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| 1 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 2 | Phylogenetic reconstruction of Aegilops section Sitopsis and the evolution of tandem repeats in the diploids and derived wheat polyploids显示文摘 | SALINA E A LIM Y K BADAEVA E D SHCHERBAN A B ADONINA I G AMOSOVA A V SAMATADZE T E VATOLINA T ZOSHCHUK S A LEITCH A R | 2006 | Genome2006，49，8： | 1 |
| 3 | Transferbility of Wheat Microsateltites to Diploid Aegilops Species and Determination of Chromosomal Localizations of Microsatellites in the S genome 显示文摘 | ADONINA I G SALINA E A PESTSOVA E G | 2005 | Genome2005，48，： | 1 |
| 4 | Leisure-time physical activity and lung cancer: a meta-analysis显示文摘 | Adonina Tardon Won Jin Lee Miguel Delgado-Rodriguez Mustafa Dosemeci Demetrius Albanes Robert Hoover Aaron Blair | 2005 | Cancer Causes & Control2005，，： | 1 |
| 5 | Transferability of Wheat Microsatellites to Diploid Aegilops Species and Determination of Chromosomal Localizations of Microsatellites in the S genome显示文摘 | ADONINA I G SALINA E A PESTSOVA E G | | Genome0，48，： | 1 |
| 6 | Transferbility of wheat microsatellites to diploid Aegilops species and determination of chromosomal localizations of microsatellites in the S genome 显示文摘 | Adonina I G Salina E A Pestsova E G etal | 2005 | Genome2005，48，： | 1 |
| 7 | NAT2 slow acetylation, GSTM1 null genotype, and risk of bladder cancer: results from the Spanish Bladder Cancer Study and meta-analyses显示文摘 | Montserrat García-Closas Núria Malats Debra Silverman Mustafa Dosemeci Manolis Kogevinas David W Hein Adonina Tardón Consol Serra Alfredo Carrato Reina García-Closas Josep Lloreta Gemma Casta?o-Vinyals Meredith Yeager Robert Welch Stephen Chanock Nilanjan | 2005 | The Lancet2005，，9486： | 1 |
| 8 | 生命早期室外空气污染暴露与婴幼儿呼吸系统健康、耳部感染和湿疹:INMA研究显示文摘[背景]产前和生命早期可能是空气污染对婴幼儿健康造成有害影响的重要窗口期。[目的]选择西班牙出生队列中2199名婴儿,研究他们在孕期和出生第1年空气污染暴露与年龄为12~18个月时的呼吸系统疾病、耳部感染和湿疹之间的关联。[方法]父母提供医生诊断的呼吸道感染(LRTI)、喘息、湿疹和耳部感染等信息。使用经时间调整的土地利用回归模型,估计个体二氧化氮(NO2)和苯的暴露情况。采用对数二项式回归模型和联合随机效应meta分析,评估4个研究地点空气污染暴露对健康结果的影响。[结果]在孕期,NO2均值每增加10μg/m3与LRT[I相对危险度(RR)=1.05,95%CI:0.98~1.12]和耳部感染(RR=1.18,95%CI:0.98~1.41)相关联。NO2每增加1个四分位距(IQR),LRTI的RR为1.08(95%CI:0.97~1.21),耳部感染的RR为1.31(95%CI:0.97~1.76)。与NO2相比,苯暴露均值每增加1个IQR,其与LRTI具有类似的关联性(RR=1.06,95%CI:0.94~1.19),与耳部感染的关联性稍弱(RR=1.17,95%CI:0.93~1.46)。母亲孕期大多数时间在家里的婴幼儿,其关联性稍强。由于出生第1年的空气污染暴露与产前暴露高度相关,所以无法分辨各个暴露时期的相对重要性。[结论]研究结果表明生命早期环境空气污染暴露可能增加婴幼儿上、下呼吸道感染的风险。 | Inmaculada Aguilera Marie Pedersen Raquel Garcia-Esteban Ferran Ballester Mikel Basterrechea Ana Esplugues Ana Fernández-Somoano Aitana Lertxundi Adonina Tardón Jordi Sunyer | 2013 | 环境与职业医学2013，30，6： | 0 |
| 9 | 孕期体重增加与新生儿持久性有机污染物暴露显示文摘[背景]胎儿发育期间持久性有机污染物(POPs)暴露可以增加儿童期不良健康影响的风险。产妇的特征和妊娠期间的生理变化,例如孕期体重增加(GWG),可能对新生儿的POPs总负荷有一定影响。然而,尚无研究充分阐明GWG与POPs浓度之间的关联。[目的]校正孕前母体的体质指数(BMI)和其他影响POPs转移进入新生儿体内的潜在决定因素之后,研究GWG与脐带血清POPs浓度之间的关联。参考美国医学研究所(IOM)的指南对妊娠妇女进行分组,并估算GWG值。[方法]测定一个西班牙出生队列中325份脐带血清样本中14种有机氯杀虫剂、7种多氯联苯(PCBs)和14种多溴联苯醚(PBDEs)的水平。采用多变量模型估算GWG、孕前BMI和其他产妇的决定性因素与脐带血清POPs浓度的关联。[结果]在校正了年龄、孕前BMI、受教育程度以及鱼类消费等因素后,新生儿的POPs浓度与GWG呈负性相关。平均而言,与GWG不足的母亲所生的新生儿相比,符合IOM建议的GWG妇女所生的新生儿具有较低的POPs浓度。[结论]目前的研究结果提示新生儿POPs暴露与怀孕期间GWG不足之间存在关联。鼓励怀孕妇女达到IOM指南推荐的GWG,可能会降低POPs在新生儿中的蓄积。 | Esther Vizcaino Joan O.Grimalt Berit Glomstad Ana Fernández-Somoano Adonina Tardón | 2014 | 环境与职业医学2014，31，12： | 0 |
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