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| 1 | Functional Metabolomics Reveals that Astragalus Polysaccharides Improve Lipids Metabolism through Microbial Metabolite 2-Hydroxybutyric Acid in Obese Mice显示文摘Polysaccharides are widely present in herbs with multiple activities,especially immunity regulation and metabolic benefits for metabolic disorders.However,the underlying mechanisms are not well under-stood.Functional metabolomics is increasingly used to investigate systemic effects on the host by iden-tifying metabolites with particular functions.This study explores the mechanisms underlying the metabolic benefits of Astragalus polysaccharides(APS)by adopting a functional metabolomics strategy.The effects of APS were determined in eight-week high-fat diet(HFD)-fed obese mice.Then,gas chromatography–time-of-flight mass spectrometry(GC–TOFMS)-based untargeted metabolomics was performed for an analysis of serum and liver tissues,and liquid chromatography–tandem mass spectrom-etry(LC–MS/MS)-based targeted metabolomics was performed.The potential functions of the metabo-lites were tested with in vitro and in vivo models of metabolic disorders.Our results first confirmed the metabolic benefits of APS in obese mice.Then,metabolomics analysis revealed that APS supplemen-tation reversed the HFD-induced metabolic changes,and identified 2-hydroxybutyric acid(2-HB)as a potential functional metabolite for APS activity that was significantly decreased by a HFD and reversed by APS.Further study indicated that 2-HB inhibited oleic acid(OA)-induced triglyceride(TG)accumula-tion.It was also found to stimulate the expression of proteins in lipid degradation in hepatocytes and TG lipolysis in 3T3-L1 cells.Moreover,it was found to reduce serum TG and regulate the proteins involved in lipid degradation in high-fat and high-sucrose(HFHS)-fed mice.In conclusion,our study demonstrates that the metabolic benefits of APS are at least partially due to 2-HB generation,which modulated lipid metabolism both in vitro and in vivo.Our results also highlight that functional metabolomics is practical for investigating the mechanism underlying the systemic benefits of plant polysaccharides. | Bingbing Li Ying Hong Yu Gu Shengjie Ye Kaili Hu Jian Yao Kan Ding Aihua Zhao Wei Jia Houkai Li | 2022 | Engineering2022，8，2： | 6 |
| 2 | Selective Chemosensor of Fe3+ Based on Fluorescence Quenching by 2,2'-Bisbenzimidazole Derivative in Aqueous Media显示文摘2,2-Bisbenzimidazole 衍生物(L) 是被设计一荧光灯为 Fe3+ 的 chemosensor。简单 chemosensor 显示重要荧光与增加 Fe3+ 的集中熄灭的这在结构上。L 在水的媒介在环境地相关的金属离子之中为 Fe3+ 展出了高选择和 antidisturbance。工作的阴谋的方法显示了在 L 和 Fe3+ 之间复杂的 1:2 的形成,并且系统的可能的有约束力的模式也被建议。另外,进一步的学习证明到 Fe3+ 的传感器的荧光反应上的察觉限制对 107 摩尔敧獬感到不满吗?? | Taibao Wei Jun Liu Hong Yao Qi Lin Yongqiang Xie Bingbing Shi Peng Zhang Xingmei You Youming Zhang | 2013 | Chinese Journal of Chemistry2013，31，4： | 2 |
| 3 | Nanoparticle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of neurotoxin 显示文摘 | RUAN Yeping YAO Li ZHANG Bingbing | 2012 | Drug Dev Ind Pharm2012，38，1： | 1 |
| 4 | Ionic conductive gels based on deep eutectic solvents显示文摘Ionic conductive gels are promising soft conductors for stretchable and flexible electronics.Unfortunately,the basic requirements for an ideal ionic conductive gel,including environmental and chemical stability as well as low toxicity and low cost do not usually coincide in one material.Here we report an ionic conductive gel containing deep eutectic solvents(DES),which are specialized ionic liquids composed of propylene glycol(PG,hydrogen bonding donor)and various salts.In experiments,the DES-gel loses about 10%of the original weight in dry air(5–9%relative humidity)for 7 days and its conductivity remains unaltered.Comparing to regular salt-containing hydrogels,it exhibits exceptional resistance to metal corrosion.We demonstrate the advantage of DES-gels as the ionic electrode in a flexible and stretchable electroluminescent device,especially in cold environment(−20°C).Through this study,we discover a new candidate for cheap and safe soft ionic conductors with excellent environmental and chemical stability. | Cuiping Liu Jinfan Qi Bingbing He Huan Zhang Jie Ju Xi Yao | 2021 | International Journal of Smart and Nano Materials2021，12，3： | 1 |
| 5 | Anti-inflammatory effects of Neurotoxin-Nna,a peptide separated from the venom of Naja naja atra显示文摘 | Yeping Ruan Li Yao Bingbing Zhang | 2013 | BMC Complementary and Alternative Medicine2013，15，13： | 1 |
| 6 | Nanoparti- cle-mediated delivery of Neurotoxin-II to the brain with intranasal administration: an effective strategy to improve antinociceptive activity of Neurotoxin显示文摘 | Yeping Ruan Li Yao Bingbing Zhag | 2012 | Drug Development and Industrial Pharmacy2012，38，1： | 1 |
| 7 | Distillability sudden death for two-qutrit states under an XY quantum environment显示文摘distillability sudden death;;bound entangled states;;negativity;;realignment criterion;;entanglement | Yao Wang ChangCheng Cheng BingBing Chai JinLiang Guo | 2018 | Science China(Physics,Mechanics & Astronomy)2018，61，2： | 1 |
| 8 | Genome-wide analysis of GH3 gene family in soybean( Glycine max)显示文摘 | Wei ZHAO Xinjie SHEN Wei GUO Qingbo YOU Yanjie YAO Jianhua LU Juncheng ZHANG Lei HUANG Bingbing DUAN Huarong LV Aili BAO Yongqing JIAO | 2016 | Oil Crop Science2016，1，2： | 1 |
| 9 | Effects of alcohols on shape-tuning and luminescence-enhancing of C 70 nanocrystals显示文摘 | Dedi Liu Wen Cui Mingguang Yao Quanjun Li Tian Cui Bingbing Liu Dongping Liu Bertil Sundqvist | 2013 | Optical Materials2013，，2： | 1 |
| 10 | Deletion of CHD8 in cerebellar granule neuron progenitors leads to severe cerebellar hypoplasia,ataxia,and psychiatric behavior in mice显示文摘CHD8 is a candidate gene for autism spectrum disorders and neurological development delay.It has been reported to be essential for neurogenesis in the cerebral cortex,but the function of CHD8 in cerebellum has not been comprehensively investigated.The potential relationship of cerebellum dysplasia with psychiatric disorders in patients with CHD8 mutations is still not clear.In this study,we establish different conditional knockout mouse models to investigate the roles of CHD8 in cerebellar development.Mice with neural stem cell-specific Chd8 deletion exhibit significant reduction of cerebellum volume and no layering structure is detected.Genetic deletion of Chd8 in cerebellar granule neuron progenitors(GNPs)leads to cerebellar hypoplasia,absent of proliferation layer and ectopic of Purkinje neuron.However,no substantial cerebellar dysplasia is detected in mice with Purkinje neuron-or oligodendrocyte-specific Chd8 ablation.Single-cell RNA sequencing indicates that ribosome-related genes and pathways are most significantly disrupted in GNPs,indicating the potential mechanism.Importantly,in addition to the ataxia phenotype,mice with GNPspecific Chd8 ablation present a neuropsychiatric phenotype in three-chamber and light/dark tests.Taken together,our results provide insights not only into the function of CHD8 in cerebellar development,but also the pathogenesis of neuropsychiatric disorders in patients with CHD8 mutations. | Xiang Chen Tong Chen Chen Dong Huiyao Chen Xinran Dong Lin Yang Liyuan Hu Huijun Wang Bingbing Wu Ye Yao Yu Xiong Man Xiong Yifeng Lin Wenhao Zhou | 2022 | Journal of Genetics and Genomics2022，49，9： | 1 |
| 11 | High power-efficient asynchronous SAR ADC for IoT devices显示文摘This paper presents a power-efficient 100-MS/s,10-bit asynchronous successive approximation register(SAR) ADC.It includes an on-chip reference buffer and the total power dissipation is 6.8 mW.To achieve high performance with high power-efficiency in the proposed ADC,bootstrapped switch,redundancy,set-and-down switching approach,dynamic comparator and dynamic logic techniques are employed.The prototype was fabricated using 65 nm standard CMOS technology.At a 1.2-V supply and 100 MS/s,the ADC achieves an SNDR of 56.2 dB and a SFDR of 65.1 dB.The ADC core consumes only 3.1 mW,resulting in a figure of merit(FOM) of 30.27 fJ/conversionstep and occupies an active area of only 0.009 mm^2. | Beichen Zhang Bingbing Yao Liyuan Liu Jian Liu Nanjian Wu | 2017 | Journal of Semiconductors2017，38，10： | 0 |
| 12 | A Rational Designed Dual-channel Chemosensor for Mercury Ions Based on Hydrolysis of Schiff Base显示文摘A bilateral Schiff base is reported for the colorimetric and fluorometric dual-channel sensing of Hg^(2+)ions by taking advantage of the hydrolysis of carbon-nitrogen double bond,altering an ICT state mechanism and then Hg^(2+) ions coordinating with amino moieties of 1,5-DAN and leading to the aggregation of 1,5-DAN.Meanwhile,it formed a stable neutral complex of amino-Hg-amino.In addition,test strips based on L were fabricated,which also exhibited a good selectivity to Hg^(2+) as in solution.This work provides a novel approach for the selective recognition of mercury ions.Notably,the color changes are very significant and all the recognition processes can be observed by the naked eyes.We believe the test strips can act as a convenient and efficient Hg^(2+) test kit. | Guiyuan Wu Bingbing Shi Bing Hu Youming Zhang Qi Lin Hong Yao Taibao Wei | 2014 | Chinese Journal of Chemistry2014，32，7： | 0 |
| 13 | Novel conductive metallo-supramolecular polymer AIE gel for multi-channel highly sensitive detection of hydrazine hydrate显示文摘Hydrazine hydrate(DH)is an important fine chemical intermediate and as fuel for rockets,however,it also has serious toxic for humans and environment.Developing novel materials and methods for sensitive detection of DH in water and air is an important task.In order to effectively detect DH,a novel conductive supramolecular polymer metallogel(PQ-Ag)has been constructed by the coordination of bis-5-hydroxyquinoline functionalized pillar[5]arene(PQ5)with Ag+.The metallogel PQ-Ag could realize the multi-channel sensitive detection of DH through naked-eye,fluorescence,and electrochemical methods.The lowest limit of detection(LOD)is 0.1 mg/m^(3)in air and 2.68×10^(−8)mol/L in water,which is lower than the standard of the US Environmental Protection Agency(EPA)for DH of maximum allowable concentration in drinking water.More importantly,an electronic device for DH detection based on the metallogel PQ-Ag was designed and prepared,which can realize conveniently and efficiently multi-channel detection and alert of DH through sound and light alarms not only in water but also in air. | Yu Jia Wen-Li Guan Juan Liu Jian-Peng Hu Bingbing Shi Hong Yao You-Ming Zhang Tai-Bao Wei Qi Lin | 2023 | Chinese Chemical Letters2023，34，8： | 0 |
| 14 | Systemic and single cell level responses to 1 nm size biomaterials demonstrate distinct biological effects revealed by multi-omics atlas显示文摘Although ultra-small nanoclusters(USNCs,<2 nm)have immense application capabilities in biomedicine,the investigation on body-wide organ responses towards USNCs is scant.Here,applying a novel strategy of single-cell mass cytometry combined with Nano Genome Atlas of multi-tissues,we systematically evaluate the interactions between the host and calcium phosphate(CaP)USNCs at the organism level.Combining single-cell mass cytometry,and magnetic luminex assay results,we identify dynamic immune responses to CaP USNCs at the single cell resolution.The innate immune is initially activated and followed by adaptive immune activation,as evidenced by dynamic immune cells proportions.Furthermore,using Nano Genome Atlas of multi-tissues,we uncover CaP USNCs induce stronger activation of the immune responses in the cartilage and subchondral bone among the five local tissues while promote metabolic activities in the liver and kidney.Moreover,based on the immunological response profiles,histological evaluation of major organs and local tissue,and a body-wide transcriptomics,we demonstrate that CaP USNCs are not more hazardous than the Food and Drug Administration-approved CaP nanoparticles after 14 days of injection.Our findings provide valuable information on the future clinical applications of USNCs and introduce an innovative strategy to decipher the whole body response to implants. | Tao Zhang Tingyun Lei Ruojin Yan Bo Zhou Chunmei Fan Yanyan Zhao Shasha Yao Haihua Pan Yangwu Chen Bingbing Wu Yuwei Yang Lijuan Hu Shen Gu Xiaoyi Chen Fangyuan Bao Yu Li Hanqi Xie Ruikang Tang Xiao Chen Zi Yin | 2022 | Bioactive Materials2022，7，12： | 0 |
| 15 | The underappreciated role of fugitive VOCs in ozone formation and health risk assessment emitted from seven typical industries in China显示文摘Fugitive emission from industrial sources may result in ozone formation and health risk,while the exact contribution of this source remains incompletely understood.In this study,emission characteristics,ozone formation potential(OFP)and health risk of fugitive VOCs in7 representative industries were investigated.Chemical material industry was the dominant contributor to VOCs of fugitive emission in comparison with other industries.The OFP of VOCs from fugitive emission was in the range of 1.45×10^(3)-3.98×10^(5)μg/m^(3),with a higher value than that of organized emission in seven industries except for the coking industry and the chemical material industry,suggesting that fugitive VOCs should be taken into account while developing control strategies.Acetaldehyde,m,p-xylene,n-nonane,ethylene,vinyl chloridethe and other high OFP-contributing species were the major reactive species that should be targeted.Health risk assessment investigated non-cancer and cancer risks of fugitive VOCs in 7 industries were all above safe level(HR>1 and LCR>1×10^(-4)),posing remarkable health threats to human health.OVOCs were the main contributor to non-cancer risk,while halohydrocarbons and aromatics contributed most to cancer risks,posing remarkable health threat on human health.Our findings highlighted the contribution of fugitive VOCs on ozone formation and health risk was underestimated,indicating which should be considered in emission control strategies of industrial sources. | Zhiling Liang Yunjiang Yu Bingbing Sun Qian Yao Xihua Lin Yongsheng Wang Jianping Zhang Yingzi Li Xuefeng Wang Zhengzheng Tang Shexia Ma | 2024 | Journal of Environmental Sciences2024，，2： | 0 |
| 16 | Synthesis of Copillar[5]arene by Co-oligomerization of Different Monomers and Its Application to Supramolecular Polymer Gel显示文摘A copillar[5]arene derivative with different repeating units was synthesized by co-oligomerization of different alkyl ethers.Copillar[5]arene-based supramolecular polymer gel was formed by a self-inclusion complexing in acetonitrile.The supramolecular polymer gel was driven by the C-H•πinteractions,and presented two phases as time went on,and finally,constructed the supramolecular organic framework.Notably,the supramolecular polymer gel showed reversible gel-sol phase transitions upon heating and cooling.Meanwhile,the transparent films formed by the supramloecular gel show the potential application in the field of anti-acid rain materials. | Hui Li Yuanrong Zhu Bingbing Shi Guiyuan Wu Youming Zhang Qi Lin Hong Yao Taibao Wei | 2015 | Chinese Journal of Chemistry2015，33，3： | 0 |
| 17 | A Pd_(2)L_(4) Metallacage-Cored Supramolecular Amphiphile and Its Application in Dual-Responsive Controllable Release显示文摘The construction of multi-responsive supramolecular systems for drug delivery is a challenging task.In this work,a Pd_(2)L_(4) metallacage 1·([BF_(4)]^(−))_(4) with four pyrene units was first designed and synthesized through coordination-driven self-assembly.After the introduction ofγ-CD,a supramolecular amphiphile 1–γ-CD was successfully constructed based on the host–guest molecular recognition betweenγ-CD and the pyrene unit of 1·([BF_(4)]^(−))_(4),which further self-assembled into dual-responsive supramolecular vesicles in aqueous solution.DOX·HCl was used as a model molecule to study the drug encapsulation and release behavior of the supramolecular vesicles.By adjusting the pH of the solution to acidic condition or adding a certain amount ofα-amylase,the vesicle structure was destroyed to achieve rapid and effective release of the drug molecules.This study provides an example for the rational design of efficient dual-responsive supramolecular nanocarriers,which have potential application value in the field of controlled drug delivery. | Yongping Chai Peng Qin Xupeng Li Tai-Bao Wei Qi Lin You-Ming Zhang Hong Yao Wen-Juan Qu Bingbing Shi | 2022 | Chinese Journal of Chemistry2022，40，20： | 0 |
| 18 | Fabricating a novel supramolecular light-activated platform based on internal-driven forces induced by the UV-light显示文摘Recently,exploiting a novel supramolecular fabrication pathway have drawn great attention.To this endeavor,we firstly designed and reported an original light-activated platform based on the internal-driven forces of macrocyclic host by hiring the pillar[5]arene as the host molecule(H)and phenazine derivatives acting as an energetic guest molecule(G).Surprisingly,after adding the H solution into G system,the intensive fluorescence emission of the G molecule rapidly decreased under the irradiation of the UV-light(254 nm)until absolutely quenching.Delightfully,different from the traditional supramolecular host-guest interaction,the fluorescent emission of G molecule could be recovered after irradiating under the nature light.In view of this interesting observations,the interaction mechanism was carefully investigated by a series of characterizations.Those results suggested that the G molecule was easily threaded into the macrocyclic cavity(H)under the internal-driven forces induced by the UV-light irradiation,forming a 1:1 host-guest complex.Moreover,taking advantage of this especial feature,the light-activated platform of host-guest complex was further applied for ink-free light-driven printing materials,exhibiting great potential in the real application. | Xiaoni Qi Weichun Li Bingbing Shi Youming Zhang Hong Yao Qi Lin Taibao Wei | 2022 | Chinese Chemical Letters2022，33，12： | 0 |
| 19 | Tuning host-guest binding model by different intramolecular alkyl chain lengths in tripodal hosts:An evidence on structure control supramolecular interactions显示文摘Supramolecular chemistry has received considerable attention in host-guest recognition.The structureresponse relationship of host-guest recognition system is a meaningful issue.Herein,a series of tripodal nitrogen mustard derivatives(TMs)have been developed in this paper.By rationally design the intramolecular alkyl chain lengths of host,the host-guest binding model have been successfully tuned,which underwent a transformation fromπ-πto multiple hydrogen bonds.This process enhances the host-guest binding force and recognition efficiency. | Zheng-Hua Zhang You-Ming Zhang Wen-Juan Qu Bingbing Shi Hong Yao Tai-Bao Wei | 2023 | Chinese Chemical Letters2023，34，1： | 0 |
| 20 | Pillar[n]arenes-based materials for detection and separation of pesticides显示文摘The effective materials and methods for detection and separation of pesticides are urgently needed because most of pesticides show very harmful influence on life and environment. As a new kind of macrocyclic host compound, pillar[n]arenes show very good performance in the detection and separation of pesticides, especially for paraquat(PQ). For the pesticide detection and separation materials, their structures determine performance. Therefore, this review summarizes the recent progress of pillar[n]arenes-based materials for detection and separation of pesticides covering single/multi-pillar[n]arenes, pillar[n]arenes-based polymers, frameworks, composites, nanomaterials, etc.The structure-performance relationships of these materials have been discussed according to the cavity size, the synergistic or collaboration effect, the structure of the polymer or framework, the substrate of the composites and the size of nanomaterials and so on. Based on these, we also look forward to the future and point out the possible way for improving the pesticides detection sensitivity and separation efficiency of this kind of materials. | Zhong-Di Tang Xiao-Mei Sun Ting-Ting Huang Juan Liu Bingbing Shi Hong Yao You-Ming Zhang Tai-Bao Wei Qi Lin | 2023 | Chinese Chemical Letters2023，34，4： | 0 |
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