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| 1 | MiR-181a-5p inhibits cell proliferation and migration by targeting Kras in non-small cell lung cancer A549 cells显示文摘MicroRNAs 玩在 carcinogenesis 和肿瘤的重要角色进行。肺癌症是世界范围的癌症死亡的领先的原因。在这研究, miR-181a-5p 的功能在 non-small-cell 肺癌症(NSCLC ) 被调查。结果证明 miR-181a-5p 显著地在 NSCLC 纸巾和房间线被减少。有 miR-181a-5p 的 A549 房间 transfected 的增长和迁居模仿显著地被禁止。酶活动试金结果证明 Kras 的二个有约束力的地点能被 miR-181a-5p 直接指向。而且, Kras 由在 transcriptional 和翻译层次的 miR-181a-5p 是下面调整的。调停 SiRNA 的 Kras 下面规定能模仿 miR-181a-5p 的效果在 A549 模仿房间。我们的调查结果建议 miR-181a-5p 由部分指向 Kras 在肿瘤抑制起一个潜在的作用并且在 NSCLC 病人有潜在的治疗学的申请。 | Zhongliang Ma Xiang Qiu Detao Wang Yanli Li Bingjie Zhang Tianwei Yuan Jiali Wei Botao Zhao Xintai Zhao Jiatao LOU Yan Jin Youxin Jin | 2015 | Acta Biochimica et Biophysica Sinica2015，47，8： | 8 |
| 2 | Glial U87 cells protect neuronal SH-SY5Y cells from indirect effect of radiation by reducing oxidative stress and apoptosis显示文摘最近的研究在 neurodegeneration 表明了放射的间接效果的角色。然而,在对放射的间接效果的 neuroprotection 的 glial 房间的角色仍然不是清楚的,尽管他们被知道在中央神经系统在压力条件下面保护神经原。我们的学习证明放射的那间接效果增加了进一步提高关键 apoptotic 蛋白质的表示并且导致 neuronal 房间死亡的氧化压力。我们也在一个 transwell 合作文化系统面对 glial 房间在 neuronal 房间上调查了放射的间接效果,当我们的分析集中于 neuronal 房间时。当间接放射和 neuroprotective 效果的来源被各种各样的端点分析,照耀的调节房间的中等 ICCM 被使用。导致 ICCM 的反应氧化种类水平显著地在与 glial U87 房间 co 有教养的 SH-SY5Y 房间被减少,这被观察,它可能帮助维持 mitochondrial 膜潜力的正直。抗氧化剂酶 superoxide dismutase 和抗氧化剂谷胱甘肽的增加的层次在与 glial U87 房间 co 有教养的 SH-SY5Y 房间被观察。而且,有 glial 房间的合作文化禁止导致 ICCM 的 apoptotic 蛋白质的表示,这也被观察,即在 SH-SY5Y 房间的 Bax,细胞色素 c,和 caspase-3。因此,在合作文化系统 glial,房间可以由减少导致 ICCM 的氧化压力和 apoptotic 死亡保护 neuronal SH-SY5Y 房间,这能被推测。 | Yasmeen Saeed Bingjie Xie JinXu Abdur Rehman Ma Hong Qing Hong Yulin Deng | 2015 | Acta Biochimica et Biophysica Sinica2015，47，4： | 2 |
| 3 | Physicochemical properties and biological activities of polysaccharides from the peel of Dioscorea opposita Thunb.extracted by four different methods显示文摘Polysaccharides are the important biologically active components found in the peel of Dioscorea opposita Thunb.(DTTP).The influences of 4 extraction methods,namely hot water extraction(W),acidic extraction(HA),hot-compressed water extraction(HCW)and enzyme-assisted extraction(EAE),on the yields,physicochemical properties,hypoglycemic and antioxidant activities of polysaccharides from DTTP were studied and compared.Among these DTTP polysaccharides,DTTP-HA was outstanding in several respects.DTTP-HA was the most water soluble;it had the highest total carbohydrate content(85.08%),the highest uronic acid(13.20%)and the highest thermal stability.DTTP-HA and DTTP-W possessed a triple-helix structure.These 4 kinds of polysaccharides have the same types of monosaccharides,but in different molar percentages.Extraction method had a significant impact on the microstructures of the extracted polysaccharides.DTT-HA exhibited irregular structure with many holes.Among the 4 extracted methods,the DTTP-HA and DTTP-W initially exhibited higher hypoglycemic and antioxidant activities.The better bioactivities of DTTP-HA may be related to the above factors.The findings indicated that acid extraction is an effective method to extract polysaccharides with high biological activities from DTTP. | Zuowei Zhao Li Wang Yuan Ruan Chunnan Wen Menghuan Ge Yanyan Qian Bingji Ma | 2023 | Food Science and Human Wellness2023，12，1： | 1 |
| 4 | Plasmacytoid dendritic cells promote acute kidney injury by producing interferon-α显示文摘Acute kidney injury(AKI)is a common clinical complication associated with high mortality in patients.Immune cells and cytokines have recently been described to play essential roles in AKI pathogenesis.Plasmacytoid dendritic cells(pDCs)are a unique DC subset that specializes in type Ⅰ interferon(IFN)production.Here,we showed that pDCs rapidly infiltrated the kidney in response to AKI and contributed to kidney damage by producing IFN-α.Deletion of pDCs using DTR^(BDCA2) transgenic(Tg)mice suppressed cisplatin-induced AKI,accompanied by marked reductions in proinflammatory cytokine production,immune cell infiltration and apoptosis in the kidney.In contrast,adoptive transfer of pDCs during AKI exacerbated kidney damage.We further identified IFN-α as the key factor that mediated the functions of pDCs during AKI,as IFN-α neutralization significantly attenuated kidney injury.Furthermore,IFN-α produced by pDCs directly induced the apoptosis of renal tubular epithelial cells(TECs)in vitro.In addition,our data demonstrated that apoptotic TECs induced the activation of pDCs,which was inhibited in the presence of an apoptosis inhibitor.Furthermore,similar deleterious effects of pDCs were observed in an ischemia reperfusion(IR)-induced AKI model.Clinically,increased expression of IFN-α in kidney biopsies was observed in kidney transplants with AKI.Taken together,the results of our study reveal that pDCs play a detrimental role in AKI via IFN-α. | Bo Deng Yuli Lin Yusheng Chen Shuai Ma Qian Cai Wenji Wang Bingji Li Tingyan Liu Peihui Zhou Rui He Feng Ding | 2021 | Cellular & Molecular Immunology2021，18，1： | 1 |
| 5 | Tanshinones suppress non-small cell lung cancer through up-regulating miR-137显示文摘大进步在肺癌症的治疗被取得了,尤其是在基于 PD-1 包括象那些那样的免疫疗法的治疗学的药的多样化。在这些之中,有许多反疾病分子,从中国传统的药提取,例如 artemisinin 和 tanshinones。Tanshinones,包括 Tanshinone 我(T1 ) , Tanshinone IIA (T2A ) ,并且 ? cryptotanshinone (CT ) ,是 Salia miltiorrhiza 的 liposoluble 成分,传统的植物,它有利药用的价值。特别兴趣中是 tanshinone 在肿瘤房间上有的细胞毒素的效果,它被认为首先通过 apoptosis 的正式就职和房间周期前进, angiogenesis,房间侵略,和转移的禁止发生。以前的研究显示了 tanshinones 的导致 apoptosis 效果可能有效地指向并且禁止人的肺癌症细胞的生长[1 ] 。因此,推测那 tanshinones 是合理的可以在非小的房间肺癌症(NSCLC ) 的治疗起一个重要作用。研究已经证明了 tanshinone 分子能在 vitro 禁止肺癌症细胞的生长[2 ] ,并且机制可能通过细胞周期前进和细胞 apoptosis 的正式就职的打断,导致 miR-137 的起来规定表示。 | Bingjie Zhang Zhongliang Ma Xue Li Caiyan Zhang Yang Shao Zhenguo Liu Yanli Li Youxin Jin | 2016 | Acta Biochimica et Biophysica Sinica2016，48，8： | 1 |
| 6 | Soybean isoflavone alleviates β-amyloid 1-42 induced, inflammatory response to improve learning and memory ability by down regulation of Toll- like receptor 4 expression and nuclear factor-κB activity in rats 显示文摘 | DING Bingjie MA Weiwei HE Lingling | 2011 | Int J Dev Neurosci2011，29，5： | 1 |
| 7 | Genistein as a neuroprotective antioxidant attenuates redox imbalance induced by β-amyloid peptides 25–35 in PC12 cells显示文摘 | Weiwei Ma Linhong Yuan Huanling Yu Bingjie Ding Yuandi Xi Jinfang Feng Rong Xiao | 2010 | International Journal of Developmental Neuroscience2010，，4： | 1 |
| 8 | Optical spectroscopy study of Ca_3(Ru_(0.91)Mn_(0.09))_2O_7 single crystal in high magnetic fields显示文摘The magneto-optical spectrum, with magnetic fields up to 42 T, of double layered ruthenates Ca_3(Ru_(0.91)Mn_(0.09))_2O_7(CRMO) single crystal is studied. Both the temperature and magnetic field induced insulator-to-metal transitions(IMTs) are observed via magneto-optical properties of the crystal. The critical magnetic field(H//c) of IMT for CRMO is found to be as large as 35 T at 5 K. The fine structure of optical spectra identified the antiferromagnetic/ferro-orbital-ordering configurations of Ru 4d orbitals at low temperatures. Meanwhile, the configuration of orbital polarization of such double-layer CRMO single crystal is discussed. These results suggest that the orbital degree of freedom plays an important role in the field induced IMT of multi-orbital system. | Xueli Xu Jin Peng Junpei Zhang Zongwei Ma Cheng Chen Junbo Han Bingjie Liu Lingfang Lin Xiaoshan Wu Zhiqiang Mao Zhe Qu Zhigao Sheng | 2019 | Science Bulletin2019，64，1： | 0 |
| 9 | Optical experimental solution for the multiway number partitioning problem and its application to computing power scheduling显示文摘Quantum computing is an emerging technology that is expected to realize an exponential increase in computing power. Recently,its theoretical foundation and application scenarios have been extensively researched and explored. In this work, we propose efficient quantum algorithms suitable for solving computing power scheduling problems in the cloud-rendering domain, which can be viewed mathematically as a generalized form of a typical NP-complete problem, i.e., a multiway number partitioning problem.In our algorithm, the matching pattern between tasks and computing resources with the shortest completion time or optimal load balancing is encoded into the ground state of the Hamiltonian;it is then solved using the optical coherent Ising machine, a practical quantum computing device with at least 100 qubits. The experimental results show that the proposed quantum scheme can achieve significant acceleration and save 97% of the time required to solve combinatorial optimization problems compared with classical algorithms. This demonstrates the computational advantages of optical quantum devices in solving combinatorial optimization problems. Our algorithmic and experimental work will advance the utilization of quantum computers to solve specific NP problems and will broaden the range of possible applications. | Jingwei Wen Zhenming Wang Zhiguo Huang Dunbo Cai Bingjie Jia Chongyu Cao Yin Ma Hai Wei Kai Wen Ling Qian | 2023 | Science China(Physics,Mechanics & Astronomy)2023，66，9： | 0 |
| 10 | Sulfation of the extracellular polysaccharide from the edible fungus Stropharia rugosoannulata with its antioxidant activity显示文摘An acidic extracellular polysaccharide(EPS)was gained from Stropharia rugosoannulata fermentation broth by the alcohol precipitate method.Sulfated derivative of EPS(S-EPS)was gained by chlorosulfonic acid-pyridine method and the conditions were as follows:pyridine as the reaction solvent,temperature 80°C,and reaction time 90 min.The chemical structure and chain conformation of EPS and S-EPS were characterized by FT-IR,NMR and size exclusion chromatography(SEC)coupled with multi-angle laser light scattering(MALLS)detection.FT-IR spectra indicated the sulfated group was linked to the polymer.The EPS mainly consists of mannose,glucose and glucuronic acid,and the glycosidic bond type is mainly(1→4)-linked and(1→6)-linked.C6 and C2 were substituted by sulfate groups.The EPS was degraded into smaller molecular weight(Mw)polysaccharides with the larger molecular size(Rg)after sulfation and S-EPS has better hydrophilicity.Moreover,the sulfated derivative S-EPS was found to have a better scavenging ability on hydroxyl radicals than EPS.It proved that the chemical modification of S.rugosoannulata polysaccharides by sulfation effectively enhanced their antioxidant activity. | Hui Hao Chun Cui Yuqing Xing Xuewei Jia Bingjie Ma Wenyi Kang Tianxiao Li Mingqi Gao Chunping Xu | 2023 | Journal of Future Foods2023，3，1： | 0 |
| 11 | Practical continuous-variable quantum key distribution with feasible optimization parameters显示文摘Continuous-variable quantum key distribution(CV-QKD)offers an approach to achieve a potential high secret key rate(SKR)in metropolitan areas.There are several challenges in developing a practical CV-QKD system from the laboratory to the real world.One of the most significant points is that it is really hard to adapt different practical optical fiber conditions for CV-QKD systems with unified hardware.Thus,how to improve the performance of practical CV-QKD systems in the field without modification of the hardware is very important.Here,a systematic optimization method,combining the modulation variance and error correction matrix optimization,is proposed to improve the performance of a practical CV-QKD system with a restricted capacity of postprocessing.The effect of restricted postprocessing capacity on the SKR is modeled as a nonlinear programming problem with modulation variance as an optimization parameter,and the selection of an optimal error correction matrix is studied under the same scheme.The results show that the SKR of a CV-QKD system can be improved by 24%and 200%compared with previous frequently used optimization methods theoretically with a transmission distance of 50 km.Furthermore,the experimental results verify the feasibility and robustness of the proposed method,where the achieved optimal SKR achieved practically deviates<1.6%from the theoretical optimal value.Our results pave the way to deploy high-performance CV-QKD in the real world. | Li MA Jie YANG Tao ZHANG Yun SHAO Jinlu LIU Yujie LUO Heng WANG Wei HUANG Fan FAN Chuang ZHOU Liangliang ZHANG Shuai ZHANG Yichen ZHANG Yang LI Bingjie XU | 2023 | Science China(Information Sciences)2023，66，8： | 0 |
| 12 | Pyrene-tethered bismoviologens for visible light-induced C(sp^(3))-P and C(sp^(2))-P bonds formation显示文摘Developing efficient photosensitizers for C-P bond construction is highly important and remains a challenge due to the urgently needed for the synthesis of modified nucleosides,nucleotides,and other phosphine-containing ligands.Herein,two pyrene-tethered bismoviologen derivatives(Py-BiV^(2+))were designed and synthesized for visible-light-induced C-P bonds formation.The photochemical and electrochemical properties of Py-BiV^(2+)were studied systemically,certifying fine-tunable opto-electronic properties through the number of pyrene groups(4,n=1;6,n=2).The prepared Py-BiV^(2+)showed strong light absorption,while retaining good redox features and chromic response features that were inherent to viologens.4 exhibited accelerated photoinduced electron transfer in the presence of the electron donor(pyrene)and the generated 4(radical cation)showed higher stability.Accordingly,Py-BiV^(2+)directly served as photosensitizers for the first time in the visible-light-induced C(sp^(3))-P and C(sp^(2))-P bonds formation.As expected,these novel viologen derivatives exhibited good catalytic performance and good substrate expansibility under ambient conditions. | Wenqiang Ma Sikun Zhang Liang Xu Bingjie Zhang Guoping Li Bin Rao Mingming Zhang Gang He | 2023 | Chinese Chemical Letters2023，34，6： | 0 |
| 13 | A new generation M^(pro)inhibitor with potent activity against SARS-CoV-2 Omicron variants显示文摘Emerging SARS-CoV-2 variants, particularly the Omicron variant and its sublineages, continually threaten the global public health.Small molecule antivirals are an effective treatment strategy to fight against the virus. However, the first-generation antivirals eithershow limited clinical efficacy and/or have some defects in pharmacokinetic (PK) properties. Moreover, with increased use of thesedrugs across the globe, they face great pressure of drug resistance. We herein present the discovery and characterization of a newgeneration antiviral drug candidate (SY110), which is a potent and selective inhibitor of SARS-CoV-2 main protease (Mpro). Thiscompound displayed potent in vitro antiviral activity against not only the predominant SARS-CoV-2 Omicron sublineage BA.5, butalso other highly pathogenic human coronaviruses including SARS-CoV-1 and MERS-CoV. In the Omicron-infected K18-hACE2mouse model, oral treatment with SY110 significantly lowered the viral burdens in lung and alleviated the virus-induced pathology.Importantly, SY110 possesses favorable PK properties with high oral drug exposure and oral bioavailability, and also an outstandingsafety profile. Furthermore, SY110 exhibited sensitivity to several drug-resistance Mpro mutations. Collectively, this investigationprovides a promising new drug candidate against Omicron and other variants of SARS-CoV-2. | Chong Huang Huiping Shuai Jingxin Qiao Yuxin Hou Rui Zeng Anjie Xia Lingwan Xie Zhen Fang Yueyue Li Chaemin Yoon Qiao Huang Bingjie Hu Jing You Baoxue Quan Xiu Zhao Nihong Guo Shiyu Zhang Ronggang Ma Jiahao Zhang Yifei Wang Ruicheng Yang Shanshan Zhang Jinshan Nan Haixing Xu Falu Wang Jian Lei Hin Chu Shengyong Yang | 2023 | Signal Transduction and Targeted Therapy2023，8，4： | 0 |
| 14 | Altered expression profile of long non-coding RNAs during heart aging in mice显示文摘Objective:Long noncoding RNAs(lncRNAs)play an important role in regulating the occurrence and development of cardiovascular diseases.However,the role of lncRNAs in heart aging remains poorly understood.The objective of this study was to identify differentially expressed lncRNAs in the heart of aging mice and elucidate the relevant regulatory pathways of cardiac aging.Materials and methods:Echocardiography was used to detect the cardiac function of 18-months(aged)and 3-months(young)old C57BL/6 mice.Microarray analysis was performed to unravel the expression profiles of lncRNAs and mRNAs,and qRT-PCR to verify the highly dysregulated lncRNAs.Results:Our results demonstrated that the heart function in aged mice was impaired relative to young ones.Microarray results showed that 155 lncRNAs were upregulated and 37 were downregulated,and 170 mRNAs were significantly upregulated and 44 were remarkably downregulated in aging hearts.Gene ontology analysis indicated that differentially expressed genes are mainly related to immune function,cell proliferation,copper ion response,and cellular cation homeostasis.KEGG pathway analysis showed that the differentially expressed mRNAs are related to cytokine-cytokine receptor interaction,inflammatory mediator regulation of TRP channels,and the NF-kappa B signaling pathway.Conclusion:These results imply that the differentially expressed lncRNAs may regulate the development of heart aging.This study provides a new perspective on the potential effects and mechanisms of lncRNAs in heart aging. | Xiuxiu Wang Bingjie Hua Meixi Yu Shenzhen Liu Wenya Ma Fengzhi Ding Qi Huang Lai Zhang Chongwei Bi Ye Yuan Mengyu Jin Tianyi Liu Ying Yu Benzhi Cai Baofeng Yang | 2022 | Frigid Zone Medicine2022，2，2： | 0 |
| 15 | Synthesis of LaFeO_3 catalytic materials and their sensing properties显示文摘LaFeO3 is a p-type semiconductor catalytic material of perovskite structure (ABO3). Its magnetic and photocatalytic properties have been widely investigated,but the gas sensing properties are seldom reported,especially for toxic and noxious gases of NO2 and CO. The nanocomposites of LaFeO3 and LaFe1-xMgxO3 (x = 0.02,0.04,0.06) were prepared by various methods of the wet chemical process and their exact composition,crystal structures,grain sizes,specific surfaces,morphology and the electronic interaction between components were characterized by EDX,XRD,BET,SEM and XPS analysis. The sensors based on these nanocomposites have been fabricated to examine the sensing responses to gases,and the results show that these sensors exhibited high response to both oxidizing gas (NO2) and reducing gas (CO),and the response was greatly enhanced by the surface modification of MgO. The additive method,amount of additives,and their effects on the LaFeO3 structure and gas response have been analyzed and discussed by temperature-programmed desorption (TPD) and X-ray photoelectron spectroscopic (XPS) analysis. | BAI ShouLi,SHI BingJie,MA LiJing,YANG PengCheng,LIU ZhiYong,LI DianQing & CHEN AiFan State Key Laboratory of Chemical Resource Engineering,College of Science,Beijing University of Chemical Technology,Beijing 100029,China | 2009 | Science China Chemistry2009，52，12： | 0 |
| 16 | Functional biochar for efficient residue treatment of sulfonylurea herbicides by weak molecular interaction显示文摘Pesticide residues have seriously damaged the natural environment and social security.Here,we prepared the efficient functional biochar(FB)for sulfonylurea herbicides from cotton straw cellulose(CSC)by hydrothermal carbonization with the methacrylic acid.The molecular simulation of FB indicated thatπ-πelectron-donor-acceptor(EDA)interaction and formation of charge-assisted H-bond were both the main factors for effective adsorption process.The adsorption process can match the pseudo-second-order kinetic equation and Freundlich model.The whole process is physical adsorption,spontaneous and rapid,and can quickly reach equilibrium.The FB with carbon-oxygen functional groups and aromatic conjugated structures can remove pesticides in water very quickly(within 30 s),with effective adsorption over 95%of Sulfonylurea herbicides(SUHs).Therefore,functional FB might be an effective way to get excellent absorbent for pesticide treatment. | Yunpeng Zhang Bingjie Zhang Jingyang Yu Meng Yuan Jiawen Ji Huizhe Lu Yongqiang Ma Yunlong Guo | 2021 | Biochar2021，3，4： | 0 |
| 17 | Catalytic activity of Mn-substituted barium hexaaluminates for methane combustion显示文摘The catalysts of hexaaluminate (BaMnxAl12-xO19-δ , x = 1.0, 2.0, 3.0, 4.0) to be used in methane combustion have been successfully synthesized by co-precipitation method and supercritical drying. The crystalline structure and surface area of catalyst were characterized by X-ray diffraction (XRD) and nitrogen adsorption analysis of BET method. BET analysis revealed that the preparing and drying method proposed here provides stable materials with higher surface area of 51.4 m2/g in comparison to materials prepared using conventional ambient drying method for BaMnxAl12?xO19-δ calcined at 1200℃ under oxygen. XRD analysis indicated that formation of a pure single phase BaMnxAl12-xO19-δ occurred up to x = 3 in the case of Mn-substituted barium hexaaluminates. Incorporation of Mn in excess leads to BaAl2O4 phase formation. As far as the valence state of Manganese ions was concerned, the introduced Mn ions were either divalent or trivalent. The first Mn ions were introduced in the matrix essentially as Mn2+ and only for BaMn3Al9O19-δ does manganese exist exclusively as Mn3+; the higher the Mn concen- tration, the higher the proportion of Mn3+. Catalytic activity for methane combustion has been measured for Mn-substituted barium hexaaluminates, light-off temperature was observed in the 512-624℃ range. The highest activity was obtained for catalysts containing 3 Mn ions per unit cell, which reveals that the BaMnxAl12-xO19-δ catalyst was a promising methane combustion catalyst with high activity and good thermal stability. Temperature programmed reduction (TPR) under hydrogen has been used to correlate the catalytic activity with the amount of easily reducible species. | MA LiJing SHI BingJie CUI MeiSheng WANG LinHong LI DianQing CHEN AiFan | 2008 | Science China Chemistry2008，51，3： | 0 |
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