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1Effects of Saccharomycesboulardiion fecal short-chain fatty acids and microflora in patients on long-term total enteral nutrition显示文摘AIM: To assess the effects of Sb on fecal flora and shortchain fatty acids (SCFA) in patients on long-term TEN.METHODS: Ten patients (3 females, 7 males, 59±5.5 years),on TEN for a median of 13 mo (1-125), and 15 healthy volunteers (4 females, 11 males, 32±2.0 years) received Sb (0.5 g bid PO) for 6 d. Two stool samples were taken before, on the last 2 d and 9-10 d after treatment, for SCFA measurement and for culture and bacterial identification.Values (mean±SE) were compared using sign tests and ANOVA.RESULTS: Fecal butyrate levels were lower in patients(10.1±2.9 mmol/kg) than in controls (19.2±3.9, P= 0.02).Treatment with Sb increased total fecal SCFA levels in patients (150.2±27.2 vs 107.5±18.2 mmol/kg, P = 0.02)but not in controls (129.0±28.6 vs 113.0±15.2 mmol/kg,NS). At the end of treatment with Sb, patients had higher fecal butyrate (16.0±4.4 vs 10.1 [2.9] mmol/kg, P = 0.004).Total SCFAs remained high 9 d after treatment was discontinued. Before the treatment, the anaerobe to aerobe ratio was lower in patients compared to controls (2.4±2.3 vs69.8±1.8, P = 0.003). There were no significant changes in the fecal flora of TEN patients.CONCLUSION: Sb-induced increase of fecal SCFA concentrations (especially butyrate) may explain the preventive effects of this yeast on TEN-induced diarrhea.Stéphane M Schneider Fernand Girard-Pipau Jér(o|^)me Filippi Xavier Hébuterne Dominique Moyse Gustavo Calle Hinojosa Anne Pompei Patrick Rampal 2005World Journal of Gastroenterology2005,11,39:26
2Comparison of inhaled milrinone, nitric oxide and prostacyclin in acute respiratory distress syndrome显示文摘AIM To evaluate the safety and efficacy of inhaled milrinone in acute respiratory distress syndrome(ARDS).METHODS Open-label prospective cross-over pilot study where fifteen adult patients with hypoxemic failure meeting standard ARDS criteria and monitored with a pulmonary artery catheter were recruited in an academic 24-bed medico-surgical intensive care unit. Random sequential administration of i NO(20 ppm) or nebulized epoprostenol(10 μg/mL) was done in all patients. Thereafter, inhaled milrinone(1 mg/mL) alone followed by inhaled milrinone in association with inhaled nitric oxide(iN O) was administered. A jet nebulization device synchronized with the mechanical ventilation was use to administrate the epoprostenol and the milrinone. Hemodynamic measurements and partial pressure of arterial oxygen(PaO_2) were recorded before and after each inhaled therapyadministration.RESULTS The majority of ARDS were of pulmonary cause(n = 13) and pneumonia(n = 7) was the leading underlying initial disease. Other pulmonary causes of ARDS were: Post cardiopulmonary bypass(n = 2), smoke inhalation injury(n = 1), thoracic trauma and pulmonary contusions(n = 2) and aspiration(n = 1). Two patients had an extra pulmonary cause of ARDS: A polytrauma patient and an intra-abdominal abscess Inhaled nitric oxide, epoprostenol, inhaled milrinone and the combination of inhaled milrinone and i NO had no impact on systemic hemodynamics. No significant adverse events related to study medications were observed. The median increase of PaO 2 from baseline was 8.8 mmH g [interquartile range(IQR) = 16.3], 6.0 mm Hg(IQR = 18.4), 6 mm Hg(IQR = 15.8) and 9.2 mm Hg(IQR = 20.2) respectively with i NO, epoprostenol, inhaled milrinone, and i NO added to milrinone. Only i NO and the combination of inhaled milrinone and i NO had a statistically significant effect on PaO 2. CONCLUSION When comparing the effects of inhaled NO, milrinone and epoprostenol, only NO significantly improved oxygenation. Inhaled milrinone appeared safe but failed to improve oxygenation in ARDS.Martin Albert Daniel Corsilli David R Williamson Marc Brosseau Patrick Bellemare Stéphane Delisle Anne QN Nguyen France Varin 2017World Journal of Critical Care Medicine2017,6,1:4
3运用ICF评定肌肉骨骼系统健康状况的影响显示文摘目的建议联合使用国际疾病分类(ICD)及国际功能、残疾和健康分类(ICF),并应用肌肉骨骼系统(MSK)状况的例子来说明运用方法。方法根据在ICD中MSK状况的分类和现有的ICF核心分类集(ICF Core Sets)MSK状况的类目作为备选类目来专门说明专项功能。另一方法是考虑来自在文献中出现的已经应用的测量方法或工具的类目。结果从6个MSK状况的核心分类集、两种特定的保健治疗环境、一种MSK临床研究环境和8篇工具相关的文献中抽取相关的ICF类目。结论 ICD-ICF联合使用通过考虑疾病和功能状况来强调健康状况的影响,从而促进临床保健治疗。因此,有证据显示,在ICD修订版背景下ICD和ICF之间有可操作性的联系和互补作用。Nenad Kostanjsek Reuben Escorpizo Annelies Boonen Nicolas E.Walsh Tefvik Bedirhan stün Gerold Stucki 李晶晶 祝捷 邹智 荀芳 邱卓英 2011中国康复理论与实践2011,17,2:4
4Increased Risk for Nonmelanoma Skin Cancers in Patients Who Receive Thiopurines for Inflammatory Bowel Disease显示文摘Laurent Peyrin–Biroulet Kiarash Khosrotehrani Fabrice Carrat Anne–Marie Bouvier Jean–Baptiste Chevaux Tabassome Simon Frank Carbonnel Jean–Frédéric Colombel Jean–Louis Dupas Philippe Godeberge Jean–Pierre Hugot Marc Lémann Stéphane Nahon Jean–Marc Sabaté 2011Gastroenterology2011,,5:3
5Endoscopy-based management decreases the risk of postoperative recurrences in Crohn's disease显示文摘AIM: To investigate whether an endoscopy-based management could prevent the long-term risk of postoperative recurrence.METHODS: From the pathology department database, we retrospectively retrieved the data of all the patients operated on for Crohn's disease(CD) in our center(1986-2015). Endoscopy-based management was defined as systematic postoperative colonoscopy(median time after surgery = 9.5 mo) in patients with no clinical postoperative recurrence at the time of endoscopy. RESULTS: From 205 patients who underwent surgery, 161 patients(follow-up > 6 mo) were included. Endoscopic postoperative recurrence occurred in 67.6%, 79.7%, and 95.5% of the patients, respectively 5, 10 and 20 years after surgery. The rate of clinical postoperative recurrence was 61.4%, 75.9%, and 92.5% at 5, 10 and 20 years, respectively. The rate of surgical postoperative recurrence was 19.0%, 38.9% and 64.7%, respectively, 5, 10 and 20 years after surgery. In multivariate analysis, previous intestinal resection, prior exposure to anti-TNF therapy before surgery, and fistulizing phenotype(B3) were postoperative risk factors. Previous perianal abscess/fistula(other perianal lesions excluded), were predictive of only symptomatic recurrence. In multivariate analysis, an endoscopy-based management(n = 49/161) prevented clinical(HR = 0.4, 95%CI: 0.25-0.66, P < 0.001) and surgical postoperative recurrence(HR = 0.30, 95%CI: 0.13-0.70, P = 0.006).CONCLUSION: Endoscopy-based management should be recommended in all CD patients within the first year after surgery as it highly decreases the long-term risk of clinical recurrence and reoperation.Anne-Laure Boucher Bruno Pereira Stéphanie Decousus Marion Goutte Felix Goutorbe Anne Dubois Johan Gagniere Corinne Borderon Juliette Joubert Denis Pezet Michel Dapoigny Pierre J Déchelotte Gilles Bommelaer Anthony Buisson 2016World Journal of Gastroenterology2016,22,21:3
6Molecular phylogeny of Trametes and related genera,and description of a new genus Leiotrametes显示文摘A phylogenetic analysis of Trametes and related taxa is proposed,based on a wide sampling of temperate and tropical species.Concatenate sequences of ribosomal DNA(ITS1-5.8S-ITS2)and RPB2 gene from mycelia cultures were analyzed by Maximum Likelihood and Bayesian methods,whilst morphological features were documented from the corresponding herbarium vouchers.Congruent results were obtained from analyses of ribosomal LSU sequences downloaded from Genbank.The Bayesian analysis of ITS+RPB2 sequences gave the best resolution for the phylogenetic reconstructions and revealed the existence of three main lineages in the Trametes-clade:1)a monospecific lineage represented by Artolenzites elegans 2)a lineage including the genus Pycnoporus in its traditional sense and several species usually classified in the genus Trametes(T.cingulata,T.lactinea,T.ljubarskyi,T.menziesii)&3)a lineage corresponding to the core genus Trametes,including type species of Trametes,Coriolopsis and Lenzites.The presence of a pseudostipe,aspect and structure of the abhymenial surface,colour change with 5%aqueous solutions of potassium hydroxide and topography of pigments on skeletal hyphae gave relevant morphological support to these clades.When the structure of the hymenial surface,presence of a black line below the tomentum and color of context(except for genus Pycnoporus)usually used in traditional polypore-classifications did not reveal any phylogenetic significance.A partial systematic arrangement of the Trametes clade is proposed,with the introduction of a new genus:Leiotrametes Welti&Courtec.gen.nov..Two new combinations:Leiotrametes lactinea(Berk.)Welti&Courtec.comb.nov.and L.menziesii(Berk.)Welti&Courtec.comb.nov.are proposed.Stéphane Welti Pierre-Arthur Moreau Anne Favel Régis Courtecuisse Mireille Haon David Navarro Sabine Taussac Laurence Lesage-Meessen 2012Fungal Diversity2012,,4:3
7Taste and mouth-feel properties of different types of tannin-like polyphenolic compounds and anthocyanins in wine显示文摘Stéphane Vidal Leigh Francis Ann Noble Mariola Kwiatkowski Véronique Cheynier Elizabeth Waters 2003Analytica Chimica Acta2003,,1:2
8Lessons from French national guidelines on the treatment of venous thrombosis and central venous catheter thrombosis in cancer patients显示文摘Dominique Farge Cecile Durant Stéphane Villiers Anne Long Alfred Mahr Michel Marty Philippe Debourdeau 2010Thrombosis Research2010,,:2
9Early Administration of Azathioprine vs Conventional Management of Crohn’s Disease: a Randomized Controlled Trial显示文摘Jacques Cosnes Anne Bourrier David Laharie Stéphane Nahon Yoram Bouhnik Franck Carbonnel Matthieu Allez Jean-Louis Dupas Jean-Marie Reimund Guillaume Savoye Pauline Jouet Jacques Moreau Jean-Yves Mary Jean-Frédéric Colombel 2013Gastroenterology2013,,:2
10Wet spinning of solid pnlyamic acid fibers显示文摘William E Dorogy Jr Anne K ST Clair 1991Journal of Applied Polym Science1991,43,3:1
11Functional Toll-like receptors in primary first-trimester trophoblasts显示文摘Line H. Tanger?s Guro S. St?dle Guro D. Olsen Ann-Helen Leknes Astrid S. Gundersen Bente Skei Anne Jorunn Vikdal Liv Ryan Bj?rg Steinkjer Merete F. Myklebost Mette Langaas Rigmor Austgulen Ann-Charlotte Iversen 2014Journal of Reproductive Immunology2014,,:1
12Half-fourier rare MR Cholan- giop ancreatography : experence in 300 subjects 显示文摘Ann ST Mary AT Gerald WC 1998Radiology1998,207,1:1
13Clair,Enhancement of dimensional stability in soluble fluorinated polyimides via the in situ formation of lanthanum(Ⅲ)-oxo-polyimide nanocomposites显示文摘Robin E Southward D Scott Thompson David W Thompson Anne K St 1998Chem Mater1998,10,:1
14Molecularly oriented films for space applications显示文摘Fay Catharine C Stoakley Diane M Clair Anne K St 0,,11:1
15Identification of Adipose Tissue Dendritic Cells Correlated With Obesity-Associated Insulin-Resistance and Inducing Th17 Responses in Mice and Patients显示文摘Adeline Bertola Thomas Ciucci Déborah Rousseau Virginie Bourlier Carine Duffaut Stéphanie Bonnafous Claudine Blin-Wakkach Rodolphe Anty Antonio Iannelli Jean Gugenheim Albert Tran Anne Bouloumié Philippe Gual Abdelilah Wakkach 2012Diabetes2012,,9:1
16Keratin 8/18 regulation of glucose metabolism in normal versus cancerous hepatic cells through differential modulation of hexokinase status and insulin signaling显示文摘Jasmin Mathew Anne Loranger Stéphane Gilbert Robert Faure Normand Marceau 2012Experimental Cell Research2012,,:1
17Molecular changes associated with the endolymphatic hydrops model 显示文摘Anne S Kisley LB Tajuddin ST 2007Otol Neurotol2007,28,6:1
18Endothelial function and dysfunction. Part II: Association with cardiovascular risk factors and diseases. A statement by the Working Group on Endothelins and Endothelial Factors of the European Society of Hypertension*显示文摘Hanspeter Brunner John R Cockcroft John Deanfield Ann Donald Ele Ferrannini Julian Halcox Wolfgang Kiowski Thomas F Lüscher Giuseppe Mancia Andrea Natali James J Oliver Achille C Pessina Damiano Rizzoni Gian Paolo Rossi Antonio Salvetti Lukas E Spieker St 2005Journal of Hypertension2005,,2:1
19Genome-Wide Association Study Identifies Variants Associated With Progression of Liver Fibrosis From HCV Infection显示文摘Etienne Patin Zoltán Kutalik Julien Guergnon Stéphanie Bibert Bertrand Nalpas Emmanuelle Jouanguy Mona Munteanu Laurence Bousquet Laurent Argiro Philippe Halfon Anne Boland Beat Müllhaupt David Semela Jean–Fran?ois Dufour Markus H. Heim Darius Moradpour A 2012Gastroenterology2012,,5:1
20The role of calcium in mammalian ooeyte maturation and egg activation 显示文摘Hom a ST C afro 11 J Sw ann K 1993Hum Reprod1993,8,:1
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