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| 1 | Differential Inhibition of Nav1.7 and Neuropathic Pain by Hybridoma-Produced and Recombinant Monoclonal Antibodies that Target Nav1.7显示文摘The voltage-gated Na^+ channel subtype Nav1.7 is important for pain and itch in rodents and humans. We previously showed that a Nav1.7-targeting monoclonal antibody(SVmab) reduces Na+ currents and pain and itch responses in mice. Here, we investigated whether recombinant SVmab(rSVmab) binds to and blocks Nav1.7 similar to SVmab. ELISA tests revealed that SVmab was capable of binding to Nav1.7-expressing HEK293 cells,mouse DRG neurons, human nerve tissue, and the voltagesensor domain Ⅱ of Nav1.7. In contrast, rSVmab showed no or weak binding to Nav1.7 in these tests. Patch-clamp recordings showed that SVmab, but not rSVmab, markedly inhibited Na+ currents in Nav1.7-expressing HEK293 cells. Notably, electrical field stimulation increased the blocking activity of SVmab and rSVmab in Nav1.7-expressing HEK293 cells. SVmab was more effective than rSVmab in inhibiting paclitaxel-induced mechanical allodynia. SVmab also bound to human DRG neurons and inhibited their Na^+ currents. Finally, potential reasons for the differential efficacy of SVmab and rSVmab and future directions are discussed. | Sangsu Bang Jiho Yoo Xingrui Gong Di Liu Qingjian Han Xin Luo Wonseok Chang Gang Chen Sang-Taek Im Yong Ho Kim Judith A.Strong Ma-Zhong Zhang Jun-Ming Zhang Seok-Yong Lee Ru-Rong Ji | 2018 | Neuroscience Bulletin2018，34，1： | 2 |
| 2 | Attacks on adult females with infants by non-resident males in the Franois langur显示文摘Infanticide by males is a common phenomenon in mammals, especially primates, as lactation lasts much longer than gestation in many species. Usually, infanticidal episodes occur soon after group takeovers, and are traditionally considered a male reproductive strategy (i.e., support the sexual selection hypothesis, Hrdy, 1974). To verify the validity of this conception, we observed one group of Franois' langurs in the Nonggang Nature Reserve, China, between August 2003 and July 2004. During the study period, a Franois' langur female with the youngest infant in the group was attacked three times by immigrating males, and later disappeared by the third day after the final attack. We suggest that these attacks on the female-infant dyad represent infanticide attempts by males, and may be the cause of the adult female and her infant's disappearance. Presumably, that female dispersed with her infant to avoid infanticide and was not killed. Though these observations do not completely verify the sexual selection hypothesis, they are not inconsistent with it. | Qi-Hai ZHOU Bang LUO Cheng-Ming HUANG | 2013 | Zoological Research2013，34，1： | 2 |
| 3 | Habitat use and locomotion of the François’langur(Trachypithecus francoisi)in limestone habitats of Nonggang,China显示文摘We collected data on habitat use and locomotion of the François’langur(Trachypithecus francoisi)between August 2003 and July 2004 at Nonggang Nature Reserve,China.A total of 739 h of behavioral data were collected during this study.We tested 2 predictions:(1)that the langurs may have special patterns of habitat use and locomotion adaptive to the limestone habitat,and(2)the langurs may exhibit different patterns of habitat use and locomotion among different zones of limestone hill.Our results indicated that François’langurs spent more time in the low-risk,relatively food-poor cliff-hilltop areas.When young leaves and fruit were scarce in the dry season,the langurs increased their time in the high-risk,food-rich valley basin.François’langurs were semi-terrestrial,and leaping and climbing were their main locomotor modes.These behavioral patterns are considered to be related to characteristics of topography and vegetation in limestone habitat,such as large areas of cliff and discontinuous canopy.Our results also supported Prediction 2.The langurs confined locomotion to the main canopy and frequently adopted leaping while traveling in the hillside and valley basin.While traveling in cliff-hilltop areas,they tended to stay in the lower stratus(≤5 m)or move on the ground,and walking and climbing were their dominant traveling modes. | Qihai ZHOU Bang LUO Fuwen WEI Chengming HUANG | 2013 | Integrative Zoology2013，8，4： | 2 |
| 4 | Diet and Food Choice of Trachypithecus francoisi in the Nonggang Nature Reserve, China显示文摘 | Qihai Zhou Fuwen Wei Ming Li Chengming Huang Bang Luo | 2006 | International Journal of Primatology2006，，5： | 1 |
| 5 | External rectal prolapse:abdominal or perineal repair for men?A retrospective cohort study显示文摘Background:External rectal prolapse is a relatively rare disease,in which male patients account for a minority.The selection of abdominal repair or perineal repair for male patients has rarely been investigated.Methods:Fifty-one male patients receiving abdominal repair(laparoscopic ventral rectopexy)or perineal repair(Delorme or Altemeier procedures)at the Sixth Affiliated Hospital of Sun Yat-sen University(Guangzhou,China)between March 2013 and September 2019 were retrospectively analysed.We compared the recurrence,complication rate,post-operative defecation disorder,length of stay,and quality of life between the abdominal and perineal groups.Results:Of the 51 patients,45 had a complete follow-up,with a median of 48.5 months(range,22.8–101.8 months).A total of 35 patients were under age 40 years.The complication rate associated with abdominal repair was less than that associated with perineal repair(0%vs 20.7%,P=0.031)and the recurrence rate was also lower(9.5%vs 41.7%,P=0.018).Multivariate analysis showed that perineal repair(odds ratio,9.827;95%confidence interval,1.296–74.50;P=0.027)might be a risk factor for recurrence.Moreover,only perineal repair significantly improved post-operative constipation status(preoperative vs post-operative,72.4%vs 25.0%,P=0.001).There was no reported mortality in either of the groups.No patient’s sexual function was affected by the surgery.Conclusions:Both surgical approaches were safe in men.Compared with perineal repair,the complication rate and recurrence rate for abdominal repair were lower.However,perineal repair was better able to correct constipation. | Bang Hu Qi Zou Zhenyu Xian Dan Su Chao Liu Li Lu Minyi Luo Zixu Chen Keyu Cai Han Gao Hui Peng Wuteng Cao Donglin Ren | 2022 | Gastroenterology Report2022，10，1： | 0 |
| 6 | A Kinetic Study on Dismutation of Superoxide Ion by Macrocyclic Dioxotetramine-Copper(Ⅱ) Complex by Using Pulse Radiolysis显示文摘We studied the reaction kinetics of dismutation for superoxide ion by copper (Ⅱ) complex of macrocycllc dioxotetramine ligand 12- ( 4’ - nitro )- benzyl-1,4,7,10- tetraazacy-clotridecane-11,13-dionato copper (Ⅱ) by using pulse radiolysis. The rate constants of dismutation kcat’s were measured to be 1. 78×106 mor-1 . L.s-1(at pH 7. 0) and 1. 06×106 mol-1. L. s-1(at pH 7. 8). The reaction mechanism is similar to that catalyzed by super-oxide dismutase. | Shen Mengchang, Luo Qinhui, Zhu Shourong, Tu Qingyun and Dai An bang(Coordination Chemistry Institute, Nanjing University, Nanjing)Liu Andong, Ou Hongchun, Li Fengmei and Di Shaojie(Institute of Law Energy Nuclear Physics, Beijing Normal University, Beijing) | 1990 | Chemical Research in Chinese Universities1990，6，4： | 0 |
| 7 | Attacks on adult females with infants by non-resident males in the François langur显示文摘Infanticide by males is a common phenomenon in mammals,especially primates,as lactation lasts much longer than gestation in many species.Usually,infanticidal episodes occur soon after group takeovers,and are traditionally considered a male reproductive strategy(i.e.,support the sexual selection hypothesis,Hrdy,1974).To verify the validity of this conception,we observed one group of François’langurs in the Nonggang Nature Reserve,China,between August 2003 and July 2004.During the study period,a François’langur female with the youngest infant in the group was attacked three times by immigrating males,and later disappeared by the third day after the final attack.We suggest that these attacks on the female-infant dyad represent infanticide attempts by males,and may be the cause of the adult female and her infant’s disappearance.Presumably,that female dispersed with her infant to avoid infanticide and was not killed.Though these observations do not completely verify the sexual selection hypothesis,they are not inconsistent with it. | Qi-Hai ZHOU Bang LUO Cheng-Ming HUANG | 2013 | Zoological Research2013，34，S01： | 0 |
| 8 | Improvement of a Genetic Back Propagation Algorithm and Its Application to Diagnosis in Mechanical Failure显示文摘A new improved genetic BP algorithm was put forward in the paper. To determine whether the network falls into local minimum point, a discriminant of local minimum was put forth in the training process of a neural network. A genetic algorithm was used to revise the weights of the neural network if the BP algorithm fell into minimums. The mechanical faults were diagnosed using the algorithm put forward in the paper, which verified the validity of this improved genetic BP algorithm. | LUO Yue gang 1,2 , LI Xiao peng 1, WEN Bang chun 2 1 Shenyang University of Technology, Shenyang 110023, P.R.China 2 Northeast University, Shenyang 110006, P.R.China | 2001 | International Journal of Plant Engineering and Management2001，6，4： | 0 |
| 9 | Mechanical properties and thermal shock resistance of tungsten alloys strengthened by laser fragmentation-processed zirconium carbide nanoparticles显示文摘Zirconium carbide(ZrC)nanoparticles with an average size of 5.6 nm were synthesized through laser fragmentation(LF)from as-received 20-60 nm ZrC particles,and LF-ZrC nanoparticle dispersion-strengthened tungsten(LF-WZC)samples were fabricated by spark plasma sintering method.The average grain size of LF-WZC is 1.91μm and most ZrC particles in LF-WZC are smaller than 10 nm.LF-WZC exhibits finer grain size,higher yield strength and hardness but lower ductility as compared with W-ZrC samples using as-received ZrC(WZC).The results showed that finer ZrC nanoparticles dispersed in tungsten can enhance the strength by hindering the motion of dislocations,but they may also introduce stress concentra-tion and thus reduce the ductility.The thermal shock resistance of the WZC and LF-WZC samples was investigated using an electron beam device.The LF-WZC sample also exhibits a higher cracking threshold(0.33-0.44 GW·m^(−2))than WZC(0.22-0.33 GW·m^(−2))at room temperature.The enhanced thermal shock resistance of LF-WZC could be attributed to its high yield strength. | Ke Jing Chao Zhang Rui Liu Zhuo‑Ming Xie Lin‑Chao Zhang Li‑Feng Zhang Jun Liu Rui Gao Jun‑Feng Yang Xian‑Ping Wang Ting Hao Xue‑Bang Wu Qian‑Feng Fang Chang‑Hao Liang Guang‑Nan Luo You‑Yun Lian Xiang Liu Chang‑Song Liu | 2020 | Tungsten2020，2，4： | 0 |
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