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| 1 | Role of antispasmodics in the treatment of irritable bowel syndrome显示文摘Irritable bowel syndrome(IBS)is a long-lasting,relapsing disorder characterized by abdominal pain/discomfort and altered bowel habits.Intestinal motility impairment and visceral hypersensitivity are the key factors among its multifactorial pathogenesis,both of which require effective treatment.Voltage-gated calcium channels mediate smooth muscle contraction and endocrine secretion and play important roles in neuronal transmission.Antispasmodics are a group of drugs that have been used in the treatment of IBS for decades.Alverine citrate,a spasmolytic,decreases the sensitivity of smooth muscle contractile proteins to calcium,and it is a selective 5-HT1A receptor antagonist.Alverine,in combination with simethicone,has been demonstrated to effectively reduce abdominal pain and discomfort in a large placebo-controlled trial.Mebeverine is a musculotropic agent that potently blocks intestinal peristalsis.Non-placebo-controlled trials have shown positive effects of mebeverine in IBS regarding symptom control;nevertheless,in recent placebo-controlled studies,mebeverine did not exhibit superiority over placebo.Otilonium bromide is poorly absorbed from the GI tract,where it acts locally as an L-type calcium channel blocker,an antimuscarinic and a tachykinin NK2receptor antagonist.Otilonium has effectively reduced pain and improved defecation alterations in placebocontrolled trials in IBS patients.Pinaverium bromide is also an L-type calcium channel blocker that acts locally in the GI tract.Pinaverium improves motility disorders and consequently reduces stool problems in IBS patients.Phloroglucinol and trimethylphloroglucinol are non-specific antispasmodics that reduced pain in IBS patients in a placebo-controlled trial.Antispasmodics have excellent safety profiles.T-type calcium channel blockers can abolish visceral hypersensitivity in animal models,which makes them potential candidates for the development of novel therapeutic agents in the treatment of IBS. | Anita Annaházi Richárd Róka András Rosztóczy Tibor Wittmann | 2014 | World Journal of Gastroenterology2014，20，20： | 15 |
| 2 | Epidemiologic characteristics of Helicobacter pylori infection in southeast Hungary显示文摘BACKGROUND Epidemiologic studies have revealed a decrease in the prevalence of Helicobacter pylori(H.pylori)infection in Western Europe.AIM To obtain data regarding the prevalence of H.pylori in Csongrád and Békés Counties in Hungary,evaluate the differences in its prevalence between urban and rural areas,and establish factors associated with positive seroprevalence.METHODS One-thousand and one healthy blood donors[male/female:501/500,mean age:40(19–65)years]were enrolled in this study.Subjects were tested for H.pylori IgG antibody positivity via enzyme-linked immunosorbent assay.Subgroup analysis by age,gender,smoking habits,alcohol consumption,and urban vs nonurban residence was also performed.RESULTS The overall seropositivity of H.pylori was 32%.It was higher in males(34.93%vs 29.2%,P=0.0521)and in rural areas(36.2%vs 27.94%,P=0.0051).Agricultural/industrial workers were more likely to be positive for infection than office workers(38.35%vs 30.11%,P=0.0095)and rural subjects in Békés County than those in Csongrád County(43.36%vs 33.33%,P=0.0015).CONCLUSION Although the prevalence of H.pylori infection decreased in recent decades in Southeast Hungary,it remains high in middle-aged rural populations.Generally accepted risk factors for H.pylori positivity appeared to be valid for the studied population. | Lenke Bálint Andrea Tiszai Gábor Kozák Ilona Dóczi Veronika Szekeres Orsolya Inczefi Georgina Ollé Krisztina Helle Richárd Róka András Rosztóczy | 2019 | World Journal of Gastroenterology2019，25，42： | 5 |
| 3 | Sustained long-term improvement of arterial endothelial function in heterozygous familial hypercholesterolemia patients treated with simvastatin 显示文摘 | Alonso R Mata P Andres RD | 2001 | Atherosclerosis2001，157，： | 1 |
| 4 | Gustatory perception alterations in obesity: An fMRI study显示文摘 | Csaba Szalay Mihály Aradi Attila Schwarcz Gergely Orsi Gábor Perlaki Lívia Németh Sophia Hanna Gábor Takács István Szabó László Bajnok András Vereczkei Tamás Dóczi József Janszky Sámuel Komoly Péter ?rs Horváth László Lénárd Zoltán Karadi | 2012 | Brain Research2012，，： | 1 |
| 5 | Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed inrat brain 显示文摘 | Andre R Wheeler RD Collins PD | 2003 | J Neuroimmunol2003，145，12： | 1 |
| 6 | Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice显示文摘 | Anita Annaházi Krisztina Gecse Marta Dabek Afifa Ait-Belgnaoui András Rosztóczy Richárd Róka Tamás Molnár Vassilia Theodorou Tibor Wittmann Lionel Bueno Helene Eutamene | 2009 | Pain2009，，1： | 1 |
| 7 | Identification of a truncated IL-18R beta mRNA:a putative regulator of IL-18 expressed in rat brain显示文摘 | Andre R Wheeler RD Collins PD | 2003 | J Neuroimmunol2003，145，1： | 1 |
| 8 | Tomic A longitudinal study of teacher burn-out and perceived self-efficacy in classroom management显示文摘 | Andre Browers Wel RD | 2000 | Teaching and teacher education2000，10，5： | 1 |
| 9 | Necrotizing Colitis Caused by Systemic Aspergillosis in a Burn Patient显示文摘 | Andres LA Ford RD Wilcox RM | 2007 | J Burn Care Res2007，3，： | 1 |
| 10 | Isolated splenic me tastasis from lung squamous cell earcinoma显示文摘 | Andre RD Rodrigo AP Juliana NR | 2012 | World J of Surg Oncol2012，10，1： | 1 |
| 11 | Tyrosine isomers and hormonal signaling:A possible role for the hydroxyl free radical in insulin resistance显示文摘Oxidative stress processes play a major role in the development of the complications associated with diabetes and other diseases via non-enzymatic glycation,the hexosamine pathway,the polyol pathway and diacylglycerol-protein kinase C.Oxidative stress may lead to the production of hydroxyl free radicals,which can attack macromolecules,such as lipids,nucleic acids or amino acids.Phenylalanine(Phe) can be enzymatically converted to the physiological para-tyrosine(p-Tyr);however,a hydroxyl free radical attack on Phe may yield meta-and ortho-tyrosine(m-and o-Tyr,respectively) in addition to p-Tyr.Hence,m-and o-Tyr may be regarded as markers of hydroxyl free radical-induced damage.Their accumulation has been described;e.g.,this accumulation has been found in the urine of patients with diabetes mellitus(DM) and/or chronic kidney disease,in cataract lenses,in vessel walls,in irradiated food and in amniotic fluid,and it may serve as an indicator of oxidative stress.The use of resveratrol to treat patients with type 2 DM led to a decrease in the urinary excretion of o-Tyr and concomitantly led to an improvement in insulin signaling and insulin sensitivity.Literature data also suggest that m-and o-Tyr may interfere with intracellular signaling.Our group has shown that erythropoietin(EPO) has insulin-like metabolic effects on fat cells in addition to its ability to promote the proliferation of erythroid precursor cells.We have shown that the supplementation of cell culture medium with m-and o-Tyr inhibits erythroblast cell proliferation,which could be ameliorated by p-Tyr.Additionally,in vivo,the o-Tyr/p-Tyr ratio is higher in patients with renal replacement therapy and a greater need for EPO.However,the o-Tyr/p-Tyr ratio was an independent determinant of EPO-resistance indices in our human study.The o-Tyr content of blood vessel walls inversely correlates with insulin-and acetylcholineinduced vasodilation,which could be further impaired by artificial oxidative stress and improved by the use of antioxidants.In rats that receive o-Tyr supplements,decreased vasorelaxation is detected in response to insulin.Additionally,o-Tyr supplementation led to the incorporation of the unnatural amino acid into cellular proteins and caused a decrease in the insulin-induced phosphorylation of endothelial nitric oxide synthase.Our data suggest that m-and o-Tyr may not only be markers of oxidative stress;instead,they may also be incorporated into cellular proteins,leading to resistance to insulin,EPO and acetylcholine. | Gerg A Molnár Esztella Zsóka Mikolás István András Szijártó Szilárd Kun Eszter Sélley István Wittmann | 2015 | World Journal of Diabetes2015，6，3： | 1 |
| 12 | Identification of a truncated IL18R beta mRNA:a putative regulator of IL-18 expressed in rat brain显示文摘 | Andre R Wheeler RD Collins PD | 2003 | J Neuroimmunol2003，145，12： | 1 |
| 13 | Identification of a truncated IL-18R beta mRNA:a putative regulator of IL-18 expressed in rat brain显示文摘 | Andre R Wheeler RD Collins PD | | 0，，1： | 1 |
| 14 | Weight loss reduces c- reactive protein levels in obese postmenopausal women 显示文摘 | Andre Jchem of phD Amy Nolan RD | 2002 | Circulation2002，105，： | 1 |
| 15 | Identification of a truncated IL-18R beta mRNA: a putative regulator of IL-18 expressed in rat brain 显示文摘 | Andre R Wheeler RD Collins PD | 2003 | J Neuroimmunol2003，145，12： | 1 |
| 16 | Fecal proteases from diarrheic-IBS and ulcerative colitis patients exert opposite effect on visceral sensitivity in mice显示文摘 | Anita Annaházi Krisztina Gecse Marta Dabek Afifa Ait-Belgnaoui András Rosztóczy Richárd Róka Tamás Molnár Vassilia Theodorou Tibor Wittmann Lionel Bueno Helene Eutamene | 2009 | Pain2009，，1： | 1 |
| 17 | A Pilot Study of Fecal Serine-Protease Activity: A Pathophysiologic Factor in Diarrhea-Predominant Irritable Bowel Syndrome显示文摘 | Richárd Róka András Rosztóczy Mathilde Leveque Ferenc Izbéki Ferenc Nagy Tamás Molnár János Lonovics Rafael Garcia–Villar Jean Fioramonti Tibor Wittmann Lionel Bueno | 2007 | Clinical Gastroenterology and Hepatology2007，，5： | 1 |
| 18 | Effect of herpesvirus infection on pancreatic duct cell secretion显示文摘AIM: To examine the effect of acute infection caused by herpesvirus (pseudorabies virus, PRV) on pancreatic ductal secretion.METHODS: The virulent Ba-DupGreen (BDG) and nonvirulent Ka-RREpOlacgfp (KEG) genetically modified strains of PRV were used in this study and both of them contain the gene for green fluorescent protein (GFP). Small intra/interlobular ducts were infected with BDG virus (107 PFU/mL for 6 h) or with KEG virus (1010 PFU/mL for 6 h), while non-infected ducts were incubated only with the culture media. The ducts were then cultured for a further 18 h.The rate of HCO3- secretion [base efflux -J(B-)] was determined from the buffering capacity of the cells and the initial rate of intracellular acidification (1) after sudden blockage of basolateral base loaders with dihydro-4,4,-diisothiocyanatostilbene-2,2,-disulfonic acid (500 μmol/L)and amiloride (200 μmol/L), and (2) after alkali loading the ducts by exposure to NH4Cl. All the experiments were performed in HCO3--buffered Ringer solution at 37 ℃ (n = 5ducts for each experimental condition). Viral structural proteins were visualized by immunohistochemistry. Virallyencoded GFP and immunofluorescence signals were recorded by a confocal laser scanning microscope.RESULTS: The BDG virus infected the majority of accessible cells of the duct as judged by the appearance of GFP and viral antigens in the ductal cells. KEG virus caused a similarly high efficiency of infection. After blockage of basolateral base loaders, BDG infection significantly elevated -J(B-) 24 h after the infection, compared to the non-infected group. However, KEG infection did not modify -J(B-). After alkali loading the ducts, -J(B-) was significantly elevated in the BDG group compared to the control group 24 h after the infection. As we found with the inhibitor stop method, no change was observed in the group KEG compared to the non-infected group.CONCLUSION: Incubation with the BDG or KEG strains of PRV results in an effective infection of ductal epithelial cells. The BDG strain of PRV, which is able to initiate a lytic viral cycle, stimulates HcO3- secretion in guinea pig pancreatic duct by about four- to fivefold, 24 h after the infection. However, the KEG strain of PRV, which can infect,but fails to replicate, has no effect on HCO3- secretion.We suggest that this response of pancreatic ducts to virulent PRV infection may represent a defense mechanism against invasive pathogens to avoid pancreatic injury. | Péter Hegyi Balázs rdg Zoltán Rakonczai Jr Tamás Takács János Lonovics Annamária Szabolcs Réka Sári András Tóth Julius G Papp András Varró Mária K Kovács Mike A Gray Barry E Argent Zsolt Boldogki | 2005 | World Journal of Gastroenterology2005，11，38： | 0 |
| 19 | Effects of neoadjuvant chemotherapy vs chemoradiotherapy in the treatment of esophageal adenocarcinoma:A systematic review and meta-analysis显示文摘BACKGROUND Neoadjuvant therapy is an essential modality for reducing the clinical stage of esophageal cancer;however,the superiority of neoadjuvant chemotherapy(nCT)or neoadjuvant chemoradiotherapy(nCRT)is unclear.Therefore,a discussion of these two modalities is necessary.AIM To investigate the benefits and complications of neoadjuvant modalities.METHODS To address this concern,predefined criteria were established using the PICO protocol.Two independent authors performed comprehensive searches using predetermined keywords.Statistical analyses were performed to identify significant differences between groups.Potential publication bias was visualized using funnel plots.The quality of the data was evaluated using the Risk of Bias Tool 2(RoB2)and the GRADE approach.RESULTS Ten articles,including 1928 patients,were included for the analysis.Significant difference was detected in pathological complete response(pCR)[P<0.001;odds ratio(OR):0.27;95%CI:0.16-0.46],30-d mortality(P=0.015;OR:0.4;95%CI:0.22-0.71)favoring the nCRT,and renal failure(P=0.039;OR:1.04;95%CI:0.66-1.64)favoring the nCT.No significant differences were observed in terms of survival,local or distal recurrence,or other clinical or surgical complications.The result of RoB2 was moderate,and that of the GRADE approach was low or very low in almost all cases.CONCLUSION Although nCRT may have a higher pCR rate,it does not translate to greater long-term survival.Moreover,nCRT is associated with higher 30-d mortality,although the specific cause for postoperative complications could not be identified.In the case of nCT,toxic side effects are suspected,which can reduce the quality of life.Given the quality of available studies,further randomized trials are required. | Armand Csontos Alíz Fazekas Lajos Szakó Nelli Farkas Csenge Papp Szilárd Ferenczi Szabolcs Bellyei Péter Hegyi András Papp | 2024 | World Journal of Gastroenterology2024，30，11： | 0 |
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