|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | Aberrant cholesterol metabolic signaling impairs antitumor immunosurveillance through natural killer T cell dysfunction in obese liver显示文摘Obesity is a major risk factor for cancers including hepatocellular carcinoma(HCC)that develops from a background of non-alcoholic fatty liver disease(NAFLD).Hypercholesterolemia is a common comorbidity of obesity.Although cholesterol biosynthesis mainly occurs in the liver,its role in HCC development of obese people remains obscure.Using high-fat high-carbohydrate diet-associated orthotopic and spontaneous NAFLD-HCC mouse models,we found that hepatic cholesterol accumulation in obesity selectively suppressed natural killer T(NKT)cell-mediated antitumor immunosurveillance.Transcriptome analysis of human liver revealed aberrant cholesterol metabolism and NKT cell dysfunction in NAFLD patients.Notably,cholesterol-lowering rosuvastatin restored NKT expansion and cytotoxicity to prevent obesogenic diet-promoted HCC development.Moreover,suppression of hepatic cholesterol biosynthesis by a mammalian target of rapamycin(mTOR)inhibitor vistusertib preceded tumor regression,which was abolished by NKT inactivation but not CD8^(+)T cell depletion.Mechanistically,sterol regulatory element-binding protein 2(SREBP2)-driven excessive cholesterol production from hepatocytes induced lipid peroxide accumulation and deficient cytotoxicity in NKT cells,which were supported by findings in people with obesity,NAFLD and NAFLD-HCC.This study highlights mTORC1/SREBP2/cholesterol-mediated NKT dysfunction in the tumor-promoting NAFLD liver microenvironment,providing intervention strategies that invigorating NKT cells to control HCC in the obesity epidemic. | Wenshu Tang Jingying Zhou Weiqin Yang Yu Feng Haoran Wu Myth T.S.Mok Lingyun Zhang Zhixian Liang Xiaoyu Liu Zhewen Xiong Xuezhen Zeng Jing Wang Jiahuan Lu Jingqing Li Hanyong Sun Xiaoyu Tian Philip Chun Yeung Yong Hou Heung Man Lee Candice C.H.Lam Howard H.W.Leung Anthony W.H.Chan Ka Fai To John Wong Paul B.S.Lai Kelvin K.C.Ng Simon K.H.Wong Vincent W.S.Wong Alice P.S.Kong Joseph J.Y.Sung Alfred S.L.Cheng | 2022 | Cellular & Molecular Immunology2022，19，7： | 3 |
| 2 | Percutaneous Coronary Intervention in the Current Era Compared With 1985–1986: The National Heart, Lung, and Blood Institute Registries显示文摘 | David O. Williams Richard Holubkov Wanlin Yeh Martial G. Bourassa Mahdi Al-Bassam Peter C. Block Paul Coady Howard Cohen Michael Cowley Gerald Dorros David Faxon David R. Holmes Alice Jacobs Sheryl F. Kelsey Spencer B. King Richard Myler James Slater Vlad | 2000 | Circulation: Journal of the American Heart Association2000，，24： | 1 |
| 3 | Transfusion practices and costs in dogs显示文摘 | Alice Howard Beth Callan Mark Sweeney | 1992 | JAVMA1992，201，11： | 1 |
| 4 | Raphides of calcium oxalate in Grape (Vitis):Implications for crystal stability and function显示文摘 | Howard J Arnott Mary Alice Webb | 2000 | Int J Plant Sci2000，161，： | 1 |
| 5 | Plasma apolipoprotein A1 as a biomarker for Parkinson disease显示文摘 | Judy K. Qiang Yvette C. Wong Andrew Siderowf Howard I. Hurtig Sharon X. Xie Virginia M.‐Y. Lee John Q. Trojanowski Dora Yearout James B. Leverenz Thomas J. Montine Matt Stern Susan Mendick Danna Jennings Cyrus Zabetian Ken Marek Alice S. Chen‐Plotkin | 2013 | Ann Neurol2013，，1： | 1 |
| 6 | Novel CSF biomarkers for Alzheimer’s disease and mild cognitive impairment显示文摘 | William T. Hu Alice Chen-Plotkin Steven E. Arnold Murray Grossman Christopher M. Clark Leslie M. Shaw Eve Pickering Max Kuhn Yu Chen Leo McCluskey Lauren Elman Jason Karlawish Howard I. Hurtig Andrew Siderowf Virginia M.-Y. Lee Holly Soares John Q. Trojan | 2010 | Acta Neuropathologica2010，，： | 1 |
| 7 | 创意新生代——2018伦敦New Designers展览显示文摘New Designers 2018展览将于今年的6月27日至7月7日在伊斯灵顿商业设计中心举办。作为已有33年历史的"New Designers"是英国最前沿的设计展览之一,每年都有许多英国的设计新星从中崭露头角。今年夏天,New Designers将会精心挑选3000多位年轻的在读设计师的作品呈现给观众,有大部分是从未面世的毕业生作品。展会旨在挖掘新生代的优秀设计师,让大众了解新生代设计师的想法与理念,通过创意的碰撞让灵感迸发。 | Alice Funge Angie Packer Azmy Anything Anna Manfield Alex O'Connor Silver Bronwen Grieves Dominika Kupcova Laura-Jane Atkinson Leszek Sikon Vlajeda Clarke Verity Howard Vanessa Stopforth Yeshen Venema 范嘉苑 | 2018 | 现代装饰2018，0，5： | 0 |
您所在的机构暂未开通此部分的功能，请联系管理员