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| 1 | Diverse modes of clonal evolution in HBV-related hepatocellular carcinoma revealed by single-cell genome sequencing显示文摘Hepatocellular 癌(HCC ) 是癌症实质词法,基因并且 phenotypic 差异。然而,我们不理解在 intratumor 异质和肿瘤的联系词法 / 组织学的特征之间的关系。用介绍 96 个肿瘤房间(30-36 各个) 和 15 个正常的肝房间(5 各个) 的单个房间的整个染色体的定序,与联系 HBV 的 HCC 从三个男病人收集了,我们证实拷贝数字变化在 hepatocarcinogenesis 早发生,但是此后在整个肿瘤仍然保持相对稳定前进。重要地,我们证明特定的 HCC 能具有 monoclonal 或 polyclonal 起源。有汇合的 multinodular 形态学的肿瘤是典型 polyclonal 肿瘤并且显示最高的 intratumor 异质。除了 mutational 和拷贝数字侧面,我们把了用导出 HBV 的外国 genomic 标记的 HCC 的同种细胞的起源。在 monoclonal HCC,所有肿瘤单身者房间展出一样的 HBV 集成,显示 HBV 集成是一个早司机事件并且在肿瘤前进期间仍然保持极其稳定。另外,我们的结果显示那两个都转移,迟了的传播并且早播种当模特儿,在 HCC 有一个角色前进。尤其是,开始的克隆传播的早 intrahepatic 导致同步 multifocal 肿瘤的形成。同时,我们在 HCC 识别了潜在的司机基因 ZNF717,它展出变化的高频率在单个房间并且人口铺平,,通过调整 IL-6/STAT3 小径行动的肿瘤 suppressor。这些调查结果热点多重不同肿瘤在 HCC 的进化机制,它为特定的处理策略建议需要。 | Meng Duan, Shu Zhang, Zhichao Wang, Jieyi Shi, Longzi Liu, Xiaoying Wang, Aiwu Ke, Jian Zhou, Jia Fan, Qiang Gao Junfeng Hao, Chong Li Sijia Cui Daniel L Worthley Ya Cao Ruibin Xi Xiaoming Zhang Jian Zhou, Jia Fan Qiang Gao | 2018 | Cell Research2018，28，3： | 21 |
| 2 | Nest-site selection and breeding ecology of Streaked Wren-Babbler(Napothera brevicaudata)in a tropical limestone forest of southern China显示文摘Background: The breeding information of most birds in Asian tropical areas,especially in limestone forests,is still poorly known.The Streaked Wren-Babbler(Napothera brevicaudata) is an uncommon tropical limestone bird with a small range.We studied its nest-site selection and breeding ecology,in order to understand the adaptations of birds to the conditions of tropical limestone forest in southern China.Methods: We used methods of systematical searching and parent-following to locate the nests of the Streaked Wren-Babbler.We measured characteristics of nest sites and rock cavities.Data loggers and video cameras were used to monitor the breeding behavior.Results: All the observed nests of the Streaked Wren-Babbler were placed in natural shallow cavities or deep holes in large boulders or limestone cliffs.The great majority(96.6%) of Streaked Wren-Babbler nests had three eggs with an average fresh weight of 3.46-± 0.43 g(n = 36,range 2.52-4.20 g).Most(80.4%) females laid their first eggs between March and April(n = 46).The average incubation and nestling period of the Streaked Wren-Babbler was 10.2 range 9-11 days),respectively.Most(87.9%) nests h± 0.4 days(n = 5,range 1011 days) and 10.5 ± 0.8 days(n = 6,ad at least one nestling fledge between 2011 and 2013(n = 33).Conclusions: Our study suggests that several features of the breeding ecology of the Streaked Wren-Babbler,including building nests in rocky cavities,commencing breeding earlier than most species,and reducing foraging times during the incubation period,are well-adapted to the unique habitat of tropical limestone forest. | Aiwu Jiang Demeng Jiang Fang Zhou Eben Goodale | 2017 | Avian Research2017，8，4： | 7 |
| 3 | The influence of ^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography on the N-and M-staging and subsequent clinical management of intrahepatic cholangiocarcinoma显示文摘Background:Intrahepatic cholangiocarcinoma(ICC)is a highly metastatic cancer.^(18)F-fluorodeoxyglucose positron emission tomography/computed tomography(^(18)F-FDG PET/CT)enables sensitive tumor and metastasis detection.Our aim is to evaluate the influence of pre-treatment PET/CT on the N-and M-staging and subsequent clinical management in ICC patients.Methods:Between August 2010 and August 2018,660 consecutive ICC patients,without prior anti-tumor treatments nor other malignancies,were enrolled.The diagnostic performance of PET/CT on the N-and M-staging was compared with conventional imaging,and the preoperative staging accuracy and treatment re-allocation by PET/CT were retrospectively calculated.Survival difference was compared between patients receiving PET/CT or not after propensity score matching.Results:Patients were divided into group A(n=291)and group B(n=369)according to whether PET/CT was performed.Among 291 patients with both PET/CT and conventional imaging for staging in group A,PET/CT showed significantly higher sensitivity(83.0%vs.70.5%,P=0.001),specificity(88.3%vs.74.9%,P<0.001)and accuracy(86.3%vs.73.2%,P<0.001)than conventional imaging in diagnosing regional lymph node metastasis,as well as higher sensitivity(87.8%vs.67.6%,P<0.001)and accuracy(93.5%vs.89.3%,P=0.023)in diagnosing distant metastasis.Overall,PET/CT improved the accuracy of preoperative staging from 60.1%to 71.8%(P<0.001),and modified clinical treatment strategy in 5.8%(17/291)of ICC patients,with unique roles in different tumor-node-metastasis(TNM)stages.High tumor-to-non-tumor ratio(TNR)predicted poor overall survival[hazard ratio(HR)=2.17;95%confidence interval(CI):1.49-3.15;P<0.001].Furthermore,patients performing PET/CT had longer overall survival compared with those without PET/CT(HR=0.74;95%CI:0.58-0.93;P=0.011)after propensity score matching.Conclusions:PET/CT was valuable for diagnosing regional lymph node metastasis and distant metastasis in ICC patients,and facilitated accurate tumor staging and optimal treatment allocation. | Youpei Lin Huanhuan Chong Guohe Song Chenhao Zhang Liangqing Dong Ling Aye Fei Liang Shuaixi Yang Mengsu Zeng Guangyu Ding Shu Zhang Jieyi Shi Aiwu Ke Xiaoying Wang Jian Zhou Jia Fan Qiang Gao | 2022 | Hepatobiliary Surgery and Nutrition2022，11，5： | 3 |
| 4 | A 3D-printed modular magnetic digital microfluidic architecture for on-demand bioanalysis显示文摘Magnetic digital microfluidics(MDM)manipulates fluids in the form of droplets on an open substrate,and incorporates surface energy traps(SETs)to facilitate the droplet manipulation.Conventional MDM devices are fabricated monolithically,which makes it difficult to modify the device configuration without completely overhauling the original design.In this paper,we present a modular MDM architecture that enables rapid on-demand configuration and re-configuration of MDM platforms for customized bioanalyses.Each modular component contains a SET and a Lego-like antistud that fits onto a base board with Lego-like studs.We illustrate the versatility of the modular MDM architecture in biomarker sensing,pathogen identification,antibiotic resistance determination,and biochemical quantification by demonstrating immunoassays,phenotypical assays and enzymatic assays on various modular MDM platforms configured on demand to accomplish the fluidic operations required by assorted bioanalytical assays.The modular MDM architecture promises great potential for point-of-care diagnostics by offering on-demand customization of testing platforms for various categories of diagnostic assays.It also provides a new avenue for microfluidic assay development with its high configurability which would significantly reduce the time and cost of the development cycle. | Pojchanun Kanitthamniyom Aiwu Zhou Shilun Feng Aiqun Liu Shawn Vasoo Yi Zhang | 2020 | Microsystems & Nanoengineering2020，6，1： | 3 |
| 5 | 3D hierarchical architecture collaborating with 2D/2D interface interaction in Ni Al-LDH/Ti_(3)C_(2) nanocomposite for efficient and selective photoconversion of CO_(2)显示文摘Photocatalytic conversion of CO_(2)into a special chemical fuel with high yield and selectivity is still a major challenge.Herein,a 3 D hierarchical Ni Al-LDH/Ti_(3)C_(2)MXene(LDH/TC)nanocomposite is constructed through in situ loading of Ti_(3)C_(2)nanosheets on the Ni Al-LDH scaffold during the hydrothermal process.The formation of a uniform and well-defined 2 D/2 D heterogeneous interface can be realized by optimizing the ratio of Ti_(3)C_(2)and the precursors for Ni Al-LDH.The 3 D hierarchical scaffold with high specific surface area contributes to the favourable photon adsorption and utilization.The intimate contact between Ti_(3)C_(2)and Ni Al-LDH with numerous interfaces effectively promotes the separation of the photoinduced electron-hole pairs in Ni Al-LDH.Together with the highly exposed oxidation-reduction active sites and the enhanced CO_(2)capture and activation.The maximum photocatalytic CO production rate on Ni AlLDH/Ti_(3)C_(2)reaches 11.82 lmol g^(-1)h^(-1)with 92%selectivity and superior stability.This work provides an effective approach for the development of an ideal photocatalyst by collaborative utilization of materials with different dimensionalities. | Qunrong Shi Xiaoyue Zhang Yong Yang Junjie Huang Xiaolong Fu Tianyu Wang Xiaodong Liu Aiwu Sun Jianhua Ge Jinyou Shen Yong Zhou Zuliang Liu | 2021 | Journal of Energy Chemistry2021，30，8： | 1 |
| 6 | A New Species of Babbler (Timaliidae: Stachyris) from the Sino-Vietnamese Border Region of China显示文摘 | Fang Zhou Aiwu Jiang | 2008 | The Auk2008，，2： | 1 |
| 7 | Influence of comofbidity on the choice of treatment and survival of elderly patients with ad- vanced non- small cell lung cancer 显示文摘 | Li Aiwu Zhou Caicun Xu Jianfang | 2008 | Chinese German J Clin Oncol2008，7，5： | 1 |
| 8 | Parthenolide reveals an allosteric mode to inhibit the delSGylation activity of SARS-CoV-2 papain-like protease显示文摘The coronavirus papain-like protease(PLpro)of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)is responsible for viral polypeptide cleavage and the deISGylation of interferon-stimulated gene 15(ISG15),which enable it to participate in virus replication and host innate immune pathways.Therefore,PLpro is considered an attractive antiviral drug target.Here,we show that parthenolide,a germacrane sesquiterpene lactone,has SARS-CoV-2 PLpro inhibitory activity.Parthenolide covalently binds to Cys-191 or Cys-194 of the PLpro protein,but not the Cys-111 at the PLpro catalytic site.Mutation of Cys-191 or Cys-194 reduces the activity of PLpro.Molecular docking studies show that parthenolide may also form hydrogen bonds with Lys-192,Thr-193,and Gln-231.Furthermore,parthenolide inhibits the deISGylation but not the deubiquitinating activity of PLpro in vitro.These results reveal that parthenolide inhibits PLpro activity by allosteric regulation. | Zhihui Zou Huizhuang Shan Demeng Sun Li Xia Yulong Shi Jiahui Wan Aiwu Zhou Yunzhao Wu Hanzhang Xu Hu Lei Zhijian Xu Yingli Wu | 2022 | Acta Biochimica et Biophysica Sinica2022，54，8： | 0 |
| 9 | A 3D-printed magnetic digital microfluidic diagnostic platform for rapid colorimetric sensing of carbapenemase-producing Enterobacteriaceae显示文摘Carbapenemase-producing Enterobacteriaceae(CPE)are a group of drug-resistant Gram-negative pathogens that are classified as a critical threat by the World Health Organization(WHO).Conventional methods of detecting antibiotic-resistant pathogens do not assess the resistance mechanism and are often time-consuming and laborious.We have developed a magnetic digital microfluidic(MDM)platform,known as MDM Carba,for the identification of CPE by measuring their ability to hydrolyze carbapenem antibiotics.MDM Carba offers the ability to rapidly test CPE and reduce the amount of reagents used compared with conventional phenotypic testing.On the MDM Carba platform,tests are performed in droplets that function as reaction chambers,and fluidic operations are accomplished by manipulating these droplets with magnetic force.The simple droplet-based magnetic fluidic operation allows easy system automation and simplified hands-on operation.Because of the unique“power-free”operation of MDM technology,the MDM Carba platform can also be operated manually,showing great potential for point-of-care testing in resource-limited settings.We tested 27 bacterial isolates on the MDM Carba platform,and the results showed sensitivity and specificity that were comparable to those of the widely used Carba NP test.MDM Carba may shorten the overall turnaround time for CPE identification,thereby enabling more timely clinical decisions for better clinical outcomes.MDM Carba is a technological platform that can be further developed to improve diagnostics for other types of antibiotic resistance with minor modifications. | Pojchanun Kanitthamniyom Pei Yun Hon Aiwu Zhou Mohammad Yazid Abdad Zhi Yun Leow Nurhidayah Binte Mohamed Yazid Vanessa Lim Wei Xun Shawn Vasoo Yi Zhang | 2021 | Microsystems & Nanoengineering2021，7，3： | 0 |
| 10 | 合并症对老年晚期NSCLC患者治疗和生存期的影响(英文)显示文摘在治疗的选择和老病人的幸存上识别 comorbidity 的影响的目的(≥
70 年) 与先进非小的房间肺癌症(NSCLC ) 。方法临床的特征和 177 个老病人,有好表演地位,的治疗的选择 PS ≤
1 ) 回顾地在肿瘤学部门被分析,上海肺的医院,在到 2005 年 12 月的 2005 年 1 月之间。幸存数据仅仅在收到了化疗的那些被分析。所有病人被 comorbidity 的数字作为没有(0 ) 成层,温和(1 2 ) 并且严重(≥
3 ) 组。结果病人,收到了化疗,的比例温和、严重的 comorbidity 是显著地不同的(79.3%,76.2%和57.4%, P = 0.038 ),并且也有关于在三个组之中的辩解的放射疗法率显著地不同(21.7%,11.7%和37.0%, P = 0.014 )。中部的幸存和 1 年的幸存在没有评价,温和、严重的 comorbidity 组,是 13.6 对 10.2 对 7.6 个月并且 53.5% 对 41.3% 对 20.8% 分别地(木头等级, P = 0.071 ) 。在 univariate 并且多,变量考克斯为分析建模,仅仅严重的 comorbidity 是有 NSCLC 的老病人的幸存的一个独立危险因素。相对比率(RR, 95% CI ) :(2.09, 1.06 4.15 ) , P = 0.034。结论 Comorbidity 可以稍微与先进 NSCLC 影响老病人的治疗的选择,但是仅仅严重的 comorbidity 是幸存的一个独立预示的因素。 | Aiwu Li Caicun Zhou Jianfang Xu Ren Zhu Jie Luo Shanhao Chen | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，5： | 0 |
| 11 | A network meta-analysis on comparison of invasive and non-invasive sampling methods to characterize intestinal microbiota of birds显示文摘Birds maintain complex and intimate associations with a diverse community of microbes in their intestine.Multiple invasive and non-invasive sampling methods are used to characterize these communities to answer a multitude of eco-evolutionary questions related to host-gut microbiome symbioses.However,the comparability of these invasive and non-invasive sampling methods is sparse with contradicting findings.Through performing a network meta-analysis for 13 published bird gut microbiome studies,here we attempt to investigate the comparability of these invasive and non-invasive sampling methods.The two most used non-invasive sampling methods(cloacal swabs and fecal samples)showed significantly different results in alpha diversity and taxonomic relative abundances compared to invasive samples.Overall,non-invasive samples showed decreased alpha diversity compared to intestinal samples,but the alpha diversities of fecal samples were more comparable to the intestinal samples.On the contrary,the cloacal swabs characterized significantly lower alpha diversities than in intestinal samples,but the taxonomic relative abundances acquired from cloacal swabs were similar to the intestinal samples.Phylogenetic status,diet,and domestication degree of host birds also influenced the differences in microbiota characterization between invasive and non-invasive samples.Our results indicate a general pattern in microbiota differences among intestinal mucosal and non-invasive samples across multiple bird taxa,while highlighting the importance of evaluating the appropriateness of the microbiome sampling methods used to answer specific research questions.The overall results also suggest the potential importance of using both fecal and cloacal swab sampling together to properly characterize bird microbiomes. | Tianlong Zhou Kasun H.Bodawatta Aiwu Jiang | 2023 | Avian Research2023，14，2： | 0 |
| 12 | 吉非替尼治疗晚期复治性非小细胞肺癌41例(英文)显示文摘Objective: We observe the curative effect, median survival time, time to progression, quality of life and adverse effect of patients with advanced refractory non-small cell lung cancer (NSCLC) after gefitinib (Iressa) treatment. Methods: Forty-one patients with grade IIIb to IV NSCLC previously treated with two chemotherapy including 85.4% of patients after second line therapy were chosen. The regimen was oral intake of gefitinib 250 mg once daily until the disease progression or toxic reaction has become intolerable. The patients were required to receive tumor evaluation before the treatment, one month, two month and every three months after Iressa administration. Results: All of 41 patients were evaluable for therapeutic effect. Without complete regression being observed, partial response rate (PR), stable disease (SD) and progression of disease (PD) were 43.9% (18/41), 34.1% (14/41) and 22.1% (9/41), respectively. The overall response rate was 43.9% (18/41) and disease control rate (PR + SD) was 78% (32/41). The response rate in male was 42.1%, while it in female was 45.5% (P > 0.05). Twenty-two of them (53.7%, 22/41) were still alive with 10.1 months of MST when the follow-up ended in November 2006. TTP and MST of patients who died was 2.7 and 5.0 months, respectively. The rate of symptom improvement was 78% of all patients with 13 months of MST of PR patients. The Karnofsky enhanced 20 ± 5 after 28 days treatment without 3–4 degree of reactive toxicity. Conclusion: Iressa has significant antitumor activity in advanced NSCLC patients who have previously failed in second or third line chemotherapy. Iressa is effective and safe for patients with poor performance status . | Jianfang Xu Caicun Zhou Aiwu Li | 2009 | The Chinese-German Journal of Clinical Oncology2009，8，6： | 0 |
| 13 | 依立替康联合顺铂二线治疗小细胞肺癌(英文)显示文摘Objective: To evaluate the efficacy and safety of irinotecan (CPT-11) plus cisplatin (DDP) in patients with small cell lung cancer (SCLC) as second-line chemotherapy. Methods: Patients received irinotecan 60 mg/m2 on days 1, 8, 15, and cisplatin 25 mg/m2 on days 1-3, every 28 days one cycle. Response was evaluated every two cycles and patients were follow-up for two years or until death. Results: Among the 28 evaluable patients, there were 1 CR, 7 PR, 8 SD and 12 PD. The response rate was 28.6% (8/28). Median time to progression (TTP) was 3.2 (0.8-5.6) months. Median survival after second-line treatment was 7.5 (1.5-31) months and overall survival was 15 (2.3-43.5) months. The most common adverse effect was hematological toxicity with 36.7% (11/30), grades III-IV neutroperia. Hepatic toxicity was another major side effect. Only one patient developed grade III diarrhea. Conclusion: The combination of irinotecan and cisplatin is feasible, effective, and safe for SCLC as second-line treatment. | Jie Luo Ying Xu Songwen Zhou Aiwu Li Di Zheng Jianfang Xu Caicun Zhou | 2008 | The Chinese-German Journal of Clinical Oncology2008，7，8： | 0 |
| 14 | Analysis of the clinical characteristics between cavitating squamous cell lung carcinoma and non-cavitating squamous cell lung carcinoma显示文摘Objective: To identify the differences between cavitating squamous cell lung carcinoma (cSLC) and non-cavitating squamous cell lung carcinoma (ncSLC). Methods: Fifty-one patients with cSLC and 281 with ncSLC confirmed by surgery in our hospital between 1999 to 2000 were collected and their clinical, histological and survival features were retrospectively analyzed. Results: Patients with cSLC had more frequent manifestation of infection and weight loss. They usually experienced longer duration of pre-diagnosis and showed bigger tumor mass, larger primary tumor invasion with worse differentiated than ncSLC patients. There was no significant difference in age, sex, smoking history, family tumor history, personal tuberculosis history, disease location, TNM stage, lymph node invasion, and metastasis between the two groups. Median survival time was 29 months for cSLC and 35 months for ncSLC. One- and 3- year survival rates were 86.3% and 43.1% for cSLC vs. 91.1% and 47.0% for ncSLC respectively (P>0.05). Conclusion: Patients with cSLC presented with a bigger mass, a larger extent of primary tumor invasion, worse differentiated, more obstructed pneumonia that might result in longer duration of pre-diagnosis and more weight loss. As lack of differences in disease stages, lymph node invasion, metastasis and especially survival time with ncSLC, cSLC couldn’t be classified as a special type of squamous cell carcinoma by present evidences. | Aiwu Li Caicun Zhou Jianfang Xu Jian Ni Jie Zhang Jingyun Shi Jie Luo | 2007 | The Chinese-German Journal of Clinical Oncology2007，6，2： | 0 |
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