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| 1 | Comprehensive functional annotation of susceptibility variants identifies genetic heterogeneity between lung adenocarcinoma and squamous cell carcinoma显示文摘Although genome-wide association studies have identified more than eighty genetic variants associated with non-small cell lung cancer(NSCLC)risk,biological mechanisms of these variants remain largely unknown.By integrating a large-scale genotype data of 15581 lung adenocarcinoma(AD)cases,8350 squamous cell carcinoma(SqCC)cases,and 27355 controls,as well as multiple transcriptome and epigenomic databases,we conducted histology-specific meta-analyses and functional annotations of both reported and novel susceptibility variants.We identified 3064 credible risk variants for NSCLC,which were overrepresented in enhancer-like and promoter-like histone modification peaks as well as DNase I hypersensitive sites.Transcription factor enrichment analysis revealed that USF1 was AD-specific while CREB1 was SqCC-specific.Functional annotation and genebased analysis implicated 894 target genes,including 274 specifics for AD and 123 for SqCC,which were overrepresented in somatic driver genes(ER=1.95,P=0.005).Pathway enrichment analysis and Gene-Set Enrichment Analysis revealed that AD genes were primarily involved in immune-related pathways,while SqCC genes were homologous recombination deficiency related.Our results illustrate the molecular basis of both wellstudied and new susceptibility loci of NSCLC,providing not only novel insights into the genetic heterogeneity between AD and SqCC but also a set of plausible gene targets for post-GWAS functional experiments. | Na Qin Yuancheng Li Cheng Wang Meng Zhu Juncheng Dai Tongtong Hong Demetrius Albanes Stephen Lam Adonina Tardon Chu Chen Gary Goodman Stig EBojesen Maria Teresa Landi Mattias Johansson Angela Risch H-Erich Wichmann Heike Bickeboller Gadi Rennert Susanne Arnold Paul Brennan John KField Sanjay Shete Loic Le Marchand Olle Melander Hans Brunnstrom Geoffrey Liu Rayjean JHung Angeline Andrew Lambertus AKiemeney Shan Zienolddiny Kjell Grankvist Mikael Johansson Neil Caporaso Penella Woll Philip Lazarus Matthew BSchabath Melinda CAldrich Victoria LStevens Guangfu Jin David CChristiani Zhibin Hu Christopher IAmos Hongxia Ma Hongbing Shen | 2021 | Frontiers of Medicine2021，15，2： | 3 |
| 2 | Small Intestinal Bacterial Overgrowth in Irritable Bowel Syndrome: Systematic Review and Meta-analysis显示文摘 | Alexander C. Ford Brennan M.R. Spiegel Nicholas J. Talley Paul Moayyedi | 2009 | Clinical Gastroenterology and Hepatology2009，，12： | 2 |
| 3 | Water-in-Silicone Oil Emulsion Stabilizing Surfactants Formed From Native Albumin and, ,ω -Triethoxysilylpropyl -Polydimethylsiloxane 显示文摘 | Paul M Zelisko Kulwinder K Flora John D Brennan | 2008 | Biomacromolecules2008，9，： | 1 |
| 4 | Incidence and Types of Adverse Events and Negligent Care in Utah and Colorado显示文摘 | Eric J. Thomas David M. Studdert Helen R. Burstin E. John Orav Timothy Zeena Elliott J. Williams K. Mason Howard Paul C. Weiler Troyen A. Brennan | 2000 | Medical Care2000，，3： | 1 |
| 5 | Association of common polymorphisms in inflammatory genes with risk of developing cancers of the upper aerodigestive tract显示文摘 | Daniele Campa Mia Hashibe David Zaridze Neonila Szeszenia-Dabrowska Ioan Nicolae Mates Vladimir Janout Ivana Holcatova Eleonóra Fabiánová Valérie Gaborieau Rayjean J. Hung Paolo Boffetta Paul Brennan Federico Canzian | 2007 | Cancer Causes & Control2007，，4： | 1 |
| 6 | Hierarchical modeling identifies novel lung cancer susceptibility variants in inflammation pathways among 10,140 cases and 11,012 controls显示文摘 | Darren R. Brenner Paul Brennan Paolo Boffetta Christopher I. Amos Margaret R. Spitz Chu Chen Gary Goodman Joachim Heinrich Heike Bickeb?ller Albert Rosenberger Angela Risch Thomas Muley John R. McLaughlin Simone Benhamou Christine Bouchardy Juan Pablo Lew | 2013 | Human Genetics2013，，： | 1 |
| 7 | Staging Laparoscopy in the Management of Gastric Cancer: A Population-Based Analysis显示文摘 | Paul J. Karanicolas Elena B. Elkin Lindsay M. Jacks Coral L. Atoria Vivian E. Strong Murray F. Brennan Daniel G. Coit | 2011 | Journal of the American College of Surgeons2011，，5： | 1 |
| 8 | Conversion of secondary furfuryl alcohols and isomaltol into maltol and related γ-pyrones显示文摘 | Weeks Paul D Brennan Thomas M Brannegan Daniel P | 1980 | J Org Chem1980，45，： | 1 |
| 9 | The Oxfordshire Community Stroke Project classification: Correlation with imaging, associated complications, and prediction of outcome in acute ischemic stroke显示文摘 | Sean J. Pittock Dara Meldrum Orla Hardiman John Thornton Paul Brennan Joan T. Moroney | 2003 | Journal of Stroke and Cerebrovascular Diseases2003，，1： | 1 |
| 10 | Genetics of lung-cancer susceptibility显示文摘 | Paul Brennan Pierre Hainaut Paolo Boffetta | 2011 | Lancet Oncology2011，，4： | 1 |
| 11 | Medical history and risk of lymphoma: results of a European case–control study (EPILYMPH)显示文摘 | Nikolaus Becker Joan Fortuny Tomas Alvaro Alexandra Nieters Marc Maynadié Lenka Foretova Anthony Staines Paul Brennan Paolo Boffetta Pier Luigi Cocco Silvia Sanjose | 2009 | Journal of Cancer Research and Clinical Oncology2009，，8： | 1 |
| 12 | Genetics of lung-cancer susceptibility显示文摘 | Paul Brennan Pierre Hainaut Paolo Boffetta | 2011 | Lancet Oncology2011，，4： | 1 |
| 13 | Gene Expression Profiling of Alcoholic Liver Disease in the Baboon ( Papio hamadryas ) and Human Liver显示文摘 | Devanshi Seth Maria A. Leo Peter H. McGuinness Charles S. Lieber Yvonne Brennan Rohan Williams Xin M. Wang Geoffrey W. McCaughan Mark D. Gorrell Paul S. Haber | 2003 | The American Journal of Pathology2003，，6： | 1 |
| 14 | Determining the role for uric acid in non-alcoholic steatohepatitis development and the utility of urate metabolites in diagnosis:An opinion review显示文摘There has long been a recognised association between non-alcoholic fatty liver disease(NAFLD)and the composite aspects of the metabolic syndrome.Part of this association highlighted the supposed co-existence of elevated uric acid levels in those with NAFLD.There is interest in exploitation of this as a putative diagnostic and prognostic biomarker in NAFLD.Given the increased economic and health burden associated with the NAFLD epidemic,improved methods of population-based,minimally-invasive methods and biomarkers are clearly highly sought and necessary.In this opinion review we review the proposed role of uric acid in the pathogenesis of NAFLD and its potential utilisation in the diagnosis and monitoring of the disease process. | Paul Brennan Kathleen Clare Jacob George John F Dillon | 2020 | World Journal of Gastroenterology2020，26，15： | 1 |
| 15 | A high- throughput monolithic HPLC method for rapid Vc phenotyping of berry fruit显示文摘 | Paul G W Gordon SL Brennan R M | 2006 | Phytochemical Analysis2006，17，5： | 1 |
| 16 | Pharmacological and immunochemical characterization of α2* nicotinic acetylcholine receptors (nAChRs) in mouse brain显示文摘 | Paul WHITEAKER Jennifer A WILKING Robert WB BROWN Robert J BRENNAN Allan C COLLINS Jon M LINDSTROM Jim BOULTER | 2009 | Acta Pharmacologica Sinica2009，30，6： | 1 |
| 17 | Adult Spermatic Cord Sarcomas: Management and Results显示文摘 | Jonathan Coleman MD Murray F. Brennan MD Kaled Alektiar MD Paul Russo MD | 2003 | Annals of Surgical Oncology2003，，6： | 1 |
| 18 | Traumatic bilateral carotid dissection with concomitant cerebral infarction显示文摘 | Sean J Pittock Joan T Moroney Michael Alexander Paul Brennan David Moorhouse | 2001 | Journal of Emergency Medicine2001，，1： | 1 |
| 19 | Di-diabody: a novel tetravalent bispecific antibody molecule by design显示文摘 | Dan Lu Xenia Jimenez Haifan Zhang Amanda Atkins Laura Brennan Paul Balderes Peter Bohlen Larry Witte Zhenping Zhu | 2003 | Journal of Immunological Methods2003，，1： | 1 |
| 20 | Resolution of cranial nerve paresis after endovascular management of cerebral aneurysms显示文摘 | Nassir Mansour Mahmoud Hamdy Kamel Michael Kelleher Kristian Aquilina John Thornton Paul Brennan Ciaran Bolger | 2007 | Surgical Neurology2007，，5： | 1 |
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