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| 1 | A ASLD guidelines for treatment of chronic hepatitis B显示文摘 | Norah A. Terrault Natalie H. Bzowej Kyong‐Mi Chang Jessica P. Hwang Maureen M. Jonas M. Hassan Murad | 2016 | Hepatology2016，，： | 6 |
| 2 | Indirect traumatic optic neuropathy显示文摘Indirect traumatic optic neuropathy(ITON) refers to optic nerve injury resulting from impact remote to the optic nerve. The mechanism of injury is not understood, and there are no confirmed protocols for prevention, mitigation or treatment. Most data concerning this condition comes from case series of civilian patients suffering blunt injury, such as from sports- or motor vehicle-related concussion, rather than military-related ballistic or blast damage. Research in this field will likely require the development of robust databases to identify patients with ITON and follow related outcomes, in addition to both in-vivo animal and virtual human models to study the mechanisms of damage and potential therapies. | Eric L.Singman Nitin Daphalapurkar Helen White Thao D.Nguyen Lijo Panghat Jessica Chang Timothy McCulley | 2016 | Journal of Medical Colleges of PLA(China)2016，31，2： | 3 |
| 3 | Prevention of De Novo Hepatitis B in Recipients of Core Antibody-Positive Livers With Lamivudine and Other Nucleos(t)ides: A 12-Year Experience显示文摘 | Matthew S. Chang Sonja K. Olsen Elsa M. Pichardo Jessica B. Stiles Lori Rosenthal-Cogan William D. Brubaker James V. Guarrera Jean C. Emond Robert S. Brown | 2013 | Transplantation Journal2013，，7： | 2 |
| 4 | Intravascular large B-cell lymphoma presenting with altered mental status: A case report显示文摘BACKGROUND Intravascular large B-cell lymphoma(IVLBCL)is a rare and aggressive subtype of non-Hodgkin lymphoma with a varied presentation and no pathognomonic findings.Early diagnosis is critical to altering the disease course as early treatment with chemoimmunotherapy is required to prevent a rapidly fatal outcome.Strategies including improved awareness of this clinical entity through publication of cases with unique presentations are essential to prompt consideration of IVLBCL early in the disease workup.Here,we present a case of IVLBCL presenting with altered mental status and systemic organ dysfunction.CASE SUMMARY A 61-year-old male patient presented with flu-like symptoms and a high fever.He experienced rapid clinical deterioration with liver,kidney failure,and shock despite rapid antibiotic administration and supportive care.A broad infectious workup was negative.Intracranial imaging revealed nonspecific changes to the corpus callosum suspicious for vasculitis.Renal biopsy was non-diagnostic.After further progression of his symptoms,the family elected to withdraw care and the patient died shortly thereafter.Post-mortem analysis revealed clear multi-organ involvement by IVLBCL,prompting re-examination of the ante-mortem renal biopsy that also identified IVLBCL involvement.CONCLUSION IVLBCL is a rare disease.Communication with specialties and early biopsy is critical to establishing the diagnosis and initiating therapy. | Christopher Robert D’Angelo Kimberly Ku Jessica Gulliver Julie Chang | 2019 | World Journal of Clinical Oncology2019，10，12： | 2 |
| 5 | Antiviral effect of interferon lambda against West Nile virus显示文摘 | Dongling Ma Dong Jiang Min Qing Jessica M. Weidner Xiaowang Qu Haitao Guo Jinhong Chang Baohua Gu Pei-Yong Shi Timothy M. Block Ju-Tao Guo | 2009 | Antiviral Research2009，，1： | 1 |
| 6 | Risk Factors Associated with Incident Cataracts and Cataract Surgery in the Age-Related Eye Disease Study (AREDS)显示文摘 | Jessica R. Chang Euna Koo Elvira Agrón Joelle Hallak Traci Clemons Dimitri Azar Robert D. Sperduto Frederick L. Ferris Emily Y. Chew | 2011 | Ophthalmology2011，，11： | 1 |
| 7 | NAFLD Recurrence in Liver Transplant Recipients显示文摘 | Parul Dureja Jessica Mellinger Rashmi Agni Faye Chang Gregory Avey Michael Lucey Adnan Said | 2011 | Transplantation2011，，6： | 1 |
| 8 | Roquin-2 Shares Functions with Its Paralog Roquin-1 in the Repression of mRNAs Controlling T Follicular Helper Cells and Systemic Inflammation显示文摘 | Alvin Pratama Roybel R. Ramiscal Diego G. Silva Souvik K. Das Vicki Athanasopoulos Jessica Fitch Natalia K. Botelho Pheh-Ping Chang Xin Hu Jennifer J. Hogan Paula Ma?a David Bernal Heinrich Korner Di Yu Christopher C. Goodnow Matthew C. Cook Carola G. Vin | 2013 | Immunity2013，，4： | 1 |
| 9 | Overcoming the challenges of cancer drug resistance through bacterial-mediated therapy显示文摘Despite tremendous efforts to fight cancer,it remains a major public health problem and a leading cause of death worldwide.With increased knowledge of cancer pathways and improved technological platforms,precision therapeutics that specifically target aberrant cancer pathways have improved patient outcomes.Nevertheless,a primary cause of unsuccessful cancer therapy remains cancer drug resistance.In this review,we summarize the broad classes of resistance to cancer therapy,particularly pharmacokinetics,the tumor microenvironment,and drug resistance mechanisms.Furthermore,we describe how bacterial-mediated cancer therapy,a bygone mode of treatment,has been revitalized by synthetic biology and is uniquely suited to address the primary resistance mechanisms that confound traditional therapies.Through genetic engineering,we discuss how bacteria can be potent anticancer agents given their tumor targeting potential,anti-tumor activity,safety,and coordinated delivery of anti-cancer drugs. | Amin Zargar Samantha Chang Ankita Kothari Antoine M.Snijders Jian-Hua Mao Jessica Wang Amanda C.Hernandez Jay D.Keasling Trever G.Bivona | 2019 | Chronic Diseases and Translational Medicine2019，5，4： | 1 |
| 10 | Epigenetic signature and en- hancer activity of the human ApoE gene 显示文摘 | Chang EY Eiron C Jessica F | 2013 | Human Molecular Ge- netics2013，22，24： | 1 |
| 11 | Identification of five interferon-induced cellular proteins that inhibit west nile virus and dengue virus infections显示文摘 | Dong Jiang Jessica M Weidner Min Qing Xiao Ben Pan Haitao Guo Chunxiao Xu Xianchao Zhang Alex Birk Jinhong Chang Pei Yong Shi Timothy M Block Ju Tao Guo | 2010 | J Virol2010，84，16： | 1 |
| 12 | Ten-Year Incidence Rates of Age-Related Cataract in the Age-Related Eye Disease Study (AREDS): AREDS Report No. 33显示文摘 | Euna Koo Jessica R. Chang Elvira Agrón Traci E. Clemons Robert D. Sperduto Frederick L. Ferris Emily Y. Chew | 2013 | Ophthalmic Epidemiology2013，，2： | 1 |
| 13 | Targeted expression of islet neogenesis associated protein to beta cells enhances glucose tolerance and confers resistance to streptozotocin-induced hyperglycemia显示文摘 | Tien-Jyun Chang Jessica R. Weaver Angela Bowman Kendall Leone Rebekah Raab Aaron I. Vinik Gary L. Pittenger David A. Taylor-Fishwick | 2011 | Molecular and Cellular Endocrinology2011，，2： | 1 |
| 14 | 脾脏在肝癌合并肝硬化中的临床价值显示文摘脾脏作为人体最大的淋巴器官,可通过门静脉系统影响肝脏的免疫微环境。肝癌病人往往因为肝硬化和门静脉高压而出现脾功能亢进(脾亢)和脾肿大。脾脏功能失调不仅诱发肝脏纤维化,还改变肝脏的免疫调节,加速肝硬化和抑制肝脏再生能力,且使肝内微环境和免疫系统趋向“促肿瘤生成”与“肿瘤耐受”的状态。脾脏切除术已被证实在术后短期内可改善肝癌病人的一般状态、肝功能,甚至免疫力。因此,脾脏切除术可能提高肝癌病人术后抗癌治疗的耐受性。但对于合并门静脉高压和脾亢的肝癌病人选择进行肝脾联合切除是否存在远期效益或提高生存率仍有争议。 | Chang Jessica 陈旭晓 陈拥军 | 2023 | 外科理论与实践2023，28，4： | 0 |
| 15 | Disrupted Maturation of Prefrontal Layer 5 Neuronal Circuits in an Alzheimer’s Mouse Model of Amyloid Deposition显示文摘Mutations in genes encoding amyloid precursor protein(APP)and presenilins(PSs)cause familial forms of Alzheimer’s disease(AD),a neurodegenerative disorder strongly associated with aging.It is currently unknown whether and how AD risks affect early brain development,and to what extent subtle synaptic pathology may occur prior to overt hallmark AD pathology.Transgenic mutant APP/PS1 over-expression mouse lines are key tools for studying the molecular mechanisms of AD pathogenesis.Among these lines,the 5XFAD mice rapidly develop key features of AD pathology and have proven utility in studying amyloid plaque formation and amyloidβ(Aβ)-induced neurodegeneration.We reasoned that transgenic mutant APP/PS1 over-expression in 5XFAD mice may lead to neurodevelopmental defects in early cortical neurons,and performed detailed synaptic physiological characterization of layer 5(L5)neurons from the prefrontal cortex(PFC)of 5XFAD and wild-type littermate controls.L5 PFC neurons from 5XFAD mice show early APP/Aβimmunolabeling.Whole-cell patch-clamp recording at an early post-weaning age(P22–30)revealed functional impairments;although 5XFAD PFC-L5 neurons exhibited similar membrane properties,they were intrinsically less excitable.In addition,these neurons received smaller amplitude and frequency of miniature excitatory synaptic inputs.These functional disturbances were further corroborated by decreased dendritic spine density and spine head volumes that indicated impaired synapse maturation.Slice biotinylation followed by Western blot analysis of PFC-L5 tissue revealed that 5XFAD mice showed reduced synaptic AMPA receptor subunit GluA1 and decreased synaptic NMDA receptor subunit GluN2A.Consistent with this,patch-clamp recording of the evoked L23>L5 synaptic responses revealed a reduced AMPA/NMDA receptor current ratio,and an increased level of AMPAR-lacking silent synapses.These results suggest that transgenic mutant forms of APP/PS1 overexpression in 5XFAD mice leads to early developmental defects of cortical circuits,which could contribute to the age-dependent synaptic pathology and neurodegeneration later in life. | Chang Chen Jing Wei Xiaokuang Ma Baomei Xia Neha Shakir Jessica K.Zhang Le Zhang Yuehua Cui Deveroux Ferguson Shenfeng Qiu Feng Bai | 2023 | Neuroscience Bulletin2023，39，6： | 0 |
| 16 | Helper T Cell(CD4^(+))Targeted Tacrolimus Delivery Mediates Precise Suppression of Allogeneic Humoral Immunity显示文摘Antibody-mediated rejection(ABMR)is a major cause of dysfunction and loss of transplanted kidney.The current treatments for ABMR involve nonspecific inhibition and clearance of T/B cells or plasma cells.However,the prognosis of patients following current treatment is poor.T follicular helper cells(Tfh)play an important role in allograft-specific antibodies secreting plasma cell(PC)development.Tfh cells are therefore considered to be important therapeutic targets for the treatment of antibody hypersecretion disorders,such as transplant rejection and autoimmune diseases.Tacrolimus(Tac),the primary immunosuppressant,prevents rejection by reducing T cell activation.However,its administration should be closely monitored to avoid serious side effects.In this study,we investigated whether Tac delivery to helper T(CD4^(+))cells using functionalized mesoporous nanoparticles can block Tfh cell differentiation after alloantigen exposure.Results showed that Tac delivery ameliorated humoral rejection injury in rodent kidney graft by suppressing Tfh cell development,PC,and donor-specific antibody(DSA)generation without causing severe side effects compared with delivery through the drug administration pathway.This study provides a promising therapeutic strategy for preventing humoral rejection in solid organ transplantation.The specific and controllable drug delivery avoids multiple disorder risks and side effects observed in currently used clinical approaches. | Jia Shen Chang Liu Pengpeng Yan Meifang Wang Luying Guo Shuaihui Liu Jianghua Chen Jessica MRosenholm Hongfeng Huang Rending Wang Hongbo Zhang | 2022 | Research2022，，3： | 0 |
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