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| 1 | Type 1 regulatory T cells: a new mechanism of periphera immune tolerance显示文摘对抗原的有免疫力的反应的缺乏,作为有免疫力的忍耐知道的一个过程,为有免疫力的动态平衡的保藏是必要的。迄今为止,驾驶有免疫力的忍耐的二机制广泛地被描述了:中央忍耐和外部忍耐。在新名称下面,导出胸腺的规章的 T (tT reg ) 房间是中央有免疫力的忍耐的主要调停人,而外围地发源规章的 T (磅 reg ) 房间工作调整外部有免疫力的忍耐。T reg 房间,称为它 reg , 仅仅代表在里面导致 vitro 的 T reg 房间 1 。取决于房间是否稳定地表示 Foxp3,磅 reg , 和它 reg 房间可以被划分成二个子集:古典 CD4 + Foxp3 + T reg 房间和 CD4 + Foxp3 − 类型 1 规章的 T (Tr1 ) 房间 2 。这评论集中于发现,联系 biomarkers,规章的功能,正式就职的方法,有疾病的协会,和 Tr1 房间的临床的试用。 | Hanyu Zeng Rong Zhang Boquan Jin Lihua Chen | 2015 | Cellular & Molecular Immunology2015，12，5： | 19 |
| 2 | A novel interface consisting of homologous immunoglobulin superfamily members with multiple functions显示文摘Immunoglobulin superfamily(IgSF)members account for a large proportion of cell adhesion molecules that perform important immunological functions,including recognizing a variety of counterpart molecules on the cell surface or extracellular matrix.The findings that CD155/poliovirus receptor(PVR)and CD112/nectin-2 are the ligands for CD226/platelet and T-cell activation antigen 1(PTA1)/DNAX accessory molecular-1(DNAM-1),CD96/tactile and Washington University cell adhesion molecule(WUCAM)and that CD226 is physically and functionally associated with lymphocyte function-associated antigen-1(LFA-1)on natural killer(NK)and activated T cells have largely expanded our knowledge about the functions of CD226,CD96,WUCAM and LFA-1 and their respective ligands,CD155,CD112,intercellular adhesion molecule(ICAM)-1 and junctional adhesion molecule(JAM)-1.The interactions of these receptors and their ligands are involved in many key functions of immune cells including naive T cells,cytotoxic T cells,NK cells,NK T cells,monocytes,dendritic cells,mast cells and platelets/megakaryocytes. | Zhuwei Xu Boquan Jin | 2010 | Cellular & Molecular Immunology2010，7，1： | 8 |
| 3 | Characterization of the neutralizing activity of three anti-human TNF monoclonal antibodies and prediction of their TNF epitopes by molecular modeling and mutant protein approach显示文摘 | Cansheng Zhu Xuesong Liu Jiannan Feng Wei Zhang Beifen Shen Weiming Ou'yang Yunxin Cao Boquan Jin | 2006 | 中国生物学文摘2006，20，1： | 5 |
| 4 | High-energy all-fiber gain-switched thulium-doped fiber laser for volumetric photoacoustic imaging of lipids显示文摘We demonstrate a high-energy all-fiber short wavelength gain-switched thulium-doped fiber laser for volumetric photoacoustic(PA)imaging of lipids.The laser cavity is constructed by embedding a short piece of gain fiber between a pair of fiber Bragg gratings(FBGs).Through using three pairs of FBGs with operation wavelengths at1700,1725,and 1750 nm,three similar lasers are realized with a cavity length of around 25 cm.Under a maximum pump energy of 300μJ at 1560 nm,laser pulse energies of 58.2,66.8,and 75.3μJ are,respectively,achieved with a minimum pulse width of<16.7 ns at a repetition rate of 10 kHz.Volumetric imaging of lipids is validated through scanning a fat beef slice with a PA microscopy system incorporated with the newly developed source,and a lateral resolution of 18.8μm and an axial resolution of 172.9μm are achieved.Moreover,the higher shooting speed of the developed source can potentially allow for increasing at twice the frame rate of current intravascular PA imaging. | CAN LI JIAWEI SHI XIATIAN WANG BOQUAN WANG XIAOJING GONG LIANG SONG KENNETH K.Y.WONG | 2020 | Photonics Research2020，8，2： | 4 |
| 5 | Sema 4D/CDlOO-plexin B is a multifunctiona counter-receptor显示文摘 | Yusi Zhang Bei Liu Ying Ma Boquan Jin | 2013 | Cellular & Molecular Immunology2013，10，2： | 3 |
| 6 | Pore Size Distribution and Its Quantitative Relationship with Strength of Corundum Based Castables显示文摘A series of corundum based castables with 0,2%,4%,6%,and 8% α-Al2O3 micropowders were prepared using tabular alumina aggregates (6-3,3-1 and ≤1 mm) and fines (≤0.088 and ≤0.045 mm),calcium aluminate cement,and α-Al2O3 micropowders (d50=1.754 μm) as starting materials. Cold mechanical strength and pore size distribution of the castables specimens after heat treatment at 110,1 100 and 1 500 ℃ were tested,respectively. The quantitative relationship between strength and apparent porosity,and that between strength and median pore diameter were verified by Atzeni equation. The correlation between interval of pore size and mechanical strength of specimens was also studied by means of gray relational theory. The results show that:(1) the pore size distribution of castables is strongly influenced by both micropowders filling and matrix sintering; the addition of micropowders decreases median pore diameter while the sintering process increases it; (2) when adding a constant correction term,Atzeni equation can substantially describe the quantitative relationship between median pore diameter and strength of castables specimens after heat treatment at the same temperature; the significant differences of the gray relational degree between the interval of pore size and castables strength are characterized; it is also found that for the same interval of pore size,the gray relational degree isaffected by the heat treatment temperature; the pore size interval <0.5 μm has the highest gray relational degree with the strength at 110-1 500 ℃. | FANG Binxiang ZHU Boquan LI Xiangcheng WAN Hongbo | 2010 | China's Refractories2010，19，4： | 2 |
| 7 | Numerical simulation of excess-enthalpy combustion flame propagation of coal mine methane in ceramic foam显示文摘Based on the assumption of a local non-equilibrium of heat transfer between a solid matrix and gas,a mathematic model of coal mine methane combustion in a porous medium was established,as well the solid-gas boundary conditions.We simulated numerically the flame propagation characteristics.The results show that the flame velocity in ceramic foam is higher than that of free laminar flows;the maximum flame velocity depends on the combined effects of a radiation extinction coefficient and convection heat transfer in ceramic foam and rises with an increase in the chemical equivalent ratio.The radiation extinction coefficient cannot be used alone to determine the heat regeneration effects in the design of ceramic foam burners. | SONG, Zhengchang LIN, Boquan | 2010 | Mining Science and Technology2010，20，2： | 2 |
| 8 | Synthesis and electrochemical performance of La-doped Li_3V_(2-x)La_x(PO_4)_3 cathode materials for lithium batteries显示文摘La-doped Li3V2-xLax(PO4)3 (x=0.01,0.02,and 0.03) cathode materials for lithium ion batteries were synthesized by the microwave-assisted carbothermal reduction method (MW-CTR).The structures and properties of the prepared samples were investigated by X-ray diffraction (XRD) and electrochemical measurements.The results showed that all the three Li3V2-xLax(PO4)3 samples had the same monoclinic structures and sharper diffraction peaks of the crystal plane compared with those of the undoped Li3V2(PO4)3.The initial charge/discharge specific capacity,coulomb efficiency,and discharge decay rate of all the three Li3V2-xLax(PO4)3 samples were superior to those of the undoped Li3V2(PO4)3 sample,and the Li3V1.98La0.02(PO4)3 sample exhibited the best features among the three La-doped Li3V2-xLax(PO4)3 samples.Electrochemical impedance spectroscopy (EIS) demonstrated that the Li3V1.98La0.02(PO4)3 sample had a lower charge transfer resistance and a higher Li ion diffusion coefficient compared with the undoped Li3V2(PO4)3 sample. | JIANG Boquan HU Shufen WANG Minwei OUYANG Xiaoping GONG Zhenyu | 2011 | Rare Metals2011，30，2： | 2 |
| 9 | Influence of Dispersants on Flow Ability of Colloidal Alumina Bonded Corundum Castables显示文摘In order to make corundum castables satisfy more severe service conditions in high temperature industries,colloidal alumina due to the same main component with corundum castables was introduced for a pure binding system.The influence of three dispersants(citric acid,FS10 and urea)on the flow ability of colloidal alumina bonded corundum castables was researched to choose a suitable dispersant for solving the shaping problem.In order to further understand the influence of dispersants on the flow ability and the mechanism,the rheological property and Zeta potential value of the colloidal aluminadispersant system and the matrix-colloidal alumina-urea-water system were tested.The results show the castables added with the urea have the best flow ability,and the appropriate addition of the urea is 0.5%. | ZHANG Xiaohui YU Xingguo WANG Baoyu ZHU Boquan | 2019 | China's Refractories2019，28，4： | 1 |
| 10 | Selective Synthesis of Dimethylamine Over Rare Earth Modified Mordenites显示文摘 | QIU ZUMIN LI FENGYI JIANG BOQUAN | 1998 | Journal of Natural Gas Chemistry1998，7，4： | 1 |
| 11 | Synthesis and hydra- tion kinetics of calcium aluminate cement with micro MgA12 04 spi- nels 显示文摘 | Zhu Boquan Song Yanan Li Xiangcheng | 2015 | Mater Chem Phys2015，154，： | 1 |
| 12 | PMTED: a plant miRNA target expression database显示文摘 | Xiuli S Boquan D Lingjie Y | 2013 | BMC Bioinf2013，14，： | 1 |
| 13 | Effect of ceramic bonding phases on the thermo-mechanical properties of Al 2 O 3 –C refractories显示文摘 | Boquan Zhu Yuenan Zhu Xiangcheng Li Fei Zhao | 2013 | Ceramics International2013，，6： | 1 |
| 14 | Enzyme-linked immunosorbent assay of changes in serum levels of growth hormone(cGH)in common carps(Cyprinus carpio)显示文摘The aim of the present study was to purify the common native carp growth hormone (ncGH), produce monoclonal antibodies (mAbs) to common native carp growth hormone (ncGH), and further enhance the sensitivity of enzyme-linked immunosorbent assays (ELISA) for ncGH. Additionally, we investigated changes in serum ncGH levels in carps raised in different environmental conditions. The recombinant grass carp (Ctenopharyngodon idella) growth hormone was purified and used as antigen to immunize the rabbit. The natural ncGH was isolated from the pituitaries of common carp. SDS-PAGE and Western blot utilizing the polyclonal anti-rgcGH antibody confirmed the purification of ncGH from pituitaries. Purified ncGH was then used as an immunogen in the B lymphocyte hybridoma technique. A total of 14 hybridoma cell lines (FMU-cGH 1-14) were established that were able to stably secrete mAbs against ncGH. Among them, eight clones (FMU-cGH1-6, 12 and 13) were successfully used for Western blot while nine clones (FMU-cGH 1-7, 9 and 10) were used in fluorescent staining and immunohistochemistry. Epitope mapping by competitive ELISA demonstrated that these mAbs recognized five different epitopes. A sensitive sandwich ELISA for detection of ncGH was developed using FMU-cGH12 as the coating mAb and FMU-cGH6 as the enzyme labeled mAb. This detection system was found to be highly stable and sensitive, with detection levels of 70 pg/mL. Additionally, we found that serum ncGH levels in restricted food group and in the net cage group increased 6.9-and 5.8-fold, respectively, when compared to controls, demonstrating differences in the GH stress response in common carp under different living conditions. | WU Gang CHEN LiHua ZHONG Shan LI Qi SONG ChaoJun JIN BoQuan ZHU ZuoYan | 2008 | Science China(Life Sciences)2008，51，2： | 1 |
| 15 | Experimental investigation of reinforced concrete t-beams strengthened with steel wire mesh embedded in polymer mortar overlay 显示文摘 | Xing Guohua Wu Tao Liu Boquan | 2010 | Advances in Structural Engineering2010，13，1： | 1 |
| 16 | Effect of initial microstructure on the hot compression deformation behavior of a 2219 aluminum alloy显示文摘 | Jing Zhang Boquan Chen Zhang Baoxiang | 2011 | Materials and Design2011，，： | 1 |
| 17 | Thrombopoietin induced proliferation and differentiation of fetal liver CD34^+ cells with phenotype change from hemopoiesis to neurogenesis显示文摘BACKGROUND: Previous studies have reported a neurotrophin-like motif in the N-terminal receptor binding region of the thrombopoietin (TPO) molecule, and have described localization of TPO and TPO receptor in the brain. Therefore, it is believed that TPO may be involved in regulation of neurogenesis. OBJECTIVE: To validate the effect of TPO on trans-differentiation, or differentiation from hematopoietic stem cells (HSCs) to neural stem cells (NSCs). DESIGN, TIME AND SETTING: Comparative studies were performed from March 2004 to April 2007 at the Department of Experimental Medicine, Northern Hospital, and the Department of Immunology, Fourth Military Medical University of Chinese PLA. MATERIALS: Human fetal liver (FL) was obtained from fetuses after water-balloon abortion. Gestational age ranged from 16 to 20 weeks. The study was approved by the Institutional Review Board and Ethics Committee of the Northern Hospital. TPO was kindly provided by Genentech Inc (USA). Iscove's Modified Dulbecco's Medium (IMDM) and neurobasalTM medium were purchased from Invitrogen (USA). MACS CD34 multisort kit was purchased from Miltenyi Biotec (Germany). METHODS: CD34+ cells were isolated from human FL mononuclear cells using MACS CD34 multisort kit and cultured at 1 × 105/mL in IMDM, containing TPO for 60 days with weekly changes of half of the medium. After culturing for 30 and 60 days, the TPO-induced cells were resuspended in neurobasalTM medium containing 10% fetal brain extracts and plated in an 8-well BIOCOAT poly-D-Lysine Culture Slide and cul- tured for another 7 days. MAIN OUTCOME MEASURES: Cell number, viability, phenotype and expression of hemopoiesis-related and neurogenesis-related proteins were examined by trypan blue exclusion with hemocytometer, immunoblot, immunocytochemistry and flow cytometry. RESULTS: After 60 days of induction with TPO, the cell number increased by 4.6-fold compared to the ini- tial culture. Although the proportion of the cells expressing the hemopoietic stem cell associated antigen (CD34) decreased steadily, both proportions of the cultured FL-derived CD34+ cells expressing CD41a and CD61 remained unchanged, which still accounted for 10%. Noticeably, the proportions of the cells express- ing nestin and epidermal growth factor receptor increased significantly (both > 50%), whereas the expression of more mature neural or glial proteins [microtubule-associated protein-2 (MAP2), glial fibrillary acidic pro- tein (GFAP), oligodendrocyte marker O4 (O4)] markers on the cultured fetal liver derived-CD34+ cells were at lower levels. After another 7 days incubation in neurobasal? medium, these TPO-induced cells formed neurospheres, which were labeled with nestin, and differentiated into cells with morphological characteristics of neurons, astrocytes and oligodendrocytes, which were labeled with MAP-2, GFAP, and O4, respectively. CONCLUSION: TPO can induce FL-derived HSCs to differentiate or trans-differentiate into NSCs and its progenitors. | Ning Ma Dongchu Ma Yi Tao Yinghui Sun Di Lin Huiying Yu Jinlong Jian Wei Jia Boquan Jin | 2008 | Neural Regeneration Research2008，3，4： | 1 |
| 18 | Optimization and kinetics of electroless Ni-P-B plating of quartz optical fiber显示文摘 | Boquan Jiang Lin Xiao Shufen Hu | 2009 | Optical Materials2009，31，： | 1 |
| 19 | Postt- ranslational modifications of P27^kipl determine its binding specificity to different cyclins and cyclin-dependent kinases in vivo 显示文摘 | Zhang Wenqing Bergamaschi D Jin Boquan | 2005 | Blood2005，105，： | 1 |
| 20 | Optimization and kinetics of electroless Ni-P-B plating of quartz optical fiber显示文摘 | Boquan Jiang Lin Xiao Shufen Hu | 2009 | Optical Materials2009，，31： | 1 |
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