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| 1 | Sequencing of Cultivated Peanut, Arachis hypogaea, Yields Insights into Genome Evolution and Oil Improvement显示文摘Cultivated peanut (Arachis hypogaea) is an allotetraploid crop planted in Asia, Africa, and America for edible oil and protein. To explore the origins and consequences of tetraploidy, we sequenced the allotetraploid A. hypogaea genome and compared it with the related diploid Arachis duranensis and Arachis ipaensis genomes. We annotated 39 888 A-subgenome genes and 41 526 B-subgenome genes in allotetraploid peanut. The A. hypogaea subgenomes have evolved asymmetrically, with the B subgenome resembling the ancestral state and the A subgenome undergoing more gene disruption, loss, conversion, and transposable element proliferation, and having reduced gene expression during seed development despite lacking genome-wide expression dominance. Genomic and transcriptomic analyses identified more than 2 500 oil metabolism-related genes and revealed that most of them show altered expression early in seed development while their expression ceases during desiccation, presenting a comprehensive map of peanut lipid biosynthesis. The availability of these genomic resources will facilitate a better understanding of the complex genome architecture, agronomically and economically important genes, and genetic improvement of peanut. | Xiaoping Chen Qing Lu Hao Liu Jianan Zhang Yanbin Hong Haofa Lan Haifen Li Jinpeng Wang Haiyan Liu Shaoxiong Li Manish K.Pandey Zhikang Zhang Guiyuan Zhou Jigao Yu Guoqiang Zhang Jiaqing Yuan Xingyu Li Shijie Wen Fanbo Meng Shanlin Yu Xiyin Wang Kadambot H.M.Siddique Zhong-Jian Liu Andrew H.Paterson Rajeev K.Varshney Xuanqiang Liang | 2019 | Molecular Plant2019，12，7： | 23 |
| 2 | Management of centrally located hepatocellular carcinoma:Update 2016显示文摘Centrally located hepatocellular carcinoma(HCC)is sited in the central part of the liver and adjacent to main hepatic vascular structures.This special location is associated with an increase in the difficulty of surgery,aggregation of the recurrence disease,and greater challenge in disease management.This review summarizes the evolution of our understanding for centrally located HCC and discusses the development of treatment strategies,surgical approaches and recurrence prevention methods.To improve patient survival,a multi-disciplinary modality is greatly needed throughout the whole treatment period. | Wei-Bo Yu Andrew Rao Victor Vu Lily Xu Jian-Yu Rao Jian-Xiong Wu | 2017 | World Journal of Hepatology2017，9，13： | 17 |
| 3 | Silicon and hybrid silicon photonic devices for intra-datacenter applications: state of the art and perspectives [Invited]显示文摘We review the state of the art and our perspectives on silicon and hybrid silicon photonic devices for optical interconnects in datacenters. After a brief discussion of the key requirements for intra-datacenter optical interconnects, we propose a wavelength-division-multiplexing(WDM)-based optical interconnect for intra-datacenter applications. Following our proposed interconnects configuration, the bulk of the review emphasizes recent developments concerning on-chip hybrid silicon microlasers and WDM transmitters, and silicon photonic switch fabrics for intra-datacenters. For hybrid silicon microlasers and WDM transmitters, we outline the remaining challenges and key issues toward realizing low power consumption, direct modulation, and integration of multiwavelength microlaser arrays. For silicon photonic switch fabrics, we review various topologies and configurations of high-port-count N-by-N switch fabrics using Mach–Zehnder interferometers and microring resonators as switch elements, and discuss their prospects toward practical implementations with active reconfiguration.For the microring-based switch fabrics, we review recent developments of active stabilization schemes at the subsystem level. Last, we outline several large challenges and problems for silicon and hybrid silicon photonics to meet for intra-datacenter applications and propose potential solutions. | Yu Li Yu Zhang Lei Zhang Andrew W.Poon | 2015 | Photonics Research2015，3，5： | 11 |
| 4 | Fructus Broussonetae extract improves cognitive function and endoplasmic reticulum stress in Alzheimer's disease models显示文摘This study investigated the effects and possible targets of Fructus Broussonetiae extract,a traditional Chinese medicinal herb,on a model of Alzheimer's disease induced by beta-amyloid peptide 25-35 and D-galactose.The results revealed that intragastric administration of Fructus Broussonetiae significantly increased the expression of immunoglobulin-binding protein,a key factor in the endoplasmic reticulum stress-signaling pathway in rat hippocampus.In contrast,the treatment significantly decreased expression levels of PKR-like endoplasmic reticulum kinase and C/EBP homologous protein,and substantially improved learning,memory and spatial recognition dysfunction in rats.This evidence indicates that Fructus Broussonetiae extract improves spatial learning and memory abilities in rats by affecting the regulation of hippocampal endoplasmic reticulum stress and activation of the apoptosis pathway. | Yinghong Li Li Hu Zhengzhi Wu Zhiling Yu Meiqun Cao Kehuan Sun Yu Jin Anmin Wu Andrew CJ Huang | 2011 | Neural Regeneration Research2011，6，30： | 7 |
| 5 | Phylogenomics of polyploid Fothergilla (Hamamelidaceae) by RAD-tag based GBS insights into species origin and effects of software pipelines显示文摘 | Zhe-Chen Qi Yi Yu Xiang LiuI Andrew Pais Thomas Ranney Ross Whetten Qiu-Yun (Jenny) Xiang | 2015 | Journal of Systematics and Evolution2015，53，5： | 7 |
| 6 | Optimization of variables for maximizing efficacy and efficiency in aerial spray application to cotton using unmanned aerial systems显示文摘Aerial spraying can support efficient defoliation without crop contact.With the recent introduction to unmanned aerial system(UAS)for aerial spraying in China,there is a need to determine the optimum application variables to achieve high efficacy and efficiency with low costs.The present research involved field studies across two annual cotton production seasons in North Xinjiang,China.Four factors,including volume rate(A),tank mix including spray adjuvants(B),flight altitude(C),flight speed(D)and three levels of L9(3^(4))orthogonal arrays were carried out to optimize the application parameters for three types of UASs.These included different numbers of rotors as follows:four-rotors,six-rotors and eight-rotors.Spray coverage,distribution uniformity(coefficient of variation(CV)of droplet coverage),rates of cotton defoliation and boll opening,application efficiency and cost were measured and assessed.Results showed that:(1)the rates of defoliation and boll opening by aerial cotton defoliant application could meet the requirement of cotton mechanized harvesting;(2)the optimal scenario for the three UASs was A_(3)B_(2)C_(1)D_(3),Volume rate(A3):48 L/hm^(2);Tank mix and concentration(B_(2)):(Tuotulong 225+Sujie 750+Ethephon 2250)mL/hm^(2),Flight altitude(C_(1)):1.5 m,and Flight speeds(D_(3))for unmanned helicopters with four-rotors,six-rotors and eight-rotors were 3.12 m/s,2.51 m/s and 3.76 m/s,respectively.These results can provide guidance for cotton defoliant aerial spraying in China using UAS. | Juan Liao Ying Zang Xiwen Luo Zhiyan Zhou Yubin Lan Yu Zang Xiuyan Gu Weiming Xu Andrew John Hewitt | 2019 | International Journal of Agricultural and Biological Engineering2019，12，2： | 6 |
| 7 | Pseudouridines in spliceosomal snRNAs显示文摘Spliceosomal RNAs are a family of small nuclear RNAs(snRNAs)that are essential for pre-mRNA splicing.All vertebrate spliceosomal snRNAs are extensively pseudouridylated after transcription.Pseudouridines in spliceosomal snRNAs are generally clustered in regions that are functionally important during splicing.Many of these modified nucleotides are conserved across species lines.Recent studies have demonstrated that spliceosomal snRNA pseudouridylation is catalyzed by two different mechanisms:an RNA-dependent mechanism and an RNA-independent mechanism.The functions of the pseudouridines in spliceosomal snRNAs(U2 snRNA in particular)have also been extensively studied.Experimental data indicate that virtually all pseudouridines in U2 snRNA are functionally important.Besides the currently known pseudouridines(constitutive modifications),recent work has also indicated that pseudouridylation can be induced at novel positions under stress conditions,thus strongly suggesting that pseudouridylation is also a regulatory modification. | Andrew T.Yu Junhui Ge Yi-Tao Yu | 2011 | Protein & Cell2011，2，9： | 5 |
| 8 | SUPPRESSOR OF VARIEGATION4, a New var2 Suppressor Locus, Encodes a Pioneer Protein that Is Required for Chloroplast Biogenesis显示文摘VAR2 是不可分的 thylakoid 膜蛋白质和在初核质和优核质的 metalloproteases 的万用的 FtsH 班的一个成员。在 VAR2 地点的后退的变化产生与正常出现的叶绿体与反常质体和绿部门包含白部门的使成杂色的植物(var2 ) 。在孤立 var2 上色的秒地点 suppressors 的一个持续努力,我们在这报告 ems2505 描绘,在 At4g28590 由于一个错误感觉变化有带绿色的显型的一个 suppressor 种类,为先驱蛋白质的基因。我们指明了这基因 SVR4 (为 VARIEGATION4 的 SUPPRESSOR ) 并且在 ems2505 的变异的等位基因作为 svr4-1。我们证明 SVR4 位于叶绿体并且 svr4-1 单身者异种关于叶绿体解剖和 thylakoid 膜蛋白质累积是正常的。然而,他们平常地在光化学的几个方面被损害并且提高了非光化学的熄灭(NPQ ) 能力。SVR4 的 T-DNA 插入等位基因, svr4-2,由于叶绿体开发的早阻塞是幼苗致命的。我们断定 SVR4 为叶绿体生物的续生说是必要的,并且假设那 SVR4 调停控制 NPQ 的 thylakoid 结构或功能的某方面。我们建议在 suppressor 紧张, VAR2 的缺乏引起的 photoinhibitory 压力被减少的 SVR4 活动引起的提高的 NPQ 能力在叶绿体开发早改善。这将导致能克服必要的阀值避免相片损坏并且从而发展成功能的叶绿体的叶绿体的数字的增加。 | Fei Yu ung-Soon Park Xiayan Liu Andrew Foudree Aigen Fu Marta Powikrowska Anastassia Khrouchtchova Poul Erik Jensen Jillian N. Kriger Gordon RI Gray Steven R. Rodermel | 2011 | Molecular Plant2011，4，2： | 5 |
| 9 | Unraveling a genetic roadmap for improved taste in the domesticated apple显示文摘Although taste is an important aspect of fruit quality, an understanding of its genetic control remains elusive in apple and other fruit crops. In this study, we conducted genomic sequence analysis of 497 Malus accessions and revealed erosion of genetic diversity caused by apple breeding and possible independent domestication events of dessert and cider apples. Signatures of selection for fruit acidity and size, but not for fruit sugar content, were detected during the processes of both domestication and improvement. Furthermore, we found that single mutations in major genes affecting fruit taste, including Ma1, MdTDT, and MdSOT2, dramatically decrease malate, citrate, and sorbitol accumulation, respectively, and correspond to important domestication events. Interestingly, Ma1 was identified to have pleiotropic effects on both organic acid content and sugar:acid ratio, suggesting that it plays a vital role in determining fruit taste. Fruit taste is unlikely to have been negatively affected by linkage drag associated with selection for larger fruit that resulted from the pyramiding of multiple genes with minor effects on fruit size. Collectively, our study provides new insights into the genetic basis of fruit quality and its evolutionary roadmap during apple domestication, pinpointing several candidate genes for genetic manipulation of fruit taste in apple. | Liao Liao Weihan Zhang Bo Zhang Ting Fang Xiao-Fei Wang Yarning Cai Collins Ogutu Lei Gao Gang Chen Xiaoqing Nie Jinsheng Xu Quanyan Zhang Yiran Ren Jianqiang Yu Chukun Wang Cecilia H.Deng Baiquan Ma Beibei Zheng Chun-Xiang You Da-Gang Hu Richard Espley Kui Lin-Wang Jia-Long Yao Andrew C.Allan Awais Khan Schuyler S.Korban Zhangjun Fei Ray Ming Yu-Jin Hao Li Li Yuepeng Han | 2021 | Molecular Plant2021，14，9： | 5 |
| 10 | Preferential gene retention increases the robustness of cold regulation in Brassicaceae and other plants after polyploidization显示文摘Cold stress profoundly affects plant growth and development and is a key factor affecting the geographic distribution and evolution of plants.Plants have evolved adaptive mechanisms to cope with cold stress.Here,through the genomic analysis of Arabidopsis,three Brassica species and 17 other representative species,we found that both cold-related genes(CRGs)and their collinearity were preferentially retained after polyploidization followed by genome instability,while genome-wide gene sets exhibited a variety of other expansion mechanisms.The coldrelated regulatory network was increased in Brassicaceae genomes,which were recursively affected by polyploidization.By combining our findings regarding the selective retention of CRGs from this ecological genomics study with the available knowledge of cold-induced chromosome doubling,we hypothesize that cold stress may have contributed to the success of polyploid plants through both increasing polyploidization and selectively maintaining CRGs during evolution.This hypothesis requires further biological and ecological exploration to obtain solid supporting evidence,which will potentially contribute to understanding the generation of polyploids and to the field of ecological genomics. | Xiao-Ming Song Jin-Peng Wang Peng-Chuan Sun Xiao Ma Qi-Hang Yang Jing-Jing Hu Sang-Rong Sun Yu-Xian Li Ji-Gao Yu Shu-Yan Feng Qiao-Ying Pei Tong Yu Nan-Shan Yang Yin-Zhe Liu Xiu-Qing Li Andrew H.Paterson Xi-Yin Wang | 2020 | Horticulture Research2020，7，1： | 4 |
| 11 | Anisotropically Shaped Magnetic/Plasmonic Nanocomposites for Information Encryption and Magnetic-Field-Direction Sensing显示文摘Instantaneous control over the orientation of anisotropically shaped plasmonic nanostructures allows for selective excitation of plasmon modes and enables dynamic tuning of the plasmonic properties.Herein we report the synthesis of rod-shaped magnetic/plasmonic core-shell nanocomposite particles and demonstrate the active tuning of their optical property by manipulating their orientation using an external magnetic feld.We further design and construct an IR-photoelectric coupling system,which generates an output voltage depending on the extinction property of the measured nanocomposite sample.We employ the device to demonstrate that the nanocomposite particles can serve as units for information encryption when immobilized in a polymer flm and additionally when dispersed in solution can be employed as a new type of magnetic-feld-direction sensor. | Xiaojing Wang Ji Feng Huakang Yu Yue Jin Andrew Davidson Zhiyuan Li Yadong Yin | 2018 | Research2018，，1： | 4 |
| 12 | Two-dimensional magnetic transition metal chalcogenides显示文摘The field of two-dimensional(2D)magnets has expanded rapidly during the past several years since the first demonstration of intrinsic 2D magnetism in atomically thin CrI_(3) and Cr_(2)Ge_(2)Te_(6) in 2017.2D transition metal chalcogenides(TMCs),a class of strongly correlated materials,have exhibited a wide variety of novel electronic and optical properties,and more recently magnetism.Here,we review recent experimental progress achieved in the growth of 2D magnetic TMC materials using chemical vapor deposition and molecular beam epitaxy methods.Outstanding examples include the demonstration of room temperature intrinsic and extrinsic ferromagnetism in monolayer VSe_(2),MnSe_(2),Cr_(3)Te_(4),V-doped WSe_(2),and so on.A brief discussion on the origin of the exotic magnetic properties and emergent phenomena is also presented.Finally,we summarize the remaining challenges and future perspective on the development of 2D magnetic materials for next-generation spintronic devices. | Yu Li Huang Wei Chen Andrew T.S.Wee | 2021 | SmartMat2021，2，2： | 4 |
| 13 | Is it safe to perform operation for colorectal malignancy in Chinese patients without DVT prophylaxis? An 8-year experience from a regional hospital in Hong Kong显示文摘背景 Colorectal 外科为手术后的深静脉血栓(DVT ) 和肺的栓塞被认为是高风险外科之一。在为 malignancy.Methods 数据的 colorectal 外科从从 2000 ~ 2008 的 colorectal 恶意的未来的数据库是镇定的以后,这研究瞄准了调查静脉的 thromboembolism (VTE ) 的发生。1421 colorectal 的一个总数(开并且 laparoscopic ) 没有 DVT prophylaxis.Results,手术仅仅为 colorectal 恶意被动七个病人(0.5%) 开发了征兆的 DVT,没有死亡,他们之一有肺的栓塞的复杂并发症。然而,为 colorectal 恶意的开的操作作为 DVT 的可能的风险因素被识别风险因素喜欢起作用的时间,低前面的切除术,性,在 colorectal 操作用我们的地区的汉语是低的,没有 DVT 预防,为恶意动 colorectal 手术可能是安全的以后,年龄等等不是静脉的 thromboembolism 的 identified.Conclusion 风险。 | Day Weida Lau Ying Yu Patrick Yip Wai Chun Andrew | 2010 | Chinese Medical Journal2010，，15： | 3 |
| 14 | Nat Genet:单基因突变导致过敏性皮炎的发生显示文摘最近,研究者们鉴定出了一类导致神经性皮炎发生的关键基因突变:CARDll。来自美国NIH过敏与传染病研究所的研究者们通过对四个没有血缘关系的患病家庭进行分析,发现了这一导致疾病产生的基因、 | Chi A Ma, Yuan Zhang, Michael A Weinreich, Jonathan J Lyons, Celeste G Nelson, Thomas DiMaggio, Kelly D Stone, Joshua D Milner Jeffrey R Stinson, Elisa Ruffo, Batsukh Dorjbal, Swadhinya Arjunaraja, Kelsey Voss, Andrew L Snow Jordan K Abbott, Pia J Hauk, Paul R Reynolds, Erwin W Gelfand Elisa Ruffo Salomé Glauzy, Natsuko Yamakawa, Eric Meffre Jennifer Stoddard, Julie Niemela, Sergio D Rosenzweig Yu Zhang, Helen F Matthews Joshua J McElwee Nina Jones Alejandro Palma, Matías Oleastro, Emma Prieto, Andrea R Bernasconi, Geronimo Dubra, Silvia Danielian, Jonathan Zaiat, Marcelo A Marti Brian Kim Megan A Cooper Neil Romberg | 2017 | 现代生物医学进展2017，17，27： | 3 |
| 15 | The first pulsar discovered by FAST显示文摘To assist with the commissioning [1] of the Five-hundredmeter Aperture Spherical radio Telescope (FAST), we performed a pulsar search, with the primary goal of developing and testing the pulsar data acquisition and processing pipelines. We tested and used three pipelines, two (Pl and P2 hereafter) searched for the periodic signature of pulsars whereas the other one was used to search for bright single pulses (P3 hereafter). | Lei Qian ZhiChen Pan Di Li George Hobbs WeiWei Zhu Pei Wang ZhiJie Liu YouLing Yue Yan Zhu HongFei Liu DongJun Yu JingHai Sun Peng Jiang GaoFeng Pan Hui Li HengQian Gan Rui Yao XiaoYao Xie Fernando Camilo Andrew Cameron Lei Zhang Shen Wang FAST Collaboration | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，5： | 3 |
| 16 | Importance of integrating nanotechnology with pharmacology and physiology for innovative drug delivery and therapy - an illustration with, firsthand examples显示文摘纳米技术在药交货广泛地被使用了改进各种各样的疾病的治疗学的结果。巨大的努力在与他们的生物命运和函数的关系集中于 nanoparticles 的物理化学的性质的新奇 nanoparticles 和描述的开发。然而在这些基于纳米技术的药交货系统的设计和评估,交付的药的药理学并且(patho-) 主人的生理学收到了更少的注意。在这评论,我们讨论集成于使纳米技术能的药交货系统和治疗的设计的重要药理学机制,生理的特征,和病理学的因素。第一手的例子被举由利用 1 为癌症治疗说明如此的综合设计策略的原则和优点)到克服的multidrug抵抗的癌症的药药和 drug-nanomaterial 联合的细胞内部的 synergistic 相互作用, 2 )循环系统到的血流动方向为肺转移最大化药交货到肿瘤 neovasculature 和房间 overexpressing integrin 受体, 3 )装饰 nanocarriers 和 t 的内长的脂蛋白关于在糖尿病管理的申请,一个使纳米技术能的靠近环的胰岛素交货系统被设计在生理地相关的时间规模和葡萄糖层次提供动态胰岛素版本。和另外的研究结果,这些例子建议药理学的相互影响的那利用,(patho-) 生理学和纳米技术是一条灵巧的途径与高效率和翻译潜力开发创新的药交货系统和治疗。 | Rui Xue ZHANG Jason LI Tian ZHANG Mohammad A AMINI Chunsheng HE Brian LU Taksim AHMED HoYin LIP Andrew M RAUTH Xiao Yu WU | 2018 | Acta Pharmacologica Sinica2018，39，5： | 3 |
| 17 | Geochemistry of major and trace elements and Pb–Sr isotopes of a weathering profile developed on the Lower Cambrian black shales in central Hunan, China显示文摘 | Bo Peng Andrew Rate Zhaoliang Song Changxun Yu Xiaoyan Tang Shurong Xie Xianglin Tu Changyin Tan | 2014 | Applied Geochemistry2014，，： | 2 |
| 18 | Paradoxical Increase in Ventricular Torsion and Systolic Torsion Rate in Type I Diabetic Patients Under Tight Glycemic Control显示文摘 | Jina Chung Paul Abraszewski Xin Yu Wei Liu Andrew J. Krainik Marvin Ashford Shelton D. Caruthers Janet B. McGill Samuel A. Wickline | 2006 | Journal of the American College of Cardiology2006，，2： | 2 |
| 19 | Indications for Early Postoperative Intraperitoneal Chemotherapy of Advanced Gastric Cancer: Results of a Prospective Randomized Trial显示文摘 | Wansik Yu Ilwoo Whang Ho Young Chung Andrew Averbach Paul H. Sugarbaker | 2001 | World Journal of Surgery2001，，8： | 2 |
| 20 | Dual-targeted hybrid nanoparticles of synergistic drugs for treating lung metastases of triple negative breast cancer in mice显示文摘 | Tian ZHANG Preethy PRASAD Ping CAI Chunsheng HE Dan SHAN Andrew Michael RAUTH Xiao Yu WU | 2017 | Acta Pharmacologica Sinica2017，38，6： | 2 |
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