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| 1 | 鼎湖山风景区森林游憩价值评价研究显示文摘旅行费用法(TCM法)是目前世界上应用较为广泛的森林憩价值评价方法,运用TCM法评价出鼎湖山风景区2000年的森林游憩价值为31369.0万元,人均425.1元,同时还对风景区单项旅游活动的游憩效益价值作了评价,其结果为鼎湖山林林游憩活动的经营管理及开发建设提供参考依据。 | 吴章文 罗艳菊 | 2002 | 林业经济2002，，9： | 43 |
| 2 | 中医通法浅析显示文摘'通'为常,'不通'则病。通法有广义和狭义之分。狭义通法是指宣通郁滞、通利二便。广义通法是指疏通脏腑经络气机,消除体内壅滞,畅行气血津液。 | 汤尔峰 姜惟 | 2012 | 中国中医急症2012，21，3： | 38 |
| 3 | Clinical practice guidelines for the treatment of primary liver cancer with integrative traditional Chinese and Western medicine显示文摘Traditional Chinese medicine(TCM) is an important part of the treatment of primary liver cancer(PLC) in China; however, the current instructions for the integrative use of traditional Chinese and Western medicine for PLC are mostly based on expert opinion. There is no evidence-based guideline for clinical practice in this field. Therefore, the Shanghai Association of Chinese Integrative Medicine has established amultidisciplinary working group to develop this guideline, which focuses on the most important questions about the use of TCM during PLC treatment. This guideline was developed following the methodological process recommended by the World Health Organization Handbook for Guideline Development.Two rounds of questionnaire survey were performed to identify clinical questions; published evidence was searched; the Grading of Recommendations Assessment, Development and Evaluation approach was used to evaluate the body of evidence; and recommendations were formulated by combining the quality of evidence, patient preferences and values, and other risk factors. The guideline was written based on the Reporting Items for Practice Guidelines in Healthcare tool. This guideline contains 10 recommendations related to 8 questions, including recommendations for early treatment by TCM after surgery, TCM combined with transcatheter arterial chemoembolization for advanced PLC, TCM drugs for external use, and acupuncture and moxibustion therapy. | Chang-quan Ling Jia Fan Hong-sheng Lin Feng Shen Zhen-ye Xu Li-zhu Lin Shu-kui Qin Wei-ping Zhou Xiao-feng Zhai Bai Li Qing-hui Zhou | 2018 | Journal of Integrative Medicine2018，16，4： | 38 |
| 4 | Rapid separation and identification of multiple constituents in Danhong Injection by ultra-high performance liquid chromatography coupled to electrospray ionization quadrupole time-of-flight tandem mass spectrometry显示文摘To characterize and identify multiple constituents in Danhong injection(DHI), a fast ultra-high performance liquid chromatography coupled to electrospray ionization quadrupole time-of-flight tandem mass spectrometry(UHPLC-ESI-QTOF/MS) method was established and validated in the present study. A total of 63 compounds, including 33 phenolic acids, 2 C-glycosyl quinochalcones, 6 flavonoid O-glycosides, 4 iridoid glycosides, 6 organic acids, 5 amino acids, and 3 nucleosides, were identified or tentatively characterized. In conclusion, the UHPLC-ESI-QTOF/MS method is useful and efficient for in-depth structural elucidation of chemical compounds in complex matrices of herbal medicines such as DHI. | ZHANG Qun-Qun DONG Xin LIU Xin-Guang GAO Wen LI Ping YANG Hua | 2016 | Chinese Journal of Natural Medicines2016，14，2： | 30 |
| 5 | Chinmedomics: A Powerful Approach Integrating Metabolomics with Serum Pharmacochemistry to Evaluate the Efficacy of Traditional Chinese Medicine显示文摘Evaluation of the efficacy of traditional Chinese medicines (TCMs) is an important prerequisite for discovering effective substances, lead compounds, and quality markers (Q markers). At present, there is an urgent need to develop a biological language that can act as abridge for the scientific elaboration of the efficacy of TCMs, and to further highlight the significant value of TCM. Chinese medicinal syndromes and formulae are two essential parts of TCM that directly relate to its efficacy. Syndromes and formulae have been taken as the research objects. The serum pharmacochemistry of the TCM approach with metabolomics were integrated to establish an innovative chinmedomics strategy, which is able to explore syndrome biomarkers and evaluate TCM efficacy in order to discover effective substances from TCMs. A great deal of concrete work in chinmedomics has already performed to bridge the gap between Chinese and Western medicine, and to provide a powerful approach to enhance the scientific value of TCM theory and clinical practice. This article summarizes the application of chinmedomics in identifying the candidate biomarkers of a syndrome and revealing the efficacy of the related formula. We also highlight the discovery of lead compounds and Q markers from TCMs. | Ai-Hua Zhang Hui Sun Guang-Li Yan Ying Han Qi-Qi Zhao Xi-Jun Wang | 2019 | Engineering2019，5，1： | 30 |
| 6 | Guidance for the clinical evaluation of traditional Chinese medicine-induced liver injury Issued by China Food and Drug Administration显示文摘1. Introduction Drug-induced liver injury (DILI), defined as liver injury caused by a drug and/or its metabolites, is a common clinical adverse drug reaction1–4. This type of injury can cause acute liver failure and even death in severe cases5. | Xiaohe Xiao Jianyuan Tang Yimin Mao Xiuhui Li Jiabo Wang Chenghai Liu Kewei Sun Yong’an Ye Zhengsheng Zou Cheng Peng Ling Yang Yuming Guo Zhaofang Bai Tingting He Jing Jing Fengyi Li Na An | 2019 | Acta Pharmaceutica Sinica B2019，9，3： | 22 |
| 7 | Therapeutic effect of Zijin capsule in liver fibrosis in rats显示文摘TherapeuticefectofZijincapsuleinliverfibrosisinratsCAIDaYongZHAOGang,CHENJiaChun,YEGanMei,BINGFeiHongandFANBuWuSubjecth... | CAI Da Yong, ZHAO Gang, CHEN Jia Chun, YE Gan Mei, BING Fei Hong and FAN Bu Wu | 1998 | World Journal of Gastroenterology1998，4，3： | 20 |
| 8 | Integrative Medicine in Clinical Practice:From Pattern Differentiation in Traditional Chinese Medicine to Disease Treatment显示文摘Pattern(syndrome) differentiation is the key theory in traditional Chinese medicine(TCM) and the important diagnostic principle for TCM therapy.More and more medical researchers recognize that the combination of disease diagnosis in biomedicine and pattern differentiation in TCM is essential for the clinical practice, and it has been a common practice model in China since it will produce better clinical effects. | 吕爱平 陈可冀 | 2009 | Chinese Journal of Integrative Medicine2009，15，2： | 19 |
| 9 | A survey of web resources and tools for the study of TCM network pharmacology显示文摘Background: Traditional Chinese medicine (TCM) treats diseases in a holistic manner, while TCM formulae are multi-component, multi-target agents at the molecular level. Thus there are many parallels between the key ideas of TCM pharmacology and network pharmacology. These years, TCM network pharmacology has developed as an interdisciplinary of TCM science and network pharmacology, which studies the mechanism of TCM at the molecular level and in the context of biological networks. It provides a new research paradigm that can use modern biomedical science to interpret the mechanism of TCM, which is promising to accelerate the modernization and internationalization of TCM? Results: In this paper we introduce state-of-the-art free data sources, web servers and softwares that can be used in the TCM network pharmacology, including databases of TCM, drug targets and diseases, web servers for the prediction of drug targets, and tools for network and functional analysis. Conclusions: This review could help experimental pharmacologists make better use of the existing data and methods in their study of TCM. | Jing Zhao Jian Yang Saisai Tian Weidong Zhang | 2019 | Frontiers of Electrical and Electronic Engineering in China2019，7，1： | 17 |
| 10 | Clinical Application of the TCM Classic Formulae for Treating Chronic Bronchitis显示文摘The principle of formulae corresponding to syndromes is an unique model described in the classics of traditional Chinese medicine (TCM) for treatment of diseases. Making the symptoms and signs as the therapeutic targets, in which the intuitive judgments and jumping characteristics are manifested. | 熊兴江 禇福永 李海霞 何庆勇 | 2011 | Journal of Traditional Chinese Medicine2011，31，1： | 15 |
| 11 | Review Present Situation and Prospects of TCM Treatment of Parkinson's Disease显示文摘Parkinson's disease (PD) is a chronic degenerative disease of the nervous system marked by tremor,muscle rigidity, hypokinesis, abnormal posture, and pathologically, selective loss of dopaminergic neurons in the substantia nigra of the midbrain and obvious decrease of dopamine content in the striatum.It is encountered mostly in the middle-aged and old persons and is one of main causes inducing their deformity. The morbidity of this disease tends to increase with gradual aging of the population. In recent years, TCM treatment of this disease has obtained gratifying achievements. A review follows. | 何建成 卫洪昌 袁灿兴 顾名昌 陈汝兴 | 2004 | Journal of Traditional Chinese Medicine2004，24，4： | 13 |
| 12 | A metabolic mechanism analysis of Fuzheng-Huayu formula for improving liver cirrhosis with traditional Chinese medicine syndromes显示文摘 | Ya-nan SONG Jian CHEN Fei-fei CAI Yi-yu LU Qi-long CHEN Yong-yu ZHANG Ping LIU Shi-bing SU | 2018 | Acta Pharmacologica Sinica2018，39，6： | 13 |
| 13 | 络系统与络病理论初探显示文摘络系统是经络系统的一个有机组成部分。络系统的组成主要有十五大络、阴络、阳络、缠络、孙络和浮络等。它是运行人体气血、沟通脏腑肢节、调整人体生理功能的基本功能单位。络病理论认为络病是由各种因素而导致络脉痹阻、气血津液运行不畅的一类病变。深入研究络系统和络病理论对于我们继承和发展中医传统理论 ,并对其中的脏腑经络、病因病机、诊断治疗、辨证论治等理论都有很大的帮助。并且对于运用现代医学对传统中医进行微观研究 ,提出相应的假说有一定的意义。 | 王朝阳 衣华强 睢明河 赵建新 马惠芳 谷世喆 | 2004 | 针刺研究2004，29，2： | 12 |
| 14 | Relations between Phlegm and Generation and Development of Gastric Cancer显示文摘In terms of various therapies for gastric cancer seriously affecting the human health, the therapeutic effect of chemotherapy should be further evaluated and radiotherapy is more applicable to the operation, and it is still difficult to evaluate the effects | 魏品康 许玲 孙大志 施俊 秦志丰 陆烨 段树民(译) | 2008 | Journal of Traditional Chinese Medicine2008，28，2： | 12 |
| 15 | Insights into the molecular mechanisms of Polygonum muitiflorum Thunb-induced liver injury: a computational systems toxicology approach显示文摘导致植物的肝损害(HILI ) 的越来越多的案例被报导了,提出新临床的挑战。在这研究,作为一个例子拿蓼 multiflorum Thunb (PmT ) ,我们建议了一条计算系统毒物学途径探索 HILI 的分子的机制。首先, PmT 的化学部件象与自然产品有关的文学一样从 3 个主要 TCM 数据库被提取。然后,已知的目标通过数据集成被收集,并且潜在的复合目标的相互作用(CTI ) 用我们的 substructure-drug-target 被预言基于网络的推理(SDTNBI ) 方法。在由估计 HILI 的症状为 hepatotoxicity 相关的基因屏蔽以后,一个复合目标的相互作用网络被构造。得分功能,也就是 Ascore,被开发在肝估计化学药品的毒性。我们进行了网络分析用分析工具决定 biphasic 效果的可能的机制,包括宾果游戏,小径丰富,机关分发分析和和 CYP450 酶的相互作用的预言。在 PmT 的化学部件之中,有好肠的吸收的 54 个部件被用于分析,并且 2939 CTI 被获得。在在 BioGPS 数据库分析 mRNA 表达式数据以后,与肝疾病有关的 1599 CTI 和 125 个目标被识别。在 15 加重的顶,七与 Ascore 价值 >(emodin,橡黄素, apigenin, resveratrol,法国的酸, kaempferol 和 luteolin ) 3000 显然与 hepatotoxicity 被联系。从小径丰富分析的结果建议在 apoptosis 和新陈代谢之间的多重相互作用可以位于导致 PmT 的肝损害下面。许多在特定的混合物小径被验证了,例如谷胱甘肽新陈代谢,细胞色素 P450 新陈代谢,和 p53 小径,在其它之中。肝炎症状,九胆汁酸的不安和黄或黄褐色的尿也有相应小径,认为我们的方法正当。在结论,这个计算系统毒物学方法揭示可能的有毒的部件并且能对理解 HILI 的机制很有用。这样,方法可能也便于新奇肝毒素的植物的鉴定。 | Yin-yin WANG Jie LI Zeng-rui WU Bo ZHANG Hong-bin YANG Qin WANG Ying-chun CAI Gui-xia LIU Wei-hua LI Yun TANG | 2017 | Acta Pharmacologica Sinica2017，38，5： | 12 |
| 16 | 近二十年国内旅游资源价值评价研究文献分析显示文摘以中国学术期刊全文数据库、中国优秀博硕士学位论文全文数据库以及中国重要会议论文全文数据库为主要来源,以'旅游资源'、'价值'、'评价'作为关键词进行检索,共得到相关论文62篇。重点筛选了其中的35篇进行归纳分析。在评述思路上,重点对国内文献的研究内容进行分析和归纳,探悉国内学者研究领域的变化、评价方法的使用以及研究中存在的不足,以此为基础预测未来关于旅游资源价值评价研究的发展方向,以期对今后旅游资源价值评价的相关研究有所帮助。 | 吴亚东 殷平 | 2009 | 旅游论坛2009，2，3： | 11 |
| 17 | 中医“治未病”理论应用于社区高血压病患者的防治效果及影响显示文摘目的:讨论研究应用中医'治未病'理论对社区居民高血压疾病的预防及控制效果。方法:将社区登记的100例高血压患者随机分为干预组与常规组。给予常规组日常干预;干预组在常规组基础上联合中医'治未病'理论进行干预。对两组实验者血压控制效果及血压控制情况进行比较。结果:干预后自我管理能力的比较显示干预组戒烟戒酒、遵嘱服药以及坚持运动人数均显著多于常规组(P<0.05);服药依从性比较显示干预组患者服药依从性得分显著优于普通组(P<0.05)。结论:对社区居民实行以中医'治未病'为理论指导的护理干预能够提高居民及高血压患者对疾病知识的认识并采取一定预防措施。及时跟进患者疾病发展情况和血压控制情况。有效提高患者治疗依从性,加快疾病恢复速度。 | 杨春华 | 2014 | 中医临床研究2014，6，9： | 11 |
| 18 | Anti-diabetic effects and mechanisms of action of a Chinese herbal medicine preparation JQ-R in vitro and in diabetic KKAy mice显示文摘Refined-JQ(JQ-R) is a mixture of refined extracts from Coptis chinensis(Ranunculaceae),Astragalus membranaceus(Leguminosae) and Lonicera japonica(Caprifoliaceae), the three major herbs of Jin Qi-Jiang Tang tablet, a traditional Chinese medicine(TCM) formula. The mechanisms by which JQ-R regulates glucose metabolism and improves insulin sensitivity were studied in type 2 diabetic KK^(Ay)mice and insulin-resistant L6 myotubes. To investigate the mechanisms by which JQ-R improves insulin sensitivity, a model of insulin-resistant cells induced with palmitic acid(PA) was established in L6 myotubes. Glucose uptake and expression of factors involved in insulin signaling, stress, and inflammatory pathways were detected by immunoblotting. JQ-R showed beneficial effects on glucose homeostasis and insulin resistance in a euglycemic clamp experiment and decreased fasting insulin levels in diabetic KK^(Ay)mice. JQ-R also improved the plasma lipid profiles. JQ-R directly increased the activity of superoxide dismutase(SOD) and decreased malondialdehyde(MDA) as well as inducible nitric oxide synthase(iNOS) levels in insulin-resistant L6 cells, and elevated the insulin-stimulated glucose uptake with upregulated phosphorylation of AKT. The phosphorylation levels of nuclear factor kappa B(NF-κB p65), inhibitor of NF-κB(IκBα), c-Jun N-terminal kinase(JNK1/2) and extracellular-signal-regulated kinases(ERK1/2) were also changed after JQ-R treatment compared with the control group. Together these findings suggest that JQ-R improved glucose and lipid metabolism in diabetic KK^(Ay)mice. JQ-R directly enhanced insulin-stimulated glucose uptake in insulin-resistant myotubes with improved insulin signalling and inflammatory response and oxidative stress. JQ-R could be a candidate to achieve improved glucose metabolism and insulin sensitivity in type 2 diabetes mellitus. | Quan Liu Shuainan Liu Lihui Gao Sujuan Sun Yi Huan Caina Li Yue Wang Nan Guo Zhufang Shen | 2017 | Acta Pharmaceutica Sinica B2017，7，4： | 11 |
| 19 | Synthesis of the Diverse Glycosides in Traditional Chinese Medicine显示文摘繁体中文药(TCM ) 是为现代药品的发现和发展的一件巨大的财富藏品。确实,众多的生物学上并且 pharmacologically 重要的分子从 TCM 被识别了;在他们之中,可观的部分属于 glycosides。这些 glycosides 在结构是极其多样的,由 aglycones, glycans,以及 glycosidic 连接的一个大变化组成。另外,这些 glycosides 在自然来源作为同种的物的复杂混合物经常发生。这 microheterogeneity 在可估计的数量导致同类的 glycoside 的隔离一项可怕的任务。因此,向这些自然 glycosides 的合成途径的开发收到了大注意。在这篇报道,我们总结我们在这个话题上花的 twentyyear 努力。55 代表性的 TCMrelevant glycosides 由我们的组综合了被加亮。基于 aglycone 结构,这些 glycosides 被分成三个组,即,类固醇 glycosides 和酉分的 glycosides。典型合成途径被讨论,显示出为 regio 和 glycans 和保护组的全面操作的 stereocontrolled 安装的费力的战术。这些有用、可伸缩的合成途径提供了实际选择给这些 TCM 部件并且这样的可接近性机会为他们的在里面生物的深度和药理学学习。 | Dapeng Zhu Biao Yu | 2018 | Chinese Journal of Chemistry2018，36，8： | 11 |
| 20 | Knowledge Base Grid: A Generic Grid Architecture for Semantic Web显示文摘The emergence of semantic web will result in an enormous amount of knowledge base resources on the web. In this paper, a generic Knowledge Base Grid Architecture (KB-Grid)for building large-scale knowledge systems on the semantic web is presented. KB-Grid suggests a paradigm that emphasizes how to organize, discover, utilize, and manage web knowledge base resources. Four principal components are under development: a semantic browser for retrieving and browsing semantically enriched information, a knowledge server acting as the web container for knowledge, an ontology server for managing web ontologies, and a knowledge base directory server acting as the registry and catalog of KBs. Also a referential model of knowledge service and the mechanisms required for semantic communication within KB-Grid are defined. To verify the design rationale underlying the KB-Grid, an implementation of Traditional Chinese Medicine(TCM) is described. | 吴朝晖 陈华钧 徐杰锋 | 2003 | Journal of Computer Science & Technology2003，18，4： | 11 |
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