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| 1 | Role of IL-10 and TGF-β1 in local immunosuppression in HPV-associated cervical neoplasia显示文摘Cervical cancer is a worldwide disease that constitutes a significant public health problem, especially in developing countries, not only due to its high incidence but also because the most affected population comprises women who belong to marginalized socio-economic classes. Clinical and molecular research has identified immunological impairment in squamous intraepithelial cervical lesions and cervical cancer patients. Human Papillomavirus(HPV) has several mechanisms for avoiding the immune system: it down-regulates the expression of interferon and upregulates interleukin(IL)-10and transforming growth factor(TGF)-β1 to produce a local immunosuppressive environment, which, along with altered tumor surface antigens, forms an immunosuppressive network that inhibits the antitumor immune response. In this review we analyzed the available data on several deregulated cellular immune functions in patients with NIC Ⅰ, NIC Ⅱ and NIC Ⅲ and cervical cancer. The effects of immunosuppressive cytokines on innate immune response, T-cell activation and cellular factors that promote tumor cell proliferation in cervical cancer patients are summarized. We discuss the functional consequences of HPV E2, E6, and E7 protein interactions with IL-10 and TGF-β1 promoters in the induction of these cytokines and postulate its effect on the cellular immune response in squamous intraepithelial cervical lesions and cervical cancer patients. This review provides a comprehensive picture of the immunological functions of IL-10 and TGF-β1 in response to HPV in humans. | Kirvis Torres-Poveda Margarita Bahena-Román Claudia Madrid-González Ana I Burguete-García Víctor Hugo Bermúdez-Morales Oscar Peralta-Zaragoza Vicente Madrid-Marina | 2014 | World Journal of Clinical Oncology2014，5，4： | 21 |
| 2 | Prevalence of vacA, cagA and babA2 genes in Cuban Helicobacter pylori isolates显示文摘AIM: To investigate the prevalence of vacuolating cytotoxin (vacA), cytotoxin associated gene A (cagA) and blood adhesion binding antigen (babA2) genotypes of Helicobacter pylori (H pylori) isolates from Cuban dyspeptic patients. METHODS: DNA was extracted from H pylori-positive cultures taken from 130 dyspeptic patients. Genotyping was performed by PCR, using specifi c primers for vacA (s1, s2, m1, m2), cagA and babA2 genes. Endoscopic observations and histological examinations were used to determine patient pathologies. RESULTS: vacA alleles s1 , s2 , m1 and m2 were detected in 96 (73.8%), 34 (26.2%), 75 (57.7%) and 52 isolates (40%), respectively, while the cagA gene was detected in 95 isolates (73.2%). One hundred and seven isolates (82.3%) were babA2-positive. A signif icant correlation was observed between vacAs1m1 and cagA and between vacAs1m1 and babA2 genotypes (P < 0.001 and P < 0.05, respectively) and between babA2 genotype and cagA status (P < 0.05); but, no correlation was observed between vacAs1 and babA2 genotypes. Eighty fi ve (65.4%) and 73 (56.2%) strains were type 1 (vacAs1-cagA-positive) and 'triple- positive' (vacAs1-cagA-babA2-positive), respectively, and their presence was significantly associated with duodenal ulcer (P < 0.01 and P < 0.001, respectively). CONCLUSION: The distribution of the main virulence factors in the Cuban strains in this study resembled that of the Western-type strains, and the more virulent H pylori isolates were signifi cantly associated with duodenal ulcer, ulcer disease being the worst pathology observed in the group studied. | Lino E Torres Karelia Melián Arlenis Moreno Jordis Alonso Carlos A Sabatier Mayrín Hernández Ludisleydis Bermúdez Boris L Rodríguez | 2009 | World Journal of Gastroenterology2009，15，2： | 4 |
| 3 | Mercury removal using ground and calcined mussel shell显示文摘We determined mercury retention on calcined and ground mussel shell, in presence and absence of phosphate, using batch and stirred flow chamber experiments. In batch experiments the calcined shell exhibited higher Hg adsorption, with good fitting to Freundlich equation(R2: 0.925–0.978); the presence of phosphate increased Hg adsorption; mercury desorption was 13% or lower, diminishing up to 2% under the presence of phosphates. In stirred flow chamber experiments calcined shell retained more Hg than ground shells(6300 vs. 4000–5200 μmol/kg); Hg retention increased an additional 40% on calcined shell and up to an additional 70% on ground shells when phosphates were present; mercury desorption was quite similar in all shell types(20%–34%), increasing up to 49%–60% in ground shells when phosphates were present. The higher Hg adsorption on calcined shell would be related to its calcite and dolomite concentrations; mercury-phosphate interactions would cause the increase in Hg retention when phosphates are present. Data on Hg desorption suggest that Hg retention was not easily reversible after batch experiments, increasing in the stirred flow chamber due to convective flow. Calcined and ground mussel shells could be recycled removing Hg from water, with the presence of phosphates in solution improving efcacy. | Susana Pea-Rodríguez Alipio Bermúdez-Couso Juan Carlos Nóvoa-Muoz Manuel Arias-Estvez María J.Fernndez-Sanjurjo Esperanza lvarez-Rodríguez Avelino Núez-Delgado | 2013 | Journal of Environmental Sciences2013，25，12： | 3 |
| 4 | Recombinant streptokinase vs hydrocortisone suppositories in acute hemorrhoids:A randomized controlled trial显示文摘AIM: To compare the efficacy and safety of recombinant streptokinase(rSK) vs hydrocortisone acetate-based suppositories in acute hemorrhoidal disease.METHODS: A multicenter(11 sites), randomized(1:1:1), open, controlled trial with parallel groups was performed. All participating patients gave their written,informed consent. After inclusion, patients with acute symptoms of hemorrhoids were centrally randomized to receive, as outpatients, by the rectal route, suppositories of rSK 200000 IU of one unit every 8 h(first 3 units)and afterwards every 12 h until 8 administrations were completed(schedule A), one unit every 8 h until 6 units were completed(schedule B), or 25 mg hydrocortisone acetate once every 8 h up to a maximum of 24 administrations. Evaluations were performed at 3, 5,and 10 d post-inclusion. The main end-point was the 5thday response(disappearance of pain and bleeding, and≥ 70% reduction of the lesion size). Time to response and need for thrombectomy were secondary efficacy variables. Adverse events were also evaluated.RESULTS: Groups were homogeneous with regards to demographic and baseline characteristics. Fifth day complete response rates were 156/170(91.8%; 95%CI:87.3-96.2), 155/170(91.2%; 95%CI: 86.6%-95.7%),and 46/170(27.1%; 95%CI: 20.1%-34.0%) with rSK(schedule A and B) and hydrocortisone acetate suppositories, respectively. These 64.6% and 63.9%differences(95%CI: 56.7%-72.2% and 55.7%-72.0%)were highly significant(P < 0.001). This advantage was detected since the early 3rd day evaluation(68.8% and64.1% vs 7.1% for the rSK and active control groups,respectively; P < 0.001) and was maintained even at the late 10 th day assessment(97.1% and 93.5% vs67.1% for rSK and hydrocortisone acetate, respectively;P < 0.001). Time to response was 3 d(95%CI: 2.9-3.1)for both rSK groups and 10 d(95%CI: 9.3-10.7) in the hydrocortisone acetate group. This difference was highly significant(P < 0.001). All subgroup stratified analyses(with or without thrombosis and hemorrhoid classification) showed a statistically significant advantage for the rSK groups. Thrombectomy was necessary in4/251 and 14/133 patients with baseline thrombosis in the rSK and hydrocortisone acetate groups, respectively(P < 0.001). There were no adverse events attributable to the experimental treatment.CONCLUSION: rSK suppositories showed a significant advantage over a widely-used over-the-counter hydrocortisone acetate preparation for the treatment of acute hemorrhoidal illness, as well as having an adequate safety profile. | Francisco Hernández-Bernal Georgina Castellanos-Sierra Carmen M Valenzuela-Silva Karem M Catasús-Alvarez Osmany Martínez-Serrano Odalys C Lazo-Diago Cimara H Bermúdez-Badell José R Causa-García Juan E Domínguez-Suárez Pedro A López-Saura 无 | 2015 | World Journal of Gastroenterology2015，21，23： | 2 |
| 5 | The use of ozone and associated oxidation process in drinking water treatment 显示文摘 | Camel V Berm A | 1998 | wat res1998，32，11： | 1 |
| 6 | Analysis of factors for conversion of laparoscopic to open cholecystectomy: a prospective study of 703 patients with acute cholecystitis显示文摘 | Domínguez LC Rivera A Bermúdez C | 2011 | Cir Esp2011，89，5： | 1 |
| 7 | Interstritial chemotherapy with drug polyer implants for the treatment of recurrent glioma显示文摘 | Berm H Mahaley Ms Jr Vick N A | 1991 | J Neurosurg1991，74，3： | 1 |
| 8 | Equilibrium prediction of CO2 reforming of coke oven gas: suitability for methanolproduction显示文摘 | Bermúdez J M Arenillas A Menéndez J A | 2012 | Chemical Engineering Science2012，82，1： | 1 |
| 9 | Morphological description and comparison of the dental remains from Atapuerca-Sima de los Huesos site(Spain)显示文摘 | Martinón-Torres M Bermúdez de Castro JM Gómez-Robles A | 2012 | Journal of Human Evolution2012，62，1： | 1 |
| 10 | Second trimester maternal serum analytes in triploid pregnancies:correlation with phenotype and sex chromosome complement显示文摘 | Berm PA Gainey A Ingardia C J | 2001 | Prenat Diagn2001，21，8： | 1 |
| 11 | Imiquimod 5% cream for keloid managem ent显示文摘 | Berm an B V ilia A | 2003 | Derm atol Surg2003，29，10： | 1 |
| 12 | Influence of phosphorus on Cu sorption kinetics:Stirred flow chamber experiments显示文摘 | P(E)REZ-NOVO C FERN(A)NDEZ-CALV(I)NO D BERM (U)DEZ-COUSO A | | 0，，： | 1 |
| 13 | Hysteretic linear and nonlinear acoustic responses from pressed interfaces显示文摘 | KIM J Y BALTAZAR A Hid J W BERMES C | 2006 | International Journal of Solids and Structures2006，43，21： | 1 |
| 14 | Silencing of HPV 16 e6 and e7 oncogenic activities by small interference RNA induces autophagy and apoptosis in human cervical cancer cell显示文摘 | Victor Hugo Bermúdez-Morales Claudia Gómez-Cerón María Luisa Pita-López | 2011 | J Nucl Acids Invest2011，2，1： | 1 |
| 15 | In Vitro activity of a nonmedicated handwash product, chlorhexidine, and an alcohol - based hand disinfectant against muhiply resistant gram - positive microorganisms 显示文摘 | Bermes PC Schouten MA Voss A | 2001 | Infect Control Hosp Epidemiol2001，22，4： | 1 |
| 16 | Intersitial Chemotherapy with Drug Polymer Implants for the Treatment of Recurrent Gliomas显示文摘 | Berm H Mahalty M S Nichola A V | 1991 | J Neurosurg1991，，74： | 1 |
| 17 | Transcriptional regulation of tocopherol biosynthesis in tomato显示文摘 | Leandro Quadrana Juliana Almeida Santiago N. Otaiza Tomas Duffy Junia V. Corrêa da Silva Fabiana Godoy Ramon Asís Luisa Bermúdez Alisdair R. Fernie Fernando Carrari Magdalena Rossi | 2013 | Plant Molecular Biology2013，，3： | 1 |
| 18 | Dry refor- ming of coke oven gases over activated carbon to pro- duce syngas for methanol synthesis显示文摘 | Berm Dez J M Fidalgo B Arenillas A | 2010 | Fuel2010，89，10： | 1 |
| 19 | Assessment of the new CKD-EPI equation to estimating glomerular filtration rate显示文摘 | Montanés Bermúdez R Bover Sanjuán J Oliver Samper A | 2010 | Nefrologia2010，30，2： | 1 |
| 20 | Influence of processing method on comparative digestion of white corn versus conventional steam-flaked yellow dent corn in finishing diets for feedlot cattle显示文摘 | Plascencia A Bermúdez R M Cervantes M | 2011 | Journal of Animal Science2011，89，1： | 1 |
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