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| 1 | A Chromosome-Level Genome Assembly of Garlic (Allium sativum) Provides Insights into Genome Evolution and Allicin Biosynthesis显示文摘Garlic,an economically important vegetable,spice,and medicinal crop,produces highly enlarged bulbs and unique organosulfur compounds.Here,we report a chromosome-level genome assembly for garlic,with a total size of approximately 16.24 Gb,as well as the annotation of 57561 predicted protein-coding genes,making garlic the first Allium species with a sequenced genome.Analysis of this garlic genome assembly reveals a recent burst of transposable elements,explaining the substantial expansion of the garlic genome.We examined the evolution of certain genes associated with the biosynthesis of allicin and inulin neoseries-type fructans,and provided new insights into the biosynthesis of these two compounds.Furthermore,a large-scale transcriptome was produced to characterize the expression patterns of garlic genes in different tissues and at various growth stages of enlarged bulbs.The reference genome and large-scale transcriptome data generated in this study provide valuable new resources for research on garlic biology and breeding. | Xiudong Sun Siyuan Zhu Ningyang Li Yi Cheng Jing Zhao Xuguang Qiao Li Lu Shiqi Liu Yanzhou Wang Chan Liu Benping Li Wu Guo Shuang Gao Zemao Yang Fu Li Zheng Zeng Qing Tang Yupeng Pan Mengjiao Guan Jian Zhao Xiaomi ng Lu Huanwe n Meng Zhenlin Han Chun she ng Gao Wenkai Jiang Xing Zhao Shilin Tian Jianguang Su Zhihui Cheng Touming Liu | 2020 | Molecular Plant2020，13，9： | 14 |
| 2 | 亚洲近视管理共识显示文摘指南的目标本指南是从国际近视研究所(IMI)白皮书中提取出来的有关近视管理方面的建议[1,2]。本指南所提供的内容都是根据现有最新数据(截至2022年3月)而来,其治疗可行性和执业范围因地区而异,应根据实际情况做调整。眼保健专家组通过对现有最优科学数据进行分析诠释,从而形成了本指南。在工作中,近视管理从业者应该将患者需求放在首位,全面考虑患者具体情况后再提出合适的处理意见。 | Monica Jong Serge Resnikoff Kah Ooi Tan 吕帆 Kah Meng Chung 胡楚南 Ian Morgan Oliver Kam Tong Woo 蓝卫忠 齐备 瞿佳 杨智宽 樊志诚 吴佩昌 Ian Flitcroft Murphy Hian Kee Chan Thok Chuan Tan Charlie Ho David Chai Wong Chong Liang Hwee Koh Olivia Qian Ru Cheng | 2022 | 中华眼视光学与视觉科学杂志2022，24，3： | 11 |
| 3 | Sedation depth and long-term mortality in mechanically ventilated critically ill adults: a prospective longitudinal multicentre cohort study显示文摘 | Yahya Shehabi Lucy Chan Suhaini Kadiman Anita Alias Wan Nasrudin Ismail Mohd Ali T. Ismail Tan Tien Meng Khoo Saedah Binti Ali Mat Ariffin Saman Ahmad Shaltut Cheng Cheng Tan Cow Yen Yong Michael Bailey | 2013 | Intensive Care Medicine2013，，5： | 3 |
| 4 | Control measures during the COVID-19 outbreak reduced the transmission of hand,foot,and mouth disease显示文摘Control measures during the coronavirus disease 2019(COVID-19)outbreak may have limited the spread of infectious diseases.This study aimed to analyze the impact of COVID-19 on the spread of hand,foot,and mouth disease(HFMD)in China.A mathematical model was established to fit the reported data of HFMD in six selected cities in China's Mainland from 2015 to 2020.The absolute difference(AD)and relative difference(RD)between the reported incidence in 2020,and simulated maximum,minimum,or median incidence of HFMD in 2015-2019 were calculated.The incidence and R effof HFMD have decreased in six selected cities since the outbreak of COVID-19,and in the second half of 2020,the incidence and R effof HFMD have rebounded.The results show that the total attack rate(TAR)in 2020 was lower than the maximum,minimum,and median TAR fitted in previous years in six selected cities(except Changsha City).For the maximum,median,minimum fitted TAR,the range of RD(%)is 42·20-99·20%,36·35-98·41%48·35-96·23%(except Changsha City)respectively.The preventive and control measures of COVID-19 have significantly contributed to the containment of HFMD transmission. | Yan Niu Li Luo Jia Rui Shiting Yang Bin Deng Zeyu Zhao Shengnan Lin Jingwen Xu Yuanzhao Zhu Yao Wang Meng Yang Xingchun Liu Tianlong Yang Weikang Liu Peihua Li Zhuoyang Li Chan Liu Jiefeng Huang Tianmu Chen | 2021 | Journal of Safety Science and Resilience2021，2，2： | 3 |
| 5 | Mechanical behaviour of wood compressed in radial direction-part I.New method of determining the yield stress of wood on the stress-strain curve显示文摘A test equipment was developed,which allows for real time observation of the deformation behav-ior of wood cellular structure under a compression load applied in radial direction.Compression tests were performed on jack pine(Pinus banksiana)and balsam poplar(Populus balsamifera)spec-imens to explore the relationship between the yield stress and the first failure occurring in wood cell layers during radial compression.The microstructural changes for P.banksiana and P.bal-samifera wood below and above the yield point were analyzed.The study results showed that for P.banksiana the first failure of wood cells occurred at the first earlywood layer,while for P.balsamifera it occurred at the layer with the largest vessels.The first failure of wood cell layer for each species tested was found to correspond to the yield point on the stress-strain curve.A new method of determining the yield stress for wood specimens under radial compression was developed. | Chen Huang Meng Gong Yinghei Chui Felisa Chan | 2020 | Journal of Bioresources and Bioproducts2020，5，3： | 2 |
| 6 | Non-Hodgkin's Lymphoma Primarily Presenting with Fanconi Syndrome and Acute Kidney Injury显示文摘KIDNEY involvement is common in non-Hodgkin's lymphoma (NHL) with incidence up to 30%-40% in autopsy studies.1 However,it usually occurs late in the course of the | Wen-ling Ye Bing Han Bing-yan Liu Chan Meng Wei Ye Yu-bing Wen Hang Li Xue-mei Li | 2010 | Chinese Medical Sciences Journal2010，25，3： | 2 |
| 7 | Longitudinal Measurement of Hemodynamic Changes within the Posterior Optic Nerve Head in Rodent Nonarteritic Anterior Ischemic Optic Neuropathy显示文摘ObjectiveTo assess the in vivo dynamic blood flow features of posterior optic nerve head (ONH) in rat model of nonarteritic anterior ischemic optic neuropathy (rNAION). MethodsrNAION was established with Rose Bengal and argon green laser in Sprague-Dawley rats. Fundus photography and fundus fluorescein angiography (FFA) were performed to assess the dynamic changes of optic disc in morphology in 90 days and in blood perfusion in 3 hours after the induction of disease. Histological examinations were performed to evaluate the success of modeling. Thedynamic blood flow kinetics of posterior ONH in rNAION were measured by Laser Doppler Flowmetry (LDF) on the day 3, 7, 14, 21, and 40 after the disease induction. One-way ANOVA, Student'st-test and Bonferroni adjustment were used for multiple comparisons of kinetic measurements of blood flow. ResultsOptic disc edema and subsequent resolution associated with the development of optic disc pallor were observed in rNAION. FFA showed that the optic disc was hypofluorescence in the early phase and hyperfluorescence in the late phase. Histological studies suggested edema and loosened tissues of ONH, loss of retinal ganglion cells (RGCs), optic nerve substance and gliosis. Compared to the naive rats, the blood flow kinetics of posterior ONH in rNAION significant reduced at each time point after modeling (F=175.06,P<0.0001). The reductions were specifically remarkable in 14 days after the disease induction (AllP<0.01). Conclusions Continuous blood perfusion reduction was found in rNAION, with significant alteration in 14 days after disease induction. Our results provided important information for understanding the hemodynamic changes in rNAION. | Jin Ma Ting Chen Yiwei Wang Chan Zhao Donghui Li Meng Wang Linyang Gan Yong Zhong | 2018 | Chinese Medical Sciences Journal2018，33，4： | 2 |
| 8 | Dynamic protein-protein interaction subnetworks of lung cancer in cases with smoking history显示文摘Smoking is the primary cause of lung cancer and is linked to 85% of lung cancer cases.However,how lung cancer develops in patients with smoking history remains unclear.Systems approaches that combine human protein-protein interaction (PPI) networks and gene expression data are superior to traditional methods.We performed these systems to determine the role that smoking plays in lung cancer development and used the support vector machine (SVM) model to predict PPIs.By defining expression variance (EV),we found 520 dynamic proteins (EV>0.4) using data from the Human Protein Reference Database and Gene Expression Omnibus Database,and built 7 dynamic PPI subnetworks of lung cancer in patients with smoking history.We also determined the primary functions of each subnetwork:signal transduction,apoptosis,and cell migration and adhesion for subnetwork A;cell-sustained angiogenesis for subnetwork B;apoptosis for subnetwork C;and,finally,signal transduction and cell replication and proliferation for subnetworks D-G.The probability distribution of the degree of dynamic protein and static protein differed,clearly showing that the dynamic proteins were not the core proteins which widely connected with their neighbor proteins.There were high correlations among the dynamic proteins,suggesting that the dynamic proteins tend to form specific dynamic modules.We also found that the dynamic proteins were only correlated with the expression of selected proteins but not all neighbor proteins when cancer occurred. | Wei Yu Li-Ran He Yan-Chao Zhao Man-Him Chan Meng Zhang Miao He | 2013 | Chinese Journal of Cancer2013，32，2： | 2 |
| 9 | Feasibility of Booster Vaccination in High-Risk Populations for Controlling Coronavirus Variants—China,2021显示文摘Introduction:Vaccination booster shots are completely necessary for controlling breakthrough infections of severe acute respiratory syndrome coronavirus 2(SARS-CoV-2)in China.The study aims to estimate effectiveness of booster vaccines for high-risk populations(HRPs).Methods:A vaccinated Susceptible-Exposed-Symptomatic-Asymptomatic-Recovered/Removed(SEIAR)model was developed to simulate scenarios of effective reproduction number(Reff)from 4 to 6.Total number of infectious and asymptomatic cases were used to evaluated vaccination effectiveness.Results:Our model showed that we could not prevent outbreaks when covering 80%of HRPs with booster unless Reff=4.0 or the booster vaccine had efficacy against infectivity and susceptibility of more than 90%.The results were consistent when the outcome index was confirmed cases or asymptomatic cases.Conclusions:An ideal coronavirus disease 2019(COVID-19)booster vaccination strategy for HRPs would be expected to reach the initial goal to control the transmission of the Delta variant in China.Accordingly,the recommendation for the COVID-19 booster vaccine should be implemented in HRPs who are already vaccinated and could prevent transmission to other groups. | Kangguo Li Zeyu Zhao Hongjie Wei Jia Rui Jiefeng Huang Xiaohao Guo Yichao Guo Shiting Yang Guzainuer Abudurusuli Li Luo Xingchun Liu Yao Wang Jingwen Xu Yuanzhao Zhu Meng Yang TianlongYang Weikang Liu Bin Deng Chan Liu Zhuoyang Li Peihua Li Shanshan Yu Zimei Yang Yanhua Su Benhua Zhao Yan Niu Tianmu Chen | 2021 | China CDC weekly2021，3，50： | 2 |
| 10 | Cucurb-itacin B induces apoptosis and S phase cell cycle arrest in BEL-7402human hepatocellular carcinoma cells and is effective via oral admin-istration显示文摘 | Chan KT Meng FY Li Q Ho CY Lam TS To Y | 2010 | Cancer Lett2010，294，1： | 1 |
| 11 | Mycobacterium tuberculosis induces interleukin-32 production through a caspase-1/IL-18/interferon-γ-dependent mechanism显示文摘 | Netea M G Azam T Lewis E C Joosten L A Wang M Langenberg D Meng X Chan E D Yoon D Y Ottenhoff T Kim S H and Dinarello C A | | 0，，08： | 1 |
| 12 | Ef- fects of Direct-Current (DC) Electric Fields on Flame Propagation and Combustion Characteristics of Premixed CH4/O2/N2 Flames 显示文摘 | MENG Xiangwen WU Xiaomin KANG Chan | 2012 | Energy Fuels2012，26，11： | 1 |
| 13 | Differential expression of the suppressor PML and Ki-67 identifies three subtypes of human nasopharyngeal carcinoma显示文摘 | Chan JY Meng CL To KF | 2002 | Eur J Cancer2002，38，12： | 1 |
| 14 | Surface Characterization of Transparent Conductive Oxide Al-doped ZnO Films显示文摘 | Chen Meng Pei Zhiliang Sun Chan | 2002 | Journal of Crystal Growth2002，220，： | 1 |
| 15 | Anti-allergic actions of rottlerin from Mallotus philippinensis in experimental mast cell-mediated anaphylactic models显示文摘 | Tze Khee Chan David S.W. Ng Chang Cheng Shou Ping Guan Hock Meng Koh W.S. Fred Wong | 2013 | Phytomedicine2013，，10： | 1 |
| 16 | Effects of direct-current (DC) electric fields on flame propagation and combustion characteristics of premixed CH4/O2/N2 flames显示文摘 | MENG Xiangwen WU Xiaomin KANG Chan | | 0，，11： | 1 |
| 17 | Comparisons of PWM and onecycle control for power mplifier with multilevel conrtep 显示文摘 | Chan C C Zheng Ming Ahao Qian C Meng S | 2002 | IEEETrans Ind Electronics2002，49，6： | 1 |
| 18 | Effects of direct-current (DC) electric fields on flame propagation and combustion characteristics of premixed CH4/O2/N2 flames显示文摘 | MENG Xiangwen WU Xiaomin KANG Chan | 2012 | Energy Fuels2012，26，11： | 1 |
| 19 | Resveratrol displays converse dose-related effects on 5-fluorouracil-evoked colon cancer cell apoptosis: The roles of caspase-6 and p53显示文摘 | Jason Yongsheng Chan Meng Seng Phoo Marie-Veronique Clement Shazib Pervaiz Shao Chin Lee | 2008 | Cancer Biology & Therapy2008，，： | 1 |
| 20 | Effects of direct-current(DC)electric fields on flamepropagation and combustion characteristics of premixedCH4/O2/N2 flames 显示文摘 | Meng Xiangwen Wu Xiaomin Kang Chan | 2012 | Energy Fuels2012，26，11： | 1 |
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