|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | New insights in bilirubin metabolism and their clinical implications显示文摘Bilirubin,a major end product of heme breakdown,is an important constituent of bile,responsible for its characteristic colour.Over recent decades,our understanding of bilirubin metabolism has expanded along with the processes of elimination of other endogenous and exogenous anionic substrates,mediated by the action of multiple transport systems at the sinusoidal and canalicular membrane of hepatocytes.Several inherited disorders characterised by impaired bilirubin conjugation(Crigler-Najjar syndrome typeⅠand typeⅡ,Gilbert syndrome)or transport(Dubin-Johnson and Rotor syndrome)result in various degrees of hyperbilirubinemia of either the predominantly unconjugated or predominantly conjugated type.Moreover,disrupted regulation of hepatobiliary transport systems can explain jaundice in many acquired liver disorders.In this review,we discuss the recent data on liver bilirubin handling based on the discovery of the molecular basis of Rotor syndrome.The data show that a substantial fraction of bilirubin conjugates is primarily secreted by MRP3 at the sinusoidal membrane into the blood,from where they are subsequently reuptaken by sinusoidal membrane-bound organic anion transporting polypeptides OATP1B1 and OATP1B3.OATP1B proteins are also responsible for liver clearance of bilirubin conjugated in splanchnic organs,such as the intestine and kidney,and for a number of endogenous compounds,xenobiotics and drugs.Absence of one or both OATP1B proteins thus may have serious impact on toxicity of commonly used drugs cleared by this system such as statins,sartans,methotrexate or rifampicin.The liverblood cycling of conjugated bilirubin is impaired in cholestatic and parenchymal liver diseases and this impairment most likely contributes to jaundice accompanying these disorders. | Eva Sticova Milan Jirsa | 2013 | World Journal of Gastroenterology2013，19，38： | 24 |
| 2 | Ecological hydraulic radius model to calculate instream flow requirements for transporting sediment in the western water transfer region显示文摘Transporting sediment is a natural function of the river. To maintain the normal evolution of the river certain amount of water flow is required, which is called the instream flow requirements for transporting sediment (IFRTS). We defined the permitting flow velocity by the conception of IFRTS, and also put forward the ecological hydraulic radius model (EHRM) to estimate IFRTS. The calculating process of EHRM is explained by the example of Daofu Hydrological Station on Xianshui branch of Yalong River in the west line first-stage construction of South-North Water Transfer Project. The result shows that the IFRTS occupied 29.7%―59.5% of annual mean discharge in flood season, the average of IFRTS was about 100.2 m3/s during 1966―1987, it is close to the IFRTS 90 m3/s calculated by IFRTS conception. Hence, it is feasible to use EHRM to calculate IFRTS. | MEN BaoHui1 & LIU ChangMing2 1 Renewable Energy Institute, North China Electric Power University, Beijing 102206, China 2 Key Laboratory of Water Cycle and Related Land Surface Process, Institute of Geographical Sciences and Natural Resources Research, Chinese Academy of Sciences, Beijing 100101, China | 2009 | Science China(Technological Sciences)2009，52，11： | 5 |
| 3 | 基于苊烯酰二亚胺小分子/二氧化钛双分子电子传输层的高效钙钛矿太阳能电池(英文)显示文摘设计合成高效n型小分子半导体作为钙钛矿太阳能电池的电子传输层对实现低温、可溶液加工的钙钛矿太阳能电池具有重要意义.本文合成了三个低LUMO能级、基于苊烯酰二亚胺的小分子受体材料AI1, AI2, AI3,系统表征了其光物理性质及电化学、热力学性质,研究了其在钙钛矿太阳能电池器件中的应用.当使用TiO_2/AI1作为电子传输层时,钙钛矿太阳能电池的平均光电转换效率为15%,比单独TiO_2电子传输层11.7%的平均光电转换效率有较大提升,表明基于苊烯酰二亚胺的小分子AI1, AI2, AI3是良好的电子传输层材料,可实现低温、可溶液加工的高效钙钛矿太阳能电池. | 邵佳伟 郭兴 侍男男 张幸林 刘书利 林珍华 赵保敏 常晶晶 邵进军 董晓臣 | 2019 | Science China Materials2019，62，4： | 3 |
| 4 | Experimental study on filtering,transporting, concentrating and focusing of microparticles based on optically induced dielectrophoresis显示文摘The key problem to be solved for the dielectrophoresis (DEP) application is to provide dynamically reconfigurable microelectrodes and low-cost methodology for bioparticle manipulation.The emergence of optically induced DEP (ODEP) based on photoconductive effect provides a potential solution for the above problem.In this paper,an ODEP chip is designed and fabricated,and the corresponding experimental platform was established,whereupon four types of particle manipulation regimes–filtering,transporting,concentrating and focusing based on ODEP are experimentally demonstrated and the operating performances are quantitatively analyzed.The experiment results show that the functions and performances of ODEP manipulation are heavily dependent on the geometrical shape,scales and speed of optical patterns,actuating signal frequency and the electric conductivity of the solution.The manipulation efficiency can increase by more than 50% via increasing the optical line width.Moreover,the efficiency is obviously affected by the inclination angle of the optical oblique lines in the manipulation of particle focusing.Additionally,the maximum velocity of particles increases with the increment of the inside radius and the thickness of the optical trapping ring.Particle manipulation efficiency is always related to signal frequency and solution conductivity,and empirically,satisfactory performance and high efficiency are obtained when the solution electric conductivity ranges from 5×10-4 S/m to 5×10-3 S/m. | ZHU XiaoLu,YIN ZhiFeng,GAO ZhiQiang & NI ZhongHua Jiangsu Key Laboratory for Design and Manufacture of Micro-Nano Biomedical Instruments,Southeast University,Nanjing 211189,China | 2010 | Science China(Technological Sciences)2010，53，9： | 3 |
| 5 | High fill factor over 82%enabled by a biguanide doping electron transporting layer in planar perovskite solar cells显示文摘N-type doping in electron transport materials is an effective way to improve the electron collection and enhance the performance of the perovskite solar cells (PSCs).Here,for the first time,an antibiotic and antimicrobial compound of 1-(o-Tolyl)biguanide (oTb) is used to dope the electron transport material of phenyl- C61-butyric acid methyl ester (PCBM).The oTh doping into the PCBM can increase the conductivity and reduce the work function of the PCBM.The oTb doping can significantly enhance the fill factor (FF)of the perovskite solar cells with the structure of glass/ITO/NiO]MAPbI3/(oTb)PCBM/(PEIE)/Ag.For the cells without PEIE (polyethylenimine ethoxylated)coating,the oTb doping increases the FF from 0.57 to 0.73.S-shaped of the current density-voltage (J-V)characteristic under illumination is removed after the oTb doping.For the cells with PEIE coating between the (oTb)PCBM and Ag,the oTb doping increases the FF from 0.70 to 0.82.These results show the potential of the oTb as an n-dopant in the applications of perovskite solar cells. | Ru GE Fei QIN Lin HU Sixing XIONG Yinhua ZHOU | 2018 | Frontiers of Optoelectronics2018，11，4： | 1 |
| 6 | Relationship between magnetic fabric parameters and dynamic characteristics of deposits in different environments显示文摘Comparison of magnetic fabric parameters of deposits in different modern sedimentary environments indicates that values of \%P, F\% and \%L\% of eolian deposits are lower obviously than those of hydrogenic ones respectively. On relationship diagrams of magnetic fabric parameters, data points of eolian samples concentrated in limited area near origin of coordinates indicate that dynamic intensity is lower with less variation; while those of hydrogenic ones depart from origin of coordinates suggest higher intensity of sedimentary dynamics. Analyses of dynamic characteristics of different sedimentary environments indicate that values of magnetic fabric parameters of deposits are determined by dynamic types and characteristics of depositional processes. Magnetic fabric analyses of deposits are effective in determination of sedimentary environments. | CHEN Qingqiang 1,3 , LI Congxian\+1 and CONG Youzi\+2 1. Marine Geology Laboratory, Tongji University, Shanghai 200092, China 2. First Institute of Oceanography, State Oceanic Administration of China, Qingdao 266003, China 3. Guangzhou Institute of | 1998 | Chinese Science Bulletin1998，43，22： | 1 |
| 7 | Clinical value of gadoxetic acid-enhanced magnetic resonance imaging in surgery for hepatocellular carcinoma- with a special emphasis on early hepatocellular carcinoma显示文摘Gadoxetic acid- or gadolinium ethoxybenzyl diethylenetriamine pentaacetic acid-enhanced magnetic resonance imaging(EOB-MRI) achieves excellent lesion detection and characterization for both hypervascular hepatocellular carcinoma(HCC) in arterial phase imagingand hypovascular early HCC(small well-differentiated HCC of the vaguely nodular type) in hepatobiliary phase imaging, and has become an indispensable imaging modality in the treatment of HCC. Early HCCs have been detected more frequently since the introduction of EOB-MRI into daily clinical practice. Early HCC is known to progress to conventional hypervascular HCC, and many risk factors have been identified for the hypervascularization of early HCC including the diameter of the tumor, presence of fat, and imaging findings of EOB-MRI. The rate of the development of hypervascular HCC was previously reported to be high in patients with chronic liver disease and early HCC. The presence of early HCC is regarded as a predictor for the recurrence of HCC following hepatic resection. On the other hand, although early HCC itself is currently not regarded as a target lesion for hepatic resection, early HCC at high risk of hypervascularity needs to be treated by local ablation therapy. If concomitant early HCC with progressed HCC is at high risk of hypervascularization and the functional liver reserve of a patient is sufficient, its simultaneous treatment at the time of hepatic resection for progressed HCC is recommended. Further studies on larger numbers of patients are needed before this strategy is adopted. | Masanori Matsuda | 2015 | World Journal of Hepatology2015，7，30： | 1 |
| 8 | Tetrabenzotriazacorrole and its derivatives as undopea hole transporting materials for perovskite solar cells:Synthesis,device fabrication,and device performance显示文摘Phosphorous tetrabenzotriazacorrole(TBC)and its two soluble derivatives(TBC-1 and TBC-2)were synthesized and used for the first time as undoped hole transporting materials(HTMs)in MAPbI3 perovskite solar cells(PSCs).Their performance in PSCs was measured and compared with that of SpiroOMeTAD and phthalocyanine precursor.The fundamental properties related to HTMs are also examined.These novel HTMs are easily prepared,cost-effective,and solution processable.The materials exhibited much higher hole transport mobility and broader light absorption than pristine Spiro-OMeTAD and phthalocyanine precursor.They can work efficiently in the absence of any dopant for devices composed of FTO/cp-TiO2/mp-TiO2/MAPbI3/HTM/Au.The undoped mesoscopic solar cell devices based on TBC exhibited a promising power conversion efficiency(PCE)of up to 16.2%(measured at 100 mWcm2 illumination,AM 1.5 G),together with good long-term stability under ambient conditions.This PCE of 16.2%observed using TBC is remarkably higher than the 11.2%observed using undoped Spiro-OMeTAD and also much better than the 8.70%observed using its phthalocyanine precursor.As to substitution effects,α-substituted TBC-1 was found to be a better HTM thanβ-substituted TBC-2(PCE 11.4%)and unsubstituted TBC-3(PCE 6.81%)under the same conditions.These results provide the basis for further exploiting TBC compounds as a new type of low-cost and effective HTM for PSCs. | Xian-Fu Zhang Chang Liu Jianchang Wu Baomin Xu | 2020 | Journal of Energy Chemistry2020，29，4： | 0 |
| 9 | High isotropic dispiro structure hole transporting materials for planar perovskite solar cells显示文摘Two novel fluorene-based hole transporting materials (HTMs) were synthesized to be used in perovskite solar cells (PSCs). C102 was designed based on C101 by simply linking the two carb on-carbon single bonds to compose a 'dispiro' structure. Their typically similar structures cause them sharing almost the same energy levels. However, their photovoltaic performances are quite different due to the small variations. The PSC that contained the 'dispiro' structure, C102, reached a power conversion efficiency (PCE) of 17.4%, while the device contained C101, obtained a lower PCE of 15.5%. Electrochemical properties and Photovoltaic characterization of the two materials have been investigated to explain the result. It is shown that C102 has a stronger ability to transport holes and resist the charge recombination. Thus, the dispiro structure should be more appropriate being used as HTM in PSCs. | Bin Cai Xichuan Yang Haoxin Wang Weihan Wang Jincheng An Licheng Sun | 2019 | Journal of Energy Chemistry2019，28，5： | 0 |
| 10 | ON THE MECHANISM OF DRAG REDUCTION IN HIGH CONCENTRATION NON-HOMOGENEOUS PIPE FLOW显示文摘In this paper a method for calculating the resistance force in high concentrationnon-homogeneous pipe flow is suggested.Comparing with experiment,it is shown that the theo-retical results are in good agreement with the experimental ones. | Zhang, Xingrong | 1992 | Journal of Hydrodynamics1992，4，1： | 0 |
| 11 | Highly Efficient White Organic Light-emitting Devices with Optimized Electron Transporting Layers显示文摘We fabricated three phosphorescent blue organic light-emitting devices based on blue phosphor of iri-dium(Ⅲ) bis[(4,6-difluorophenyl)-pyridinato-N,C2'](Firpic) with different electron transporting layer(ETL) materialsBy analyzing efficiency curves and spectral characteristics, the significant effect of ETL on many aspects of deviceperformance was demonstrated. With optimized ETL, the characteristics of devices, such as voltage and efficiencywere significantly improved. Combined with a yellow phosphor of iridium(Ⅲ) bis(4-phenylthieno[3,2-c]pyridinato-N,C2') acetylacetonate(PO-01), phosphorescent white organic light-emitting devices(PhWOLEDs) were obtained.Then, with an aim to promote the performance of the PhWOLEDs~ a thin layer of 4,4',4"-tri(N-carbazolyl)-triphenylamine(TCTA) was introduced between two light emission layers, and the diffusion of excitons was confined.The outperformance device fabricated with 4,7-diphenyl-l,10-phenanthroline(Bphen) as the electron transportinglayer exhibited a peak current efficiency of 36.6 cd/A, a peak power efficiency of 19.2 lm/W, and the InternationalCommission on Illumination coordinates(0.37, 0.46). | ZHANG Tianyu ZHENG Yu WANG Chengming ZHANG Yixin LIU Shihao MA Jian ZHANG Letian XIE Wenfa CHEN Ping LIN Jun LIU Yujuan | 2017 | Chemical Research in Chinese Universities2017，33，2： | 0 |
| 12 | Further study on Ca_(2+) -mediated inhibition of human erythrocyte D-glucose transporter显示文摘THE transport of D-glucose to erythrocytes is catalyzed by an integral membrane protein,i.e.the D-glucose transporter.It specifically carries D-glucose,driven by glucose’s concentrationgradient.Because of its relative abundance and higher transport activity,human erythrocyteglucose transporter has been generally used as a model system to study sugar transport,but | XIE Wensheng, TU Yaping and YANG FuyuState Key Laboratory of Biomacromolecules, Institute of Biophysics, Chinese Academy of Sciences, Beijing 100101, China | 1997 | Chinese Science Bulletin1997，42，10： | 0 |
| 13 | A NEW PATIERN OF ENERGY TRANSFORMATION IN TWO-PHASE FLOW PUMP显示文摘The efficiency of a centrifugal pump is generally regarded as lower in transporting twophase solid-liquid medium than in pumping water. S. T. Bonnington considered it inevitable that the efficiency will be reduced under the two- | 蔡保元 马宗庆 | 1985 | Chinese Science Bulletin1985，30，6： | 0 |
| 14 | CLONING,SEQUENCING AND DETERMINATION OF THE GENE FRAGMENT OF α-CHAIN OF ATP SYNTHASE IN DUNALIELLA BARDAWIL显示文摘Halophilic alga Dunaliella bardawil (Chlorophyceae) was cultivated in artificialseawater (containing 3 .0, 1. 5 or 0. 5 mol/L of NaCl respectively) for at least two weeks; total RNAswere then extracted and 8 stable differential bands were harvested after DDRT-PCR and electrophoresis.The retrieved bands were amplified, subjected to electrophoresis again, and cloned into plasmid pUCm-Trespectively. After exelusion of false positive bands, We obtained a recombinant plasmid pTE containing afragment of cDNA, which was only specilically expressed under high salinity condition. Sequencing of | 刘广发 林慧馨 | 2002 | Chinese Journal of Oceanology and Limnology2002，20，S1： | 0 |
| 15 | Self-doped n-type water/alcohol-soluble conjugated polymers ETL for high-performance polymer and perovskite solar cells显示文摘Electron transporting layer(ETL)materials have attracted much attention in recent years in the research fields of organic/polymer solar cells(OSCs/PSCs)and planar perovskite solar cells(pero-SCs),because ETL materials play very important role in improving the photovoltaic performance of devices.Among the ETL materials reported in literatures,conjugated polymer poly[(9,9-bis(3’-(N,N-dimethylamino)propyl)-2,7-fluorene)-alt-2,7-(9,9-dioctylfluorene)](PFN)show good film-forming property and excellent device performance for the small area PSCs.But the ETL of | Yongfang Li | 2016 | Science China Chemistry2016，59，11： | 0 |
| 16 | Progress of the Water Cooling System for CYCIAE-100显示文摘The water cooling system for CYCIAE-100 has achieved a significant progress in 2013,its progress can be summarized as follows:1)The deionized water production equipment and the main circulating water cooling unit are installed and tested.2)The circulating water cooling unit for high power target and circulating water cooling unit for vacuum helium compressor are installed and tested. | LI Zhen-guo WU Long-cheng LIU Geng-guo | 2013 | Annual Report of China Institute of Atomic Energy2013，，1： | 0 |
| 17 | Efficient p-i-n structured perovskite solar cells employing low-cost and highly reproducible oligomers as hole transporting materials显示文摘The development of p-i-n structured perovskite solar cells(PSCs) requires more extensive explorations on seeking efficient, low cost and stable hole transporting materials(HTMs). Small molecular HTMs are superior to polymeric ones in terms of synthetic reproducibility as well as purity. However, thin films composed of small molecules are usually labile during the solution-based perovskite deposition. Herein, we propose a molecular engineering strategy of incorporating oligothiophene as conjugation bridge to develop robust oligomer HTMs for p-i-n type PSCs. Upon increasing the oligothiophene chain length from α-bithiophene to α-quaterthiophene and α-hexathiophene, their HOMO energy levels remain unchanged, but their solubility in common organic solvents decreased remarkably, thus greatly enhancing their tolerance to the perovskite deposition. The rational design of oligothiophene chain length can effectively tune their optoelectronic properties as well as thin film stability under polar solvent soaking. The best performance is achieved by an α-quaterthiophene based HTM(QT), showing a high efficiency of 17.69% with fill factor of 0.81, which are comparable to those of a commercially available benchmark polymer HTM(poly[bis(4-phenyl)(2,4-dimethylphenyl) amine], PTAA) based devices fabricated under the same conditions. Our developed oligomer system not only provides the definite molecular structures like small molecule-type HTMs, but also exhibits the excellent filmforming like polymer-type HTMs, thus achieving the well-balanced parameters among solvent tolerance, thin film conductivity,and interfacial charge transfer efficiency, especially building up a platform to develop low cost and reproducible efficient HTMs in p-i-n structured perovskite solar cells. | Erpeng Li Wenqin Li Linchang Li Hao Zhang Chao Shen Zihua Wu Weiwei Zhang Xiaojia Xu He Tian Wei-Hong Zhu Yongzhen Wu | 2019 | Science China Chemistry2019，62，6： | 0 |
| 18 | TRUCK TRANSPORTING SYSTEM显示文摘The paper was a truck transporting system that based on system engineering theory and driver, truck-and-train, road and transporting environment were essential factors. It analyzed andstudied nine subsystems consisted of the tfour tactors, ensured running safety, high efficieney and lowconsumption of transporting truck and increased using time of truck and road. | 董希斌 | 1995 | Journal of Northeast Forestry University1995，6，4： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员