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| 1 | Using quality improvement methods to increase use of pain prevention strategies for childhood vaccination显示文摘AIM To increase evidence-based pain prevention strategy use during routine vaccinations in a pediatric primary care clinic using quality improvement methodology.METHODS Specific intervention strategies(i.e.,comfort positioning,nonnutritive sucking and sucrose analgesia,distraction) were identified,selected and introduced in three waves,using a Plan-Do-Study-Act framework.System-wide change was measured from baseline to post-intervention by:(1) percent of vaccination visits during which an evidence-based pain prevention strategy was reported as being used; and(2) caregiver satisfaction ratings following the visit.Additionally,self-reported staff and caregiver attitudes and beliefs about pain prevention were measured at baseline and 1-year post-intervention to assess for possible long-term cultural shifts.RESULTS Significant improvements were noted post-intervention.Use of at least one pain prevention strategy was documented at 99% of patient visits and 94% of caregivers were satisfied or very satisfied with the pain prevention care received.Parents/caregivers reported greater satisfaction with the specific pain prevention strategy used [t(143) = 2.50,P ≤ 0.05],as well as greater agreement that the pain prevention strategies used helped their children's pain [t(180) = 2.17,P ≤ 0.05] and that they would be willing to use the same strategy again in the future [t(179) = 3.26,P ≤ 0.001] as compared to baseline.Staff and caregivers also demonstrated a shift in attitudes from baseline to 1-year post-intervention.Specifically,staff reported greater agreement that the pain felt from vaccinations can result in harmful effects [2.47 vs 3.10; t(70) =-2.11,P ≤ 0.05],less agreement that pain from vaccinations is 'just part of the process' [3.94 vs 3.23; t(70) = 2.61,P ≤ 0.05],and less agreement that parents expect their children to experience pain during vaccinations [4.81 vs 4.38; t(69) = 2.24,P ≤ 0.05].Parents/caregivers reported more favorable attitudes about pain prevention strategies for vaccinations across a variety of areas,including safety,cost,time,and effectiveness,as well as less concern about the pain their children experience with vaccination [4.08 vs 3.26; t(557) = 6.38,P ≤ 0.001],less need for additional pain prevention strategies [3.33 vs 2.81; t(476) = 4.51,P ≤ 0.001],and greater agreement that their doctors' office currently offers pain prevention for vaccinations [3.40 vs 3.75; t(433) =-2.39,P ≤ 0.05].CONCLUSION Quality improvement methodology can be used to help close the gap in implementing pain prevention strategies during routine vaccination procedures for children. | Jennifer Verrill Schurman Amanda D Deacy Rebecca J Johnson Jolynn Parker Kristi Williams Dustin Wallace Mark Connelly Lynn Anson Kevin Mroczka | 2017 | World Journal of Clinical Pediatrics2017，6，1： | 3 |
| 2 | Wnt4/β-Catenin Signaling Induces VSMC Proliferation and Is Associated With Intimal Thickening显示文摘 | Aikaterini Tsaousi Helen Williams Cressida A. Lyon Victoria Taylor Amanda Swain Jason L. Johnson Sarah J. George | 2011 | Circulation Research2011，，4： | 3 |
| 3 | Neighborhood land use diversity and physical activity in adjacent parks显示文摘 | Andrew T. Kaczynski Amanda J. Johnson Brian E. Saelens | 2009 | Health and Place2009，，2： | 1 |
| 4 | Interruption of the OX40–OX40 Ligand Pathway in LDL Receptor–Deficient Mice Causes Regression of Atherosclerosis显示文摘 | Amanda C. Foks Gijs H. M. van Puijvelde Ilze Bot Mariette N. D. ter Borg Kim L. L. Habets Jason L. Johnson Hideo Yagita Theo J. C. van Berkel Johan Kuiper | 2013 | The Journal of Immunology2013，，9： | 1 |
| 5 | Serious Fatal and Nonfatal Non-AIDS-Defining Illnesses in Europe显示文摘 | Amanda Mocroft Peter Reiss Jacek Gasiorowski Bruno Ledergerber Justyna Kowalska Antonio Chiesi Jose Gatell Aza Rakhmanova Margaret Johnson Ole Kirk Jens Lundgren | 2010 | JAIDS Journal of Acquired Immune Deficiency Syndromes2010，，2： | 1 |
| 6 | Systolic Blood Pressure and Mortality Among Older Community-Dwelling Adults With CKD显示文摘 | Jessica W. Weiss Eric S. Johnson Amanda Petrik David H. Smith Xiuhai Yang Micah L. Thorp | 2010 | American Journal of Kidney Diseases2010，，6： | 1 |
| 7 | Sox2 induces glioblastoma cell sternness and tumor propagation by repressing TET2 and deregulating 5hmC and 5mC DNA modifications显示文摘DNA methylation is a reversible process catalyzed by the ten-eleven translocation(TET)family of enzymes(TET1,TET2,TET3)that convert 5-methylcytosine(5mC)to 5-hydroxymethylcytosine(5hmC).Altered patterns of 5hmC and 5mC are widely reported in human cancers and loss of 5hmC correlates with poor prognosis. | Hernando Lopez-Bertoni Amanda Johnson Yuan Rui Bachchu Lai Sophie Sail Maureen Malloy Jonathan BCoulter Maria Lugo-Fagundo Sweta Shudir Harmon Khela Christopher Caputo Jordan J.Green John Laterra | 2022 | Signal Transduction and Targeted Therapy2022，7，3： | 1 |
| 8 | Nature:大规模研究揭示生命所必需的基因显示文摘在哺乳动物基因组中。大约三分之一的基因是生命所必需的。在一项新的研究中,来自美国贝勒医学院等多个机构的研究人员描述了这些基因的大规模发现。以及它将如何影响对哺乳动物发育和人类疾病的理解。相关研究结果在线发表在Nature期刊上,论文标题为“High—throughput discovery of novel developmental phenotypes”。 | Dickinson, Mary E. Flenniken, Ann M. Ji, Xiao Teboul, Lydia Wong, Michael D. White, Jacqueline K. Meehan, Terrence F. Weninger, Wolfgang J. Westerberg, Henrik Adissu, Hibret Baker, Candice N. Bower, Lynette Brown, James M. Caddle, L. Brianna Chiani, Francesco Clary, Dave Cleak, James Daly, Mark J. Denegre, James M. Doe, Brendan Dolan, Mary E. Edie, Sarah M. Fuchs, Helmut Gailus-Durner, Valerie Galli, Antonella Gambadoro, Alessia Gallegos, Juan Guo, Shiying Horner, Neil R. Hsu, Chih-Wei Johnson, Sara J. Kalaga, Sowmya Keith, Lance C. Lanoue, Louise Lawson, Thomas N. Lek, Monkol Mark, Manuel Arschall, Susan M. Mason, Jeremy McElwee, Melissa L. Newbigging, Susan Nutter, Lauryl M. J. Peterson, Kevin A. Ramirez-Solis, Ramiro Rowland, Douglas J. Ryder, Edward Samocha, Kaitlin E. Seavitt, John R. Selloum, Mohammed Szoke-Kovacs, Zsombor Tamura, Masaru Trainor, Amanda G. Tudose, Ilinca Wakana, Shigeharu Warren, Jonathan Wendling, Olivia West, David B. Wong, Leeyean Yoshiki, Atsushi MacArthur, Daniel G. Tocchini-Valentini, Glauco P. Gao, Xiang Flicek, Paul Bradley, Allan Skarnes, William C. Justice, Monica J. Parkinson, Helen E. Moore, Mark Wells, Sara Braun, Robert E. Svenson, Karen L. de Angelis, Martin Hrabe Herault, Yann Mohun, Tim Mallon, Ann-Marie Henkelman, R. Mark Brown, Steve D. M. Adams, David J. Lloyd, K. C. Kent McKerlie, Colin Beaudet, Arthur L. Bucan, Maja Murray, Stephen A. | 2016 | 现代生物医学进展2016，16，31： | 1 |
| 9 | Quantitative profiling of CpG island methylation in human stool for colorectal cancer detection显示文摘 | Giles O. Elliott Ian T. Johnson Jane Scarll Jack Dainty Elizabeth A. Williams D. Garg Amanda Coupe David M. Bradburn John C. Mathers Nigel J. Belshaw | 2013 | International Journal of Colorectal Disease2013，，1： | 1 |
| 10 | Role stress in nurses: Review of related factors and strategies for moving forward显示文摘 | Esther M Chang Karen M Hancock Amanda Johnson | 2005 | Nursing & Health Sciences2005，7，1： | 1 |
| 11 | Serious Fatal and Nonfatal Non-AIDS-Defining Illnesses in Europe显示文摘 | Amanda Mocroft Peter Reiss Jacek Gasiorowski Bruno Ledergerber Justyna Kowalska Antonio Chiesi Jose Gatell Aza Rakhmanova Margaret Johnson Ole Kirk Jens Lundgren | 2010 | JAIDS Journal of Acquired Immune Deficiency Syndromes2010，，2： | 1 |
| 12 | Neigh- borhood land use diversity and physical activity in adjacent parks 显示文摘 | Andrew T Kaczynski Amanda J Johnson Brian E Saelens | 2010 | Health & Place2010，16，2： | 1 |
| 13 | Sleep is associated with problem behaviors in children and adolescents with Autism Spectrum Disorders显示文摘 | Suzanne E. Goldman Susan McGrew Kyle P. Johnson Amanda L. Richdale Traci Clemons Beth A. Malow | 2011 | Research in Autism Spectrum Disorders2011，，3： | 1 |
| 14 | Combination therapy of long-term tumor treating fields with temozolomide and bevacizumab prolongs survival in multifocal glioblastoma diagnosed patient: a case report显示文摘The multifocal glioblastomas (GBM) are tumors with multiple discrete areas of contrast enhancing tumors which have considerably poorer prognosis than solitary GBM. Median overall survival of diagnosed patients almost twice as less than solitary presentation. We present a case report of multifocal GBM. A 72-year old right-handed male was evaluated at the Neuro-Oncology Clinic of Baylor Scott and White Hospital (Central Division). Patient presented at this hospital because of persistent progressive headaches, confusion, and an incident of fall. Physical evaluation revealed neurological impairments. Brain magnetic resonance imaging (MRI) revealed heterogeneous contrast enhancing lesions with associated vasogenic oedema. Patient underwent a stereotactic biopsy analysis of the larger lesion and pathology evaluation concluded an isocitrate dehydrogenase 1 and 2 wild type GBM with unmethylated O-6-methylguanine- DNA methyltransferase. Treatment remedies: Patient received 4 weeks concurrent radiation therapy along with combination of temozolomide at dose of 75 mg/m^2 followed adjuvant temozolomide for 10 cycles with bevacizumab at 10 mg/kg every 2 weeks and Optune treatment. Post treatment evaluation: Repeat MRIs showed near complete resolution of the tumors at 26 months of treatment along with improvement of neurological status. Conclusion: Due to limitations of surgical manipulations in multifocal GBM diagnosed patients, combinational chemo and radiation therapy is the treatment of choice for most cases. Using additional novel treatment with non-invasive therapeutic device proven to be effective is another excellent approach to the established practice. Therefore, combination therapy of Optune plus temozolomide and bevacizumab might be a promising remedy for newly diagnosed multifocal glioblastomas. | Damir Nizamutdinov Kaiyang Feng Amanda Johnson Ekokobe Fonkem | 2019 | Journal of Translational Neuroscience2019，4，1： | 0 |
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