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| 1 | A reappraisal of CTLA-4 checkpoint blockade in cancer immunotherapy显示文摘anti-CTLA-4 抗体由阻止 B7-CTLA-4 相互作用接近否定发信号引起肿瘤拒绝,这被假定。在比临床上有效的 dosing 完成的血浆层次更加高的集中,令人惊讶地, anti-CTLA-4 抗体 Ipilimumab 不由 CTLA-4 也不 CTLA-4 绑定堵住任何一 B7 trans-endocytosis 到使不能调动或联系房间的 B7。因而, Ipilimumab 不从人性化的任何一个 CTLA4 基因在树枝状的房间(DC ) 上增加 B7 (Ctla4 h/h ) 或人的 CD34 + 茎重新组成房间的 NSG 老鼠。在 Ctla4 高效地表示人和老鼠 CTLA4 基因,绑在人的 anti-CTLA-4 抗体然而并非老鼠 CTLA-4 的 h/m 老鼠导致 Treg 弄空和 Fc 受体依赖者肿瘤拒绝。堵住的抗体 L3D10 比得上在引起肿瘤拒绝的非阻塞的 Ipilimumab。显著地,输在人类化期间堵住活动的 L3D10 子孙在导致 Treg 弄空和肿瘤拒绝仍然保持充分能干。有效地在淋巴的器官堵住 CD4 T 细胞激活和 de novo CD8 T 细胞 priming 的 Anti-B7 抗体否定地不影响 Ipilimumab 的 immunotherapeutic 效果。因此,临床上有效的 anti-CTLA-4 mAb 由独立于检查点封锁的机制引起肿瘤拒绝但是依赖于主人 Fc 受体。我们为 CTLA-4 检查点的一个重评价的数据电话封锁假设并且为安全、有效的 anti-CTLA-4 mAbs 的下一代提供新卓见。 | Xuexiang Du Fei Tang Mingyue Liu Juanjuan Su Yan Zhang Wei Wu Martin Devenport Christopher A Lazarski Peng Zhang Xu Wang Peiying Ye Changyu Wang Eugene Hwang Tinghui Zhu Ting Xu Pan Zheng Yang Liu | 2018 | Cell Research2018，28，4： | 25 |
| 2 | Rural E-commerce and New Model of Rural Development in China:A Comparative Study of 'Taobao Village' in Jiangsu Province显示文摘With the development of electronic commerce,there is a special phenomenon in rural areas of China that a lot of farmers in these areas depend on opening shops on Taobao online for a living. The products are made from the village workshop,and farmers become fullyfledged network businessmen. Electronic business platform mode of ' Taobao Village' is the result of integrated development of primary,secondary and tertiary industries. In this study,we take two kinds of typical Taobao villages( Dongfeng Village and Yanxia Village) as sample areas,and conduct comparative analysis of this new rural business model based on field survey data,case studies and theoretical research. We also probe into the problems in the development of Taobao villages,and set forth the recommendations for the new rural business model. | Changyu LIU Jiale LI Jing LIU | 2015 | Asian Agricultural Research2015，7，11： | 14 |
| 3 | The global oxygen budget and its future projection显示文摘Atmospheric oxygen (O_2 ) is the most crucial element on earth for the aerobic organisms that depend on it to release energy from carbon-based macromolecules. This is the first study to systematically analyze the global O_2 budget and its changes over the past 100 years. It is found that anthropogenic fossil fuel combustion is the largest contributor to the current O_2 deficit, which consumed 2.0 Gt/a in 1900 and has increased to 38.2 Gt/a by 2015. Under the Representative Concentration Pathways (RCPs) RCP8.5 scenario, approximately 100Gt (gigatonnes) of O_2 would be removed from the atmosphere per year until 2100,and the O_2 concentration will decrease from its current level of 20.946%to 20.825%. Human activities have caused irreversible decline of atmospheric O_2 . It is time to take actions to promote O_2 production and reduce O_2 consumption. | Jianping Huang Jiping Huang Xiaoyue Liu Changyu Li Lei Ding Haipeng Yu | 2018 | Science Bulletin2018，63，18： | 14 |
| 4 | Estimation of Gridded Atmospheric Oxygen Consumption from 1975 to 2018显示文摘Atmospheric Oxygen(O2)is one of the dominating features that allow the earth to be a habitable planet with advanced civilization and diverse biology.However,since the late 1980 s,observational data have indicated a steady decline in O2 content on the scale of parts-per-million level.The current scientific consensus is that the decline is caused by the fossil-fuel combustion;however,few works have been done to quantitatively evaluate the response of O2 cycle under the anthropogenic impact,at both the global and regional scales.This paper manages to quantify the land O2 flux and makes the initial step to quantificationally describe the anthropogenic impacts on the global O2 budget.Our estimation reveals that the global O2 consumption has experienced an increase from 33.69±1.11 to47.63±0.80 Gt(gigaton,109 t)O2yr^-1 between 2000 and 2018,while the land production of O2(totaling 11.34±13.48 Gt O2yr^-1 averaged over the same period)increased only slightly.In 2018,the combustion of fossil-fuel and industrial activities(38.45±0.61 Gt O2yr^-1)contributed the most to consumption,followed by wildfires(4.97±0.48 Gt O2yr^-1)as well as livestock and human respiration processes(2.48±0.16 and 1.73±0.13 Gt O2yr^-1,respectively).Burning of fossil-fuel that causes large O2 fluxes occurs in East Asia,India,North America,and Europe,while wildfires that cause large fluxes in comparable magnitude are mainly distributed in central Africa. | Xiaoyue LIU Jianping HUANG Jiping HUANG Changyu LI Lei DING Wenjun MENG | 2020 | Journal of Meteorological Research2020，34，3： | 8 |
| 5 | Flexible conductive polymer composites for smart wearable strain sensors显示文摘Wearable strain sensors based on flexible conductive polymer composites(FCPCs)have attracted great attention due to their applications in the fields of human–machine interaction,disease diagnostics,human motion detection,and soft robotic skin.In recent decades,FCPC‐based strain sensors with high stretchability and sensitivity,short response time,and excellent stability have been developed,which are expected to be more versatile and intelligent.Smart strain sensors are required to provide wearable comfort,such as breathability,selfcooling ability,and so forth.To adapt to the harsh environment,wearable strain sensors should also be highly adaptive to protect the skin and the sensor itself.In addition,portable power supply system,multisite sensing capability,and multifunctionality are crucial for the next generation of FCPC‐based strain sensor. | Kangkang Zhou Kun Dai Chuntai Liu Changyu Shen | 2020 | SmartMat2020，1，1： | 7 |
| 6 | Ni Flower/MXene-Melamine Foam Derived 3D Magnetic/Conductive Networks for Ultra-Efficient Microwave Absorption and Infrared Stealth显示文摘The development of multifunctional and efficient electromagnetic wave absorbing materials is a challenging research hotspot.Here,the magnetized Ni flower/MXene hybrids are successfully assembled on the surface of melamine foam(MF)through electrostatic self-assembly and dip-coating adsorption process,realizing the integration of microwave absorption,infrared stealth,and flame retardant.Remarkably,the Ni/MXene-MF achieves a minimum reflection loss(RLmin)of−62.7 dB with a corresponding effective absorption bandwidth(EAB)of 6.24 GHz at 2 mm and an EAB of 6.88 GHz at 1.8 mm.Strong electromagnetic wave absorption is attributed to the three-dimensional magnetic/conductive networks,which provided excellent impedance matching,dielectric loss,magnetic loss,interface polarization,and multiple attenuations.In addition,the Ni/MXene-MF endows low density,excellent heat insulation,infrared stealth,and flame-retardant functions.This work provided a new development strategy for the design of multifunctional and efficient electromagnetic wave absorbing materials. | Haoran Cheng Yamin Pan Xin Wang Chuntai Liu Changyu Shen Dirk W.Schubert Zhanhu Guo Xianhu Liu | 2022 | Nano-Micro Letters2022，14，4： | 7 |
| 7 | Simple fabrication of superhydrophobic PLA with honeycomb-like structures for high-efficiency oil-water separation显示文摘Polylactic acid(PLA) is one of the most suitable candidates for environmental pollution treatment because of its biodegradability which will not cause secondary pollution to the environment after application.However,there is still a lack of a green and facile way to prepare PLA oil-water separation materials.In this work,a water-assisted thermally induced phase separation method for the preparation of superhydrophobic PLA oil-water separation material with honeycomb-like structures is reported.The PLA material shows great ability in application and could adsorb 27.3 times oil to its own weight.In addition,it could also be applicated as a filter with excellent efficiency(50.9 m^3 m^(-2) h^(-1)). | Xiaolong Wang Yamin Pan Huan Yuan Meng Su Chunguang Shao Chuntai Liu Zhanhu Guo Changyu Shen Xianhu Liu | 2020 | Chinese Chemical Letters2020，31，2： | 7 |
| 8 | The oxygen cycle and a habitable Earth显示文摘As an important contributor to the habitability of our planet, the oxygen cycle is interconnected with the emergence and evolution of complex life and is also the basis to establish Earth system science. Investigating the global oxygen cycle provides valuable information on the evolution of the Earth system, the habitability of our planet in the geologic past, and the future of human life. Numerous investigations have expanded our knowledge of the oxygen cycle in the fields of geology,geochemistry, geobiology, and atmospheric science. However, these studies were conducted separately, which has led to onesided understandings of this critical scientific issue and an incomplete synthesis of the interactions between the different spheres of the Earth system. This review presents a five-sphere coupled model of the Earth system and clarifies the core position of the oxygen cycle in Earth system science. Based on previous research, this review comprehensively summarizes the evolution of the oxygen cycle in geological time, with a special focus on the Great Oxidation Event(GOE) and the mass extinctions, as well as the possible connections between the oxygen content and biological evolution. The possible links between the oxygen cycle and biodiversity in geologic history have profound implications for exploring the habitability of Earth in history and guiding the future of humanity. Since the Anthropocene, anthropogenic activities have gradually steered the Earth system away from its established trajectory and had a powerful impact on the oxygen cycle. The human-induced disturbance of the global oxygen cycle, if not controlled, could greatly reduce the habitability of our planet. | Jianping HUANG Xiaoyue LIU Yongsheng HE Shuzhong SHEN Zengqian HOU Shuguang LI Changyu LI Lijie YAO Jiping HUANG | 2021 | Science China Earth Sciences2021，64，4： | 5 |
| 9 | A continuous and high-efficiency process to separate coal bed methane with porous ZIF-8 slurry:Experimental study and mathematical modelling显示文摘Coal bed methane has been considered as an important energy resource.One major difficulty of purifying coal bed methane comes from the similar physical properties of CH_4 and N_2.The ZIF-8/water-glycol slurry was used as a medium to separate coal bed methane by fluidifying the solid adsorbent material.The sorption equilibrium experiment of binary mixture(CH_4/N_2)and slurry was conducted.The selectivity of CH_4 to N_2 is within the range of 2-6,which proved the feasibility of the slurry separation method.The modified Langmuir equation was used to describe the gas-slurry phase equilibrium behavior,and the calculated results were in good agreement with the experimental data.A continuous absorption-adsorption and desorption process on the separation of CH_4/N_2 in slurry is proposed and its mathematical model is also developed.Sensitivity analysis is conducted to determine the operation conditions and the energy performance of the proposed process was also evaluated.Feed gas contains 30 mol%of methane and the methane concentration in product gas is 95.46 mol%with the methane recovery ratio of 90.74%.The total energy consumption for per unit volume of product gas is determined as 1.846 kWh Nm^(-3).Experimental results and process simulation provide basic data for the design and operation of pilot and industrial plant. | Wan Chen Xiaonan Guo Enbao Zou Mengling Luo Mengzijing Chen Mingke Yang Hai Li Chongzhi Jia Chun Deng Changyu Sun Bei Liu Lanying Yang Guangjin Chen | 2020 | Green Energy & Environment2020，5，3： | 5 |
| 10 | High power and stable P-doped yolk-shell structured Si@C anode simultaneously enhancing conductivity and Li^(+)diffusion kinetics显示文摘Silicon is a low price and high capacity ancxje material for lithium-ion batteries.The yolk-shell structure can effectively accommodate Si expansion to improve stability.However,the limited rate performance of Si anodes can't meet people's growing demand for high power density.Herein,the phosphorus-doped yolk-shell Si@C materials(P-doped Si@C)were prepared through carbon coating on P-doped Si/SiO_(x)matrix to obtain high power and stable devices.Therefore,the as-prepared P-doped Si@C electrodes delivered a rapid increase in Coulombic efficiency from 74.4%to 99.6%after only 6 cycles,high capacity retention of-95%over 800 cycles at 4 A·g^(-1),and great rate capability(510 mAh·g^(-1)at 35 A·g^(-1)).As a result,P-doped Si@C anodes paired with commercial activated carbon and LiFePO_(4)cathode to assemble lithium-ion capacitor(high power density of〜61,080 W·kg^(-1)at 20 A·g^(-1))and lithium-ion full cell(good rate performance with 68.3 mAh·g^(-1)at 5 C),respectively.This work can provide an effective way tofurther improve power density and stability for energy storage devices. | Ming Chen Qinnan Zhou Jiantao Zai Asma Iqbal TsegayeTadesse Tsega Boxu Dong Xuejiao Liu Yuchi Zhang Changyu Yan Liang Zhao Ali Nazakat SharelPeisan E CheeTongJohn Low Xuefeng Qian | 2021 | Nano Research2021，14，4： | 5 |
| 11 | Robust double-layered ANF/MXene-PEDOT:PSS Janus films with excellent multi-source driven heating and electromagnetic interference shielding properties显示文摘The strategy of incorporating polymers into MXene-based functional materials has been widely used to improve their mechanical properties,however with inevitable sacrifice of their electrical conductivity and electromagnetic interference(EMI)shielding performance.This study demonstrates a facile yet efficient layering structure design to prepare the highly robust and conductive double-layer Janus films comprised of independent aramid nanofiber(ANF)and Ti3C2Tx MXene/poly(3,4-ethylenedioxythiophene):poly(styrenesulfonate)(PEDOT:PSS)layers.The ANF layer serves to provide good mechanical stability,whilst the MXene/PEDOT:PSS layer ensures excellent electrical conductivity.Doping PEDOT:PSS into the MXene layer enhances the interfacial bonding strength between the MXene and ANF layers and improves the hydrophobicity and water/oxidation resistance of MXene layer.The resultant ANF/MXene-PEDOT:PSS Janus film with a conductive layer thickness of 4.4μm was shown to display low sheet resistance(2.18Ω/sq),good EMI shielding effectiveness(EMI SE of 48.1 dB),high mechanical strength(155.9 MPa),and overall toughness(19.4 MJ/m^(3)).Moreover,the excellent electrical conductivity and light absorption capacity of the MXene-PEDOT:PSS conductive layer mean that these Janus films display multi-source driven heating functions,producing excellent Joule heating(382℃ at 4 V)and photothermal conversion(59.6℃ at 100 mW/m^(2))properties. | Bing Zhou Jianzhou Song Bo Wang Yuezhan Feng Chuntai Liu Changyu Shen | 2022 | Nano Research2022，15，10： | 4 |
| 12 | Understanding of the sodium storage mechanism in hard carbon anodes显示文摘Hard carbon has been regarded as the most promising anode material for sodiumion batteries(SIBs)due to its low cost,high reversible capacity,and low working potential.However,the uncertain sodium storage mechanism hinders the rational design and synthesis of high-performance hard carbon anode materials for practical SIBs.During the past decades,tremendous efforts have been put to stimulate the development of hard carbon materials.In this review,we discuss the recent progress of the study on the sodium storage mechanism of hard carbon anodes,and the effective strategies to improve their sodium storage performance have been summarized.It is anticipated that hard carbon anodes with high electrochemical properties will be inspired and fabricated for large-scale energy storage applications. | Xiaoyang Chen Changyu Liu Yongjin Fang Xinping Ai Faping Zhong Hanxi Yang Yuliang Cao | 2022 | Carbon Energy2022，4，6： | 3 |
| 13 | Applying DNA Barcoding to Identify Actinidia in the Northeast of China显示文摘Identification of kiwifruit germplasm materials is the basis of protecting and utilizing these resources. However,identifying Actinidia arguta varieties based on morphology is difficult,especially for non-specialists. In this study,we collected 180 specimens comprising 60 varieties of three species( A. arguta,A. kolomikta,and A. polygama) from the Northeast of China. The emphasis of our study was on the feasibility of identifying A. arguta varieties. Here,we used common analysis methods( genetic distance,phylogenetic analysis and the DNA barcoding gap) and SNPs analysis to evaluate the discriminatory power of different DNA barcoding markers. The results revealed that common methods were insufficient to identify A. arguta varieties but SNPs analysis based on DNA barcoden was the potential method for identifying A. arguta varieties. Besides,Our study agree that DNA barcoding could be used to analysis the evaluation genetic relationship of the Actinidia plants. | haishuang liu hongyan qin jun ai huifang song yiming yang shutian fan peilei xu guangli shi changyu li | 2018 | Agricultural Biotechnology2018，7，2： | 2 |
| 14 | 3D Carbon Frameworks for Ultrafast Charge/Discharge Rate Supercapacitors with High Energy‑Power Density显示文摘Carbon-based electric double layer capacitors(EDLCs)hold tremendous potentials due to their high-power performance and excellent cycle stability.However,the practical use of EDLCs is limited by the low energy density in aqueous electrolyte and sluggish diffusion kinetics in organic or/and ionic liquids electrolyte.Herein,3D carbon frameworks(3DCFs)constructed by interconnected nanocages(10-20 nm)with an ultrathin wall of ca.2 nm have been fabricated,which possess high specific surface area,hierarchical porosity and good conductive network.After deoxidization,the deoxidized 3DCF(3DCFDO)exhibits a record low IR drop of 0.064 V at 100 A g^−1 and ultrafast charge/discharge rate up to 10 V s^−1.The related device can be charged up to 77.4%of its maximum capacitance in 0.65 s at 100 A g^−1 in 6 M KOH.It has been found that the 3DCF-DO has a great affinity to EMIMBF4,resulting in a high specific capacitance of 174 F g^−1 at 1 A g^−1,and a high energy density of 34 Wh kg^−1 at an ultrahigh power density of 150 kW kg^−1 at 4 V after a fast charge in 1.11 s.This work provides a facile fabrication of novel 3D carbon frameworks for supercapacitors with ultrafast charge/discharge rate and high energy-power density. | Changyu Leng Zongbin Zhao Yinzhou Song Lulu Sun Zhuangjun Fan Yongzhen Yang Xuguang Liu Xuzhen Wang Jieshan Qiu | 2021 | Nano-Micro Letters2021，13，1： | 2 |
| 15 | Design Aspects of Hybrid HVDC System显示文摘Hybrid high voltage direct current transmission(Hybrid HVDC)is a new type of HVDC technology developed in recent years.It combines the characteristics of large-capacity and low cost of the line commutated converters(LCC)and non-commutation failure and dynamic reactive power support of the voltage sourced converters(VSCs)in one HVDC system.It has technical advantages in the fields of unidirectional power transmission and in the application of improving the stability of multi-infeed HVDCs,giving it broad application prospects.This paper defines the basic form of hybrid HVDC first and discusses the characteristics and challenges of different hybrid HVDCs.Then,it analyzes the matching characteristics between LCC and VSC in the station-station hybrid HVDC,studies the key technologies,such as VSC topologies and control strategies for clearing the DC overhead line faults,and introduces the key technologies for analyzing and suppressing the high-frequency resonances between VSC and the power grid.In this paper,using the Wudongde UHV multi-terminal HVDC as an example,the proposed key technologies are analyzed and verified. | Hong Rao Yuebin Zhou Changyue Zou Shukai Xu Yan Li Liu Yang Weihuang Huang | 2021 | CSEE Journal of Power and Energy Systems2021，7，3： | 2 |
| 16 | Cetus:an efficient symmetric searchable encryption against file-injection attack with SGX显示文摘Symmetric searchable encryption(SSE)allows the users to store and query their private data in the encrypted database.Many SSE schemes for different scenarios have been proposed in the past few years,however,most of these schemes still face more or fewer security issues.Using these security leakages,many attacks against the SSE scheme have been proposed,and especially the non-adaptive file injection attack is the most serious.Non-adaptive file injection attack(NAFA)can effectively recover some extremely important private information such as keyword plaintext.As of now,there is no scheme that can effectively defend against such attacks.We first propose the new security attribute called toward privacy to resist nonadaptive file injection attacks.We then present an efficient SSE construction called Cetus to achieve toward privacy.By setting up a buffer and designing the efficient oblivious reading algorithm based on software guard extensions(SGX),we propose the efficient one-time oblivious writing mechanism.Oblivious writing protects the update pattern and allows search operations to be performed directly on the data.The experiment results show that Cetus achieves O(aw)search time and O(1)update communication.The practical search time,communication,and computation overheads incurred by Cetus are lower than those of state-of-the-art. | Yanyu HUANG Siyi LV Zheli LIU Xiangfu SONG Jin LI Yali YUAN Changyu Dong | 2021 | Science China(Information Sciences)2021，64，8： | 2 |
| 17 | Convergence properties of nonmonotone spectral projected gradient methods显示文摘 | Changyu Wang Qian Liu Xinmin Yang | 2004 | Journal of Computational and Applied Mathematics2004，，： | 1 |
| 18 | A New Cognitive Model: Cloud Model 显示文摘 | Li Deyi Liu Changyu Gan Wenyan | 2009 | International Journal of Intelligent Systems2009，24，4： | 1 |
| 19 | Organic–inorganic hybrid material for the cells immobilization: Long-term viability mechanism and application in BOD sensors显示文摘 | Ling Liu Li Shang Shaojun Guo Dan Li Changyu Liu Li Qi Shaojun Dong | 2009 | Biosensors and Bioelectronics2009，，2： | 1 |
| 20 | Nano-hybrid shish-kebab: Isotactic polypropylene epitaxial growth on electrospun polyamide 66 nanofibers via isothermal crystallization显示文摘 | Yanyan Liang Guoqiang Zheng Wenjuan Han Chuntai Liu Jingbo Chen Qian Li Baochen Liu Changyu Shen Xiangfang Peng | 2010 | Materials Letters2010，，4： | 1 |
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