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| 1 | Clinical significance of NOD2/CARD15 and Toll-like receptor 4 gene single nucleotide polymorphisms in inflammatory bowel disease显示文摘AIM: To evaluate the role of genetic factors in the pathogenesis of Crohn's disease (CD) and ulcerative colitis (UC), we investigated the single nucleotide poly- morphisms (SNPs) of NOD2/CARD15 (R702W, G908R and L1007fi nsC), and Toll-like receptor 4 (TLR4) genes (D299G and T399I) in a selected inflammatory bowel disease (IBD) population coming from Southern Italy. METHODS: Allele and genotype frequencies of NOD2/ CARD15 (R702W, G908R and L1007finsC) and TLR4 (D299G and T399I) SNPs were examined in 133 CD pa-tients, in 45 UC patients, and in 103 healthy controls. A genotype-phenotype correlation was performed. RESULTS: NOD2/CARD15 R702W mutation was sig-nificantly more frequent in CD (9.8%) than in controls (2.4%, P = 0.001) and in UC (2.3%, P = 0.03). No sig-nificant difference was found between UC patients and control group (P > 0.05). In CD and UC patients, no signifi cant association with G908R variant was found. L1007f insC SNP showed an association with CD (9.8%) compared with controls (2.9%, P = 0.002) and UC patients (2.3%, P = 0.01). Moreover, in CD patients, G908R and L1007finsC mutations were significantly associated with different phenotypes compared to CD wild-type patients. No association of IBD with the TLR4 SNPs was found in either cohort (allele frequencies: D299G-controls 3.9%, CD 3.7%, UC 3.4%, P > 0.05; T399I-controls 2.9%, CD 3.0%, UC 3.4%, P > 0.05). CONCLUSION: These findings confirm that, in our IBD patients selected from Southern Italy, the NOD2/ CARD15, but not TLR4 SNPs, are associated with in-creased risk of CD. | Luciana Rigoli Claudio Romano Rosario Alberto Caruso Maria A Lo Presti Chiara Di Bella Vincenzo Procopio Giuseppina Lo Giudice Maria Amorini Giuseppe Costantino Maria D Sergi Caterina Cuppari Giovanna Elisa Calabrò Romina Gallizzi Carmelo Damiano Salpietro Walter Fries | 2008 | World Journal of Gastroenterology2008，14，28： | 8 |
| 2 | Serum chromogranin-A in hepatocellular carcinoma: Diagnostic utility and limits显示文摘AIM: The utility of serum alpha-fetoprotein (α-FP) for the detection of hepatocellular carcinoma (HCC) is questionable.High serum levels of chromogranin-A (CgA) have recently been reported in HCC. Impaired hepatic, renal, and heart functions influence circulating CgA. The aim of this study was to assess sensitivity and specificity of serum CgA as a marker of HCC in patients with liver cirrhosis (LC).METHODS: Serum CgA levels were measured by RIA in 339 patients of which 54 HCC, 132 LC, 45 chronic hepatitis (CH), 27 chronic heart failure (CHF), 36 chronic renal failure (CRF), 45 chronic inflammatory bowel disease (IBD)as disease controls and in 75 healthy controls. Patients with liver disease or IBD and concomitant renal and/or heart failure were excluded. Pearson correlation, nonparametric combination test and confidence interval analysis were used for statistical analysis.RESULTS: Serum CgA above normal values (100 ng/mL)were found in 83% of HCC patients, in 48% of LC patients,in 20% of CH patients, in 33% of IBD patients, in 92% of CRF patients, in 100% of CHF patients, and in none of the healthy controls. The mean CgA values in HCC (769±1 046), in LC (249±369), in CH (87±94), in CRF (1 390±1 401), in CHF (577±539), in IBD (146±287) were significantly higher than those in healthy controls (48±18).HCC patients had higher CgA values (P<0.01) than LC,CH, and IBD patients but did not differ from those with CRF or CHF. The 95% CI for the mean (250-1 289 ng/mL)in HCC patients was selected as a CgA range and the lower value of such range was assumed as cut-off.Sensitivity and specificity of CgA, calculated in relation to the cut-off in patients with cirrhosis and HCC, were respectively 61% (CI 48-73%) and 82% (CI 75-88%).Serum α-FP values were >200 ng/mL in 21% of the HCC patients and in none of the LC patients. No significant correlation was found between α-FP and CgA in patients with HCC and in patients with cirrhosis.CONCLUSION: When HCC is suspected and α-FP is normal or <200 ng/mL, CgA serum values represent a complementary diagnostic tool, unless kidney or heart failure is present. | Aldo Spadaro Antonino Ajello Carmela Morace Agata Zirilli Graziella D'arrigo Carmelo Luigiano Francesco Martino Anna Bene Domenico Migliorato Santi Turiano Oscar Ferraù Maria Antonietta Freni | 2005 | World Journal of Gastroenterology2005，11，13： | 4 |
| 3 | Gastroesophageal reflux and congenital gastrointestinal malformations显示文摘Although the outcome of newborns with surgical congenital diseases(e.g.,diaphragmatic hernia;esophageal atresia;omphalocele;gastroschisis) has improved rapidly with recent advances in perinatal intensive care and surgery,infant survivors often require intensive treatment after birth,have prolonged hospitalizations,and,after discharge,may have longterm sequelae including gastro-intestinal comorbidities,above all,gastroesophageal reflux(GER).This condition involves the involuntary retrograde passage of gastric contents into the esophagus,with or without regurgitation or vomiting.It is a well-recognized condition,typical of infants,with an incidence of 85%,which usually resolves after physiological maturation of the lower esophageal sphincter and lengthening of the intra-abdominal esophagus,in the first few months after birth.Although the exact cause of abnormal esophageal function in congenital defects is not clearly understood,it has been hypothesized that common(increased intra-abdominal pressure after closure of the abdominal defect) and/or specific(e.g.,motility disturbance of the upper gastrointestinal tract,damage of esophageal peristaltic pump) pathological mechanisms may play a role in the etiology of GER in patients with birth defects.Improvement of knowledge could positively impact the long-term prognosis of patients with surgical congenital diseases.The present manuscript provides a literature review focused on pathological and clinical characteristics of GER in patients who have undergone surgical treatment for congenital abdominal malformations. | Lucia Marseglia Sara Manti Gabriella D'Angelo Eloisa Gitto Carmelo Salpietro Antonio Centorrino Gianfranco Scalfari Giuseppe Santoro Pietro Impellizzeri Carmelo Romeo | 2015 | World Journal of Gastroenterology2015，21，28： | 3 |
| 4 | Role of the diet as a link between oxidative stress and liver diseases显示文摘Oxidative stress is caused by an imbalance between the production of reactive oxygen(free radicals) and the body's ability(antioxidant capacity) to readily detoxify the reactive intermediates or easily repair the resulting damage. An adequate diet, characterized by daily intake of foods associated with improvementsin the total antioxidant capacity of individuals and reduced incidence of diseases related to oxidation, can modulate the degree of oxidative stress. In fact, dietderived micronutrients may be direct antioxidants, or are components of antioxidant enzymes, leading to improvement of some indicators of hepatic function. However, although their increased dietary intake might be beneficial, literature data are still controversial. This review summarizes what is known about the effects of diet nutrients on oxidative stress, inflammation and liver function. Moreover, we have analyzed:(1) the main nutritional components involved in the production and/or removal of free radicals; and(2) the role of free radicals in the pathogenesis of several hepatic diseases and related comorbidities. | Teresa Arrigo Salvatore Leonardi Caterina Cuppari Sara Manti Angela Lanzafame Gabriella D'Angelo Eloisa Gitto Lucia Marseglia Carmelo Salpietro | 2015 | World Journal of Gastroenterology2015，21，2： | 2 |
| 5 | Colorectal stenting as a bridge to surgery reduces morbidity and mortality in left-sided malignant obstruction: a predictive risk score-based comparative study显示文摘 | Vincenzo Cennamo Carmelo Luigiano Gianpiero Manes Rocco Maurizio Zagari Luca Ansaloni Carlo Fabbri Liza Ceroni Fausto Catena Antonio Daniele Pinna Lorenzo Fuccio Alessandro Mussetto Tino Casetti Federico Coccolini Nicola D’Imperio Franco Bazzoli | 2012 | Digestive and Liver Disease2012，，6： | 2 |
| 6 | Endoscopic ultrasound-guided fine needle aspiration with 22- and 25-gauge needles in solid pancreatic masses: A prospective comparative study with randomisation of needle sequence显示文摘 | Carlo Fabbri Anna Maria Polifemo Carmelo Luigiano Vincenzo Cennamo Paola Baccarini Guido Collina Adele Fornelli Sandro Macchia Nicola Zanini Elio Jovine Marta Fiscaletti Angela Alibrandi Nicola D’Imperio | 2011 | Digestive and Liver Disease2011，，8： | 1 |
| 7 | Polyphenol constituents and antioxidant activity of grape pomace extracts from five Siciian red grape cultivars 显示文摘 | Giuseppe R Agatino R Carmelo D | 2007 | Food Chem2007，100，1： | 1 |
| 8 | Thermodynamics and kinetics of the thermal unfolding of plastocyanin显示文摘 | Danilo Milardi Carmelo La Rosa Grasso D | 1998 | European Biophysics Journal1998，27，3： | 1 |
| 9 | WallFlex colonic stent placement for management of malignant colonic obstruction: a prospective study at two centers显示文摘 | Alessandro Repici Giuseppe De Caro Carmelo Luigiano Carlo Fabbri Nico Pagano Paoletta Preatoni Silvio Danese Lorenzo Fucci Pierluigi Consolo Alberto Malesci Nicola D’Imperio Vincenzo Cennamo | 2008 | Gastrointestinal Endoscopy2008，，1： | 1 |
| 10 | Intertrochanteric fractures: comparison between two different locking nails显示文摘 | Carmelo D'Arrigo Alessandro Carcangiu Dario Perugia Simone Scapel- lato Raffaella Alonzo Silvia Frontini Andrea Ferretti | 2012 | Zhongguo Gu Shang2012，36，12： | 1 |
| 11 | Measuring Pro- ductivity 显示文摘 | MASSIMO D G ADRIANA D L CARMELO P | 2011 | Journal of Economic Surveys2011，25，5： | 1 |
| 12 | Proton pump in- hibitors in GORD An overview of their pharmacology, efficacy and safety 显示文摘 | Savarino V Mario F D Carmelo S | 2009 | Pharmacological Research2009，59，3： | 1 |
| 13 | Polyphenol constituents and antioxidant activity of grape pomace ex- tracts from five Sicilian red grape cultivars显示文摘 | Giuseppe R Agatino R Carmelo D | 2007 | Food Chemistry2007，100，1： | 1 |
| 14 | 7-Year Survival Results of Perioperative Chemotherapy with Epidoxorubicin, Etoposide, and Cisplatin (EEP) in Locally Advanced Resectable Gastric Cancer: Up-to-date Analysis of a Phase-II Study显示文摘 | Roberto Persiani Stefano Rausei Carmelo Pozzo Alberto Biondi Carlo Barone Ferdinando C. M. Cananzi Giovanni Schinzari Domenico D’Ugo | 2008 | Annals of Surgical Oncology2008，，8： | 1 |
| 15 | Is land-use change a cause of loss of pedodiversity? The ease of the Mazzarrone study area, Sicily 显示文摘 | Giuseppe L P Vanessa P Carmelo D | 2011 | Geomorphology2011，135，： | 1 |
| 16 | Through-the-scope large diameter self-expanding metal stent placement as a safe and effective technique for palliation of malignant colorectal obstruction: A single center experience with a long-term follow-up显示文摘 | Carmelo Luigiano Francesco Ferrara Carlo Fabbri Stefania Ghersi Marco Bassi Paola Billi Anna Maria Polifemo Patrizia Landi Vincenzo Cennamo Pierluigi Consolo Carmela Morace Angela Alibrandi Nicola D'Imperio | 2011 | Scandinavian Journal of Gastroenterology2011，，5： | 1 |
| 17 | Through-the-scope large diameter self-expanding metal stent placement as a safe and effective technique for palliation of malignant colorectal obstruction: A single center experience with a long-term follow-up显示文摘 | Carmelo Luigiano Francesco Ferrara Carlo Fabbri Stefania Ghersi Marco Bassi Paola Billi Anna Maria Polifemo Patrizia Landi Vincenzo Cennamo Pierluigi Consolo Carmela Morace Angela Alibrandi Nicola D’Imperio | 2011 | Scandinavian Journal of Gastroenterology2011，，5： | 1 |
| 18 | Prevalence of celiac disease in adult patients with refractory functional dyspepsia:Value of routine duodenal biopsy显示文摘AIM: To investigate the prevalence of celiac disease (CD) in adult patients referred to an open access gas-troenterology clinic in the south of Italy and submitted to esophago-gastro-duodenoscopy (EGD) for evaluation of refractory functional dyspepsia.METHODS: Seven hundred and twenty six consecutive dyspeptic patients (282 male, 444 female; mean age 39.6 years, range 18-75 years) with unexplained prolonged dyspepsia were prospectively enrolled. Duo-denal biopsies were taken and processed by standard staining. Histological evaluation was carried out according to the Marsh-Oberhuber criteria.RESULTS: The endoscopic findings were: normal in 61.2%, peptic lesions in 20.5%, malignancies in 0.5%, miscellaneous in 16.7%. CD was endoscopically diagnosed in 8 patients (1.1%), histologically in 15 patients (2%). The endoscopic features alone showed a sensitivity of 34.8% and specificity of 100%, with a positive predictive value (PPV) of 100% and a negative predictive value (NPP) of 97.9%.CONCLUSION: This prospective study showed that CD has a high prevalence (1:48) in adult dyspeptic patients and suggests the routine use of duodenal biopsy in this type of patient undergoing EGD. | Emiliano Giangreco Cinzia D'agate Carmelo Barbera Lidia Puzzo Giuseppe Aprile Pietro Naso Giacomo Bonanno Alessandra Nicoletti Salvatore Incarbone Giuseppe Trama Antonio Russo Francesco Paolo Russo | 2008 | World Journal of Gastroenterology2008，14，45： | 1 |
| 19 | Surgical Treatment of Craniopharyngiomas:An Evaluation of the Transsphenoidaland and Pterional Approaches显示文摘 | Maira Giulio M D Anile Carmelo Rossi Gian Franco | 1995 | Neurosurgery1995，36，4： | 1 |
| 20 | Thermodynamics and kinetics of the thermal unfolding of plastocyanin显示文摘 | DaniloMilardi Carmelo La Rosa Grasso D | 1998 | European Biophysics Journal1998，27，3： | 1 |
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