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| 1 | Epidemiological Characteristics of Echinococcosis in Non-Endemic PLADs—China,2017–2020显示文摘Summary What is already known about this topic?Echinococcosis,also known as hydatid disease,is a zoonotic parasitic disease caused by the larvae of Echinococcus granulosus.Western China has one of the most severe epidemics worldwide.Echinococcosis is endemic in 370 counties of 9 provincial-level administrative divisions(PLADs)including Inner Mongolia,Sichuan,Yunnan,Tibet,Shaanxi,Gansu,Qinghai,Ningxia,Xinjiang and Xinjiang Production and Construction Corps(XPCC). | Yan Kui Baixue Liu Xu Wang Cuizhao Xue Jingbo Xue Yalan Zhang Benguang Zhang Yang Dai Shuai Han Weiping Wu | 2021 | China CDC weekly2021，3，51： | 5 |
| 2 | The landscape of aging显示文摘Aging is characterized by a progressive deterioration of physiological integrity,leading to impaired functional ability and ultimately increased susceptibility to death.It is a major risk factor for chronic human diseases,including cardiovascular disease,diabetes,neurological degeneration,and cancer.Therefore,the growing emphasis on “healthy aging” raises a series of important questions in life and social sciences.In recent years,there has been unprecedented progress in aging research,particularly the discovery that the rate of aging is at least partly controlled by evolutionarily conserved genetic pathways and biological processes.In an attempt to bring full-fledged understanding to both the aging process and age-associated diseases,we review the descriptive,conceptual,and interventive aspects of the landscape of aging composed of a number of layers at the cellular,tissue,organ,organ system,and organismal levels. | Yusheng Cai Wei Song Jiaming Li Ying Jing Chuqian Liang Liyuan Zhang Xia Zhang Wenhui Zhang Beibei Liu Yongpan An Jingyi Li Baixue Tang Siyu Pei Xueying Wu Yuxuan Liu Cheng-Le Zhuang Yilin Ying Xuefeng Dou Yu Chen Fu-Hui Xiao Dingfeng Li Ruici Yang Ya Zhao Yang Wang Lihui Wang Yujing Li Shuai Ma Si Wang Xiaoyuan Song Jie Ren Liang Zhang Jun Wang Weiqi Zhang Zhengwei Xie Jing Qu Jianwei Wang Yichuan Xiao Ye Tian Gelin Wang Ping Hu Jing Ye Yu Sun Zhiyong Mao Qing-Peng Kong Qiang Liu Weiguo Zou Xiao-Li Tian Zhi-Xiong Xiao Yong Liu Jun-Ping Liu Moshi Song Jing-Dong J.Han Guang-Hui Liu | 2022 | Science China(Life Sciences)2022，65，12： | 4 |
| 3 | A comparison between acute large vessel occlusion in the posterior circulation and anterior circulation after endovascular treatment:the ANGEL-ACT registry experience显示文摘Background and purpose Endovascular treatment(EVT)has shown an overwhelming benefit for acute anterior circulation artery occlusion(ACO).Whether it can achieve the same outcomes in posterior circulation artery occlusion(PCO)has not been well explained.We aimed to evaluate the characteristics and prognosis of ACO and PCO after EVT in a nationwide registry.Method The present analysis was based on the prospective ANGEL-ACT Registry in China between November 2017 and March 2019.Demographic data,periprocedural times,recanalisation rate,intracranial haemorrhage(ICH)and 90-day functional outcomes were compared between the ACO and PCO groups.Results A total of 1793 patients were analysed including 397(22.1%)consecutive patients with PCO and 1396(77.9%)patients with ACO treated with EVT.A larger proportion of patients with PCO had intracranial atherosclerotic disease and received extra angioplasty during EVT.Successful recanalisation and 90-day favourable functional outcomes did not differ significantly between the two groups.Patients with PCO showed lower 24-hour ICH and symptomatic ICH rates.There was a trend towards higher mortality rate in the PCO group(22.09%vs 14.44%;adjusted OR 1.286(95%CI 0.820 to 2.017),p=0.2731),especially when the onset to puncture time was over 6 hours(30.77%vs 11.13%;adjusted OR 2.673(95%CI 1.280 to 5.583),p=0.0089,interactive p=0.0002).Conclusions In this large prospective multicentre registry,there was a significant difference in the characteristics and periprocedural features between patients with PCO and ACO.However,successful recanalisation and 90-day favourable functional outcomes in PCO were equivalent to those in ACO. | Xuan Sun Jingyu Zhang Xu Tong Baixue Jia Dapeng Mo Ning Ma Feng Gao Lian Liu Xiaochuan Huo Ligang Song Yiming Deng Zhongrong Miao | 2022 | Stroke & Vascular Neurology2022，7，4： | 4 |
| 4 | Staged angioplasty versus regular carotid artery stenting in patients with carotid artery stenosis at high risk of hyperperfusion:a randomised clinical trial显示文摘Background and purpose Hyperperfusion(HP)is a devastating complication associated with carotid artery stenting(CAS)or endarterectomy.The efficacy and safety of staged angioplasty(SAP)in patients with CAS at high risk of HP remains unclear.We sought to determine whether SAP is superior to regular CAS in patients with high risk of HP.Methods A randomised,multicentre open-label clinical trial with blinded outcome assessment(STEP)was conducted.Patients with severe carotid stenosis at high risk of HP were randomly assigned(1:1)to the SAP or regular CAS group.The primary endpoint was hyperperfusion syndrome(HPS)and intracerebral haemorrhage(ICH)within 30 days after the procedure.Results From November 2014 to January 2017,a total of 64 patients were enrolled in 11 centres.33 patients were allocated to the SAP group and 31 to the regular CAS group.At 30 days,the rate of primary endpoint was 0.0%(0/33)in the SAP group and 9.7%(3/31)in the regular CAS group(absolute risk reduction(ARR),9.7%;95%CI−20.1% to 0.7%;p=0.11).As one of the secondary endpoints,the incidence of HP phenomenon(HPP)was lower in the SAP group than the regular CAS group(0.0%vs 22.6%,ARR,−22.6%;95% CI−36.8%to−10.2%;p=0.04).Conclusion The rate of HPS and ICH was not significantly lower in SAP group;the extended secondary endpoint of HPP,however,significantly reduced,which suggested that SAP may be a safe and effective carotid revascularisation procedure to prevent HP. | Dapeng Mo Baixue Jia Huaizhang Shi Yaxuan Sun Qingan Liu Chengzhe Fan Jianping Deng Jinglin Yuan Wei Wu Changchun Jiang Guilian Zhang Hanjun Du Ning Ma Feng Gao Xuan Sun Ligang Song Lian Liu Guangge Peng Yongjun Wang Yilong Wang Zhongrong Miao the STEP Study Group | 2021 | Stroke & Vascular Neurology2021，6，1： | 3 |
| 5 | The pathology,phylogeny,and epidemiology of Echinococcus ortleppi(G5 genotype):a new case report of echinococcosis in China显示文摘Background:Cystic echinococcosis(CE),caused by the larval stage of the complex Echinococcus granulosus sensu lato(s.l.),is a zoonotic parasitic disease with a high social burden in China.E.ortleppi is a species(formerly genotype 5 of E.granulosus s.l.)with unique epidemic areas(tropical areas),transmission patterns(mainly cattle origin),and pathological characteristics(large and small hook lengths)compared to other species that cause CE.A 19-year-old female patient in an area with no history of echinococcosis in Guizhou Province,China,was diagnosed with E.ortleppi infection in 2019.This study is to understand the source of this human E.ortleppi infection.Methods:We performed computer tomography(CT)scans,surgical operation,morphological sectioning,molecular diagnosis,phylogenetic analyses,and epidemiological investigation in Anshun City,Guizhou Province,China in 2019.Results:The patient presented with intermittent distension and pain in the upper abdomen without other abnormal symptoms.Routine blood examination results were normal.However,abdominal CT revealed a fertile cyst with a diameter of approximately 8 cm,uniform density,and a clear boundary,but without an evident cyst wall in the right lobe of the liver.The cyst was fertile,and phylogenetic analyses revealed that the isolates represented a new E.ortleppi genus haplotype.A result of 10‒14 years incubation period with indigenous infection was considered available for the case through the epidemiological survey.Conclusions:CE due to E.ortleppi infection can be confused with other diseases causing liver cysts,resulting in misdiagnosis.A transmission chain of E.ortleppi may exist or existed in the past in the previously considered nonendemic areas of echinococcosis in southwestern China. | Xu Wang Aiya Zhu Hongying Cai Baixue Liu Gang Xie Rui Jiang Ji Zhang Nanzi Xie Yayi Guan Robert Bergquist Zhenghuan Wang Yang Li Weiping Wu | 2021 | Infectious Diseases of Poverty2021，10，6： | 3 |
| 6 | Oxide cathodes for sodium-ion batteries:Designs,challenges,and perspectives显示文摘Sodium-ion batteries(SIBs),which are an alternative to lithium-ion batteries(LIBs),have attracted increasing attention due to their low cost of Na resources and similar Na storage mechanism to LIBs.Compared with anode materials and electrolytes,the development of cathode materials lags behind.Therefore,the key to improving the specific energy and promoting the application of SIBs is to develop high-performance sodium intercalation cathode materials.Transition-metal oxides are one of the most promising cathode materials for SIBs owing to their excellent energy density,high specific discharge capacity,and environmentally friendly nature.In the present work,the latest progress in the research of transition-metal oxides is summarized.Moreover,the existing challenges are discussed,and a series of strategies are proposed to overcome these drawbacks.This review aims at providing guidance for the development of metal oxides in the next stage. | Tao Chen Baixue Ouyang Xiaowen Fan Weili Zhou Weifang Liu Kaiyu Liu | 2022 | Carbon Energy2022，4，2： | 3 |
| 7 | Influence of hydroxypropyl methylcellulose,methylcellulose, gelatin, poloxamer 407 and poloxamer 188 on the formation and stability of soybean oil-in-water emulsions显示文摘Macromolecules of polysaccharides, proteins and poloxamers have a hydrophobic portion and a hydrophilic one that can be used as emulsifiers. Parts of these emulsifiers are safe pharmaceutical excipients, which can replace the irritant low molecular weight surfactants to formulate emulsions for the pharmaceutical field. This project focused on preparing O/W emulsions stabilized with polymers for pharmaceuticals such as polysaccharides, proteins and poloxamers, including hydroxypropyl methylcellulose (HPMC), methylcellulose (MC),gelatin, poloxamer 407 (F127) and poloxamer 188 (F68). Emulsion physical stability was assessed by centrifugation, autoclaving sterilization and droplet size measurements. The stabilization mechanisms of emulsions were determined by interfacial tension and rheological measurements. Results stated that the efficacy of these polymers for pharmaceuticals stabilized emulsions was sorted in the order: F127 > F68 > HPMC > MC > Gelatin. | Miao Zhang Baixue Yang Wei Liu Sanming Li | 2017 | Asian Journal of Pharmaceutical Sciences2017，12，6： | 2 |
| 8 | Spatial-temporal Variation of Air Temperature for the Recent 40 Years in Lhasa显示文摘It was all known that Lhasa went through a high temperature of 30.8℃in late June 2019,which hit record highs.To better understand the reasons,based on observations recorded at automatic weather stations in Lhasa,the characteristics of temperature variation at multiple time scales were studied using the linear trend method,Mann-Kendall mutation test,Morlet wavelet analysis,R/S analysis and so on.The results showed that:(a)the annual mean temperature(AMT)is rising at a rate of 0.5℃/10 a,and the average temperature for different seasons also increased significantly,especially in winter.(b)Although there was an intersection in 1995,it was found that AMT,did not pass the reliability test of significance levelα=0.05,this means there are no abrupt changes for AMT,the values are 7.97 and 9.15℃respectively before and after the intersection point.(c)AMT has a periodic oscillation for 18-25 and 25-32 a based on a mass of data and the wavelet variance diagrams in Lhasa.AMT has a main cycle of 28 a,cyclic patterns of temperature changes in spring,summer and autumn is similar to AMT,but it is relatively complex in winter.(d)The Hurst index of AMT and different seasons demonstrates that the temperature is likely to continue to rise in the future in Lhasa. | Yang LEI Hongbin WANG Baixue YU Wenxue FU Tongsuo LU Xinyu LIU Dong WEI | 2021 | Meteorological and Environmental Research2021，12，1： | 0 |
| 9 | Bioinspired Anti-Icing Hydrogel Enabled by Ice-Nucleating Protein显示文摘Ice-nucleating proteins(INPs)are the most effective ice-nucleating agents that play a significant role in preventing freeze injuries in freeze-tolerant organisms.INPs promote ice nucleation in the extracellular space,harvesting water from cells due to the low vapor pressure of ice compared with water,thereby protecting freeze-tolerant organisms from intracellular freezing.The antifreeze mechanism of INPs offers a unique opportunity to inhibit large-scale freezing by localized control of ice formation,with valuable enlightenment in anti-icing material sciences.By learning from nature,we transferred the excellent ice nucleation-facilitating capability of INPs along with an antifreeze concept of spatially controlled ice nucleation to anti-icing material design,fabricating icephobic coatings that consisted of patterned hydrogel-encapsulated INP(PHINP).The ice patterns were templated by patterned PHINPs via the tuning of ice nucleation so that the ice coverage fraction could be controlled by<30%on almost all PHINP-coated surfaces.Combining PHINP with solar-thermal conversion surfaces endowed the composite coatings with high anti-icing performances at any time of the day. | Zhanhui Wang Baixue Lin Siyu Sheng Sicong Tan Pengchao Wang Yong Tao Zhang Liu Zhiyuan He Jianjun Wang | 2022 | CCS Chemistry2022，4，1： | 0 |
| 10 | The First Detection of Echinococcus Granulosus DNA in Residents’Hands,Dogs’Hair,and Soil in Highly Endemic Region of Echinococcosis-Naqu City,Xizang Autonomous Region,China,2020显示文摘Summary What is already known about this topic?Echinococcosis is a serious zoonotic parasitic disease that predominantly infects humans;domestic animals like cattle or sheep;as well as wild animals such as small rodents.To date,there is a lack of comprehensive information about all potential environmental transmission routes for Echinococcus.What is added by this report?This study assesses the importance of under-researched environmental factors for the transmission of Echinococcus.It concludes that hand hygiene is an important factor in the robust environmental transmission of Echinococcus granulosus.What are the implications for public health practice?This study suggests that residents are at risk of catching echinococcosis through hand-oral transmission routes.Health education given to local residents is thus a key intervention,as well as avoiding close contact with dogs and ensuring proper hand-washing practices are followed. | Baixue Liu Chuizhao Xue Xu Wang Wenting Wu Shuai Han Weiping Wu | 2022 | China CDC weekly2022，4，44： | 0 |
| 11 | Drug-coated balloons are not inferior to drug-coated stents in the treatment of acute myocardial infarction and shorten the duration of dual antiplatelet treatment显示文摘Background:Drug-coated balloons(DCBs)are an up-and-coming tactic in treating in-stent restenosis and coronary artery small vessel disease,but their efficacy in treating acute myocardial infarction needs to be further explored.Methods:A meta-analysis of 7 studies was conducted to make a comparison with the results of DCB and drug-eluting stent implantation after a median follow-up of 15 months.Results:A total of 922 patients were included in this analysis in total,including 375 patients in the DCB group and 547 patients in the stent group.A total of 962 vascular diseases were manifested in the 2 groups.After 6 to 24 months of follow-up,there was no statistically significant difference with respect to major adverse cardiovascular events(odds ratio[OR]:0.82;95%confidence interval[CI]:0.52–1.29;Z=0.85;P=0.39),cardiac death(OR:0.92;95%CI:0.39–2.12;Z=0.21;P=0.84),target lesion revascularization(OR:1.09;95%CI:0.53–2.25;Z=0.24;P=0.81),late lumen loss(MD:−0.05;95%CI:−0.15 to 0.06;Z=0.85;P=0.40),or dual antiplatelet therapy(DAPT)(OR:1.04;95%CI:0.53–2.05;Z=0.11;P=0.91)between the 2 groups.In the DCB group,persistent residual stenosis or C-F dissection occurrence necessitated that a total of 30 patients receive extra bailout implantations.The rate of bailout stenting was 11.8%(95%CI:7.1–16).Moreover,the DCB group had a shorter DAPT duration compared with the stent group.Conclusion:Drug-coated balloons with shorter DAPT durations may be as effective and safe as stent therapy in treating acute myocardial infarction. | Jing Yang Shuting Chang Jing Liu Guanzhao Zhang Yue Wang Baixue Zhang Zifan Nie Yuanbao Dong Bo Li | 2022 | Emergency and Critical Care Medicine2022，2，4： | 0 |
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