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| 1 | Current status of diagnosis and treatment of bladder cancer in China-Analyses of Chinese Bladder Cancer Consortium database显示文摘Objective:To investigate current status of diagnosis and treatment of bladder cancer in China.Methods:A database was generated by Chinese Bladder Cancer Consortium(CBCC).From January 2007 to December 2012,14,260 cases from 44 CBCC centers were included.Data of diagnosis,treatment and pathology were collected.Results:The average age was 63.5 year-old and most patients were male(84.3%).The most common histologic types were urothelial carcinoma(91.4%),adenocarcinoma(1.8%),and squamous carcinoma(1.9%).According to 1973 and 2004 WHO grading system,42.0%,41.0%,and 17.0% of patients were grade 1,2,and 3,and 16.0%,48.7%,and 35.3% of patients were papillary urothelial neoplasms of low malignant potential,low,and high grade,respectively.Non-muscle invasive bladder cancer(NMIBC)and muscle invasive bladder cancer(MIBC)were 25.2% and 74.1%,respectively(0.8% not clear).Carcinoma in situ was only 2.4%.Most patients were diagnosed by white-light cystoscopy with biopsy(74.3%).Fluorescence and narrow band imaging cystoscopy had additional detection rate of 1.0% and 4.0%,respectively.Diagnostic transurethral resection(TUR)provided detection rate of 16.9%.Most NMIBCs were treated with TUR(89.2%).After initial TUR,2.6%accepted second TUR,and 45.7%,69.9%,and 58.7% accepted immediate,induced,and maintenance chemotherapy instillation,respectively.Most MIBCs were treated with radical cystectomy(RC,59.7%).Laparoscopic RCs were 35.1%,while open RC 63.4%.Extended and standard pelvic lymph node dissection were 7% and 66%,respectively.Three most common urinary diversions were orthotopic neobladder(44%),ileal conduit(31%),and ureterocutaneostomy(23%).Only 2.3% of patients accepted neo-adjuvant chemotherapy and only 18%of T3 and T4 patients accepted adjuvant chemotherapy.Conclusion:Disease characteristics are similar to international reports,while differences of diagnosis and treatment exist.This study can provide evidences for revisions of the guideline on bladder cancer in China. | Kaiwen Li Tianxin Lin 无 Wei Xue Xin Mu Enci Xu Xu Yang Fubao Chen Guangyong Li Lulin Ma Guoliang Wang Chaozhao Liang Haoqiang Shi Ming Li Mao Tang Xueyi Xue Yisong Lv Yaoliang Deng Chengyang Li Zhiwen Chen Xiaozhou Zhou Fengshuo Jin Xudong Liu Jinxin Wei Lei Shi Xin Gou Weiyang He Liqun Zhou Lin Cai Baiye Jin Guanghou Fu Xiangbo Kong Hongyan Sun Ye Tian Lang Feng Tiejun Pan Yiyi Wu Dongwen Wang Hailong Hao Benkang Shi Yaofeng Zhu Qiang Wei Ping Han Changli Wu Dawei Tian Zhangqun Ye Zheng Liu Zhiping Wang Junqiang Tian Lin Qi Minfeng Chen Wei Li Jinchun Qi Gongxian Wang Longlong Fu Zhaolin Sun Guangheng Luo Zhoujun Shen Zhaowei Zhu Jinchun Xing Zhun Wu Dong Wei Xin Chen Yanqun Na Hongfeng Guo Chunxi Wang Zhihua Lu Chuize Kong Yang Liu Jin Yang Jianyun Hu Xin Gao Jielin Li Changjun Yin Pu Li Shan Chen Zhen Du Jiongming Li Yongji Yan Xu Zhang Shuang Huang Fangjian Zhou Zhiling Zhang Yinghao Sun Shuxiong Zeng Song Cen Jiaquan Zhou Hanzhong Li Jin Wen Jian Huang | 2015 | Asian Journal of Urology2015，2，2： | 21 |
| 2 | Effect of oxidation treatment on the adsorption and the stability of mercury on activated carbon显示文摘Oxidation treatment on the adsorption and the stability of Hg on activated carbon (AC) was inrestigated. Both MnO2-AC and FeCl3-AC were produced during oxidation treatment. The measurement of modified AC’s mercury adsorption capacity was conducted in a simulated coal-fired flue gas by adsorbing test apparatus. TCLP and column leaching methods were used to test the stability of mercury adsorbed on ACs. The results indicate that the oxidation treatment changed the pore structure of the AC and modified the carbon surface by creating chemical components such as MnO4-, Mn4+, O, NO3-, Fe3+, Cl-, etc. The Hg sorption capacity on MnO2-AC or FeCl3-AC was about three times higher than that of untreated carbon. In addition, the mercury control cost of each of the formers was about the half cost of the untreated carbon. The stability of Hg absorption was studied, it found that mercury adsorbed on the oxidation treated AC was not better than that of untreated carbon. It could concluded that the insoluble form of Hg is very important to the stability of mercury adsorbed on AC. This study suggests that the FeCl3-AC is the best absorbent for Hg with high adsorption capacity, better Hg adsorption stability in leaching environment, and lower cost among the three ACs tested. | HU Chang-xing ZHOU Jin-song LUO Zhong-yang HE Sheng WANG Guang-kai CEN Ke-fa | 2006 | Journal of Environmental Sciences2006，18，6： | 12 |
| 3 | Release characteristic of different classes of sodium during combustion of Zhun-Dong coal investigated by laser-induced breakdown spectroscopy显示文摘Serious fouling and slagging problems are associated with the combustion of Chinese Zhun-Dong coal due to its high content of sodium(Na). Understanding the release characteristic of Na during the combustion is essential to viable utilization of this coal. In this work, coal samples were treated with a sequence of solvents: water(H2O), ammonium acetate(NH4Ac), hydrochloric acid(HCl), and the release characteristics of various classes of Na during coal combustion were investigated using the technique of laser-induced breakdown spectroscopy. The relative contribution of various Na classes to the Na release during each combustion stage was found to be similar, in the order of H2O-soluble Na [ NH4 Acsoluble Na [ HCl-soluble Na [ insoluble Na. Sodium released during the devolatilization stage can be attributed to each of the sodium classes. After the devolatilization stage,H2O-soluble Na and NH4Ac-soluble Na dominated the Na release during both char and ash stages. Over 64 % of the total Na released during combustion comes from the H2O-soluble Na, which suggests that the Na release during the combustion of Zhun-Dong coal can be reduced effectively after treatment by H2 O washing. | Yong He Kunzan Qiu Ronald Whiddon Zhihua Wang Yanqun Zhu Yingzu Liu Zhongshan Li Kefa Cen | 2015 | Science Bulletin2015，60，22： | 8 |
| 4 | Experimental study on MSW gasification and melting technology显示文摘以便开发市政的稳固的浪费(MSW ) 气化和融化的技术,二预备试验和一个原则综合实验分别地被完成。当时, MSW 的气化特征在 500 750 ° C 被学习等价比率(嗯) 是 0.2 0.5 使用使流体化床的 gasifier。当温度是 550 700 ° C 时并且嗯是 0.2 0.4, syngas 的低热价值(LHV ) 到达 4000 12000 kJ/Nm3。苍蝇灰的融化的特征用一个改正床炉子在 1100 1460 ° C 被调查。超过 99.9% 戴奥辛能被分解,这被证明并且很重金属当温度是 1100 1300 ° C 时,能被团结。原则综合实验在使流体化床的气化和打漩融化系统被执行。MSW 在 550 650 ° C 高效地被气化,打漩融化炉子稳定地并且过去在 1200 1300 ° C 坚持说 95% 苍蝇灰能被打漩融化炉子抓住。结果提供了实际经验和基本数据开发 MSW 气化和融化的技术。 | XIAO Gang JIN Bao-sheng ZHONG Zhao-ping CHI Yong NI Ming-jiang CEN Ke-fa XIAO Rui HUANG Ya-ji HUANG He | 2007 | Journal of Environmental Sciences2007，19，11： | 7 |
| 5 | BMSC-derived exosomes ameliorate sulfur mustard-induced acute lung injury by regulating the GPRC5A-YAP axis显示文摘Sulfur mustard(SM)is a highly toxic chemical warfare agent that causes acute lung injury(ALI)and/or acute respiratory distress syndrome(ARDS).There are no effective therapeutic treatments or antidotes available currently to counteract its toxic effects.Our previous study shows that bone marrow-derived mesenchymal stromal cells(BMSCs)could exert therapeutic effects against SM-induced lung injury.In this study,we explored the therapeutic potential of BMSC-derived exosomes(BMSC-Exs)against ALI and the underlying mechanisms.ALI was induced in mice by injection of SM(30 mg/kg,sc)at their medial and dorsal surfaces.BMSC-Exs(20μg/kg in 200μL PBS,iv)were injected for a 5-day period after SM exposure.We showed that BMSC-Exs administration caused a protective effect against pulmonary edema.Using a lung epithelial cell barrier model,BMSC-Exs(10,20,40μg)dose-dependently inhibited SM-induced cell apoptosis and promoted the recovery of epithelial barrier function by facilitating the expression and relocalization of junction proteins(E-cadherin,claudin-1,occludin,and ZO-1).We further demonstrated that BMSC-Exs protected against apoptosis and promoted the restoration of barrier function against SM through upregulating G protein-coupled receptor family C group 5 type A(GPRC5A),a retinoic acid target gene predominately expressed in the epithelial cells of the lung.Knockdown of GPRC5A reduced the antiapoptotic and barrier regeneration abilities of BMSC-Exs and diminished their therapeutic effects in vitro and in vivo.BMSC-Exs-caused upregulation of GPRC5A promoted the expression of Bcl-2 and junction proteins via regulating the YAP pathway.In summary,BMSC-Exs treatment exerts protective effects against SM-induced ALI by promoting alveolar epithelial barrier repair and may be an alternative approach to stem cell-based therapy. | Guan-chao Mao Chu-chu Gong Zhen Wang Ming-xue Sun Zhi-peng Pei Wen-qi Meng Jin-feng Cen Xiao-wen He Ying Lu Qing-qiang Xu Kai Xiao | 2021 | Acta Pharmacologica Sinica2021，42，12： | 4 |
| 6 | The combination of chidamide with the CHOEP regimen in previously untreated patients with peripheral T-cell lymphoma: a prospective, multicenter, single arm, phase 1b/2 study显示文摘Objective:To assess the efficacy and safety of the novel histone deacetylase inhibitor,chidamide,in combination with cyclophosphamide,doxorubicin,vincristine,etoposide,and prednisone(Chi-CHOEP)for untreated peripheral T-cell lymphoma(PTCL).Methods:A prospective,multicenter,single arm,phase 1 b/2 study was conducted.A total of 128 patients with untreated PTCL(18–70 years of age)were enrolled between March 2016 and November 2019,and treated with up to 6 cycles with the Chi-CHOEP regimen.In the phase 1 b study,3 dose levels of chidamide were evaluated and the primary endpoint was determination of the maximumtolerated dose and recommended phase 2 dose(RP2 D).The primary endpoint of the phase 2 study was 2-year progression-free survival(PFS).Results:Fifteen patients were enrolled in the phase 1 b study and the RP2 D for chidamide was determined to be 20 mg,twice a week.A total of 113 patients were treated at the RP2 D in the phase 2 study,and the overall response rate was 60.2%,with a complete response rate of 40.7%.At a median follow-up of 36 months,the median PFS was 10.7 months,with 1-,2-,and 3-year PFS rates of 49.9%,38.0%,and 32.8%,respectively.The Chi-CHOEP regimen was well-tolerated,with grade 3/4 neutropenia occurring in approximately two-thirds of the patients.No unexpected adverse events(AEs)were reported and the observed AEs were manageable.Conclusions:This large cohort phase 1 b/2 study showed that Chi-CHOEP was well-tolerated with modest efficacy in previously untreated PTCL patients. | Wei Zhang Liping Su Lihong Liu Yuhuan Gao Quanshun Wang Hang Su Yuhuan Song Huilai Zhang Jing Shen Hongmei Jing Shuye Wang Xinan Cen Hui Liu Aichun Liu Zengjun Li Jianmin Luo Jianxia He Jingwen Wang O.A.O’Connor Daobin Zhou | 2021 | Cancer Biology & Medicine2021，18，3： | 4 |
| 7 | Soft error reliability in advanced CMOS technologies—trends and challenges显示文摘With the decrease of the device size,soft error induced by various particles becomes a serious problem for advanced CMOS technologies.In this paper,we review the evolution of two main aspects of soft error-SEU and SET,including the new mechanisms to induced SEUs,the advances of the MCUs and some newly observed phenomena of the SETs.The mechanisms and the trends with downscaling of these issues are briefly discussed.We also review the hardening strategies for different types of soft errors from different perspective and present the challenges in testing,modeling and hardening assurance of soft error issues we have to address in the future. | TANG Du HE ChaoHui LI YongHong ZANG Hang XIONG Cen ZHANG JinXin | 2014 | Science China(Technological Sciences)2014，57，9： | 3 |
| 8 | Fluidized-bed pyrolysis of waste bamboo显示文摘Bamboo was a popular material substituting for wood,especially for one-off commodity in China. In order to recover energy and materials from waste bamboo,the basic characteristics of bamboo pyrolysis were studied by a thermogravimetric analyzer. It implied that the reaction began at 190~210 °C,and the percentage of solid product deceased from about 25% to 17% when temperature ranged from 400 °C to 700 °C. A lab-scale fluidized-bed furnace was setup to research the detailed properties of gaseous,liquid and solid products respectively. When temperature increased from 400 °C to 700 °C,the mass percent of solid product decreased from 27% to 17% approximately,while that of syngas rose up from 19% to 35%. When temperature was about 500°C,the percentage of tar reached the top,about 31%. The mass balance of these experiments was about 93%~95%. It indicated that three reactions involved in the process: pyrolysis of exterior bamboo,pyrolysis of interior bamboo and secondary pyrolysis of heavy tar. | XIAO Gang NI Ming-jiang HUANG He CHI Yong XIAO Rui ZHONG Zhao-ping CEN Ke-fa | 2007 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2007，8，9： | 3 |
| 9 | miR-27b synergizes with anticancer drugs via p53 activation and CYPIB1 suppression显示文摘 | Wenjing Mu Chaobo Hu Haibin Zhang Zengqiang Qu Jin Cen Zhixin Qiu Chao Li Haozhen Ren Yixue Li Xianghuo He Xiaolei Shi Lijian Hui | 2015 | Cell Research2015，25，4： | 3 |
| 10 | Direct contact with bone marrow stromal cells promotes the invasions of SHI-1 leukemia cells显示文摘 | LI Zhen-jiang CHEN Zi-xing CEN Jian-nong HE Jun QIU Qiao-cheng | 2013 | Chinese Medical Journal2013，，14： | 3 |
| 11 | Differentially Expressed microRNAs as Potential Markers for Vital Reaction of Burned Skin显示文摘The identification of antemortem burns and postmortem burns is essential in forensic practice.In this study,microRNA(miRNA)microarray analysis was conducted to identify differentially expressed miRNAs in the skin of an experimental burn model.Microarray analysis revealed 24 differentially expressed miRNAs in antemortem burned mice skin,with 19 miRNAs significantly upregulated and 5 downregulated.Based on the intersection predicted using three databases(Targetscan,microRNA.org,and PITA),293 potential miRNA targets were identified.These dysregulated miRNAs and their predicted targets were further analyzed using the Gene Ontology and Kyoto Encyclopedia of Genes and Genomes databases.Several functional categories and signaling pathways were enriched,including the“fc epsilon ri signaling pathway,”“endometrial cancer,”and“mTOR signaling pathway.”Expression patterns of 10 differentially expressed miRNAs were verified by reverse transcription‑quantitative polymerase chain reaction in mice skins.The results agreed with the results of microarray analysis.These findings suggest that differentially expressed miRNAs revealed by microarray are potential markers for forensic molecular diagnosis of antemortem burns. | Hao‑Pin Lyu Ming Cheng Jin‑Cen Liu Ming‑Yuan Ye Di Xu Jie‑Tao He Xiao‑Li Xie Qi Wang | 2018 | Journal of Forensic Science and Medicine2018，4，3： | 2 |
| 12 | Few-mode fibre-optic microwave photonic links显示文摘The fibre-optic microwave photonic link has become one of the basic building blocks for microwave photonics.Increasing the optical power at the receiver is the best way to improve all link performance metrics including gain,noise figure and dynamic range.Even though lasers can produce and photodetectors can receive optical powers on the order of a Watt or more,the power-handling capability of optical fibres is orders-of-magnitude lower.In this paper,we propose and demonstrate the use of few-mode fibres to bridge this power-handling gap,exploiting their unique features of small acousto-optic effective area,large effective areas of optical modes,as well as orthogonality and walk-off among spatial modes.Using specially designed few-mode fibres,we demonstrate order-of-magnitude improvements in link performances for single-channel and multiplexed transmission.This work represents the first step in few-mode microwave photonics.The spatial degrees of freedom can also offer other functionalities such as large,tunable delays based on modal dispersion and wavelength-independent lossless signal combining,which are indispensable in microwave photonics. | He Wen Hongjun Zheng Qi Mo Amado Manuel Velázquez-Benítez Cen Xia Bin Huang Huiyuan Liu Huang Yu Pierre Sillard Jose Enrique Antonio Lopez Rodrigo Amezcua Correa Guifang Li | 2017 | Light(Science & Applications)2017，6，1： | 2 |
| 13 | Effects of La^(3+) Non-Uniformly Doping in TiO_2 Films on Photocatalytic Activities显示文摘TiO2 thin films non-uniformly doped by La 3+ were prepared by sol-gel method. The comparison of thin film activities, which was characterized by photocatalytic degradation of methyl orange, shows that doping modes have great effects on photocatalytic activities. The non-uniformly doped TiO2 films result in good photocatalytic activities with an optimal concentration; about 0.5%(atom fraction). UV-Vis transmittance spectra indicate that the absorption edges of these TiO2 thin films shift to ward longer wavelengths remarkably, and electrochemical behavior also reveales that e--h+ pairs are prone to formation and separation under UV irradiation. The mechanism of photocatalytic activities are enhanced by La 3+ non-uniformly doping was discussed on the analogy of the theory of “window effect” of solar cell heterojunction. | Cen Jiwen Li Xinjun He Mingxing Zheng Shaojian Feng Manzhi | 2005 | Journal of Rare Earths2005，23，6： | 2 |
| 14 | Effect of chemical activation of an activated carbon using zinc chloride on elemental mercury adsorption 显示文摘 | Hu C Zhou J He S Luo Z Cen K | 2009 | Fuel Processing Technology2009，90，6： | 1 |
| 15 | Identification and functional annotation of lncRNA genes with hypermethylation in colorectal cancer显示文摘 | Qi Liao Weiling He Jianfa Liu Yi Cen Liang Luo Chengliang Yu Yang Li Sitong Chen Shiwei Duan | 2015 | Gene2015，，： | 1 |
| 16 | Theory and application of near infrared reflectance spectroscopy in determination of food quality 显示文摘 | Cen H Y He Y | 2007 | Trends Food Sci Tech2007，18，： | 1 |
| 17 | Predictive analysis on electric-power supply and demand in China 显示文摘 | HUANG Min HE Yong CEN Hai-yan | 2007 | Renewable Energy2007，32，7： | 1 |
| 18 | Theory and Application of Near Infrared Reflectance Spectroscopy in Determination of Food Quality 显示文摘 | CEN Hai-yan HE Yong | 2007 | Trends in Food Seience~Technology2007，18，6： | 1 |
| 19 | Theory and application of near infrared reflectance spectroscopy indetermination of food quality显示文摘 | CEN Haiyan HE Yong | 2007 | Trends in Food Science and Technology2007，18，： | 1 |
| 20 | Stray light analysis of basic model Gaussian beam显示文摘 | Cen Zhaofeng Li Xiaotong He Zhiping | 2002 | SPIE2002，4914，： | 1 |
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