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| 1 | Analytical geometry method of planetary gear trains显示文摘This paper presents an analytical geometry method for kinematics and efficiency of planetary gear trains (PGTs). The novel method which is capable of evolution and contrast analysis of mechanism kinematics, can be applied to any typical one-and two-degree-of-freedom plane PGTs containing any number of simple, compound or complex-compound planetary gear sets. The efficiency analysis of this method features a systematized and programmed process and its independence of the speed ratio. The primary contribution of this work lies in the integration of quantitative calculation, qualitative evolution and comparative analysis of kinematics of PGTs into one diagram, and in the integration of kinematics and efficiency analysis into a single method system. First, the analytical geometry method is defined, its basic properties are given, and the systematization procedure to perform kinematic analysis is demonstrated. As an application, analytical geometry diagrams of common PGTs are exhibited in the form of a list, whose kinematic characteristics and general evolution tendency are discussed. Then, with the mapping of PGTs onto the angular speed plane, the efficiency formula of analytical geometry, which has an extremely concise form, and a simple method for power flow estimation are put forward. Moreover, a general procedure is provided to analyze the efficiency and power flow. Finally, four numerical examples including a complicated eleven-link differential PGTs are given to illustrate the simpleness and intuitiveness of the analytical geometry method. | CHEN XiaoAn CHEN Hong | 2012 | Science China(Technological Sciences)2012，55，4： | 6 |
| 2 | Synergistic antitumor activity of artesunate and HDAC inhibitors through elevating heme synthesis via synergistic upregulation of ALAS1 expression显示文摘Artemisinin and its derivatives(ARTs) were reported to display heme-dependent antitumor activity. On the other hand, histone deacetylase inhibitors(HDACi) were known to be able to promote heme synthesis in erythroid cells. Nevertheless, the effect of HDACi on heme homeostasis in nonerythrocytes remains unknown. We envisioned that the combination of HDACi and artesunate(ARS)might have synergistic antitumor activity through modulating heme synthesis. In vitro studies revealed that combination of ARS and HDACi exerted synergistic tumor inhibition by inducing cell death. Moreover, this combination exhibited more effective antitumor activity than either ARS or HDACi monotherapy in xenograft models without apparent toxicity. Importantly, mechanistic studies revealed that HDACi coordinated with ARS to increase 5-aminolevulinate synthase(ALAS1) expression, and subsequent heme production, leading to enhanced cytotoxicity of ARS. Notably, knocking down ALAS1 significantly blunted the synergistic effect of ARS and HDACi on tumor inhibition, indicating a critical role of ALAS1 upregulation in mediating ARS cytotoxicity. Collectively, our study revealed the mechanism of synergistic antitumor action of ARS and HDACi. This finding indicates that modulation of heme synthesis pathway by the combination based on ARTs and other heme synthesis modulators represents a promising therapeutic approach to solid tumors. | Cai-Ping Chen Kun Chen Zhiqi Feng Xiaoan Wen Hongbin Sun | 2019 | Acta Pharmaceutica Sinica B2019，9，5： | 4 |
| 3 | MULTI-AGENT COLLABORATIVE DESIGN SYSTEM MODEL BASED ON THE INTERNET AND EXPERIMENTS显示文摘Development of complicated products is a project of system engineering It involves extensive and complicated knowledge,design methods and auxiliary technology Various factors affect each other So,modern product development is a typical group problem with distributed and dynamic features It is apparent superiority to solve this problem with a multi agent system representing various knowledge domains Distributed artificial intelligence knowledge being used,the multi agent collaborative design system concept and model based on Internet environment are put forward The realizing method of product developing agents,interactive process among multi agents,and organization and implementing of the design project of the multi agent collaborative design system are discussed in detail Application examples are also presented. | Chen Xiaoan, Zheng Xiaoguang, Chen Bingkui (State Key Laboratory of Mechanical Transmission,Chongqing University) | 2001 | Chinese Journal of Mechanical Engineering2001，14，4： | 4 |
| 4 | The genome of Magnolia biondii Pamp. provides insights into the evolution of Magnoliales and biosynthesis of terpenoids显示文摘Magnolia biondii Pamp.(Magnoliaceae,magnoliids)is a phylogenetically,economically,and medicinally important ornamental tree species widely grown and cultivated in the north-temperate regions of China.Determining the genome sequence of M.biondii would help resolve the phylogenetic uncertainty of magnoliids and improve the understanding of individual trait evolution within the Magnolia genus.We assembled a chromosome-level reference genome of M.biondii using~67,~175,and~154Gb of raw DNA sequences generated via Pacific Biosciences single-molecule real-time sequencing,10X Genomics Chromium,and Hi-C scaffolding strategies,respectively.The final genome assembly was~2.22Gb,with a contig N50 value of 269.11 kb and a BUSCO complete gene percentage of 91.90%.Approximately 89.17%of the genome was organized into 19 chromosomes,resulting in a scaffold N50 of 92.86Mb.The genome contained 47,547 protein-coding genes,accounting for 23.47%of the genome length,whereas 66.48%of the genome length consisted of repetitive elements.We confirmed a WGD event that occurred very close to the time of the split between the Magnoliales and Laurales.Functional enrichment of the Magnolia-specific and expanded gene families highlighted genes involved in the biosynthesis of secondary metabolites,plant–pathogen interactions,and responses to stimuli,which may improve the ecological fitness and biological adaptability of the lineage.Phylogenomic analyses revealed a sister relationship of magnoliids and Chloranthaceae,which are sister to a clade comprising monocots and eudicots.The genome sequence of M.biondii could lead to trait improvement,germplasm conservation,and evolutionary studies on the rapid radiation of early angiosperms. | Shanshan Dong Min Liu Yang Liu Fei Chen Ting Yang Lu Chen Xingtan Zhang Xing Guo Dongming Fang Linzhou Li Tian Deng Zhangxiu Yao Xiaoan Lang Yiqing Gong Ernest Wu Yaling Wang Yamei Shen Xun Gong Huan Liu Shouzhou Zhang | 2021 | Horticulture Research2021，8，1： | 4 |
| 5 | Effects of tillage practices on nutrient loss and soybean growth in red-soil slope farmland显示文摘Field experiments were conducted to examine the effect of tillage practices on sediment and nutrient loss and soybean growth under natural rainfall conditions.Three tillage practices were applied:downslope ridge(check),downslope ridge+contour living hedgerow,and cross ridge.Cross ridge tillage reduced surface runoff by 69%and sediment yield by 86%,compared to the check treatment.The downslope ridge with a contour living hedgerow reduced surface runoff by 24%and sediment yield by 53%.Additionally,compared to the check plot,nutrient losses carried by runoff were reduced by over 68%and that carried in the sediment was reduced more than 85%in the cross ridge plot.Nutrient losses in runoff were reduced by 20%to 30%in the downslope ridge and contour living hedgerow plot and those carried in the sediment were reduced by 44%to 57%.Cross ridge tillage soybean yields exceeded those of the downslope ridge and downslope ridge+contour living hedgerow treatments by 16%-18%.Cross ridge tillage could contribute to the prevention sediment and nutrient loss and could improve crop yield,and thus it is recommended to be applied to mild slopes in the red soil region. | Yang Jie Zheng Haijin Chen Xiaoan Shen Le | 2013 | International Soil and Water Conservation Research2013，1，3： | 2 |
| 6 | Substrate stiffness-dependent regulatory volume decrease and calcium signaling in chondrocytes显示文摘The pericellular matrix stiffness is strongly associated with its biochemical and structural changes during the aging and osteoarthritis progress of articular cartilage.However,how substrate stiffness modulates the chondrocyte regulatory volume decrease(RVD)and calcium signaling in chondrocytes remains unknown.This study aims to investigate the effects of substrate stiffness on the chondrocyte RVD and calcium signaling by recapitulating the physiologically relevant substrate stiffness.Our results showed that substrate stiffness induces completely different dynamical deformations between the cell swelling and recovering progresses.Chondrocytes swell faster on the soft substrate but recovers slower than the stiff substrate during the RVD response induced by the hypo-osmotic challenge.We found that stiff substrate enhances the cytosolic Ca^(2+)oscillation of chondrocytes in the iso-osmotic medium.Furthermore,chondrocytes exhibit a distinctive cytosolic Ca^(2+)oscillation during the RVD response.Soft substrate significantly improves the Ca^(2+)oscillation in the cell swelling process whereas stiff substrate enhances the cytosolic Ca^(2+)oscillation in the cell recovering process.Our work also suggests that the TRPV4 channel is involved in the chondrocyte sensing substrate stiffness by mediating Ca^(2+)signaling in a stiffness-dependent manner.This helps to understand a previously unidentified relationship between substrate stiffness and RVD response under the hypo-osmotic challenge.A better understanding of substrate stiffness regulating chondrocyte volume and calcium signaling will aid the development of novel cell-instructive biomaterial to restore cellular functions. | Min Zhang Xiaoan Wu Genlai Du Weiyi Chen Quanyou Zhang | 2022 | Acta Biochimica et Biophysica Sinica2022，54，1： | 2 |
| 7 | Study of water in dough using nuclear magnetic resonance 显示文摘 | RUAN R ROGER XIAOAN WANG PAUL L CHEN | 1999 | Trends in Food and Technology1999，10，10： | 1 |
| 8 | Synthesis and applicationof polyepoxide cardanol glycidyl ether as biobased polyepoxidereactive diluent for epoxy resin显示文摘 | Chen Jie Nie Xiaoan Liu Zengshe | 2015 | ACS Sustainable Chemistry& Engineering2015，3，11： | 1 |
| 9 | Genetic variants at chromosome 9p21, 10p15 and 10q22 and breast cancer susceptibility in a Chinese population显示文摘 | Jiaping Chen Yue Jiang Xiaoan Liu Zhenzhen Qin Juncheng Dai Guangfu Jin Hongxia Ma Shui Wang Xinru Wang Zhibin Hu Hongbing Shen | 2012 | Breast Cancer Research and Treatment2012，，2： | 1 |
| 10 | Statistical determination of rainfal|-runoff erosivity indices for single storms in the Chinese Loess Plateau 显示文摘 | Zheng Mingguo Chen Xiaoan | 2015 | Plos One2015，10，17： | 1 |
| 11 | Identification and characterization of a novel subgenotype of bovine viral diarrhea virus isolated from dairy cattle in Northwestern China显示文摘 | Xiaowei Gong Xiaoan Cao Fuying Zheng Qiwei Chen Jizhang Zhou Hong Yin Lihong Liu Xuepeng Cai | 2013 | Virus Genes2013，，2： | 1 |
| 12 | NMR study of water in dough 显示文摘 | R Roger Ruan Xiaoan wang Paul L Chen | 1997 | Paper - American Society of Agricultural Engineers1997，，3： | 1 |
| 13 | Study of water in dough using nuclear magnetic resonance 显示文摘 | R Roger Ruan Xiaoan wang Paul L Chen | 1999 | Trendsin food and trchnology1999，10，10： | 1 |
| 14 | NMR study of water in dough显示文摘 | R Roger Ruan Xiaoan wang Paul L Chen | 1997 | Paper-American Society of Agricultural Engineers1997，，3： | 1 |
| 15 | NMR study of water in dough 显示文摘 | R Roger Ruan Xiaoan wang Paul L Chen | 1997 | Paper-American Society of Agricultural Engineers1997，，3： | 1 |
| 16 | Study of water in dough using nuclear magnetic resonance显示文摘 | R Roger Ruan Xiaoan wang Paul L Chen | 1999 | Trends in Food and Terchnology1999，10，10： | 1 |
| 17 | NMR study of water in dough显示文摘 | R Roger Ruan Xiaoan wang Paul L Chen | 1997 | J Paper-American Society of Agricultural Engineers1997，，3： | 1 |
| 18 | Study of water in dough using nuclear magnetic resonance显示文摘 | R Roger Ruan Xiaoan wang Paul L Chen | 1999 | J Trends in Food and Technology1999，，10： | 1 |
| 19 | NMR Sudy of Water in Dough 显示文摘 | RUAN R ROGER XIAOAN WANG PAUL L CHEN | 1997 | Paper-American Society of Agricultural Engineers1997，，3： | 1 |
| 20 | NMR study of water in dough 显示文摘 | R Roger Ruan Xiaoan wang Paul L Chen | 1997 | Paper-American Society of Agricultural Engineers1997，，3： | 1 |
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