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| 1 | Practice guidelines for the pathological diagnosis of primary liver cancer: 2015 update显示文摘In 2010, a panel of Chinese pathologists reported the first expert consensus for the pathological diagnosis of primary liver cancers to address the many contradictions and inconsistencies in the pathological characteristics and diagnostic criteria for PLC. Since then considerable clinicopathological studies have been conducted globally, prompting us to update the practice guidelines for the pathological diagnosis of PLC. In April 18, 2014, a Guideline Committee consisting of 40 specialists from seven Chinese Societies(including Chinese Society of Liver Cancer, Chinese Anti-Cancer Association; Liver Cancer Study Group, Chinese Society of Hepatology, Chinese Medical Association; Chinese Society of Pathology, Chinese Anti-Cancer Association; Digestive Disease Group, Chinese Society of Pathology, Chinese Medical Association; Chinese Society of Surgery, Chinese Medical Association; Chinese Society of Clinical Oncology, Chinese Anti-Cancer Association; Pathological Group of Hepatobiliary Tumor and Liver Transplantation, Chinese Society of Pathology, Chinese Medical Association) was created for the formulation of the first guidelines for the standardization of the pathological diagnosis of PLC, mainly focusing on the following topics: gross specimen sampling, concepts and diagnostic criteria of small hepatocellular carcinoma(SHCC), microvascular invasion(MVI), satellite nodules,and immunohistochemical and molecular diagnosis. The present updated guidelines are reflective of current clinicopathological studies, and include a novel 7-point baseline sampling protocol, which stipulate that at least four tissue specimens should be sampled at the junction of the tumor and adjacent liver tissues in a 1:1 ratio at the 12, 3, 6 and 9 o'clock reference positions. For the purposes of molecular pathological examination, at least one specimen should be sampled at the intratumoral zone, but more specimens should be sampled for tumors harboring different textures or colors. Specimens should be sampled at both adjacent and distant peritumoral liver tissues or the tumor margin in order to observe MVI, satellite nodules and dysplastic foci/nodules distributed throughout the background liver tissues. Complete sampling of whole SHCC ≤ 3 cm should be performed to assess its biological behavior, and in clinical practice, therapeutic borders should be also preserved, even in SHCC. The diagnostic criteria of MVI and satellite nodules, immunohistochemical panels, as well as molecular diagnostic principles, such as clonal typing, for recurrent HCC and multinodule HCC were also proposed and recommended. The standardized process of pathological examination is aimed at ensuring the accuracy of pathological PLC diagnoses as well as providing a valuable frame of reference for the clinical assessment of tumor invasive potential, the risk of postoperative recurrence, long-term survival, and the development of individualized treatment regimens. The updated guidelines could ensure the accuracy of pathological diagnoses of PLC, and provide a valuable frame of reference for its clinical assessment. | Wen-Ming Cong Hong Bu Jie Chen Hui Dong Yu-Yao Zhu Long-Hai Feng Jun Chen 无 | 2016 | World Journal of Gastroenterology2016，22，42： | 81 |
| 2 | High-efficiency breeding of early-maturing rice cultivars via CRISPR/Cas9-mediated genome editing显示文摘Rice is a staple food for more than half of the human population.It has been estimated that by 2030,40%more rice needs to be produced in order to meet the growing demand(Khush,2005).One of the strategies to improve rice productivity is to enlarge rice | Xiufeng Li Wenjia Zhou Yuekun Ren Xiaojie Tian Tianxiao Lv Zhenyu Wang Jun Fang Chengcai Chu Jie Yang Qingyun Bu | 2017 | Journal of Genetics and Genomics2017，44，3： | 20 |
| 3 | Molecular Typing of Brucella Suis Collected from 1960s to 2010s in China by MLVA and PFGE显示文摘Brucellosis is a bacterial anthropozoonosis usually caused by Brucella abortus, Brucella melitensis, Brucella suis and Brucella canis. Brucella suis, the causative agent of swine brucellosis, is classified into five biovars and preferentially infects different animal hosts [1] . | LI Zhen Jun CUI Bu Yun CHEN Hai CHEN Jing Diao ZHAO Hong Yan PIAO Dong Ri JIANG Hai ZHANG Li TANG Xu KE Chang Wen YAO zhen TIAN Guo Zhong | 2013 | Biomedical and Environmental Sciences2013，26，6： | 13 |
| 4 | Combinations of Hd2 and Hd4 genes determine rice adaptability to Heilongjiang Province, northern limit of China显示文摘Heading date is a key trait in rice domestication and adaption, and a number of quantitative trait loci(QTLs)have been identified. The rice(Oryza sativa L.) cultivars in the Heilongjiang Province, the northernmost region of China,have to flower extremely early to fulfill their life cycle.However, the critical genes or different gene combinations controlling early flowering in this region have not been determined. QTL and candidate gene analysis revealed that Hd2/Ghd7.1/Os PRR37 plays a major role in controlling rice distribution in Heilongjiang. Further association analysis with a collection of rice cultivars demonstrated that another three major QTL genes(Hd4/Ghd7, Hd5/DTH8/Ghd8, and Hd1)also participate in regulating heading date under natural long day(LD) conditions. Hd2/Ghd7.1/Os PRR37 and Hd4/Ghd7 are two major QTLs and function additively. With the northward rice cultivation, the Hd2/Ghd7.1/Os PRR37 and Hd4/Ghd7 haplotypes became non-functional alleles. Hd1 might be non-functional in most Heilongjiang rice varieties,implying that recessive hd1 were selected during local rice breeding. Non-functional Hd5/DTH8/Ghd8 is very rare, but constitutes a potential target for breeding extremely early flowering cultivars. Our results indicated that diverse genetic combinations of Hd1, Hd2, Hd4, and Hd5 determined the different distribution of rice varieties in this northernmost province of China. | Xiufeng Li Huazhao Liu Maoqing Wang Hualong Liu Xiaojie Tian Wenjia Zhou Tianxiao Lü Zhenyu Wang Chengcai Chu Jun Fang Qingyun Bu | 2015 | Journal of Integrative Plant Biology2015，57，8： | 13 |
| 5 | Analysis of the Sending-Side System Instability Caused by Multiple HVDC Commutation Failure显示文摘As high-voltage direct current(HVDC)lines with large capacity are being commissioned with higher frequency,the characteristics of“strong”DC and“weak”AC transmission in the power grid are topics of interest.In particular,the coupling and interaction between the sending-side and receivingside AC systems interconnected by large-scale DC links is gaining importance.In this paper,the impact of the multiple HVDC commutation failure on the stability of the sending system under different power flow directions is analyzed based on the threearea AC/DC equivalent model.The main influencing factors and the counter-measures are discussed,and the single HVDC line blocking is taken as a comparison.Finally,the results are verified using the North China-Central China-East China power grid case system.The study provides a basis and reference to ensure security and stability of the ultra-high-voltage(UHV)AC/DC hybrid power grid. | Jingzhe Tu Jian Zhang Guangquan Bu Jun Yi Yonghua Yin Junchuan Jia | 2015 | CSEE Journal of Power and Energy Systems2015，1，4： | 12 |
| 6 | Change of CMTM7 expression, a potential tumor suppressor, is associated with poor clinical outcome in human non-small cell lung cancer显示文摘 | LIU Qiang SU Yu JIANG Guan-chao ZHOU Zu-li LIU Bao-cai BU Liang YANG Fan WANG Jun | 2013 | Chinese Medical Journal2013，，16： | 10 |
| 7 | Completely video-assisted thoracoscopic lobectomy versus open lobectomy for non-small cell lung cancer greater than 5 cm:a retrospective study显示文摘背景完全帮助录像的 thoracoscopic Iobectomy 是为早阶段的 non-small-cell 肺癌症(NSCLC ) 的合理治疗在场的 .At,为这个过程的指示是阶段 la 和 Ib 外部肺癌症((<-)5 厘米) ;为更大的肿瘤,然而,这种外科的技术是否是可比较的开 Iobectomy.This 学习试图评估 thoracoscopic Iobectomy 的安全,完全性,和功效,仍然保持争论,并且在我们的 center.In 为 non-small-cell 肺癌症的治疗经历了 Iobectomy 当肿瘤的直径比从2001年5月的 5 cm.Methods 大到4月2011,802日病人时,为 non-small-cell 肺癌症的治疗把这种技术与开的 Iobectomy 作比较 133 个病人,肿瘤 | Bu Liang Li Yun Yang Fan Zhao Hui Jiang Guan-chao Li Jian-feng Liu Jun Wang Jun | 2012 | Chinese Medical Journal2012，，3： | 10 |
| 8 | Comparison of the autofluorescence bronchoscope and the white light bronchoscope in airway examination显示文摘Background and Objective: The sensitivity and accuracy of white light bronchoscopy (WLB) in airway examination are low. Autofluorescence bronchoscope (AFB) can determine early lesions in bronchial mucosa more sensitively, but it has seldom performed in China. To assess the clinical value of the AFB in airway examination, we compared the sensitivity and specificity of the AFB and WLB in detecting cancer of the airway mucosa. Methods: Between September 2009 and May 2010, bronchoscope examinations using both the AFB and WLB were performed on 136 patients, 95 men and 41 women with a median age of 61.5 years (ranged from 25 to 84 years). There were 46 lesions located in the central airway, 84 in the peripheral lung parenchyma, and 6 in the mediastinal region. All patients received local and general anesthesia and were subsequently examined with the WLB and AFB in tandem. All procedures were completed safely. Abnormal visual findings were recorded, and biopsies of the affected regions were collected for pathologic examination. Results: Of 241 regions sampled for biopsy, 76 sites contained malignant lesions, whereas 165 sites contained benign lesions. The AFB detected 72 of the 76 malignant lesions, but the WLB detected only 50. The sensitivities of the AFB and WLB were 94.7% and 65.8%, respectively, and the specificities were 57.0% and 83.6%, respectively. The negative predictive values of the AFB and WLB were 95.9% and 84.1%, respectively. Conclusions: The AFB is more sensitive than the WLB in detecting cancerous lesions in the mucosa, and is an effective airway examination. | Yun Li Xiao Li Xi-Zhao Sui Liang Bu Zu-Li Zhou Fan Yang Yan-Guo Liu Hui Zhao Jian-Feng Li Jun Liu Guan-Chao Jiang Jun Wang | 2010 | Chinese Journal of Cancer2010，29，12： | 7 |
| 9 | Application of endobronchial ultrasound-guided transbronchial needle aspiration in the diagnosis of mediastinal lesions显示文摘背景 Mediastinal 损害经常是困难的因为纵隔的唯一的解剖位置,在临床的实践诊断,它广泛地做在肺癌症和 mediastinal 淋巴节点阶段的诊断的指导超声的 transbronchial 针渴望是的 endobronchial 的活体检视 difficult.The 价值的性能 accepted.However ,很少研究在 endobronchial 的价值上被进行了在诊断和 differenti 的指导超声的 transbronchial | ZHAO Hui WANG Jun ZHOU Zu-li LI Yun BU Liang YANG Fan SUI Xi-zhao CHEN Ke-zhong LI Xiao LIU Jun LI Jian-feng JIANG Guan-chao | 2011 | Chinese Medical Journal2011，，23： | 6 |
| 10 | Three-dimensional Culture of Human Airway Epithelium in Matrigel for Evaluation of Human Rhinovirus C and Bocavirus Infections显示文摘Objective Newly identified human rhinovirus C(HRV-C) and human bocavirus(HBoV) cannot propagate in vitro in traditional cell culture models; thus obtaining knowledge about these viruses and developing related vaccines are difficult. Therefore, it is necessary to develop a novel platform for the propagation of these types of viruses. Methods A platform for culturing human airway epithelia in a three-dimensional(3 D) pattern using Matrigel as scaffold was developed. The features of 3 D culture were identified by immunochemical staining and transmission electron microscopy. Nucleic acid levels of HRV-C and HBoV in 3 D cells at designated time points were quantitated by real-time polymerase chain reaction(PCR). Levels of cytokines, whose secretion was induced by the viruses, were measured by ELISA. Results Properties of bronchial-like tissues, such as the expression of biomarkers CK5, ZO-1, and PCK, and the development of cilium-like protuberances indicative of the human respiration tract, were observed in 3 D-cultured human airway epithelial(HAE) cultures, but not in monolayer-cultured cells. Nucleic acid levels of HRV-C and HBoV and levels of virus-induced cytokines were also measured using the 3 D culture system. Conclusion Our data provide a preliminary indication that the 3 D culture model of primary epithelia using a Matrigel scaffold in vitro can be used to propagate HRV-C and HBoV. | CHEN Ya Xiong XIE Guang Cheng PAN Dong DU Ya Rong PANG Li Li SONG Jing Dong DUAN Zhao Jun HU Bu Rong | 2018 | Biomedical and Environmental Sciences2018，31，2： | 6 |
| 11 | The heterogeneity of islet autoantibodies and the progression of islet failure in type 1 diabetic patients显示文摘Type 1 diabetes mellitus is heterogeneous in many facets. The patients suffered from type 1 diabetes present several levels of islet function as well as variable number and type of islet-specific autoantibodies. This study was to investigate prevalence and heterogeneity of the islet autoantibodies and clinical phenotypes of type 1 diabetes mellitus; and also discussed the process of islet failure and its risk factors in Chinese type 1 diabetic patients. A total of 1,291 type 1 diabetic patients were enrolled in this study. Demographic information was collected. Laboratory tests including mixed-meal tolerance test, human leukocyte antigen alleles, hemoglobin A1 c, lipids, thyroid function and islet autoantibodies were conducted. The frequency of islet-specific autoantibody in newly diagnosed T1 DM patients(duration shorter than half year) was 73% in East China. According to binary logistic regressions, autoantibody positivity, longer duration and lower Body Mass Index were the risk factors of islet failure. As the disease developed, autoantibodies against glutamic acid decarboxylase declined as well as the other two autoantibodies against zinc transporter 8 and islet antigen 2. The decrease of autoantibodies was positively correlated with aggressive beta cell destruction. Autoantibodies can facilitate the identification of classic T1 DM from other subtypes and predict the progression of islet failure. As there were obvious heterogeneity in autoantibodies and clinical manifestation in different phenotypes of the disease, we should take more factors into consideration when identifying type 1 diabetes mellitus. | Jin Liu Lingling Bian Li Ji Yang Chen Heng Chen Yong Gu Bingqin Ma Wei Gu Xinyu Xu Yun Shi Jian Wang Dalong Zhu Zilin Sun Jianhua Ma Hui Jin Xing Shi Heng Miao Bing Xin Yan Zhu Zhenwen Zhang Ruifang Bu Lan Xu Guangde Shi Wei Tang Wei Li Dongmei Zhou Jun Liang Xingbo Cheng Bimin Shi Jixiang Dong Ji Hu Chen Fang Shao Zhong Weinan Yu Weiping Lu Chenguang Wu Li Qian Jiancheng Yu Jialin Gao Xiaoqiang Fei Qingqing Zhang Xueqin Wang Shiwei Cui Jinluo Cheng Ning Xu Guofeng Wang Guoqing Han Chunrong Xu Yun Xie Minmin An Wei Zhang Zhixiao Wang Yun Cai Qi Fu Yu Fu Shuai Zheng Fan Yang Qingfang Hu Hao Dai Yu Jin Zheng Zhang Kuanfeng Xu Yifan Li Jie Shen Hongwen Zhou Wei He Xuqin Zheng Xiao Han Liping Yu Jinxiong She Mei Zhang Tao Yang | 2016 | Science China(Life Sciences)2016，59，9： | 5 |
| 12 | Anatomical variation of infra-pyloric artery origination: A prospective multicenter observational study (IPA-Origin)显示文摘Objective: Infra-pyloric artery(IPA) is an important anatomical landmark in treatment of gastric cancer and is the key vessel for pylorus-preserving gastrectomy and subgroup of infra-pyloric lymph nodes. However, its anatomical variation is not thoroughly understood. Our study aimed to clarify the origination of the IPA.Methods: We did this prospective, multicenter, open-label, observational study at gastric surgery departments of34 hospitals in China. Gastric cancer patients aged 18 years or older and scheduled to undergo elective total or distal gastrectomy were assigned. During the surgery, IPA dissecting and exposing the origination point with photographs or video clips were required. The primary outcome was the origination of the IPA. Analysis of variance, χ~2 tests and Fisher's tests were used to analyze the differences between groups. The study is registered at Clinicaltrials.gov(No. NCT03071237).Results: Between May 8 and July 31, 2017, 429 patients were assigned for the study, and 419(97.7%) patients had the IPA dissected and recorded through photograph or video and were included in the primary outcome analysis. The median age was 62 years old, and 73.7% were male. Among the patients, 78.5% received laparoscopic surgery. Single IPA origination was identified in 398(95.0%) patients, including gastroduodenal artery(GDA) in154(36.8%) patients, anterior superior pancreaticoduodenal artery(ASPDA) in 130(31.0%) patients, and right gastroepiploic artery(RGEA) in 114(27.2%) patients. Fifteen(3.6%) patients were identified with multiple IPA and 6(1.4%) patients were identified as IPA absence. The differences in the distribution of surgical approach(P=0.003) and geographic area(P=0.030) were statistically significant. No difference was shown in sex, age,gastrectomy type, tumor location, and clinical T, N and M stage.Conclusions: Our study found that the IPA originates from GDA, ASPDA and RGEA in similar proportions.Laparoscopic surgery may be more helpful in dissection of the IPA than open surgery. | Rulin Miao Jianjun Qu Zhengrong Li Daguang Wang Jiang Yu Weidong Zang Yong Li Fenglin Liu Jian Zhang Wu Song Kai Ye Su Yan Wei Wang Shuangyi Ren Lu Zang Changqing Jing Li Zhang Kuan Wang Weihua Fu Lin Fan Bin Liang Gang Zhao Jun Cai Li Yang Jiaming Zhu Jun You Kun Yang Qingxing Huang Zhaojian Niu Ning Ning Xingfeng Qiu Gang Ji Feng Liang Hua Huang Chao Gao Fei Shan Shuangxi Li Yongning Jia Lianhai Zhang Xiangji Ying Yan Zhang Zhaode Bu Xiangqian Su Gang Zhao Ziyu Li Jiafu Ji | 2018 | Chinese Journal of Cancer Research2018，30，5： | 5 |
| 13 | Is delayed gastric emptying so terrible after pylorus-preserving pancreaticoduodenectomy? Prevention and management显示文摘AIM: To explore some operative techniques to prevent the occurrence of delayed gastric emptying (DGE) after pylorus-preserving pancreaticoduodenectomy (PPPD). METHODS: One hundred and eighty-six patients in a single medical center who accepted PPPD were retrospectively studied. The incidence of DGE was investigated and the influence of some operative techniques on the prevention of DGE was analyzed. RESULTS: During the operative process of PPPD, the methods of detached drainage of pancreatic fluid and bile and gastric fistulization were used. Postoperatively, six patients suffered DGE among the 186 cases; the incidence was 3.23% (6/186). One of them was complicated with intraabdominal infection at the same time, and two with pancreatic leakage. CONCLUSION: Appropriate maneuvers during operation are essential to avoid postoperative DGE in PPPD. The occurrence of DGE is avoidable. It should not be used as an argument to advocate hemigastrectomy in PPPD. | Xian-Min Bu Jin Xu Xian-Wei Dai Kai Ma Fu-Quan Yang Jun Hu Nai-Fu Wang | 2006 | World Journal of Gastroenterology2006，12，39： | 5 |
| 14 | Postoperative chemotherapy with S-1 plus oxaliplatin versus S-1alone in locally advanced gastric cancer(RESCUE-GC study): a protocol for a phase Ⅲ randomized controlled trial显示文摘Background:The ACTS-GC study had shown postoperative adjuvant therapy with S-1 improved survival of patients with locally advanced gastric cancer.Addition of oxaliplatin to S-1 is considered to be acceptable as one of the treatment options for gastric cancer patients after radical gastrectomy with D2 lymph node excision.Methods:We have commenced a randomized phase III trial in December 2016 to evaluate S-1 plus oxaliplatin compared with S-1 alone in the adjuvant setting for locally advanced gastric cancer.A total of 564 patients will be accrued from 13 Chinese institutions in two years.The primary endpoint is 3-year relapse-free survival.The secondary endpoints are 5-year overall survival,proportion of patients who complete the postoperative chemotherapy and incidence of adverse events.Ethic and dissemination:The trial has been approved by the institutional review board of each participating institution and it was activated on December,2016.The enrollment will be finished in December,2018.Patient’s follow-up will be ended until December,2023.Trial registration:Clinical Trials.gov,identifier:NCT02867839.Registered on August 4,2016. | Xiang Hu Lin Chen Yian Du Biao Fan Zhaode Bu Xin Wang Yingjiang Ye Zhongtao Zhang Gang Xiao Fei Li Qingsi He Guoli Li Xian Shen Bin Xiong Liming Zhu Jiwei Liui Lian Liu Tao Wu Jing Zhou Jun Zhang Gang Zhao Xulin Wang Pin Liang Xinxin Wang Yan Zhang Xiaojiang Wu Ji Zhang Xin Ji Xianglong Zong Tao Fu Ziyu Jia Jiafu Ji | 2017 | Chinese Journal of Cancer Research2017，29，2： | 5 |
| 15 | Changes in soil carbon sequestration and soil respiration following afforestation on paddy fields in north subtropical China显示文摘Aims Although many studies have reported net gains of soil organic carbon(SOC)after afforestation on croplands,this is uncertain for Chinese paddy rice croplands.Here,we aimed to evaluate the effects of affores-tation of paddy rice croplands on SOC sequestration and soil respiration(R).Such knowledge would improve our understanding of the efctive-ness of various land use options on greenhouse gas mitigation in China.Methods The investigation was conducted on the Chongming Island,north subtropical China.Field sites were reclaimed from coastal salt marshes in the 1960s,and soils were homogeneous with simple land use:histories.SOC stocks and R,levels were monitored over one year in a paddy rice cropland,an evergreen and a deciduous broad-leaved plantation established on previous paddy fields and a reference fal-low land site never cultivated.Laboratory incubation of soil under fast-changing temperatures was used to compare the temperature sensitivity(Q10)of SOC decomposition across land uses.Important Findings After 15-20 years of afforestation on paddy fields,SOC concentra-tion only slightly increased at the depth of 0--5 cm but decreased in deeper layers,which resulted in a net loss of SOC stock in the top 40cm.Seasonal increase of sOC was observed during the rice-growing period in croplands but not in afforested soils,suggest-ing a stronger SOC sequestration by paddy rice cropping.However,SOC sequestered under cropping was more labile,as indicated by its higher contents of dissolved organic carbon and microbial bio-mass.Also,paddy soils had higher annual R,than afforested soils;R,abruptly increased after paddy fields were drained and plowed and remained distinctively high throughout the dry farming period.Laboratory incubation revealed that paddy soils had a much higher Q10 of SOC decomposition than afforested soils.Given that tem-perature was the primary controller of R,in this region,it was con-cluded that despite the stronger SOC sequestration by paddy rice cropping,its SOC was less stable than in afforested systems and might be more easily released into the atmosphere under global warming. | Jun Cui Rongjuan Zhang Naishun Bu Huabin Zhang Boping Tang Zhaolei Li Lifeng Jiang Jiakuan Chen Changming Fang | 2013 | Journal of Plant Ecology2013，6，3： | 4 |
| 16 | Mutually trustworthy human-machine knowledge automation and hybrid augmented intelligence:mechanisms and applications of cognition,management,and control for complex systems显示文摘In this paper,we aim to illustrate the concept of mutually trustworthy human-machine knowledge automation(HM-KA)as the technical mechanism of hybrid augmented intelligence(HAI)based complex system cognition,management,and control(CMC).We describe the historical development of complex system science and analyze the limitations of human intelligence and machine intelligence.The need for using human-machine HAI in complex systems is then explained in detail.The concept of“mutually trustworthy HM-KA”mechanism is proposed to tackle the CMC challenge,and its technical procedure and pathway are demonstrated using an example of corrective control in bulk power grid dispatch.It is expected that the proposed mutually trustworthy HM-KA concept can provide a novel and canonical mechanism and benefit real-world practices of complex system CMC. | Fei-Yue WANG Jianbo GUO Guangquan BU Jun Jason ZHANG | 2022 | Frontiers of Information Technology & Electronic Engineering2022，23，8： | 4 |
| 17 | Sensitivity and vulnerability of water resources in the arid Shiyang River Basin of Northwest China显示文摘The sensitivity and vulnerability of water resources to climate change is difficult to assess. In this study, we used a conceptual hydrologic model to investigate the sensitivity of streamflow to climate change. We also proposed a framework to evaluate the vulnerability of water resources in arid regions. We applied this framework to a case study of the Shiyang River Basin in Northwest China. Results showed that the precipitation and streamflow in Shiyang River Basin exhibited no significant trends of change from 1956 to 2010. In the past five decades, however, the temperature increased significantly by 0.37°C per decade. According to the sensitivity assessment, a 10% increase in precipitation and a 1°C increase in temperature altered mean annual streamflow by averages of 14.6% and –0.5%, respectively, from 1988 to 2005. In the 2000s, the calculated vulnerability of water resources in Shiyang River Basin was more than 0.95, indicating severe vulnerability. The increase in the amount of precipitation and the implementation of water-saving measures can reduce the vulnerability of water resources in the future; if precipitation increases by 10% per decade and the use of irrigation water decreases by 15% in the 2030s, the evaluated value of water resources vulnerability will be reduced to 0.79. However, the region remains highly vulnerable. The proposed framework for vulnerability assessment can be applied to the arid regions in Northwest China, and the results of our efforts can identify adaptation strategies and improve the management of water resources in such regions. | Long WAN Jun XIA HongMei BU Si HONG JunXu CHEN LiKe NING | 2014 | Journal of Arid Land2014，6，6： | 4 |
| 18 | Anti-BCMA CAR T-cell therapy CT103A in relapsed or refractory AQP4-IgG seropositive neuromyelitis optica spectrum disorders:phase 1 trial interim results显示文摘Chimeric antigen receptor(CAR)T-cell therapy that targets B-cell maturation antigen(BCMA)have great potentials in autoimmune diseases and could be novel therapeutics for relapsed/refractory neuromyelitis optica spectrum disorder(NMOSD).To evaluate the safety and efficacy of the CT103A,a self-developed BCMA-targeting CAR construct against BCMA,in patients with AQP4-IgG seropositive NMOSD,an ongoing,investigator-initiated,open-label,single-arm,phase 1 clinical trial is conducted at our center.In total,12 patients were administered with a CAR-BCMA infusion.Ten of the 12 patients dosed were women(83.3%),with a median age of 49.5 years(range,30-67).were The most common events of grade 3 or higher were hematologic toxic effects.Seven patients(58%)developed infections,but no grade 4 infections occurred.Cytokine release syndrome was reported in all patients with only events of grade 1 or 2 observed.During the follow-up of a median 5.5 months,11 patients had no relapse;all patients generally reported improvement in disabilities and quality-of-life outcomes;11 patients’AQP-4 antibodies in serum showed a downward trend by the cutoff date.CAR T-cell expansion was associated with responses,and persisted more than 6 months post-infusion in 17%of the patients.In summary,CAR T-cell therapy shows a manageable safety profile and therapeutic potentials for patients with relapsed/refractory AQP4-IgG seropositive NMOSD.Another expansion phase is currently underway to determine the safety and efficacy of CAR T-BCMA infusion in patients with other neuro-inflammatory diseases. | Chuan Qin Dai-Shi Tian Luo-Qi Zhou Ke Shang Liang Huang Ming-Hao Dong Yun-Fan You Jun Xiao Ying Xiong Wen Wang Hao Pang Jing-Jing Guo Song-Bai Cai Di Wang Chun-Rui Li Min Zhang Bi-Tao Bu Wei Wang | 2023 | Signal Transduction and Targeted Therapy2023，8，2： | 4 |
| 19 | Myotoxic activity of a Gln-49 phospholipase A_2 from Agkistrodon blomhoffii ussurensis snake venom显示文摘新奇 myotoxic 蛋白质 phospholipase A 2( 作为作为 Gln49-PLA 2, 表示的 Gln49-PLA 2, 表示的 PLA 2), 从 Agkistrodon blomhoffii ussurensis 的蛇恶意被孤立,它有弱致命的效果和明显的抗凝剂活动,但是缺乏 PLA 2 和 hemorrhagenic 活动。Gln49-PLA 2 显然在老鼠在肌内的注射之上血浆 creatine-kinase (CK ) 增加,建议它可以导致剂量依赖者 myonecrosis。组织学的研究也在老鼠揭示词法变化在对待的动物的骨胳的肌肉,包括的广泛的 myonecrosis,出血和嗜中性的渗入。Gln49-PLA 2 导致的 myotoxic 能力能被肝磷脂部分禁止。 | BAO Yongming BU Pengcheng YANG Jun YANG Wei JIA Peilin AN Lijia | 2006 | Progress in Natural Science:Materials International2006，16，2： | 3 |
| 20 | Emerging Organic Contaminants in Chinese Surface Water:Identification of Priority Pollutants显示文摘The occurrence and impacts of emerging organic contaminants(EOCs)in the aquatic environment have gained widespread attention over the past two decades.Due to large number of potential contaminants,monitoring campaigns,treatment plants,and proposed regulations should preferentially focus on specific pollutants with the highest potential for ecological and human health effects.In the present study,a multi-criteria screening approach based on hazard and exposure potentials was developed for prioritization of 405 unregulated EOCs already present in Chinese surface water.Hazard potential,exposure potential,and risk quotients for ecological and human health effects were quantitatively analyzed and used to screen contaminants.The hazard potential was defined by contaminant persistence,bioaccumulation,ecotoxicity,and human health effects;similarly,the exposure potential was a function of contaminant concentration and detection frequency.In total,123 compounds passed the preselection process,which involved a priority index equal to the normalized hazard potential multiplied by the normalized exposure potential.Based on the prioritization scheme,11 compounds were identified as top-priority,and 37 chemicals were defined as high-priority.The results obtained by the priority index were compared with four other prioritization schemes based on exposure potential,hazard potential,or risk quotients for ecological effects or human health.The priority index effectively captured and integrated the results from the more simplistic prioritization schemes.Based on identified data gaps,four uncertainty categories were classified to recommend:①regular monitoring,derivation of environmental quality standards,and development of control strategies;②increased monitoring;③fortified hazard assessment;and④increased efforts to collect occurrence and toxicity data.Overall,20 pollutants were recommended as priority EOCs.The prioritized list of contaminants provides the necessary information for authoritative regulations to monitor,control,evaluate,and manage the risks of environmentally-relevant EOCs in Chinese surface water. | Mengmeng Zhong Tielong Wang Wenxing Zhao Jun Huang Bin Wang Lee Blaney Qingwei Bu Gang Yu | 2022 | Engineering2022，8，4： | 3 |
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