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| 1 | 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents显示文摘Syncope belongs to the transient loss of consciousness(TLOC), characterized by a rapid onset, short duration, and spontaneous complete recovery. It is common in children and adolescents, accounting for 1% to 2% of emergency department visits.Recurrent syncope can seriously affect children's physical and mental health, learning ability and quality of life and sometimes cardiac syncope even poses a risk of sudden death. The present guideline for the diagnosis and treatment of syncope in children and adolescents was developed for guiding a better clinical management of pediatric syncope. Based on the globally recent development and the evidence-based data in China, 2018 Chinese Pediatric Cardiology Society(CPCS) guideline for diagnosis and treatment of syncope in children and adolescents was jointly prepared by the Pediatric Cardiology Society, Chinese Pediatric Society, Chinese Medical Association(CMA)/Committee on Pediatric Syncope, Pediatricians Branch, Chinese Medical Doctor Association(CMDA)/Committee on Pediatric Cardiology, Chinese College of Cardiovascular Physicians, Chinese Medical Doctor Association(CMDA)/Pediatric Cardiology Society, Beijing Pediatric Society, Beijing Medical Association(BMA). The present guideline includes the underlying diseases of syncope in children and adolescents, the diagnostic procedures, methodology and clinical significance of standing test and headup tilt test, the clinical diagnosis vasovagal syncope, postural orthostatic tachycardia syndrome, orthostatic hypotension and orthostatic hypertension, and the treatment of syncope as well as follow-up. | Cheng Wang Yaqi Li Ying Liao Hong Tian Min Huang Xiangyu Dong Lin Shi Jinghui Sun Hongfang Jin Junbao Du Jindou An Jie Chen Mingwu Chen Qi Chen Sun Chen Yonghong Chen Zhi Chen Adolphus Kai-tung Chau Junbao Du Zhongdong Du Junkai Duan Hongyu Duan Xiangyu Dong Lin Feng Lijun Fu Fangqi Gong Yonghao Gui Ling Han Zhenhui Han Bing He Zhixu He Xiufen Hu Yimin Hua Guoying Huang Min Huang Ping Huang Yujuan Huang Hongfang Jin Mei Jin Bo Li Fen Li Tao Li Xiaohui Li Xiaoyan Liu Yan Li Haitao Lv Tiewei Lv Zipu Li Luyi Ma Silin Pan Yusheng Pang Hua Peng Yuming Qin Jie Shen Lin Shi Kun Sun Jinghui Sun Hong Tian Jie Tian Cheng Wang Hong Wang Lei Wang Jinju Wang Wendi Wang Yuli Wang Rongzhou Wu Tianhe Xia Yanyan Xiao Chunhong Xie Yanlin Xing Zhenyu Xiong Baoyuan Xu Yi Xu Hui Yan Shiwei Yang Qijian Yi Xia Yu Xianyi Yu Yue Yuan Hongyan Zhang Huili Zhang Li Zhang Qingyou Zhang Xi Zhang Yanmin Zhang Zhiwei Zhang Cuifen Zhao Bin Zhou Hua Zhu | 2018 | Science Bulletin2018，63，23： | 54 |
| 2 | A study on the Dushiling tungsten-copper deposit in the Miao'ershan-Yuechengling area, Northern Guangxi, China:Implications for variations in the mineralization of multi-aged composite granite plutons显示文摘The polymetallic Dushiling W-Cu deposit is a large, altered, skarn-type deposit, located in the northeastern part of the Miao'ershan-Yuechengling pluton, China. Two types of granite have been identified in the deposit: a medium-grained porphyritic biotite granite, and a medium- to fine-grained biotite granite. Both are spatially and temporally related to ore bodies, suggesting they may be the source of mineralization in the deposit. A medium- to fine-grained porphyritic biotite granite is exposed at the surface in the region of mineralization. U-Pb dating of zircons yielded magmatic ages of 423 Ma for the medium-grained porphyritic biotite granite and 421 Ma for the medium- to fine-grained porphyritic biotite granite, while a younger age(217 Ma) obtained for surface samples indicates later diagenesis. Thus, magmatism occurred during the Caledonian and Indosinian, respectively. The petrological and geochemical characteristics of the two Caledonian granites show that both are calc-alkaline and peraluminous.They are moderately enriched in Cs, Rb, U, and REE, and strongly depleted in Sr,Ba,P,and Ti; they show similar REE behavior,including negative Eu anomalies. These geochemical similarities suggest that the two granites were derived from the same source,although they were emplaced during different stages of the evolution of the magma. Furthermore, the granites are associated with mineralization, suggesting they were the source of mineralization in the Dushiling W-Cu deposit. Sm-Nd ages of scheelite from the Dushiling W-Cu deposit indicate that metallogenesis occurred at 417±35 Ma, while the two types of titanite, intergrown with scheelite, yield U-Pb ages of 423–425 Ma(in altered granite sample) and 218 Ma(in skarn sample). These ages place the main mineralization event in the late Caledonian, and later magmatic-hydrothermal activity occurred in the Indosinian. The ages obtained for the Dushiling W-Cu deposit in the western Nanling Range, northern Yuechengling, together with the occurrence and ages of the Niutangjie W deposit in southern Yuechengling, provide insight into the process of ore concentration during the Caledonian and Indosinian. | CHEN WenDi ZHANG WenLan WANG RuCheng CHU ZhuYin XIAO Rong ZHANG Di CHE XuDong | 2016 | Science China Earth Sciences2016，59，11： | 10 |
| 3 | A New Potential Caledonian–Indosinian Ore Concentration Area:Evidence from Diagenesis and Mineralization Ages of the Miao'ershan–Yuechengling Region显示文摘Objective The Miao’ershan–Yuechengling composite granite,located in northern Guangxi at the western section of the Nanling Range,is a multi-period and multi-stage composite pluton with an exposed area of more than 3000km2(Fig.1).Paleozoic and Proterozoic strata are exposed around it,and magmatic activities mainly occurred | ZHANG Wenlan CHE Xudong CHEN Wendi WANG Rucheng ZHANG Di | 2017 | Acta Geologica Sinica(English Edition)2017，91，2： | 3 |
| 4 | Attenuation ofβ-Amyloid Toxicity In Vitro and In Vivo by Accelerated Aggregation显示文摘Accumulation and aggregation of β-amyloid(Aβ) peptides result in neuronal death, leading to cognitive dysfunction in Alzheimer's disease. The self-assembled Aβ molecules form various intermediate aggregates including oligomers that are more toxic to neurons than the mature aggregates, including fibrils. Thus, one strategy to alleviate Aβ toxicity is to facilitate the conversion of Aβ intermediates to larger aggregates such as fibrils. In this study, we designed a peptide named A3 that significantly enhanced the formation of amorphous aggregates of Aβ by accelerating the aggregation kinetics. Thioflavin T fluorescence experiments revealed an accelerated aggregation of Aβ monomers, accompanying reduced Aβ cytotoxicity. Transgenic Caenorhabditis elegans over-expressing amyloid precursor protein exhibited paralysis due to the accumulation of Aβ oligomers, and this phenotype was attenuated by feeding the animals with A3 peptide. These findings suggest that the Aβ aggregation-promotion effect can potentially be useful for developing strategies to reduce Aβ toxicity. | Aihua Yang Chenxuan Wang Baomin Song Wendi Zhang Yuanyuan Guo Rong Yang Guangjun Nie Yanlian Yang Chen Wang | 2017 | Neuroscience Bulletin2017，33，4： | 3 |
| 5 | Rapid isolation and immune profiling of SARS-CoV-2 specific memory B cell in convalescent COVID-19 patients via LIBRA-seq显示文摘B cell response plays a critical role against SARS-CoV-2 infection.However,little is known about the diversity and frequency of the paired SARS-CoV-2 antigen-specific BCR repertoire after SARS-CoV-2 infection.Here,we performed single-cell RNA sequencing and VDJ sequencing using the memory and plasma B cells isolated from five convalescent COVID-19 patients,and analyzed the spectrum and transcriptional heterogeneity of antibody immune responses.Via linking BCR to antigen specificity through sequencing(LIBRA-seq),we identified a distinct activated memory B cell subgroup(CD11c^(high) CD95^(high))had a higher proportion of SARS-CoV-2 antigen-labeled cells compared with memory B cells.Our results revealed the diversity of paired BCR repertoire and the non-stochastic pairing of SARS-CoV-2 antigen-specific immunoglobulin heavy and light chains after SARS-CoV-2 infection.The public antibody clonotypes were shared by distinct convalescent individuals.Moreover,several antibodies isolated by LIBRA-seq showed high binding affinity against SARS-CoV-2 receptor-binding domain(RBD)or nucleoprotein(NP)via ELISA assay.Two RBD-reactive antibodies C14646P3S and C2767P3S isolated by LIBRA-seq exhibited high neutralizing activities against both pseudotyped and authentic SARS-CoV-2 viruses in vitro.Our study provides fundamental insights into B cell response following SARS-CoV-2 infection at the single-cell level. | Bing He Shuning Liu Yuanyuan Wang Mengxin Xu Wei Cai Jia Liu Wendi Bai Shupei Ye Yong Ma Hengrui Hu Huicui Meng Tao Sun Yanling Li Huanle Luo Mang Shi Xiangjun Du Wenjing Zhao Shoudeng Chen Jingyi Yang Haipeng Zhu Yusheng Jie Yuedong Yang Deyin Guo Qiao Wang Yuwen Liu Huimin Yan Manli Wang Yao-Qing Chen | 2021 | Signal Transduction and Targeted Therapy2021，6，6： | 2 |
| 6 | An Interaction of Race and Ethnicity With Socioeconomic Status in Rectal Cancer Outcomes显示文摘 | Joseph Kim Avo Artinyan Brian Mailey Stefanie Christopher Wendy Lee Shaun McKenzie Steven L. Chen Smita Bhatia Alessio Pigazzi Julio Garcia-Aguilar | 2011 | Annals of Surgery2011，，4： | 2 |
| 7 | Evidence for oxygenation of Fe-Mg oxides at mid-mantle conditions and the rise of deep oxygen显示文摘As the reaction product of subducted water and the iron core,FeO2 with more oxygen than hematite(Fe_(2)O_(3))has been recently recognized as an important component in the D'layer just above the Earth’s core-mantle boundary.Here,we report a new oxygen-excess phase(Mg,Fe)_(2)O_(3)+δ(0<δ<1,denoted as‘OE-phase’).It forms at pressures greater than 40 gigapascal when(Mg,Fe)-bearing hydrous materials are heated over 1500 kelvin.The OE-phase is fully recoverable to ambient conditions for ex situ investigation using transmission electron microscopy,which indicates that the OE-phase contains ferric iron(Fe^(3+))as in Fe_(2)O_(3) but holds excess oxygen through interactions between oxygen atoms.The new OE-phase provides strong evidence that H_(2)O has extraordinary oxidation power at high pressure.Unlike the formation of pyrite-type FeO_(2)H_(x) which usually requires saturated water,the OE-phase can be formed with under-saturated water at mid-mantle conditions,and is expected to be more ubiquitous at depths greater than 1000 km in the Earth’s mantle.The emergence of oxygen-excess reservoirs out of primordial or subducted(Mg,Fe)-bearing hydrous materials may revise our view on the deep-mantle redox chemistry. | Jin Liu Chenxu Wang Chaojia Lv Xiaowan Su Yijin Liu Ruilian Tang Jiuhua Chen Qingyang Hu Ho-Kwang Mao Wendy L.Mao | 2021 | National Science Review2021，8，4： | 2 |
| 8 | Ranibizumab for Macular Edema following Central Retinal Vein Occlusion显示文摘 | David M. Brown Peter A. Campochiaro Rishi P. Singh Zhengrong Li Sarah Gray Namrata Saroj Amy Chen Rundle Roman G. Rubio Wendy Yee Murahashi | 2010 | Ophthalmology2010，，6： | 2 |
| 9 | Annual Report of PR Industry Survey 2007显示文摘Under the supervision of PR Agencies Committee of China International Pub-lic Relations Association(CIPRA),the PR Industry Survey 2007 has been conducted by Research&Development section of CIPRA from January 21st to March 20th among the PR firms in Beijing,Shanghai。 | Wendy Chen John Chen | 2008 | 国际公关2008，，5： | 1 |
| 10 | QoS-aware routing based on bandwidth estimation for mobile Ad Hoc networks显示文摘 | Chen L Heinzelman Wendi B | 2005 | IEEE Journal on Selected Areas in Communications2005，23，2： | 1 |
| 11 | Global Stability of a population Dispe In a Two-Patch Environment显示文摘 | Wendi Wang lansuen Chen and Zhengyi Lu | 1997 | Dynamic systems and Applications1997，6，： | 1 |
| 12 | Identification and Cloning of an Orphan G Protein-Coupled Receptor of the Glycoprotein Hormone Receptor Subfamily显示文摘 | Terry McDonald Ruiping Wang Wendy Bailey Guochun Xie Fang Chen C.Thomas Caskey Qingyun Liu | 1998 | Biochemical and Biophysical Research Communications1998，，2： | 1 |
| 13 | QoS-aware Routing Based on Bandwidth Estimation for Mobile Ad Hoc Networks 显示文摘 | Lei Chen Wendi Heinzelman | 2005 | IEEE Journal on Selected Areas in Communications (S0733-8716)2005，23，3： | 1 |
| 14 | A predator-prey system with stage-structure for predator显示文摘 | Wang Wendi Chen Lansun | 1997 | Computers Math Applic1997，33，8： | 1 |
| 15 | A predator-prey sys- tem with stage-structure for predator显示文摘 | WANG Wendi CHEN Lansun | 1977 | Computers Mathematics with Applications1977，33，8： | 1 |
| 16 | A predator-prey system with stage-structure for predator显示文摘 | Wang Wendi Chen Lansun | 1997 | Computers Math Applic1997，，8： | 1 |
| 17 | Fo Shou San, an Ancient Herbal Decoction Prepared from Angelicae Sinensis Radix and Chuanxiong Rhizoma, Induces Erythropoietin Expression: A Signaling Mediated by the Reduced Degradation of Hypoxia-Inducible Factor in Cultured Liver Cells显示文摘 | Cathy Bi Li Xu Wendy Zhang Janis Zhan Qiang Fu Ken Zheng Vicky Chen David Lau Roy Choi Tie Wang Tina Dong Karl Tsim | 2012 | Planta Med2012，，02： | 1 |
| 18 | Association of Novel Genetic Loci With Circulating Fibrinogen Levels: A Genome-Wide Association Study in 6 Population-Based Cohorts显示文摘 | Abbas Dehghan Qiong Yang Annette Peters Saonli Basu Joshua C. Bis Alicja R. Rudnicka Maryam Kavousi Ming-Huei Chen Jens Baumert Gordon D.O. Lowe Barbara McKnight Weihong Tang Moniek de Maat Martin G. Larson Susana Eyhermendy Wendy L. McArdle Thomas Lumley | 2009 | Circulation: Cardiovascular Genetics2009，，2： | 1 |
| 19 | Management of acral myxoinflammatory fibroblastic sarcoma 显示文摘 | Ajay Tejwani Wendy Kobayashi Yen-Lin Evelyn Chen | 2010 | Cancer2010，116，： | 1 |
| 20 | Characterizing Alzheimer’s disease using a hypometabolic convergence index显示文摘 | Kewei Chen Napatkamon Ayutyanont Jessica B.S. Langbaum Adam S. Fleisher Cole Reschke Wendy Lee Xiaofen Liu Dan Bandy Gene E. Alexander Paul M. Thompson Leslie Shaw John Q. Trojanowski Clifford R. Jack Susan M. Landau Norman L. Foster Danielle J. Harvey Mi | 2011 | Neuroimage2011，，1： | 1 |
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