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| 1 | The JAK/STAT signaling pathway:from bench to clinic显示文摘The Janus kinase/signal transducer and activator of transcription(JAK/STAT)signaling pathway was discovered more than a quarter-century ago.As a fulcrum of many vital cellular processes,the JAK/STAT pathway constitutes a rapid membrane-to-nucleus signaling module and induces the expression of various critical mediators of cancer and inflammation.Growing evidence suggests that dysregulation of the JAK/STAT pathway is associated with various cancers and autoimmune diseases.In this review,we discuss the current knowledge about the composition,activation,and regulation of the JAK/STAT pathway.Moreover,we highlight the role of the JAK/STAT pathway and its inhibitors in various diseases. | Xiaoyi Hu Jing li Maorong Fu Xia Zhao Wei Wang | 2021 | Signal Transduction and Targeted Therapy2021，6，12： | 21 |
| 2 | High Precision Orbit Determination of CHAMP Satellite显示文摘The precision orbit determination of challenging minisatellite payload(CHAMP) satellite was done based on position and navigation data analyst(PANDA) software which is developed in Wuhan University, using the onboard GPS data of year 2002 from day 126 to 131. The orbit accuracy was assessed by analyzing the difference from GFZ post-processed science orbits (PSO), the GPS carrier and pseudo-range data residuals and the satellite laser ranging (SLR) residuals. | ZHAO Qile LIU Jingnan GE Maorong | 2006 | Geo-Spatial Information Science2006，9，3： | 9 |
| 3 | LEO Enhanced Global Navigation Satellite System(LeGNSS):progress,opportunities,and challenges显示文摘With the completion of Chinese BeiDou Navigation Satellite System(BDS),the world has begun to enjoy the Positioning,Navigation,and Timing(PNT)services of four Global Navigation Satellite Systems(GNSS).In order to improve the GNSS performance and expand its applications,Low Earth Orbit(LEO)Enhanced Global Navigation Satellite System(LeGNSS)is being vigorously advocated.Combined with high-,medium-,and low-earth orbit satellites,it can improve GNSS performance in terms of orbit determination,Precise Point Positioning(PPP)convergence time,etc.This paper comprehensively reviews the current status of LeGNSS,focusing on analyzing its advantages and challenges for precise orbit and clock determination,PPP convergence,earth rotation parameter estimation,and global ionosphere modeling.Thanks to the fast geometric change brought by LEO satellites,LeGNSS is expected to fundamentally solve the problem of the long convergence time of PPP without any augmentation.The convergence time can be shortened within 1 minute if appropriate LEO constellations are deployed.However,there are still some issues to overcome,such as the optimization of LEO constellation as well as the real time LEO precise orbit and clock determination. | Haibo Ge Bofeng Li Song Jia Liangwei Nie Tianhao Wu Zhe Yang Jingzhe Shang Yanning Zheng Maorong Ge | 2022 | Geo-Spatial Information Science2022，25，1： | 4 |
| 4 | Precise Relative Orbit Determination of Twin GRACE Satellites显示文摘当形成飞时,太空船被用作站台获得土面向的观察,在这些太空船之间的精确基线总是是必要的。严肃恢复和气候实验(优雅) 使命针对印射全球严肃地和它的变化。优雅卫星的精确基线为当模特儿的严肃地是必要的。成双的卫星的运动学、减少的动态相对轨道的决心为动态相对轨道在 2 公里的这份报纸,和精确性被学习了,为运动学的 5 公里能被获得,大多数在 GPS 歧义上的双差别由此被解决。 | ZHAO Qile HU Zhigang GUO Jing LI Min GE Maorong | 2010 | Geo-Spatial Information Science2010，13，3： | 3 |
| 5 | Cognitive effects of atypical antipsychotic drugs in first-episode drug-nave schizophrenic patients显示文摘Cognitive impairment is a core feature of schizophrenia. The present randomized open study enrolled antipsychotic-nave patients who were experiencing their first episode of schizophrenia. After baseline neurocognitive tests and clinical assessment, subjects were randomly assigned to olanzapine, risperidone and aripiprazole treatment groups. A battery of neurocognitive tests showed that risperidone produced cognitive benefits in all five cognitive domains, including verbal learning and memory, visual learning and memory, working memory, processing speed, and selective attention; olanzapine improved processing speed and selective attention; and aripiprazole improved visual learning and memory, and working memory. However, the three atypical antipsychotic drugs failed to reveal any significant differences in the composite cognitive scores at the study endpoint. In addition, the three drugs all significantly improved clinical measures without significant differences between the drugs after 6 months. These results suggest that the atypical antipsychotics, olanzapine, risperidone and aripiprazole may improve specific cognitive domains with similar global clinical efficacy. In clinical practice, it may be feasible to choose corresponding atypical antipsychotics according to impaired cognitive domains. | Juan Wang Maorong Hu Xiaofeng Guo Renrong Wu Lehua Li Jingping Zhao | 2013 | Neural Regeneration Research2013，8，3： | 3 |
| 6 | PtNi-W/C with Atomically Dispersed Tungsten Sites Toward Boosted ORR in Proton Exchange Membrane Fuel Cell Devices显示文摘The performance of proton exchange membrane fuel cells is heavily dependent on the microstructure of electrode catalyst especially at low catalyst loadings.This work shows a hybrid electrocatalyst consisting of PtNi-W alloy nanocrystals loaded on carbon surface with atomically dispersed W sites by a two-step straightforward method.Single-atomic W can be found on the carbon surface,which can form protonic acid sites and establish an extended proton transport network at the catalyst surface.When implemented in membrane electrode assembly as cathode at ultra-low loading of 0.05 mgPt cm^(−2),the peak power density of the cell is enhanced by 64.4%compared to that with the commercial Pt/C catalyst.The theoretical calculation suggests that the single-atomic W possesses a favorable energetics toward the formation of*OOH whereby the intermediates can be efficiently converted and further reduced to water,revealing a interfacial cascade catalysis facilitated by the single-atomic W.This work highlights a novel functional hybrid electrocatalyst design from the atomic level that enables to solve the bottle-neck issues at device level. | Huawei Wang Jialong Gao Changli Chen Wei Zhao Zihou Zhang Dong Li Ying Chen Chenyue Wang Cheng Zhu Xiaoxing Ke Jiajing Pei Juncai Dong Qi Chen Haibo Jin Maorong Chai Yujing Li | 2023 | Nano-Micro Letters2023，15，9： | 3 |
| 7 | Organosilicon modified method to improve Li^+ storage capacity of graphene oxide (GO)显示文摘Organosilicon modified reduced graphene oxide(Mr GO) has been fabricated by direct organosilicon modification of graphene oxide(GO). Interestingly,it is observed that 3D rGO-like structures occurred after directly carrying out the organosilicon modification on the surface of GO. The obtained organosilicon Mr GO displays the more remarkable improvement of electrochemical performances than GO,which was verified by electrochemical measurements in detail. For instance,the organosilicon MrGO shows the cycling performances at 901 mA hg^-1 after 200 cycles at 0.1 Ag^-1 and 446 mA hg^-1 after 300 cycles at 2.0 Ag^-1,respectively. These results unveil that organic modification method is an effective way to improve the Li^+ storage capacity of general carbon materials. | WANG Kun JU DongYing XU GuiYing HAN BeiBei CHAI MaoRong WANG YingXin Li LiXiang ZHANG XueHu UCIDA Masaya ZHOU WeiMin | 2020 | Science China(Technological Sciences)2020，63，12： | 2 |
| 8 | A square root information filter for multi-GNSS real-time precise clock estimation显示文摘Real-time satellite orbit and clock estimations are the prerequisite for Global Navigation Satellite System(GNSS)real-time precise positioning services.To meet the high-rate update requirement of satellite clock corrections,the computational efficiency is a key factor and a challenge due to the rapid development of multi-GNSS constellations.The Square Root Information Filter(SRIF)is widely used in real-time GNSS data processing thanks to its high numerical stability and computational efficiency.In real-time clock estimation,the outlier detection and elimination are critical to guarantee the precision and stability of the product but could be time-consuming.In this study,we developed a new quality control procedure including the three standard steps:i.e.,detection,identification,and adaption,for real-time data processing of huge GNSS networks.Effort is made to improve the computational efficiency by optimizing the algorithm to provide only the essential information required in the processing,so that it can be applied in real-time and high-rate estimation of satellite clocks.The processing procedure is implemented in the PANDA(Positioning and Navigation Data Analyst)software package and evaluated in the operational generation of real-time GNSS orbit and clock products.We demonstrated that the new algorithm can efficiently eliminate outliers,and a clock precision of 0.06 ns,0.24 ns,0.06 ns,and 0.11 ns can be achieved for the GPS,GLONASS,Galileo,and BDS-2 IGSO/MEO satellites,respectively.The computation time per epoch is about 2 to 3 s depending on the number of existing outliers.Overall,the algorithm can satisfy the IGS real-time clock estimation in terms of both the computational efficiency and product quality. | Xiang Zuo Xinyuan Jiang Pan Li Jungang Wang Maorong Ge Harald Schuh | 2021 | Satellite Navigation2021，2，1： | 2 |
| 9 | Bioactive hyaluronic acid fragments inhibit lipopolysaccharideinduced inflammatory responses via the Toll-like receptor 4 signaling pathway显示文摘The high-and the low-molecular weight hyaluronic acids(HMW-HA and LMW-HA,respectively)showed different biological activities in inflammation.However,the role of LMW-HA in inflammatory response is controversial.In this study,we aimed to investigate the effect of bioactive hyaluronan(B-HA)on lipopolysaccharide(LPS)-induced inflammatory responses in human macrophages and mice.B-HA was produced from HA treated with glycosylated recombinant human hyaluronidase PH20.Human THP-1 cells were induced to differentiate into macrophages.THP-1-derived macrophages were treated with B-HA,LPS,or B-HA+LPS.The mRNA expression and the production of inflammatory cytokines were determined using quantitative real-time PCR and enzyme-linked immunosorbent assay.The phosphorylation levels of proteins in the nuclear factor-kB(NF-kB),mitogen-activated protein kinase(MAPK),and IRF-3 signaling pathways were measured using Western blot.The in vivo efficacy of B-HA was assessed in a mouse model of LPS-induced inflammation.Results showed that B-HA inhibited the expression of TNF-α,IL-6,IL-1,and IFN-β,and enhanced the expression of the antiinflammatory cytokine IL-10 in LPS-induced inflammatory responses in THP-1-derived macrophages and in vivo.B-HA significantly suppressed the phosphorylation of the TLR4 signaling pathway proteins p65,IKKα/β,IkBα,JNK1/2,ERK1/2,p38,and IRF-3.In conclusion,our results demonstrated that the B-HA attenuated the LPSstimulated inflammatory response by inhibiting the activation of the TLR4 signaling pathway.B-HA could be a potential anti-inflammatory drug in the treatment of inflammatory disease. | Na You Sasa Chu Binggang Cai Youfang Gao Mizhou Hui Jin Zhu Maorong Wang | 2021 | Frontiers of Medicine2021，15，2： | 2 |
| 10 | Development of a GNSS Water Vapour Tomography System Using Algebraic Reconstruction Techniques 显示文摘 | BENDER M GALINA D GE Maorong | 2011 | Advances in Space Research2011，47，10： | 1 |
| 11 | The promotion of peripheral nerve regeneration by chitooligosaccharides in the rat nerve crush injury model显示文摘 | Maorong Jiang Xiaoming Zhuge Yumin Yang Xiaosong Gu Fei Ding | 2009 | Neuroscience Letters2009，，3： | 1 |
| 12 | Rapid re-convergences to ambiguity-fixed solutions in precise point positioning显示文摘 | Jianghui Geng Xiaolin Meng Alan H. Dodson Maorong Ge Felix N. Teferle | 2010 | Journal of Geodesy2010，，12： | 1 |
| 13 | Hepatitis E virus genotype 4 isolated from a patient with liver failure: full-length sequence analysis showing potential determinants of virus pathogenesis显示文摘 | Qiuning Bu Xiaojuan Wang Ling Wang Peng Liu Jiabao Geng Maorong Wang Jian Han Yonghong Zhu Hui Zhuang | 2013 | Archives of Virology2013，，1： | 1 |
| 14 | GPS Data Processing of Networks with Mixed Single and Dual Frequency Receivers for Deformation Monito- ring显示文摘 | Zou Xuan Deng Zhiguo Ge Maorong | 2010 | Advances in Space Research2010，46，2： | 1 |
| 15 | Regional reference network augmented precise point positioning for instantaneous ambiguity resolution 显示文摘 | LIXingxing ZHANG Xiaohong GE Maorong | 2011 | Journal of Geodesy2011，85，3： | 1 |
| 16 | Lipopolysaccharide Stimulation of Human Aortic Valve Interstitial Cells Activates Inflammation and Osteogenesis显示文摘 | Ashok N. Babu Xianzhong Meng Ning Zou Xiaoping Yang Maorong Wang Yong Song Joseph C. Cleveland Michael Weyant Anirban Banerjee David A. Fullerton | 2008 | The Annals of Thoracic Surgery2008，，1： | 1 |
| 17 | Tenofovir disoproxil fumarate therapy in patients with chronic hepatitis B and advanced fibrosis or compensated cirrhosis显示文摘Background and aims:Tenofovir disoproxil fumarate(TDF)is the first-line therapy for chronic hepatitis B.This interim analysis presents the efficacy and safety data for TDF at Week 144 in patients with chronic hepatitis B and advanced fibrosis or compensated cirrhosis from China.Methods:Patients were assessed for incidence of newly diagnosed hepatocellular carcinoma(HCC)and disease progression,liver stiffness measurement(LSM),virological suppression(serum hepatitis B virus DNA<20 IU/mL),alanine aminotransferase normalization,hepatitis B e antigen(HBeAg)loss and seroconversion,histological liver fibrosis score,and safety at Week 144.Results:Overall,197 patients were enrolled.At Week 144,the incidence of newly diagnosed HCC was observed in 2.1%patients,and the incidence of disease progression was observed in 3.6%patients.The mean(standard deviation)change in LSM from baseline was5.1(5.85)kPa.Serum hepatitis B virus DNA<20 IU/mL was observed in 94.1%patients,alanine aminotransferase normalization in 33.5%patients,HBeAg loss in 35.6%patients,and HBeAg seroconversion in 14.4%patients.Among patients with stage F3 or F4 fibrosis at baseline by LSM,38.3%patients regressed to stage F0/1,and 22.0%of patients regressed to stage F2 at Week 144.Overall,67.7%patients experienced≥1 adverse events,13.8%patients experienced TDF-related adverse events,and 16.4%patients experienced serious(none were TDF-related).Conclusions:At Week 144 of TDF treatment,low incidence of HCC and disease progression were reported.Virological suppression was observed in 94.1%patients,which was associated with fibrosis regression.No new safety events were identified. | Huiying Rao Jia Shang Qing Xie Jianqi Lian Pujun Gao Junping Shi Xinyue Chen Jiefei Wang Min Xu Liaoyun Zhang Yingren Zhao QingMao Maorong Wang Wei Zhao Zong Zhang Jidong Jia Hong Tang Jiming Zhang Xin Zheng Chang Liu Lai Wei | 2022 | iLIVER2022，1，3： | 1 |
| 18 | A New Data Processing Strategy for Huge GNSS Global Net works显示文摘 | Ge Maorong Gendt G Dick G etal | 2006 | J Geod2006，80，4： | 1 |
| 19 | Resolution of GPS Carrier-Phase Ambiguities in Precise Point Positioning (PPP) with Daily Observations 显示文摘 | Ge Maorong Gendt G Rothacher M | 2007 | J Geod2007，82，7： | 1 |
| 20 | Improving Cartier-phase Ambiguity Resolution in Global GPS Network Solutions显示文摘 | Ge Maorong Gendt G Dick G | 2005 | J Geod2005，79，13： | 1 |
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