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| 1 | The wonders of BMP9:From mesenchymal stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism to regenerative medicine显示文摘Although bone morphogenetic proteins(BMPs)initially showed effective induction of ectopic bone growth in muscle,it has since been determined that these proteins,as members of the TGF-b superfamily,play a diverse and critical array of biological roles.These roles include regulating skeletal and bone formation,angiogenesis,and development and homeostasis of multiple organ systems.Disruptions of the members of the TGF-b/BMP superfamily result in severe skeletal and extra-skeletal irregularities,suggesting high therapeutic potential from understanding this family of BMP proteins.Although it was once one of the least characterized BMPs,BMP9 has revealed itself to have the highest osteogenic potential across numerous experiments both in vitro and in vivo,with recent studies suggesting that the exceptional potency of BMP9 may result from unique signaling pathways that differentiate it from other BMPs.The effectiveness of BMP9 in inducing bone formation was recently revealed in promising experiments that demonstrated efficacy in the repair of critical sized cranial defects as well as compatibility with bone-inducing bio-implants,revealing the great translational promise of BMP9.Furthermore,emerging evidence indicates that,besides its osteogenic activity,BMP9 exerts a broad range of biological functions,including stem cell differentiation,angiogenesis,neurogenesis,tumorigenesis,and metabolism.This review aims to summarize our current understanding of BMP9 across biology and the body. | Sami Mostafa Mikhail Pakvasa Elam Coalson Allen Zhu Alex Alverdy Hector Castillo Jiaming Fan Alex Li Yixiao Feng Di Wu Elliott Bishop Scott Du Mia Spezia Alissa Li Ofir Hagag Alison Deng Winny Liu Mingyang Li Sherwin S·Ho Aravind Athiviraham Michael J·Lee Jennifer Moriatis Wolf Guillermo A·Ameer Hue H·Luu Rex C·Haydon Jason Strelzow Kelly Hynes Tong-Chuan He Russell R·Reid | 2019 | Genes & Diseases2019，6，3： | 15 |
| 2 | 查看详情显示文摘 | H?pfl H Farfán N Castillo D Santillan R Gutierrez A Daran J C | | 0，，： | 1 |
| 3 | Influence of salinity on germination and seeds viability of two primary colonizers of Mediterranean salt pans显示文摘 | Rubio-Casal A E Castillo J M Luque C J | 2003 | J Arid Environ2003，53，2： | 1 |
| 4 | Oleic and doc- osahexaenoic acid differentially phase separate from lipid raft mole- cules: a comparative NMR, DSC, AFM, and detergent extraction study 显示文摘 | SHAIKH S R DUMAUAL A C CASTILLO A | 2004 | Biophysical Journal2004，87，3： | 1 |
| 5 | Genetic profile characterization and segregation analysis of 10 X-STRs in a sample from Santander,Colombia显示文摘 | Pico A Castillo A Vargas C | 2008 | Int J Legal Med2008，122，4： | 1 |
| 6 | Influence of salinity on germination and seeds viability of two primary colonizers of Mediterranean salt pans显示文摘 | Rubio-Casal A E Castillo J M Luque C J | 2003 | Journal of Arid Environments2003，53，： | 1 |
| 7 | Development and use of a multiplex real-time quantitative polymerase chain reaction assay for detection and differentiation of porcine circovirus-2 genotypes 2a and 2b in an epidemiological survey显示文摘 | Gagnon C A Del Castillo J R Music N | 2008 | J Vet Diagn Invest2008，20，5： | 1 |
| 8 | Methodological improvement on local Gabor face recognition based on feature selec- tion and enhanced Borda count显示文摘 | Perez C A Cament L A Castillo L E | 2011 | Pattern Recognition2011，44，4： | 1 |
| 9 | Pitfalls of distal pancreatectomy for relief of pain in chronic pancreatitis显示文摘 | Rattner D W Fernandez-del Castillo C Warshaw A L | 1996 | Am J Surg1996，171，1： | 1 |
| 10 | Autoradiographic study of serotonin transporter during memory formation显示文摘 | Tellez R Rocha L Castillo C Meneses A | | 0，，： | 1 |
| 11 | Sensitivity analysis in ordered and restricted parameter models显示文摘 | Castillo E Castillo C Hadi A S | | 0，，6： | 1 |
| 12 | Luminescent properties of transparent nanostructured Eu3 + doped SnO2-SiO2 glass-ceramics prepared by the sol-gel method显示文摘 | Del Castillo J Rodríguez V D Yanes A C | 2005 | Nanotechnology2005，16，5： | 1 |
| 13 | On the protective mechanisms of nitric oxide in acute pancreatitis显示文摘 | Werner J Fernndez-del Castillo C Rivera J A | 1998 | Gut1998，43，3： | 1 |
| 14 | Optical flow or image subtraction in human detection from infrared camera on mobile robot 显示文摘 | Fernandez-Caballero A Castillo J C Martinez- Cantos j | 2010 | Robotics and Autonomous Systems2010，58，12： | 1 |
| 15 | Effect of Transient High Temperature on High Strength Concrete显示文摘 | Durrani A J | 1990 | ACI Materials Journal1990，87，1： | 1 |
| 16 | Cystitis and ketamine associated bladder dysfunction显示文摘 | Garcia-Larrosa A Castillo C Ventura M | 2012 | Actas Urol Esp2012，36，1： | 1 |
| 17 | Effect of Sn addition to Pt/CeO2-Al2O3 and Pt/Al2O3 catalysts:an XPS,119 Sn M6ssbauer and microcalorimetry study显示文摘 | Serrano Ruiz J C Huber G W Sanchez Castillo M A | | 0，，02： | 1 |
| 18 | The diagnostic importance of species specific and cross-reactive components of Taenia solium,Echinococcus granulosus,and Hymenolepis nana显示文摘 | Montenegro T Gilman RH Castillo R Tsang V Brandt J Guevara A Sanabria H Verastegui M Sterling C Miranda E 1994 | 1994 | Rev Inst Med Trop Sao Paulo1994，36，4： | 1 |
| 19 | Lens fluorophotometry after trabeculectomy in primary open angle glaucoma显示文摘 | Lazazo C Benitez-del-Castillo JM Castillo A | 2002 | Ophthalmology2002，109，1： | 1 |
| 20 | Phosphodiesterase-3 inhibition augments the myocardial infarct size-limiting effects of exenatide in mice with type 2 diabetes显示文摘 | Ye Y Qian J Castillo A C | 2013 | Am J Physiol Heart Circ Physiol2013，304，1： | 1 |
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