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| 1 | Differential diagnosis of left-sided abdominal pain:Primary epiploic appendagitis vs colonic diverticulitis显示文摘AIM:To investigate the clinical characteristics of left primary epiploic appendagitis and to compare them with those of left colonic diverticulitis.METHODS:We retrospectively reviewed the clinical records and radiologic images of the patients who presented with left-sided acute abdominal pain and had computer tomography(CT) performed at the time of presentation showing radiological signs of left primary epiploic appendagitis(PEA) or left acute colonic diverticulitis(ACD) between January 2001 and December 2011. A total of 53 consecutive patients were enrolled and evaluated. We also compared the clinical characteristics,laboratory findings,treatments,and clinical results of left PEA with those of left ACD.RESULTS:Twenty-eight patients and twenty-five patients were diagnosed with symptomatic left PEA and ACD,respectively. The patients with left PEA had focal abdominal tenderness on the left lower quadrant(82.1%). On CT examination,most(89.3%) of the patients with left PEA were found to have an oval fatty mass with a hyperattenuated ring sign. In cases of left ACD,the patients presented with a more diffuse abdominal tenderness throughout the left side(52.0%vs 14.3%; P = 0.003). The patients with left ACD had fever and rebound tenderness more often than those with left PEA(40.0% vs 7.1%,P = 0.004; 52.0% vs14.3%,P = 0.003,respectively). Laboratory abnormalities such as leukocytosis were also more frequently observed in left ACD(52.0% vs 15.4%,P = 0.006).CONCLUSION:If patients have left-sided localized abdominal pain without associated symptoms or laboratory abnormalities,clinicians should suspect the diagnosis of PEA and consider a CT scan. | Jeong Ah Hwang Sun Moon Kim Hyun Jung Song Yu Mi Lee Kyung Min Moon Chang Gi Moon Hoon Sup Koo Kyung Ho Song Yong Seok Kim Tae Hee Lee Kyu Chan Huh Young Woo Choi Young Woo Kang Woo Suk Chung | 2013 | World Journal of Gastroenterology2013，19，40： | 6 |
| 2 | Correlation of fatty liver and abdominal fat distribution using a simple fat computed tomography protocol显示文摘AIM: To evaluate the relationship between hepatic fat infiltration and abdominal fat volume by using computed tomography (CT).METHODS: Three hundred and six patients who visited our obesity clinic between November 2007 and April 2008 underwent fat protocol CT scans.The age range of the patients was 19 to 79 years and the mean age was 49 years.The male to female ratio was 116:190.Liver and spleen attenuation measurements were taken with three regions of interests (ROIs) from the liver and two ROIs from the spleen.Hepatic attenuation indices (HAIs) were measured as follows: (1) hepatic parenchymal attenuation (CTLP);(2) liver to spleen attenuation ratio (LS ratio);and (3) difference between hepatic and splenic attenuation (LSdif).Abdominal fat volume was measured using a 3 mm slice CT scan starting at the level of the umbilicus and was automatically calculated by a workstation.Abdominal fat was classified into total fat (TF),visceral fat (VF),and subcutaneous fat (SF).We used a bivariate correlation method to assess the relationship between the three HAIs and TF,VF,and SF.RESULTS: There were significant negative correlations between CTLP,LS ratio,and LSdif with TF,VF,and SF,respectively.The CTLP showed a strong negative correlation with TF and VF (r = -0.415 and -0.434,respectively,P < 0.001).The correlation between CTLP and SF was less significant (r = -0.313,P < 0.001).CONCLUSION: Fatty infiltration of the liver was correlated with amount of abdominal fat and VF was more strongly associated with fatty liver than SF. | Seonah Jang Chang Hee Lee Kyung Mook Choi Jongmee Lee Jae Woong Choi Kyeong Ah Kim Cheol Min Park | 2011 | World Journal of Gastroenterology2011，17，28： | 5 |
| 3 | Effects of feeding a diet containing Gymnema sylvestre extract: attenuating progression of obesity in C57BL/6J mice显示文摘Objective: To investigate the effect of Gymnema sylvestre extract(GS) on initial anti-obesity, liver injury, and glucose homeostasis induced by a high-fat diet(HFD). Methods: The dry powder of GS was extracted with methanol, and gymnemic acid was identified by high performance liquid chromatography as deacyl gymnemic acid. Male C57BL/6J mice that fed on either a normal diet, normal diet containing 1 g/kg GS(CON+GS) HFD, or HFD containing 1.0 g/kg GS(HFD+GS) for 4 weeks were used to test the initial anti-obesity effect of GS. Body weight gain and food intake, and serum levels about lipid and liver injury markers were measured. Histopathology of adipose tissue and liver stained with hematoxylin and eosin(H&E) and oil-red O were analyzed. After 4 weeks of GS extract feeding, intraperitoneal glucose tolerance test(IPGTT) was performed. Results: The methanol extracts of GS exerted significant anti-obesity effects in HFD+GS group. They decreased body weight gain, a lower food and energy efficiency ratio, and showed lower serum levels of total cholesterol(TC), triglyceride(TG), low-density lipoprotein(LDL)-cholesterol, very-low density lipoprotein(VLDL)-cholesterol and leptin compared with the HFD group. The decreases of abdominal as well as epididymal fat weight and adipocyte hypertrophy, lipid droplets in liver, and serum levels of aspartate aminotransferase(AST) and alanine transaminase(ALT) were also observed. The CON+GS group showed an effect of glucose homeostasis compared to the CON group. Conclusions: This study shows that GS provide the possibility as a key role in an initial anti-obesity effects feeding with a HFD. | Hyeon-Jeong Kim Seong-Ho Hong Seung-Hee Chang Sanghwa Kim Ah Young Lee Yoonjeong Jang Orkhonselenge Davaadamdin Kyeong-Nam Yu Ji-Eun Kim Myung-Haing Cho | 2016 | Asian Pacific Journal of Tropical Medicine2016，9，5： | 3 |
| 4 | Robot-assisted spleen-preserving distal pancreatectomy: a single surgeon’s experiences and proposal of clinical application显示文摘 | Ho Kyoung Hwang Chang Moo Kang Young Eun Chung Kyung Ah Kim Sung Hoon Choi Woo Jung Lee | 2013 | Surgical Endoscopy2013，，3： | 2 |
| 5 | A case of hypereosinophilic syndrome presenting with intractable gastric ulcers显示文摘We report a rare case of hypereosinophilic syndrome(HES)presenting with intractable gastric ulcers.A 71-year-old man was admitted with epigastric pain.Initial endoscopic findings revealed multiple,active gastric ulcers in the gastric antrum.He underwent Helicobacter pylori(H pylori)eradication therapy followed by proton pump inhibitor(PPI)therapy.However,follow-up endoscopy at 4,6,10 and 14 mo revealed persistent multiple gastric ulcers without significant improvement.The proportion of his eosinophil count increased to 43%(total count:7903/mm 3).Abdominal-pelvic and chest computed tomography scans showed multiple small nodules in the liver and both lungs.The endoscopic biopsy specimen taken from the gastric antrum revealed prominent eosinophilic infiltration,and the liver biopsy specimen also showed eosinophilic infiltration in the portal tract and sinusoid.A bone marrow biopsy disclosed eosinophilic hyperplasia as well as increased cellularity of 70%.The patient was finally diagnosed with HES involving the stomach,liver,lung,and bone marrow.When gastric ulcers do not improve despite H pylori eradication and prolonged PPI therapy,infiltrative gastric disorders such as HES should be considered. | Tae Young Park Chang Hwan Choi Suh Yoon Yang InSoo Oh In-Do Song Hyun Woong Lee Hyung Joon Kim Jae Hyuk Do Sae Kyung Chang Ah Ra Cho Young Joo Cha | 2009 | World Journal of Gastroenterology2009，15，48： | 2 |
| 6 | The immune resp- onse to tuberculosis infection in the setting of helicobacter pylori and helminth infections显示文摘 | Perry S Chang AH Sanchez L | 2013 | Epidemiollnfect2013，141，6： | 1 |
| 7 | Potentiation of opioid analygesia in dopamine 2 receptor knock-out mice:evidence for a tonically active antiopioid system显示文摘 | King MA Bradshaw S Chang AH | 2001 | J Neurosci2001，21，19： | 1 |
| 8 | Joint effect of HSD3B1 and HSD3B2 genes is associated with hereditary and sporadic prostate cancer susceptibility 显示文摘 | Chang Baoli Siqun LZH Gregory AH | 2002 | Cancer Res2002，62，： | 1 |
| 9 | Oncogenic pathway signatures in human cancers as a guide to targeted therapies 显示文摘 | Bild AH Yao G Chang JT | 2006 | Nature2006，439，7074： | 1 |
| 10 | Lower extremity reconstruc- tion with the anterolateral thigh flap 显示文摘 | Nosrati N Chao AH Chang DW | 2012 | J Reconstr Microsurg2012，28，4： | 1 |
| 11 | Role of the B7-CD28/CTLA-4 pathway in autoimmune disease显示文摘 | Chang TT Kuchroo VK Sharpe AH | 2002 | Curt Dir Autoimmun2002，5，： | 1 |
| 12 | Classification of cultivation area of ginseng by near infrared spectroscopy and ICP- AES 显示文摘 | Young - ah Woo Chang - hee Cho Hyo - jin Kim Jong - soo Yang Ki - yong Seong | 2002 | Microchemical Journal2002，73，3： | 1 |
| 13 | Oncogenic pathway signatures in human cancers as a guide to targeted therapies显示文摘 | Bild AH Yao G Chang JT | 2006 | Nature2006，439，7074： | 1 |
| 14 | Intrathoracic patterns of failure for non-small-cell lung cancer with positron-emission tomography/computed tomography-defined target delineation 显示文摘 | Klopp AH Chang JY Tucker SL | 2007 | Int J Radiat Oncol Biol Phys2007，69，5： | 1 |
| 15 | The use of human acellular dermal matrix for the correction of secondary deformities after breast augmentation:results and costs显示文摘 | Hartzell TL Taghinia AH Chang J | 2010 | Plast Reconstr Surg2010，126，5： | 1 |
| 16 | Pelvic congestion syndrome( pelvic venous incompetence) : impact of ovarian and internal lilac vein embolotherapy on menstrual cycle and chronic pelvic pain 显示文摘 | Venbrux AC Chang AH Kim HS | 2002 | J Vasc lnterv Radiol2002，13，21： | 1 |
| 17 | Rapid identification of yeasts in positive blood cultures by a multiplex PCR method显示文摘 | Chang HC Leaw SN Huang AH | 2001 | J Clin Mierobiol2001，39，10： | 1 |
| 18 | Characterization of breast lesions: comparison of digital breast tomosynthesis and ultra- sonography显示文摘 | Sun Ah Kim Jung Min Chang Nariya Cho | 2015 | Korean j Radiol2015，16，： | 1 |
| 19 | Rapid Identification of Yeasts in Positive Blood Cultures by a Multiplex PCR Method显示文摘 | Chang HC Leaw SN Huang AH | 2001 | J Clinical Microbiology2001，39，10： | 1 |
| 20 | Race and insurance sta- tus as risk factors for trauma mortality 显示文摘 | Haider AH Chang DC Efron DT | 2008 | Arch Surg2008，143，10： | 1 |
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