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| 1 | miR-182参与调节胶质母细胞瘤的凋亡、生长和分化(英文)显示文摘Glioblastoma multiforme(GBM)is a lethal,therapy-resistant brain cancer consisting of numerous tumor cell subpopulations,including stem-like glioma-initiating cells(GICs),which contribute to tumor recurrence following initial response to therapy.Here,we identified miR-182 as a regulator of apoptosis,growth,and differentiation programs whose expression level is correlated with GBM patient survival.Repression of Bcl2-like12(Bcl2L12),c-Met,and hypoxia-inducible factor 2α(HIF2A)is of central importance to miR-182 anti-tumor activity,as it results in enhanced therapy susceptibility,decreased GIC sphere size,expansion,and stemness in vitro.To evaluate the tumor-suppressive function of miR-182 in vivo,we synthesized miR-182-based spherical nucleic acids(182-SNAs);i.e.,gold nanoparticles covalently functionalized with mature miR-182 duplexes.Intravenously administered 182-SNAs penetrated the bloodbrain/blood-tumor barriers(BBB/BTB)in orthotopic GBM xenografts and selectively disseminated throughout extravascular glioma parenchyma,causing reduced tumor burden and increased animal survival.Our results indicate that harnessing the anti-tumor activities of miR-182 via safe and robust delivery of 182-SNAs represents a novel strategy for therapeutic intervention in GBM. | Kouri FM Hurley LA Daniel WL Day ES Hua Y Hao L Peng CY Merkel TJ Queisser MA Ritner C Zhang H James CD Sznajder JI Chin L Giljohann DA Kessler JA Peter ME Mirkin CA Stegh AH | 2015 | 中华神经外科疾病研究杂志2015，14，2： | 14 |
| 2 | Acute effects of physical exercise in type 2 diabetes: A review显示文摘The literature has shown the efficiency of exercise in the control of type 2 diabetes(T2D), being suggested as one of the best kinds of non-pharmacological treatments for its population. Thus, the scientific production related to this phenomenon has growing exponentially. However, despite its advances, still there is a lack of studies that have carried out a review on the acute effects of physical exercise on metabolic and hemodynamic markers and possible control mechanisms of these indicators in individuals with T2 D, not to mention that in a related way, these themes have been very little studied today. Therefore, the aim of this study was to organize and analyze the current scientific production about the acute effects of physical exercise on metabolic and hemodynamic markers and possible control mechanisms of these indicators in T2 D individuals. For such, a research with the following keywords was performed:-exercise; diabetes and post-exercise hypotension; diabetes and excess post-exercise oxygen consumption; diabetes and acute effects in PUBMED, SCIELO and HIGHWIRE databases. From the analyzed studies, it is possible to conclude that, a single exercise session can promote an increase in the bioavailability of nitric oxide and elicit decreases in postexercise blood pressure. Furthermore, the metabolic stress from physical exercise can increase the oxidation of carbohydrate during the exercise and keep it, in high levels, the post exercise consumption of O2, this phenomenon increases the rate of fat oxidation during recovery periods after exercise, improves glucose tolerance and insulin sensitivity and reduces glycemia between 2-72 h, which seems to be dependent on the exercise intensity and duration of the effort. | Ricardo Yukio Asano Marcelo Magalhes Sales Rodrigo Alberto Vieira Browne José Fernando Vila Nova Moraes Hélio José Coelho Júnior Milton Rocha Moraes Hebert Gustavo Simoes | 2014 | World Journal of Diabetes2014，5，5： | 8 |
| 3 | 不育妇女的功能障碍、精神病症状和生活质量:一项来自土耳其横断面研究(英文)显示文摘背景:不孕不育是一种重大的生活危机,它可以导致精神病症状的发展并且对夫妻的生活质量产生负面影响,但其影响程度可能取决于文化背景。目标:我们比较了土耳其城市中生育妇女和不孕妇女的精神病症状程度、功能障碍水平和生活质量。方法:该横断面研究纳入了100名在里泽教育和研究医院的妇产科门诊治疗不孕不育的已婚女性和100名已婚已育的妇女作为对照组。对所有参与者均采用社会人口信息筛查表、医院焦虑抑郁量表(Hospital Anxiety and Depression Scale,HADS)、简单功能障碍问卷(Brief Disability Questionnaire,BDQ)和健康状况问卷(Short Form Health Survey,SF-36)进行评估。结果:不育女性的平均焦虑分量表得分和抑郁分量表得分稍高于对照组,但差异无统计学意义。不孕组妇女中有显著临床焦虑症状的比例(即焦虑分量表得分>11)显著高于育龄妇女(31%v.17%,X^2=5.37,p=0.020),但有显著临床抑郁症状的比例(即抑郁分量表评分HADS>8)在两组间没有显著性差异(43%v.33%,X^2=2.12,p=0.145)。不育女性自我报告前一个月的功能障碍显著比对照组严重,并且不育女性在SF-36的8个分量表中4个(一般健康、活力、社会功能和心理健康)显著差于对照组。与目前工作的不育女性相比,目前没有工作的女性不育患者报告的抑郁和焦虑程度较轻,且一般健康状况、活力和心理健康状况较好。结论:未发现土耳其城市地区中寻求治疗的不孕不育已婚女性并比已婚已育妇女有更严重的抑郁症状,但他们确实报告有较大的躯体和心理障碍并且生活质量较差。不孕不育的负面影响对在职不孕女性妇女比无业的不孕妇女更严重。西方国家这通常报告不孕患者抑郁和焦虑的患病率更高,我们需要更大规模的随访研究以评估这些结果与西方国家报告的结果不同的原因。 | Sezgin H Hocaoglu C Guvendag-Guven ES | 2016 | 上海精神医学2016，28，2： | 7 |
| 4 | 螺内酯与可乐定作为难治性高血压第4种治疗药物的比较:难治性高血压的最佳治疗随机研究显示文摘该研究旨在通过一个多中心随机试验对作为难治性高血压患者的第4种治疗药物的螺内酯与可乐定进行比较。采用药丸计数评估药物治疗依从性。难治性高血压患者(定义为包括1种利尿剂在内的3种药物治疗12周,诊室及动态血压监测血压仍未控制)随机给予螺内酯(12.5~50 mg/d)或可乐定(0.1~0.3mg,2次/d)继续治疗12周。 | Krieger EM Drager LF Giorgi DMA Pereira AC Barreto-Filho JAS Nogueira AR Mill JG Lotufo PA Amodeo C Batista MC Bodanese LC Carvalho ACC Castro I Chaves H Costa EAS Feitosa GS Franco RJS Fuchs FD Guimarāes AC Jardim PC Machado CA Magalhāes ME Mion D Jr Nascimento RM Nobre F Nóbrega AC Ribeiro ALP Rodrigues-Sobrinho CR Sanjuliani AF Teixeira MDCB Krieger JE ReHOT Investigators 赵狄 练桂丽 | 2018 | 中华高血压杂志2018，26，3： | 7 |
| 5 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 6 | Interleukin-6 levels and HPA axis activation in breast cancer patients with major depressive disorder显示文摘 | Soygur H Palaoglu O Akarsu ES | 2007 | Prog Neuropsychopharmacol Biol Psychiatry2007，31，6： | 1 |
| 7 | An exaggerated sensory component of the gastro colonic response in patients with irritable bowel syndrome 显示文摘 | Simren M Abrahamsson H Bjomsson ES | 2001 | Gut2001，48，1： | 1 |
| 8 | Dramatic interstrain differences in the replication of human cytomegalovirus in SCID -hu mice显示文摘 | Brown JM Kaneshima H Mokarski ES | 1995 | Infect Dis1995，171，6： | 1 |
| 9 | Caught up in a Wnt storm~ Wnt signaling in cancer显示文摘 | Giles R H van Es J H Clevers H | 2003 | Biochim Biophys Acta2003，1653，： | 1 |
| 10 | Thyroid disease and glaucoma显示文摘 | Cheng H Perkins ES | 1967 | Br J Ophthahnol1967，51，： | 1 |
| 11 | Enhanced endothelialization of a new stent polymer through surface enhancement and incorporation of growth factor-delivering microparticles 显示文摘 | Xu H Nguyen KT Brilakis ES | 2012 | J Cardiovasc Transl Res2012，5，4： | 1 |
| 12 | Opposing activities of two novel members of the IL-ligand family regulate skin inflammation显示文摘 | Blumberg H Dinh H Trueblood ES | 2007 | J Exp Med2007，204，： | 1 |
| 13 | Tuberous sclerosis complex consensus conference:revised clinical diagnos-tic criteria显示文摘 | Roach ES Gomez MR Northrup H | 1998 | J Child Neurol1998，13，12： | 1 |
| 14 | Effects of selective cyclooxygenase enzyme inhibitors on lipopolysaecharide-induced dual thermoregulatory changes in rats 显示文摘 | Dogma MD Ataogle H Akarsu ES | 2002 | Brain Res Bull2002，57，： | 1 |
| 15 | Actin dynamics: growth from dendritic branches 显示文摘 | Nicholson-Dykstra S Higgs H N Harris ES | 2005 | Curr Biol2005，15，9： | 1 |
| 16 | Arachidonic acid potentiates acid-sensing ion channels in rat sensory neurons by a direct action显示文摘 | Smith ES Cadiou H Naughton PA | 2007 | Neuroscience2007，145，2： | 1 |
| 17 | TCF: Lady Justice casting the final verdict on the outcome of Wnt signalling 显示文摘 | Brantjes H Barker N van Es J | 2002 | Biol Chem2002，383，2： | 1 |
| 18 | Restoration of peri- implant defects in immediate implant installations by Choukroun platelet-rich fibrin and silk fibroin powder combination graft显示文摘 | Jang ES Park JW Kweon H | 2010 | Oral Surg Oral Med Oral Pathol Oral Radiol Endod2010，109，6： | 1 |
| 19 | A revised Eruopena-American classfication of lymphoid neoplasmas:a proposal from the International Lymphoma Study Group显示文摘 | Harris NL Jaffe ES Stein H | 1994 | Blood1994，84，： | 1 |
| 20 | Identification of stem cells in small intestine and colon by marker gene Lgr5显示文摘 | Barker N van Es J H Kuipers J | | Nature0，449，7165： | 1 |
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