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| 1 | Transforming bacterial disease surveillance and investigation using whole-genome sequence to probe the trace显示文摘二十年后来过去了第一细菌的整个染色体的定序,它为微生物引起的染色体提供新机会。因而,可观的基因差异由细菌的染色体编码了,在在一样的种类之中,种类被揭示了。在最近的年里,染色体定序技术和生物信息学很快发展了,它导致了转变并且为在传染疾病流行病的解剖使用的细菌的染色体比较帮助了策略和方法论的应用程序。细菌的整个染色体的定序并且生物信息的计算允许 genotyping 在疾病控制满足流行病学的学习的要求。在这评论,我们构画出意义并且总结细菌的染色体在细菌的疾病控制和预防的上下文定序的角色。我们讨论细菌的染色体在爆发察觉,跟踪的来源,传播模式发现,和新流行克隆定序的应用程序鉴定。染色体在传染疾病监视网络定序并且数据分享的宽应用程序将更加支持爆发察觉和早警告阻止细菌的疾病的传播。 | Biao Kan Haijian Zhou Pengcheng Du Wen Zhang Xin Lu Tian Qin Jianguo Xu | 2018 | Frontiers of Medicine2018，12，1： | 11 |
| 2 | Enteroaggregative Escherichia aoliisolated from Chinese diarrhea patients with high-pathogenicity island of Yersinia'xs involved in synthesis of siderophore yersiniabactin显示文摘AIM: To investigate the distribution of 12 high-pathogenicity island (HPI) genes and the relation between HPI genes and expression of yersiniabactin (Ybt) in enteroaggregative E.coli(EAggEC) isolated from Chinese diarrhea patients.METHODS: The distribution of 12 HPI genes was investigated by PCR and DNA hybridization in two prototype strains of EAggEC, EAggEC 17-2, EAggEC O42, and 6 clinical EAggEC isolates from China. The production of siderophore Ybt in HPI-positive strains was detected by reporter gene bioassay to determine the relation between HPI genes and expression of Ybt. Flow cytometry was used to detect fluorescent signal of the reporter strain that could designate production of Ybt.RESULTS: Seven strains were HPI-positive and one strain was HPI-negative. Six of the seven HPI-positive strains were inserted into asnT-tRNA site. Moreover, seven EAggEC HPI-positive strains revealed enhanced fluorescence signal but the EAggEC HPI-negative strain did not. However, there was a difference in Ybt expression condition and level among these seven EAggEC HPI-positive strains. Although UFT073 strain, the prototype strain of uropathogenic E.coli(UPEC), carried the complete HPI core part, we did not detect the expression of Ybt in it.CONCLUSION: EAggEC HPI-positive strains can express the Ybt system, but the presence of HPI core part does not mean the functional expression of Ybt. | Jing Hu Biao Kan Zhi-Hua Liu Shou-Yi Yu | 2005 | World Journal of Gastroenterology2005，11，37： | 5 |
| 3 | Association between the incidence of typhoid and paratyphoid fever and meteorological variables in Guizhou, China显示文摘背景 Typhoid/paratyphoid 发烧( TPF )在 Guizhou.We 是地方性的进行了小浪分析和枪兵的等级关联分析在贵州在 TPF 感染上探索气象学的变化的影响,在估计与我们检验了的 TPF epidemics.Methods 联系的风险因素的一次尝试在在贵州和温度的 TPF 发生之间的协会,用 24 年从 TPF 发生的 1984~2007 .Periodicities 和气候因素的影响的数据的 | Wang Lu-xi Li Xiu-jun Fang Li-qun Wang Duo-chun Cao Wu-chun Kan Biao | 2012 | Chinese Medical Journal2012，，3： | 4 |
| 4 | PulseNet China,a model for future laboratory-based bacterial infectious disease surveillance in China显示文摘Surveillance is critical for the prevention and control of infectious disease.China’s real-time web-based infectious disease reporting system is a distinguished achievement.However,many aspects of the current China Infectious Disease Surveillance System do not yet meet the demand for timely outbreak detection and identification of emerging infectious disease.PulseNet,the national molecular typing network for foodborne disease surveillance was first established by the Centers for Disease Control and Prevention of the United States in 1995 and has proven valuable in the early detection of outbreaks and tracing the pathogen source.Since 2001,the China CDC laboratory for bacterial pathogen analysis has been a member of the PulseNet International family;and has been adapting the idea and methodology of PulseNet to develop a model for a future national laboratory-based surveillance system for all bacterial infectious disease.We summarized the development progress for the PulseNet China system and discussed it as a model for the future of China’s national laboratory-based surveillance system. | Wei Li Shan Lu Zhigang Cui Jinghua Cui Haijian Zhou Yiqing Wang Zhujun Shao Changyun Ye Biao Kan Jianguo Xu | 2012 | Frontiers of Medicine2012，6，4： | 4 |
| 5 | Plasticity of Regulation of Mannitol Phosphotransferase System Operon by CRP-cAMP Complex in Vibrio cholerae显示文摘Objective The complex of the cyclic AMP receptor protein(CRP) and cAMP is an important transcriptional regulator of numerous genes in prokaryotes.The transport of mannitol through the phosphotransferase systems(PTS) is regulated by the CRP-cAMP complex.The aim of the study is to investigate how the CRP-cAMP complex acting on the mannitol PTS operon mtl of the Vibrio cholerae El Tor biotype.Methods The crp mutant strain was generated by homologous recombination to assess the need of CRP to activate the mannitol PTS operon of V.cholerae El Tor.Electrophoretic mobility shift assays(EMSA) and the reporter plasmid pBBRlux were used to confirm the role that the CRP-cAMP complex playing on themannitol PTS operon mtl.Results In this study,we confirmed that CRP is strictly needed for the activation of the mtl operon.We further experimentally identified five CRP binding sites within the promoter region upstream of the mannitol PTS operon mtl of the Vibrio cholerae El Tor biotype and found that these sites display different affinities for CRP and provide different contributions to the activation of the operon.Conclusion The five binding sites collectively confer the strong activation of mannitol transfer by CRP in V.cholerae,indicating an elaborate and subtle CRP activation mechanism. | ZHOU Yan Yan ZHANG Hong Zhi LIANG Wei Li ZHANG Li Juan ZHU Jun KAN Biao | 2013 | Biomedical and Environmental Sciences2013，26，10： | 3 |
| 6 | Cholera Caused by a New Clone of Serogroup O1 Vibrio cholerae-Beijing Municipality,China,June 2021显示文摘Several lineages have been identified in the population of serogroup O1 Vibrio cholerae(V.cholerae)(1-3).The strains,which were responsible for the ongoing seventh cholera pandemic,were in Lineage 2.Nearly all the V.cholerae strains in this lineage carried genes coding cholera toxin(ctxAB)(1-2).Lineage 3b consists of strains isolated from different continents and the vast majority of strains in this lineage lack the ctxAB genes. | Hanqiu Yan Bo Pang Xin Lu Zhiyong Gao Pan Lu Xin Zhang Mengyu Wang Lingyu Shen Wenxuan Zhao Jianhong Zhao Weili Liang Lei Jia Haijian Zhou Zhigang Cui Xiaoli Du Biao Kan Quanyi Wang | 2022 | China CDC weekly2022，4，2： | 3 |
| 7 | Identification and characterization of phosphodiesterases that specifically degrade 3'3'-cyclic GMP-AMP显示文摘 | Juyi Gao Jianli Tao Weili Liang Meng Zhao Xiaoxia Du Shan Cui Haifeng Duan Biao Kan Xiaodong Su Zhengfan Jiang | 2015 | Cell Research2015，25，5： | 2 |
| 8 | Structural Variation of the Superintegron in the Toxigenic Vibrio cholerae O1 El Tor显示文摘在 Vibrio cholerae 理解 superintegron (SI ) 的基因结构和变化的目的在第七霍乱孤立流行。方法聚合酶链反应扫描并且碎片定序被使用。六十 toxigenic V。在 1961 和 2008 之间孤立的 cholerae O1 El 岩山紧张被分析。一些变化被发现的结果,包括的插入,代替,和删除。大多数删除可能是在 V 之间的再结合的结果。cholerae 重复序列。一起聚类的变化的多数。而在紧张的 SI 盒子变化在 1990 年代孤立并且在以后,在 1960 年代和 1970 年代孤立的紧张的 SI 显示出更多的差异更低,与 24 kb 签名顺序删除。这在 1990 年代并且在以后在流行病期间在主人显示占优势的 SI。插入盒子从另外的 V 的 SI 建议了动员。cholerae serogroups 和 Vibrio mimicus。学习揭示了那的结论 SI 的结构的变化在在不同十年在流行病孤立的紧张是明显的,而分叉在这些 El 基于 SI 的 syntenic 结构,岩山拉紧。另外,持续盒子在第七霍乱 pandemics 期间流动在主人紧张的 SI 被显示。 | GAO Yan PANG Bo WANG Hai Yin ZHOU Hai Jian CUI Zhi Gang KAN Biao | 2011 | Biomedical and Environmental Sciences2011，24，6： | 2 |
| 9 | Chinese Pathogen Identification Net:A Laboratory Network for Surveillance and Response of Bacterial Infectious Diseases显示文摘Infectious diseases are a sustained threat to social development and public health.Bacterial infectious diseases,including plague,cholera,anthrax,brucellosis,typhoid fever,meningitis,and even those caused by antimicrobial-resistant bacteria,have been prevalent around the world for a long time,and still trigger outbreaks and long-term epidemics in different countries or regions nowadays(1),and trans-regional spread of diseases has frequently exhibited epidemic patterns. | Zhigang Cui Haijian Zhou Shuang Meng Xiaoli Du Jianguo Xu Biao Kan | 2022 | China CDC weekly2022，4，12： | 2 |
| 10 | Comparative Study of the Genetic Diversity, Antimicrobial Resistance, and Pathogenicity of Aeromonas Isolates from Clinical Patients and Healthy Individuals显示文摘Objective This study was performed to compare the genetic diversity,virulence,and antimicrobial resistance of Aeromonas strains isolated from patients and healthy individuals.Methods A total of 38 clinical strains and 19 strains from healthy individuals were isolated from the samples collected in Ma’anshan City,Anhui Province.Their taxonomy was investigated using concatenated gyrB-cpn60 sequences,and their resistance to 12 antibiotics was evaluated.The pathogenicity of these strains was examined through beta-hemolysis,protease activity,and virulence gene assays.Results The 57 Aeromonas strains were divided into 55 sequence types.Of these types,21 were novel,suggesting that their genetic diversity was high.These Aeromonas isolates could be divided into 7 species,and the positive rates of beta-hemolysis and protease activity were 49.1%and 73.7%,respectively.The detection rate of clinical patients in terms of beta-hemolysis and protease activity was higher than that of healthy individuals.Among the four most common Aeromonas strains,A.dhakensis had the highest detection rate of virulence genes.The multidrug resistance rate of the clinical isolates was much higher than that of the strains isolated from healthy individuals.Conclusions The taxonomy,virulence properties,and antibiotic resistance of Aeromonas isolates from patients differ from those of the isolates from healthy individuals. | MENG Shuang DU Xiao Li WANG Yong Lu QU Feng Tian XIE Gui Lin ZHOU Hai Jian HU Jin Rui QIN Zheng WANG Yue KAN Biao CUI Zhi Gang | 2021 | Biomedical and Environmental Sciences2021，34，6： | 2 |
| 11 | Safety and Effectiveness of SA58 Nasal Spray Against COVID-19 Infection in Medical Personnel:An Open-Label,Blank-Controlled Study—Hohhot City,Inner Mongolia Autonomous Region,China,2022显示文摘Summary What is already known about this topic?The active ingredient of the SA58 Nasal Spray is a broad-spectrum neutralizing antibody with a high neutralizing capacity against different Omicron subvariants in vitro studies.What is added by this report?This study demonstrated the safety and effectiveness of SA58 Nasal Spray against coronavirus disease 2019(COVID-19)infection in medical personnel for the first time.What are the implications for public health practice?This study provides an effective approach for the public to reduce their risk of COVID-19 infection.The findings of this research have the potential to significantly reduce the risk of infection and limit human-to-human transmission in the event of a COVID-19 outbreak. | Shujie Si Canrui Jin Jianping Li Yunlong Cao Biao Kan Feng Xue Xiaoliang Sunney Xie Liang Fang Gang Zeng Shuo Zhang Yaling Hu Xiaoping Dong | 2023 | China CDC weekly2023，5，10： | 1 |
| 12 | District prediction of cholera risk in China based on environmental factors显示文摘The epidemics of cholera are impacted by many climatic and environmental factors such as precipitation, temperature, elevation and so on. The paper analyzed the suitable degree of V. cholerae in China using MaxEnt based on some geographic and climatic factors, and predicted the cholera risk in each district of China according to the suitable degree. The result shows that the areas in coastal southeast, central China and western Sichuan Basin are relatively suitable for V. cholerae and the suitable degree is higher in the Xinjiang Basin than in surrounding areas. The variables of precipitation, temperature and DEM are three main environmental risky factors that affecting the distribution of cholera in China. The variables of relative humidity, the distance to the sea and air pressure also have impacts on cholera, but sunshine duration and drainage density have little impact. The AUC value of MaxEnt based model is above 0.9 which indicates a high accuracy. | XU Min CAO ChunXiang WANG DuoChun KAN Biao JIA HuiCong XU YunFei LI XiaoWen | 2013 | Chinese Science Bulletin2013，58，23： | 1 |
| 13 | Transverse electric field–induced deformation of armchair single-walled carbon nanotube显示文摘 | Biao Kan Jianning Ding Ningyi Yuan Junxiong Wang Zhigang Chen Xiaoshuang Chen | 2010 | Nanoscale Research Letters2010，，7： | 1 |
| 14 | Human Plague Case Diagnosed in Ningxia Tracked to Animal Reservoirs—Inner Mongolia Autonomous Region,China,2021显示文摘Summary What is already known about this topic?There were a total of 4 and 3 human plague cases that occurred in the Inner Mongolia Autonomous Region in 2019 and 2020,respectively,with 1 and 2 deaths in 2019 and 2020 respectively,which indicated that plague still poses a significant threat to human health especially for farmers,shepherds,or residents living in native plague foci.What is added by this report?On August 14,2021,1 patient from the Otog Qi(County)in the Inner Mongolia sought treatment in Yinchuan City(the capital of Ningxia Hui Autonomous Region). | Jianwei Gao Yanhong Hu Cheng Ju Jingyuan Liu Yiting Wang Jiangtao Ma Xiaona Shen Fang Liu Jin Guo Xinxin Yu Wen Zhang Shuyi Wang Kun Li Zhongbing Zhang Biao Kan Wenrui Wang Xianbin Cong Mengguang Fan Wei Li Kuidong Shao Tao Zhang Jianyun Li Yumeng Wang | 2021 | China CDC weekly2021，3，52： | 1 |
| 15 | Evaluation of Four Candidate VNTR Loci for Genotyping 225 Chinese Clinical Mycobacterium Tuberculosis Complex Strains显示文摘Objective To evaluate four candidate variable number tandem repeat (VNTR) loci for genotyping Mycobacterium tuberculosis complex strains.Methods Genomic sequences for two M.tuberculosis strains (CCDC5079 and CCDC5180) were generated,and using published sequence data,four candidate VNTR loci were identified.The VNTRs were used to genotype 225 Chinese clinical M.tuberculosis complex strains.The discriminatory power of the VNTRs was evaluated using BioNumerics 5.0 software.Results The Hunter-Gaston Index (HGI) for BJ1,BJ2,BJ3,and BJ4 loci was 0.634,0.917,0.697,and 0.910,respectively.Combining all four loci gave an HGI value of 0.995,thus confirming that the genotyping had good discriminatory power.The HGI values for BJ1,BJ2,BJ3,and BJ4,obtained from Beijing family strain genotyping,were 0.447,0.878,0.315,and 0.850,respectively.Combining all four loci produced an HGI value of 0.988 for genotyping the Beijing family strains.We observed unique patterns for M.bovis and M.africanum strains from the four loci.Conclusion We have shown that the four VNTR loci can be successfully used for genotyping M.tuberculosis complex strains.Notably,these new loci may provide additional information about Chinese M.tuberculosis isolates than that currently afforded by established VNTR loci typing. | JIANG Yi LIU Hai Can ZHENG Hua Jun TANG Biao DOU Xiang Feng ZHAO Xiu Qin ZHU Yong Qiang LU Bing WANG Sheng Yue DONG Hai Yan ZHAO Guo Ping ZHANG Yuan Yuan KAN Biao WAN Kang Lin | 2012 | Biomedical and Environmental Sciences2012，25，1： | 1 |
| 16 | Genetic source tracking of an anthrax outbreak in Shaanxi province,China显示文摘Background:Anthrax is an acute zoonotic infectious disease caused by the bacterium known as Bacillus anthracis.From 26 July to 8 August 2015,an outbreak with 20 suspected cutaneous anthrax cases was reported in Ganquan County,Shaanxi province in China.The genetic source tracking analysis of the anthrax outbreak was performed by molecular epidemiological methods in this study.Methods:Three molecular typing methods,namely canonical single nucleotide polymorphisms(canSNP),multiple-locus variable-number tandem repeat analysis(MLVA),and single nucleotide repeat(SNR)analysis,were used to investigate the possible source of transmission and identify the genetic relationship among the strains isolated from human cases and diseased animals during the outbreak.Results:Five strains isolated from diseased mules were clustered together with patients’isolates using canSNP typing and MLVA.The causative B.anthracis lineages in this outbreak belonged to the A.Br.001/002 canSNP subgroup and the MLVA15-31 genotype(the 31 genotype in MLVA15 scheme).Because nine isolates from another four provinces in China were clustered together with outbreak-related strains by the canSNP(A.Br.001/002 subgroup)and MLVA15 method(MLVA15-31 genotype),still another SNR analysis(CL10,CL12,CL33,and CL35)was used to source track the outbreak,and the results suggesting that these patients in the anthrax outbreak were probably infected by the same pathogen clone.Conclusions:It was deduced that the anthrax outbreak occurred in Shaanxi province,China in 2015 was a local occurrence. | Dong-Li Liu Jian-Chun Wei Qiu-Lan Chen Xue-Jun Guo En-Min Zhang Li He Xu-Dong Liang Guo-Zhu Ma Ti-Cao Zhou Wen-Wu Yin Wei Liu Kai Liu Yi Shi Jian-Jun Ji Hui-Juan Zhang Lin Ma Fa-Xin Zhang Zhi-Kai Zhang Hang Zhou Hong-Jie Yu Biao Kan Jian-Guo Xu Feng Liu Wei Li | 2017 | Infectious Diseases of Poverty2017，6，1： | 1 |
| 17 | Trans-Regional and Cross-Host Spread of mcr-Carrying Plasmids Revealed by Complete Plasmid Sequences——44 Countries,1998−2020显示文摘Background:The surveillance of antimicrobial resistance genes(ARGs)and bacteria is one critical approach to prevent and control antimicrobial resistance(AMR).Next-generation sequencing(NGS)is a powerful tool in monitoring the emergence and spread of ARGs and resistant bacteria.The horizontal transfer of ARGs across host bacteria mediated by plasmids is a challenge in NGS surveillance for resistance because short-read sequencing can hardly generate the complete plasmid genome sequence,and the correlation between ARGs and plasmids are difficult to determine.Methods:The complete genome sequences of 455 mcr-carrying plasmids(pMCRs),and the data of their host bacteria and isolation regions were collected from the NCBI database.Genes of Inc types and ARGs were searched for each plasmid.The genome similarity of these plasmids was analyzed by pangenome clustering and genome alignment.Results:A total of 52 Inc types,including a variety of fusion plasmids containing 2 or more Inc types were identified in these pMCRs and carried by complex host bacteria.The cooccurrence of ARGs in pMCRs was generally observed,with an average of 3.9 ARGs per plasmid.Twenty-two clusters with consistent or highly similar sequences and gene compositions were identified by the pangenome clustering,which were characterized with distributions in different countries/regions,years or host bacteria in each cluster.Discussion:Based on the complete plasmid sequences,distribution of mcr genes in different Inc type plasmids,their co-existence with other AMRs,and transmission of one pMCR across regions and host bacteria can be revealed definitively.Complete plasmid genomes and comparisons in the laboratory network are necessary for spread tracing of ARG-carrying plasmids and risk assessment in AMR surveillance. | Zhe Li Zhenpeng Li Yao Peng Xin Lu Biao Kan | 2022 | China CDC weekly2022，4，12： | 1 |
| 18 | Master Quorum Sensing Regulator HapR Acts as A Repressor of the Mannitol Phosphotransferase System Operon in Vibrio cholerae显示文摘The phosphoenolpyruvate(PEP):carbohydrate phosphotransferase system(PTS)is widely used by bacteria to take up sugars or sugar derivatives;.PTS is usually composed of a histidine protein(HPr),enzyme I(EI),and several enzyme II(EII)proteins,such as EIIA,EIIB,EIIC,and EIID[1]. | ZHANG Yi Quan MA Li Zhi GAO Yue QIN Qin LI Jie LOU Jing ZHANG Miao Miao XUE Xing Fan KAN Biao GAO He | 2022 | Biomedical and Environmental Sciences2022，35，1： | 0 |
| 19 | Relationship Between Climate Change and Marmot Plague of Marmota himalayana Plague Focus—the Altun Mountains of the Qinghai-Xizang Plateau,China,2000–2022显示文摘Introduction:Plague is a zoonotic disease that occurs naturally in specific geographic areas.Climate change can influence the populations of the plague host or vector,leading to variations in the occurrence and epidemiology of plague in animals.Methods:In this study,we collected meteorological and plague epidemiological data from the Marmota himalayana plague focus in the Altun Mountains of the Qinghai-Xizang Plateau.The data spanned from 2000 to 2022.We describe the climatic factors and plague epidemic conditions and we describe their analysis by Pearson’s correlation.Results:During the period from 2000 to 2022,the isolation rates of Yersinia pestis(Y.pestis)from marmots and fleas were 9.27%(451/4,864)and 7.17%(118/1,646),respectively.Additionally,we observed a positive rate of F1 antibody of 11.25%(443/3,937)in marmots and 18.16%(142/782)in dogs.With regards to climate,there was little variation,and a decreasing trend in blowing-sand days was observed.The temperature in the previous year showed a negative correlation with the Y.pestis isolation rate in marmots(r=−0.555,P=0.011)and the positive rate of F1 antibody in marmots(r=−0.552,P=0.012)in the current year.The average annual precipitation in the previous two years showed a positive correlation with marmot density(r=0.514,P=0.024),while blowingsand days showed a negative correlation with marmot density(r=−0.701,P=0.001).Furthermore,the average annual precipitation in the previous three years showed a positive correlation with the isolation rate of Y.pestis from marmots(r=0.666,P=0.003),and blowing-sand days showed a negative correlation with marmot density(r=−0.597,P=0.009).Conclusions:The findings of this study indicate that there is a hysteresis effect of climate change on the prevalence of plague.Therefore,monitoring climate conditions can offer significant insights for implementing timely preventive and control measures to combat plague epidemics. | Qun Duan Xiaojin Zheng Zhiqiang Gan Dongyue Lyu Hanyu Sha Xinmin Lu Xiaoling Zhao Asaiti Bukai Ran Duan Shuai Qin Li Wang Jinxiao Xi Di Wu Peng Zhang Deming Tang Zhaokai He Huaiqi Jing Biao Kan Xin Wang | 2024 | China CDC weekly2024，6，4： | 0 |
| 20 | Comparison of Lipopolysaccharide and Protein Immunogens from Pathogenic Yersinia enterocolitica Bio-serotype 1B/O:8 and 2/O:9 using SDS-PAGE显示文摘Objective Yersinia enterocolitica is an extracellular pathogen and its related antigens interact with the host immune system.We investigated the difference in immunological characteristics between a highly pathogenic and poorly pathogenic strain of Y.enterocolitica.Methods We used SDS-PAGE and western blotting to characterize lipopolysaccharide (LPS),Yersinia outer membrane proteins (Yops),membrane proteins,and whole-cell proteins from poorly pathogenic Y.enterocolitica bio-serotype 2/O:9,isolated from China,and highly pathogenic bio-serotype 1B/O:8,isolated from Japan.Results These two strains of Y.enterocolitica had different LPS immune response patterns.Comparison of their Yops also showed differences that could have accounted for their differences in pathogenicity.The membrane and whole-cell proteins of both strains were similar;immunoblottting showed that the 35 kD and perhaps the 10 kD proteins were immunogens in both strains.Conclusion The major antigens of the two strains eliciting the host immune response were the LPS and membrane proteins,as shown by comparing protein samples with reference and purified preparations. | GU Wen Peng WANG Xin QIU Hai Yan LUO Xia XIAO Yu Chun TANG Liu Ying KAN Biao XU Jian Guo JING Huai Qi | 2012 | Biomedical and Environmental Sciences2012，25，3： | 0 |
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