU Shu Ming 2 | 1997 | World Journal of Gastroenterology1997，3，2： | 21 |
| 3 | Systemic treatment strategies for triple-negative breast cancer显示文摘Triple-negative breast cancer(TNBC) is defined by the lack of immunohistochemical expression of the estrogen and progesterone receptors and human epidermal growth factor receptor 2(EGFR2). Most TNBC has a basal-like molecular phenotype by gene expression profiling and shares clinical and pathological features with hereditary BRCA1 related breast cancers. This review evaluates the activity of available chemotherapy and targeted agents in TNBC. A systematic review of PubM ed and conference databases was carried out to identify randomised clinical trials reporting outcomes in women with TNBC treated with chemotherapy and targeted agents. Our review identified TNBC studies of chemotherapy and targeted agents with different mechanisms of action, including induction of synthetic lethality and inhibition of angiogenesis, growth and survival pathways. TNBC is sensitive to taxanes and anthracyclins. Platinum agents are effective in TNBC patients with BRCA1 mutation, either alone or in combination with poly adenosine diphosphate polymerase 1 inhibitors. Combinations of ixabepilone and capecitabine have added to progression-free survival(PFS) without survival benefit in metastatic TNBC. Antiangiogenic agents, tyrosine kinase inhibitors and EGFR inhibitorsin combination with chemotherapy produced only modest gains in PFS and had little impact on survival. TNBC subgroups respond differentially to specific targeted agents. In future, the treatment needs to be tailored for a specific patient, depending on the molecular characteristics of their malignancy. TNBC being a chemosensitive entity, combination with targeted agents have not produced substantial improvements in outcomes. Appropriate patient selection with rationale combinations of targeted agents is needed for success. | Budhi Singh Yadav Suresh C Sharma Priyanka Chanana Swaty Jhamb | 2014 | World Journal of Clinical Oncology2014，5，2： | 18 |
| 4 | A candidate targeting molecule of insulin-like growth factor-Ⅰ receptor for gastrointestinal cancers显示文摘Advances in molecular research in cancer have brought new therapeutic strategies into clinical usage.One new group of targets is tyrosine kinase receptors,which can be treated by several strategies,including small molecule tyrosine kinase inhibitors(TKIs) and monoclonal antibodies(mAbs).Aberrant activation of growth factors/receptors and their signal pathways are required for malignant transformation and progression in gastrointestinal(GI) carcinomas.The concept of targeting specif ic carcinogenic receptors has been validated by successful clinical application of many new drugs.Type I insulin-like growth factor(IGF) receptor(IGF-IR) signaling potently stimulates tumor progression and cellular differentiation,and is a promising new molecular target in human malignancies.In this review,we focus on this promising therapeutic target,IGF-IR.The IGF/IGF-IR axis is an important modifier of tumor cell proliferation,survival,growth,and treatment sensitivity in many malignant diseases,including human GI cancers.Preclinical studies demonstrated that downregulation of IGF-IR signals reversed the neoplastic phenotype and sensitized cells to anticancer treatments.These results were mainly obtained through our strategy of adenoviruses expressing dominant negative IGF-IR(IGF-IR/dn) against gastrointestinal cancers,including esophagus,stomach,colon,and pancreas.We also summarize a variety of strategies to interrupt the IGFs/IGF-IR axis and their preclinical experiences.Several mAbs and TKIs targeting IGF-IR have entered clinical trials,and early results have suggested that these agents have generally acceptable safety profiles as single agents.We summarize the advantages and disadvantages of each strategy and discuss the merits/demerits of dual targeting of IGF-IR and other growth factor receptors,including Her2 and the insulin receptor,as well as other alternatives and possible drug combinations.Thus,IGF-IR might be a candidate for a molecular therapeutic target in human GI carcinomas. | Yasushi Adachi Hiroyuki Yamamoto Hirokazu Ohashi Takao Endo David P Carbone Kohzoh Imai Yasuhisa Shinomura | 2010 | World Journal of Gastroenterology2010，16，46： | 14 |
| 5 | 鱼类胰岛素样生长因子(IGF)系统的研究进展显示文摘鱼类胰岛素样生长因子 (insulin likegrowthfactors,IGFs)是进化上相当保守的多肽 ,能促进组织细胞的增殖、分化和凋亡 ,对鱼类的生长和发育有重要的调节作用。IGF系统包括IGF- Ⅰ、IGF -Ⅱ、IGF -ⅠR、IGF- ⅡR和IGFBP家族。本文从IGF家族成员的分子结构、生理功能和表达调节等方面综述了有关鱼类IGF体系的研究进展。 | 章力 黄希贵 王德寿 | 2005 | 动物学杂志2005，40，2： | 14 |
| 6 | Novel role of toll-like receptors in Helicobacter pylori-induced gastric malignancy显示文摘Helicobacter pylori(H.pylori)infects the human stomach during infancy and develops into chronic activeinflammation.The majority of H.pylori tend to colonize within the mucous gel layer of the stomach.Thestomach lacks its own immune function,thus innateimmunity as the first line of defense is vital for specificimmunity against H.pylori.We review recent discoveries in the pathophysiologic roles of toll-like receptors(TLRs),mainly TLR2 and TLR4,in H.pylori-induced inflammation.In addition,the TLR pathways activated byH.pylori-induced inflammation have been shown to beclosely associated not only with gastric carcinogenesis,but also with formation of the tumor microenvironmentthrough the production of pro-inflammatory cytokines,chemokines,and reactive oxygen species.Althoughthe correlation between single nucleotide polymorphisms of TLRs and gastric cancer risk remains unclear,a recent study demonstrated that STAT3-driven upregulation of TLR2 might promote gastric tumorigenesis independent of inflammation.Further research onthe regulation of TLRs in H.pylori-associated gastriccarcinogenesis will uncover diagnostic/predictive biomarkers and therapeutic targets for gastric cancer. | Kaname Uno Katsuaki Kato Tooru Shimosegawa | 2014 | World Journal of Gastroenterology2014，20，18： | 14 |
| 7 | Plant HP1 protein ADCP1 links multivalent H3K9 methylation readout to heterochromatin formation显示文摘Heterochromatin Protein 1 (HP1) recognizes histone H3 lysine 9 methylation (H3K9me) through its conserved chromodomain and maintains heterochromatin from fission yeast to mammals. However, in Arabidopsis, Like Heterochromatin Protein 1 (LHP1) recognizes and colocalizes genome-wide with H3K27me3, and is the functional homolog of Polycomb protein. This raises the question whether genuine HP1 homologs exist in plants. Here, we report on the discovery of ADCP1, a plant-specific triple tandem Agenet protein, as a multivalent H3K9me reader in Arabidopsis, and establish that ADCP1 is essential for heterochromatin formation and transposon silencing through modulating H3K9 and DNA methylation levels. Structural studies revealed the molecular basis underlying H3K9me-specific recognition by tandem Agenet of ADCP1. Similar to human HP1α and fly HP1a, ADCP1 mediates heterochromatin phase separation. Our results demonstrate that despite its distinct domain compositions, ADCP1 convergently evolves as an HP1-equivalent protein in plants to regulate heterochromatin formation. | Shuai Zhao Lingling Cheng Yifei Gao Baichao Zhang Xiangdong Zheng Liang Wang Pilong Li Qianwen Sun Haitao Li | 2019 | Cell Research2019，29，1： | 10 |
| 8 | Glucagon-like peptide-1 analogue prevents nonalcoholic steatohepatitis in non-obese mice显示文摘AIM: To investigate whether a glucagon-like peptide-1(GLP-1) analogue inhibits nonalcoholic steatohepatitis(NASH), which is being increasingly recognized in Asia, in non-obese mice. METHODS: A methionine-choline-deficient diet(MCD) along with exendin-4(20 μg/kg per day, ip), a GLP-1 analogue, or saline was administered to male db/db mice(non-obese NASH model). Four or eight weeks after commencement of the diet, the mice were sacrificed and their livers were excised. The excised livers were examined by histochemistry for evidence of hepatic steatosis and inflammation. Hepatic triglyceride(TG) and free fatty acid(FFA) content was measured, and the expression of hepatic fat metabolism- and inflammation-related genes was evaluated. Oxidative stress-related parameters and macrophage recruitment were also examined using immunohistochemistry.RESULTS: Four weeks of MCD feeding induced hepatic steatosis and inflammation and increased the hepatic TG and FFA content. The expression of fattyacid transport protein 4(FATP4), a hepatic FFA influxrelated gene; macrophage recruitment; and the level of malondialdehyde(MDA), an oxidative stress marker, were significantly augmented by a 4-wk MCD. The levels of hepatic sterol regulatory element-binding protein-1c(SREBP-1c) m RNA(lipogenesis-related gene) and acyl-coenzyme A oxidase 1(ACOX1) m RNA(β-oxidation-related gene) had decreased at 4 wk and further decreased at 8 wk. However, the level of microsomal triglyceride transfer protein m RNA(a lipid excretion-related gene) remained unchanged. The administration of exendin-4 significantly attenuated the MCD-induced increase in hepatic steatosis, hepatic TG and FFA content, and FATP4 expression as well as the MCD-induced augmentation of hepatic inflammation, macrophage recruitment, and MDA levels. Additionally, it further decreased the hepatic SREBP-1c level and alleviated the MCD-mediated inhibition of the ACOX1 m RNA level. CONCLUSION: These results suggest that GLP-1 inhibits hepatic steatosis and inflammation through the inhibition of hepatic FFA influx and oxidative stress in a non-obese NASH model. | Takaya Yamamoto Yukiomi Nakade Taeko Yamauchi Yuji Kobayashi Norimitsu Ishii Tomohiko Ohashi Kiyoaki Ito Ken Sato Yoshitaka Fukuzawa Masashi Yoneda | 2016 | World Journal of Gastroenterology2016，22，8： | 10 |
| 9 | Tribological behavior of different films on Ti-6Al-4V alloy prepared by plasma-based ion implantation显示文摘The tribological behaviors of TiN coating and TiN+TiC+Ti(C, N)/diamond like carbon (DLC), TiN/DLC, TiC/DLC multilayers on Ti 6Al 4V alloy prepared by plasma based ion implantation (PBII) were compared. Under the test conditions of counterbody AISI 52100, load 1 N and speed 0.05 m/s, the tribological properties of the alloy are improved by these films in the order of TiN, TiC/DLC, TiN/DLC and TiN+TiC+Ti(C,N)/DLC. Tribological behavior is affected by the conditions of surface modification and triboexperiments. The appearance of “peaks” in the wear dynamic resistance profiles may be due or correspond to the process of formation and breaking apart of transition films. The breakthrough of the DLC coated samples may start from partially wearing out, and end with joining piece dilamination. There are transition films on all counterbodies AISI 52100. When AISI 52100 counterbody is changed to Ti 6Al 4V, the wear of most modified samples is changed from only disc to both disc and ball abrasive dominated. | 季红兵 夏立芳 马欣新 孙跃 | 2000 | 中国有色金属学会会刊:英文版2000，10，4： | 8 |
| 10 | 痤疮患者病灶及外周血中TLRs家族的表达量及其对炎症介质合成的调节作用显示文摘目的:研究痤疮患者病灶及外周血中Toll样受体(toll like receptors,TLRs)家族的表达量及其对炎症介质合成的调节作用。方法:选择2013年6月~2016年7月期间在我院就诊的60例寻常型痤疮患者作为痤疮组,同期在我院接受清创缝合的48例外伤患者作为对照组。收集痤疮病灶组织及清创后的皮肤组织并测定TLRs及炎症介质的表达量,采集外周血单个核细胞并测定TLRs的表达量。结果:痤疮组患者皮肤组织及外周血单个核细胞中TLR2、TLR4的蛋白表达量显著高于对照组(P<0.05),TLR3、TLR5、TLR7、TLR9的蛋白表达量与对照组比较差异无统计学意义(P>0.05);TLR2和TLR4高表达的痤疮组织中白介素(IL)-1α、IL-1β、IL-8、肿瘤坏死因子(TNF)-α的含量显著高于TLR2和TLR4低表达的痤疮组织(P<0.05)。结论:痤疮患者病灶及外周血中TLR2、TLR4呈高表达趋势且对炎症介质的合成具有促进作用。 | 薛强东 李青 周荣华 张雅洁 王启操 邱佳玲 | 2017 | 海南医学院学报2017，23，11： | 8 |
| 11 | Insulin like growth factor-1 increases fatty liver preservation in IGL-1 solution显示文摘AIM: To investigate the benefits of insulin like growth factor-1 (IGF-1) supplementation to serum-free institut georges lopez-1 (IGL-1) solution to protect fatty liver against cold ischemia reperfusion injury. METHODS: Steatotic livers were preserved for 24 h in IGL-1 solution supplemented with or without IGF-1 and then perfused 'ex vivo ' for 2 h at 37℃. We examined the effects of IGF-1 on hepatic damage and function (transaminases, percentage of sulfobromophthalein clearance in bile and vascular resistance). We also studied other factors associated with the poor tolerance of fatty livers to cold ischemia reperfusion injury such as mitochondrial damage, oxidative stress, nitric oxide, tumor necrosis factor-α (TNF-α) and mitogen-activated protein kinases.RESULTS: Steatotic livers preserved in IGL-1 solutionsupplemented with IGF-1 showed lower transaminase levels, increased bile clearance and a reduction in vascular resistance when compared to those preserved in IGL-1solution alone. These benefits are mediated by activation of AKT and constitutive endothelial nitric oxide synthase (eNOS), as well as the inhibition of inflammatory cytokines such as TNF-α. Mitochondrial damage and oxidative stress were also prevented.CONCLUSION: IGL-1 enrichment with IGF-1 increasedfatty liver graft preservation through AKT and eNOS activation, and prevented TNF-α release during normothermic reperfusion. | Mohamed Amine Zaouali Susagna Padrissa-Altés Ismail Ben Mosbah Hassen Ben Abdennebi Olivier Boillot Antoni Rimola Dalila Saidane-Mosbahi Joan Roselló-Catafau | 2010 | World Journal of Gastroenterology2010，16，45： | 6 |
| 12 | 二穗短柄草MADS-BOX基因AGL6和FUL1的可变拼接和表达模式分析显示文摘MADS-BOX基因家族是一类调控植物发育的重要转录因子,AGAMOUS LIKE 6(AGL6)和FRUITFULL(FUL1)属于其亚家族。本研究克隆了二穗短柄草(Brachypodium distachyon)2个MADS-BOX基因Bd AGL6和Bd FUL1的c DNA序列,分析了这2个基因的可变拼接和表达模式。结果表明,Bd AGL6基因在转录过程中,由于内含子部分保留机制,发生可变拼接,形成了3个转录本(Bd AGL6-1、Bd AGL6-2和Bd AGL6-3);Bd AGL6-3与水稻(Oryza sativa)、玉米(Zea maize)等禾本科植物中的AGL6转录因子序列高度同源;和Bd AGL6-3相比,Bd AGL6-1在C末端结构域插入额外的7个氨基酸;Bd AGL6-2在C末端结构域插入额外的5个氨基酸。q RT-PCR结果显示,Bd AGL6在花中高水平表达,其中Bd AGL6-3表达最强,Bd AGL6-1和Bd AGL6-2表达较弱。Bd FUL1基因的前体m RNA同样发生了可变拼接,产生2个转录本(Bd FUL1-1和Bd FUL1-2);两者的表达模式相似,除了在花和茎中表达之外,在幼苗的叶中也有表达。研究结果为进一步了解MADS-BOX基因家族的生物学功能提供了参考资料。 | 窦艳华 韩萌萌 孙其信 李海峰 | 2015 | 农业生物技术学报2015，23，4： | 6 |
| 13 | The Relationships between Serum Concentration of IGF-I and Left Ventricular Function as well as Coronary Collateral Circulation in Patients with Coronary Artery Disease显示文摘Objective To investigate therelationships between serum concentration of insulin -like growth factor - I (IGF-I) and left ventricular function as well as coronary collateral circulation in patients with coronary artery disease (CAD) . Methods In 41 patients with CAD and 15 control subjects without CAD, the concentrations of serum IGF - I were measured using radioimmunoassay. The relationships between the concentration of serum IGF - I and Leaman coronary artery score, Rentrop grade of coronary collateral circulation, left ventricular ejection fraction (LVEF) as well as left ventricular wall motion Cortina score were assessed. Results 1. There was no significant difference in the mean level of serum IGF -I between the CAD group and the control group (107. 92±44.74 ng/ml vs 113.05 ±33. 65 ng/ml, P> 0. 05), but the IGF - I concentrations in the subgroup with collateral circulation were significantly greater than that in the control group (147. 33 ±29. 92 ng/ml vs 113. 05±33. 65 ng/ml, P < 0. 01) or | 杜志民 罗初凡 胡承桓 李怡 伍贵富 唐安丽 马虹 | 2001 | South China Journal of Cardiology2001，2，1： | 6 |
| 14 | Pressure Gradient Force,Saffman Lift,and Magnus Lift on the Fiber-like Particle in Fluid显示文摘Flher-like particle suspensions are common in both na-ture and industry, but there is little work reported on it.The forces acting on the fiber - like particle in fluid arestudied in this paper, and the Magnus lift, Saffman lift,pressure gradient force, and then the dynamics modelhave been received. The numerical study of the simpleshear flow past the cylinders shows that the particles ’motion is controlled by the vortex. | 朱泽飞 林建忠 | 2000 | Journal of China Textile University(English Edition)2000，17，2： | 5 |
| 15 | 血清钙C-反应蛋白及血清淀粉酶样蛋白A水平对重症急性胰腺炎早期预测价值的研究显示文摘目的:探讨血清钙、C-反应蛋白( C-reactive protein, CRP)及血清淀粉酶样蛋白A( serum amylase like protein A , SAA)水平对重症急性胰腺炎( severe acute pancreatitis , SAP)的早期预测价值。方法120例急性胰腺炎患者,分为轻症( MAP)组91例,SAP组29例,同期健康体检者61例为对照组;比较三组血清钙、SAA和CRP水平。结果 MAP和SAP组CRP和SAA水平均较对照组显著升高,第2天达到峰值,SAP组显著高于MAP组;两组血清钙水平显著低于对照组,SAP组显著低于MAP组。三者联合测定的诊断敏感度96.9%和特异度97.4%。结论动态测定血清钙、SAA和CRP水平对评估SAP具有重要的临床价值。 | 梁科展 | 2014 | 中国急救医学2014，34，8： | 5 |
| 16 | 脑梗死患者血清胰岛素样生长因子-1与颈动脉粥样硬化斑块的关系显示文摘目的探讨脑梗死患者血清胰岛素样生长因子-1(IGF-1)与颈动脉粥样硬化斑块的关系。方法选取100例急性脑梗死患者及50例健康对照者,采用ELISA法测定血清IGF-1水平,并进行颈动脉彩超检查,根据结果分成不稳定斑块组、稳定斑块组、无斑块组三亚组。结果脑梗死组颈动脉粥样硬化斑块及不稳定斑块的检出率分别为67.0%及42.0%,均明显高于对照组26.0%和8.0%,P<0.01。不稳定斑块组的血清IGF-1水平明显低于稳定斑块组及无斑块组(均P<0.01),稳定斑块组血清IGF-1水平明显低于无斑块组(P<0.05)。结论脑梗死患者的颈动脉粥样硬化斑块发生率明显增高;血清IGF-1水平减少与不稳定性颈动脉粥样硬化斑块形成密切相关。 | 张伟萍 张宝荣 | 2014 | 浙江医学2014，36，1： | 5 |
| 17 | 磷掺杂类金刚石薄膜的制备与性能研究显示文摘应用等离子体浸没离子注入与沉积方法合成了磷掺杂的类金刚石(P doped diamond like carbon,P-aopea DLC)薄膜。结构分析表明磷以微米级岛状结构分散于DLC薄膜表层,P的掺杂增加了DLC薄膜的无序性,俄歇能谱证明岛型区域是由P、C、O三种元素形成的化合物,衰减全反射傅里叶红外光谱(ATR-FTIR)的分析结果显示存在P-O-P和P-P-C的非对称伸缩振动。掺杂表面表现出强烈的亲水性(水接触角为16.9°),体外血小板粘附实验结果显示,P掺杂DLC薄膜表面粘附的血小板少且变形小,表现出的血液相容性优于热解碳和未改性DLCo。P-doped DLC薄膜与水的界面张力为2.7 nJ/cm2,具有较理想的接近于血细胞的界面张力,因此与血液保持了较高的相容性。 | 王进 Sunny C.H.Kwok 陈俊英 杨萍 黄楠 P.K.Chu | 2005 | 真空科学与技术学报2005，25，2： | 5 |
| 18 | SLP-2基因在喉鳞状细胞癌和乳腺浸润性癌组织中的表达及其与预后的关系显示文摘目的探讨两种恶性上皮性肿瘤组织——喉鳞状细胞癌(简称喉癌)和乳腺浸润性癌(简称乳腺癌)中stomatin like protein-2(SLP-2)基因在mRNA和蛋白水平的表达,及其与肿瘤的临床病理参数和预后的相关性。方法应用逆转录聚合酶链反应(RT—PCR)检测了46对喉癌及喉正常上皮组织中SLP-2基因的表达,Westernblot方法检测了其中10对标本的SLP-2蛋白表达,同时采用免疫组织化学方法分别检测了104例喉癌组织芯片和263例乳腺癌组织芯片中SLP-2蛋白的表达水平,分析SLP-2蛋白的表达与临床病理变量之间的关系。结果RT—PCR结果显示SLP-2基因在46例喉癌中的38例肿瘤组织中的表达升高(83%,38/46),喉正常上皮组织中表达阴性。Westernblot结果显示,有7例喉癌组织中SLP-2蛋白表达显著高于对应的喉正常上皮组织。喉癌组织芯片的免疫组织化学染色结果显示,与全部20例喉正常上皮组织的阴性表达(0/20)相比,SLP-2蛋白染色在104例喉癌组织中有36例出现了过表达(34.6%,36/104;P=0.000)。与喉正常上皮表达相比,喉癌组织中SLP-2基因在mRNA和蛋白水平的表达均明显升高。SLP-2蛋白过表达与喉癌患者的临床分期较晚(P〈0.01)和淋巴结发生转移(P=0.003)密切相关。乳腺癌组织芯片免疫组织化学染色结果显示,与在正常乳腺组织中的阴性表达(0/10)相比,SLP-2蛋白在乳腺癌组织中呈现过表达(52.5%,138/263),差异有统计学意义(P=0.000),且该蛋白的过表达与乳腺肿物的大小(P=0.020)、淋巴结转移(P〈0.01)、临床分期Ⅲ期(P〈0.01)以及发生远处转移(P=0.002)密切相关。此外,还与HER2/neu蛋白的表达存在显著相关性(P=0.037),生存分析表明,SLP-2蛋白过表达乳腺癌患者总生存率显著降低。多因素分析显示淋巴结状态、HER2/neu蛋白表达和SLP-2蛋白表达可能作为独立的预后因子。结论SLP-2蛋白的过表达可能与喉癌和乳腺癌的侵袭、转移过程密切相关,并可能作为独立的预后指标提示乳腺癌患者预后不良。 | 曹文枫 张立勇 张斌 刘明波 刘芝华 孙保存 | 2010 | 中华病理学杂志2010，39，5： | 4 |
| 19 | Depressive symptoms in neurodegenerative diseases显示文摘Depressive symptoms are very common in chronic conditions. This is true so for neurodegenerative diseases. A number of patients with cognitive decline and dementia due to Alzheimer's disease and related conditions like Parkinson's disease, Lewy body disease, vascular dementia, frontotemporal degeneration amongst other entities, experience depressive symptoms in greater or lesser grade at some point during the course of the illness. Depressive symptoms have aparticular significance in neurological disorders, specially in neurodegenerative diseases, because brain, mind, behavior and mood relationship. A number of patients may develop depressive symptoms in early stages of the neurologic disease, occurring without clear presence of cognitive decline with only mild cognitive deterioration. Classically, depression constitutes a reliable diagnostic challenge in this setting. However, actually we can recognize and evaluate depressive, cognitive or motor symptoms of neurodegenerative disease in order to establish their clinical significance and to plan some therapeutic strategies. Depressive symptoms can appear also lately, when the neurodegenerative disease is fully developed. The presence of depression and other neuropsychiatric symptoms have a negative impact on the quality-of-life of patients and caregivers. Besides, patients with depressive symptoms also tend to further decrease function and reduce cognitive abilities and also uses to present more affected clinical status, compared with patients without depression. Depressive symptoms are treatable. Early detection of depressive symptoms is very important in patients with neurodegenerative disorders, in order to initiate the most adequate treatment. We review in this paper the main neurodegenerative diseases, focusing in depressive symptoms of each other entities and current recommendations of management and treatment. | Miquel Baquero Nuria Martín | 2015 | World Journal of Clinical Cases2015，3，8： | 4 |
| 20 | The change of insulin-like growth factor-1 in diabetic patients with neuropathy显示文摘Diabeticneuropathy(DNP)isahighlydebilitatingcomplicationfordiabeticindividuals.Unfortunately,thepathogenesisofDNPisstilpoorly... | 郭淮莲 杨毅 耿稚萍 朱良湘 袁申元 赵毅 高玉红 付汉菁 | 1999 | Chinese Medical Journal1999，，1： | 4 |
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