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| 1 | sLe^(x) expression in invasive micropapillary breast carcinoma is associated with poor prognosis and can be combined with MUC1/EMA as a supplementary diagnostic indicator显示文摘Objective: Mucin 1(MUC1/EMA) and sialyl Lewis X(sLe^(x)) indicate polarity reversal in invasive micropapillary carcinoma(IMPC). The purpose of this study was to evaluate the expression of MUC1/EMA and sLe^(x) and to assess their diagnostic and prognostic value in patients with IMPC.Methods: The expression of sLe^(x) and MUC1/EMA in 100 patients with IMPC and a control group of 89 patients with invasive ductal carcinoma not otherwise specified(IDC-NOS) were analyzed with IHC. Fresh tumor tissues were collected from patients with IMPC or IDC-NOS for primary culture and immunofluorescence analysis.Results: The rate of nodal metastasis was higher in patients with IMPC than those with IDC-NOS, and IMPC cells tended to express more sLe^(x) and MUC1/EMA in the cytomembranes(the stroma-facing surfaces of the micropapillary clusters) than IDC-NOS cells. In IMPC, high cytomembrane expression of sLe^(x), but not MUC1/EMA, indicated poor prognosis. In addition, among the 100 patients with IMPC, 10 patients had sLe^(x)+/EMA-expression patterns, and 8 patients had sLe^(x)-/EMA+ expression patterns. The primary IMPC cells were suspended, non-adherent tumor cell clusters, whereas the primary IDC cells were adherent tumor cells. Immunofluorescence analysis showed that MUC1/EMA and sLe^(x) were co-expressed on the cytomembranes in IMPC cell clusters and in the cytoplasm in IDC-NOS cells.Conclusions: sLe^(x) can be used as a prognostic indicator and can be combined with MUC1/EMA as a complementary diagnostic indicator to avoid missed IMPC diagnosis. | Yawen Song Hui Sun Kailiang Wu Jianke Lyu Jingyue Zhang Feng Gu Yongjie Ma Beibei Shen Chijuan Wang Xiaojiao Chen Jing Xu Weidong Li Fangfang Liu Li Fu | 2021 | Cancer Biology & Medicine2021，18，2： | 7 |
| 2 | Research and Evaluation on Key Technological Indicators for Airborne and Shipborne Gravimetry显示文摘Gravimetry technical guides are the scientific basis for air-sea gravimetry. However, the existing technical guides in China are behind the application requirements. This study analyzed the most important indicators of air-sea gravimetry, including the density of survey lines, gravimetry accuracy and space resolution, stability and reliability of the air-sea gravimeter, and proposed a gravimetry accuracy assessment system consisting of gravity RMS of error, systematic error and mean error, and an assessment system for the gravimeter stability consisting of the relative accuracy of the scale value, monthly zero-drift, RMS of the monthly nonlinear zero-drift variation and the threshold of the monthly nonlinear zero-drift variation. The mathematic models for the measurement point determination in shipborne gravimetry, E tv s correction for airborne gravimetry, platform tilt correction and evaluation air-sea gravimetry were also analyzed and modified. This work will provide technology support for the composition of the military-civil air-sea gravimetry technical guides. | Motao HUANG Kailiang DENG Taiqi WU Xiuping LU Guojun ZHAI Yongzhong OUYANG Xin CHEN Min LIU | 2019 | Journal of Geodesy and Geoinformation Science2019，2，3： | 6 |
| 3 | Environmental Embrittlement in A_3B-type Intermetallic Alloys显示文摘Environmental embrittlement in A3B-type intermetallics based on Ni3Al and Fe3Al has been studied in this paper. For the Ni3Al doped with 120 wt ppm B and Ni,(Al,Cr.Zr) doped with 80 wt ppm B,their elongation and ultimate tensile strength decreased in the sequence:of vacuum > air >hydrogen. while for Ni,(Al,Mn) doped with 400 wt ppm B no envifonmental degradation was ob served, although a -Ni3(Al,Mn) alloy without B showed a decrease in ductility when tested in air in stead of oxygen. It is supposed that boron and hydrogen compete for the occupation of interstitial sites near grain boundaries. If boron content is sufficiently low, hydrogen embrittlement occurs ;however, if its content is sufficiently high. boron addition is capable of eliminating envjronmental ef fect in Ni3Al-based alloysi As to the micromechanism of hydrogen embrittlement in Ni3Al+B. S EM in situ observations showed that both grain boundary decohesion and a high stress concentration con tributed to hydrogen-assisted jntergranu lar cracking in this alloy. For the Fe3Al and Fe3 (Al.Cr) alloys.their mechanical properties depended strongly on grain size / grain shape and testing environment. A strain rate effect on ductiIity and fracture strength was also observed in the Fe3Al and Fe,(Al,Cr)+B aIloys. Preoxidation increased the ductility of the Fe,(Al,Cr)+B alloy. All these results can be rationalized from a hypothesis that surface reaction is the controlling process in embrittling Fe3Al-based alloys. | Xiaojing WAN Jiahong ZHU Kailiang JING Weijie CHEN and Yue WU(Institute of Metallurgy and Materials Science, Shanghai University of Technology, Shanghai, 200072, China) | 1994 | Journal of Materials Science & Technology1994，10，1： | 3 |
| 4 | Monolayer MoS_(2)-based transistors with low contact resistance by inserting ultrathin Al_(2)O_(3)interfacial layer显示文摘Transition metal dichalcogenides(TMDCs)are promising high performance electronic materials due to their interesting semiconductor properties.However,it is acknowledged that the effective electrical contact between TMDCs-layered materials and metals remains one of the major challenges.In this work,the homogeneous monolayer MoS_(2)films with high crystalline quality were prepared by chemical vapor deposition method on SiO2/Si substrates.The back-gate field-effect transistors(FETs)were fabricated by inserting an ultrathin Al_(2)O_(3)interlayer between the metal electrodes and MoS_(2)nanosheets.With the addition of an ultrathin 0.8 nm Al_(2)O_(3)interlayer,the contact resistance decreased dramatically from 59.9 to 1.3 kΩμm and the Schottky barrier height(SBH)dropped from 102 to 27 meV compared with devices without the Al_(2)O_(3)interlayer.At the same time,the switching ratio increased from~106to~108,and both the on-current and field-effect mobility were greatly improved.We find that the ultrathin Al_(2)O_(3)interlayer can not only reduce the SBH to alleviate the Fermi level pinning phenomenon at the interface,but also protect the channel materials from the influence of air and moisture as a covering layer.In addition,the lattice and band structures of Al_(2)O_(3)/MoS_(2)film were calculated and analyzed by first-principles calculation.It is found that the total density of states of the Al_(2)O_(3)/MoS_(2)film exhibits interfacial polarized metals property,which proves the higher carrier transport characteristics.FETs with Al_(2)O_(3)interlayers have excellent stability and repeatability,which can provide effective references for future low power and high performance electronic devices. | CHEN Gang LIN Xin LIU Yuan WANG Fang HU Kai SHAN Xin WU ZeYu ZHANG YuPeng NIE WeiCan ZHONG JiXiang REN TianLing ZHANG KaiLiang | 2023 | Science China(Technological Sciences)2023，66，6： | 2 |
| 5 | A Continuous Analytic Model for Undoped (Lightly Doped) Cylindrical Surrounding-Gate MOSFETs by a Carrier-Based Approach显示文摘 | HE Jin LIU Feng BIAN Wei TAO Yadong FENG Jie HU Jinghua LU Kailiang WU Wen WANG Ting CHAN Mansun | 2007 | Chinese Journal of Electronics2007，16，2： | 1 |
| 6 | m -CPBA/TFA: an efficient nonmetallic reagent for oxidative coupling of 1,2-diarylethylenes显示文摘 | Kailiang Wang Yanna Hu Meng Wu Zheng Li Zhihui Liu Bo Su Ao Yu Yu Liu Qingmin Wang | 2010 | Tetrahedron2010，，47： | 1 |
| 7 | Synthesis and SAR studies of phenanthroindolizidine and phenanthroquinolizidine alkaloids as potent anti-tumor agents显示文摘 | Ziwen Wang Meng Wu Yi Wang Zheng Li Lei Wang Guifang Han Fazhong Chen Yuxiu Liu Kailiang Wang Ao Zhang Linghua Meng Qingmin Wang | 2012 | European Journal of Medicinal Chemistry2012，，： | 1 |
| 8 | Sequential Approximation of Functions in Sobolev Spaces Using Random Samples显示文摘We present an iterative algorithm for approximating an unknown function sequentially using random samples of the function values and gradients. This is an extension of the recently developed sequential approximation (SA) method, which approximates a target function using samples of function values only. The current paper extends the development of the SA methods to the Sobolev space and allows the use of gradient information naturally. The algorithm is easy to implement, as it requires only vector operations and does not involve any matrices. We present tight error bound of the algorithm, and derive an optimal sampling probability measure that results in fastest error convergence. Numerical examples are provided to verify the theoretical error analysis and the effectiveness of the proposed SA algorithm. | Kailiang Wu Dongbin Xiu | 2019 | Communications on Applied Mathematics and Computation2019，1，3： | 0 |
| 9 | A Newton multigrid method for steady-state shallow water equations with topography and dry areas显示文摘A Newton multigrid method is developed for one-dimensional(1D) and twodimensional(2D) steady-state shallow water equations(SWEs) with topography and dry areas. The nonlinear system arising from the well-balanced finite volume discretization of the steady-state SWEs is solved by the Newton method as the outer iteration and a geometric multigrid method with the block symmetric Gauss-Seidel smoother as the inner iteration. The proposed Newton multigrid method makes use of the local residual to regularize the Jacobian matrix of the Newton iteration, and can handle the steadystate problem with wet/dry transition. Several numerical experiments are conducted to demonstrate the efficiency, robustness, and well-balanced property of the proposed method. The relation between the convergence behavior of the Newton multigrid method and the distribution of the eigenvalues of the iteration matrix is detailedly discussed. | Kailiang WU Huazhong TANG | 2016 | Applied Mathematics and Mechanics(English Edition)2016，37，11： | 0 |
| 10 | Trabecular spacing estimation based on quadratic transformation algorithm显示文摘The quadratic transformation method is proposed to estimate the trabecular spacing(Tb.Sp),an important index for osteoporosis diagnosis.The performance of this algorithm was investigated by scatter model,two-dimension finite difference time domain(2D-FDTD)simulation and in vitro experiments of bovine cancellous bone specimens.Comparing with the other four methods— autoregressive cepstrum(AR),adaptive filter- autoregressive cepstral(AFAR),inverse filter-autoregressive cepstrum(InvAR),and simplified inverse filter tracking(SIFT),quadratic transformation is much more stable and accurate.The results demonstrated that quadratic transformation is a great algorithm for Tb.Sp estimation. | XU Yiwen HOU Li SHU Xiao WU Guangli LIU Chengcheng XU Kailiang TA De'an | 2015 | Chinese Journal of Acoustics2015，34，2： | 0 |
| 11 | A Non-intrusive Correction Algorithm for Classification Problems with Corrupted Data显示文摘A novel correction algorithm is proposed for multi-class classification problems with corrupted training data.The algorithm is non-intrusive,in the sense that it post-processes a trained classification model by adding a correction procedure to the model prediction.The correction procedure can be coupled with any approximators,such as logistic regression,neural networks of various architectures,etc.When the training dataset is sufficiently large,we theoretically prove(in the limiting case)and numerically show that the corrected models deliver correct classification results as if there is no corruption in the training data.For datasets of finite size,the corrected models produce significantly better recovery results,compared to the models without the correction algorithm.All of the theoretical findings in the paper are verified by our numerical examples. | Jun Hou Tong Qin Kailiang Wu Dongbin Xiu | 2021 | Communications on Applied Mathematics and Computation2021，3，2： | 0 |
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