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| 1 | Dendrobium officinale Kimura et Migo and American ginseng mixture: A Chinese herbal formulation for gut microbiota modulation显示文摘Dendrobium officinale Kimura et Migo(D. officinale) is a famous traditional Chinese medicine(TCM). A mixture of D. officinale and American ginseng has been shown to enhance cell-mediated immunity, humoral immunity, and monocyte/macrophage functions in mice. Here, the effects of a D. officinale and American ginseng mixture on the structure of gut microbial community in dogs were examined using high-throughput 16S rRNA gene amplicon sequencing. The data revealed that while the mixture did not change the diversity of gut microbial community significantly, differences among individuals were significantly reduced. Furthermore, the mixture-responsive operational taxonomic units(OTUs) exhibited a phase-dependent expression pattern. Fifty-five OTUs were found to exhibit a mixture-induced expression pattern, among which one third were short-chain fatty acid(SCFA)-producing genera and the others were probiotic genera included Lactobacillus spp., Sutterella, Alistipes, Anaerovorax, Bilophila, Coprococcus, Gordonibacter, Oscillibacter, among others. By contrast, 36% of the OTUs exhibiting a mixture-repressed expression pattern were disease-associated microorganisms, and six genera, namely Actinomyces, Escherichia/Shigella, Fusobacterium, Slackia, Streptococcus and Solobacterium, were associated with cancer. In addition, five genera were closely associated with diabetes, namely Collinsella,Rothia, Howardella, Slackia and Intestinibacter. Our results indicate that this D. officinale and American ginseng mixture may be used as a prebiotic agent to enhance SCFA-producing genera and prevent gut dysbiosis. | LIU Cheng-Zhi CHEN Wei WANG Mei-Xia WANG Ying CHEN Li-Qing ZHAO Feng SHI Ya LIU Hui-Jun DOU Xiao-Bing LIU Chao CHEN Huan | 2020 | Chinese Journal of Natural Medicines2020，18，6： | 10 |
| 2 | Adsorption behavior of carbon dioxide and methane in bituminous coal:A molecular simulation study显示文摘The adsorption behavior of CO_2, CH_4 and their mixtures in bituminous coal was investigated in this study. First, a bituminous coal model was built through molecular dynamic(MD) simulations, and it was confirmed to be reasonable by comparing the simulated results with the experimental data. Grand Canonical Monte Carlo(GCMC)simulations were then carried out to investigate the single and binary component adsorption of CO_2 and CH_4with the built bituminous coal model. For the single component adsorption, the isosteric heat of CO_2 adsorption is greater than that of CH_4 adsorption. CO_2 also exhibits stronger electrostatic interactions with the heteroatom groups in the bituminous coal model compared with CH_4, which can account for the larger adsorption capacity of CO_2 in the bituminous coal model. In the case of binary adsorption of CO_2 and CH_4mixtures, CO_2 exhibits the preferential adsorption compared with CH_4 under the studied conditions. The adsorption selectivity of CO_2 exhibited obvious change with increasing pressure. At lower pressure, the adsorption selectivity of CO_2 shows a rapid decrease with increasing the temperature, whereas it becomes insensitive to temperature at higher pressure. Additionally, the adsorption selectivity of CO_2 decreases gradually with the increase of the bulk CO_2 mole fraction and the depth of CO_2 injection site. | Jing You Li Tian Chao Zhang Hongxing Yao Wu Dou Bin Fan Songqing Hu | 2016 | Chinese Journal of Chemical Engineering2016，24，9： | 10 |
| 3 | Recent progress in thermoelectric materials显示文摘Direct conversion of heat into electricity through advanced thermoelectric(TE)materials has been one of the most attractive solutions to the severe environmental and energy issues facing humanity.In recent years,great progress has been made in improving their dimensionless figure of merit(ZT),which determines the conversion efficiency of TE devices.ZT is related to three‘‘interlocked’’factors—the Seebeck coefficient,electrical conductivity,and thermal conductivity.These three factors are interdependent in bulk TE materials,and altering one changes the other two.The difficulty in simultaneously optimizing them caused TE research to stagnate,until great reductions in thermal conductivity were both theoretically and experimentally proven in nanomaterials in 1993.In this review,we first introduce some TE fundamentals and then review the most recently improvements in ZT in different kinds of inorganic and organic TE materials,which is followed by an investigation of the outlook for new directions in TE technology. | Chao Han Zhen Li Shixue Dou | 2014 | Chinese Science Bulletin2014，59，18： | 9 |
| 4 | Effects of nanostructure on clean energy: big solutions gained from small features显示文摘The increasing energy consumption and environmental concerns have driven the development of costeffective, high-efficiency clean energy. Advanced functional nanomaterials and relevant nanotechnologies are playing a crucial role and showing promise in resolving some energy issues. In this view, we focus on recent advances of functional nanomaterials in clean energy applications, including solar energy conversion, water splitting, photodegradation, electrochemical energy conversion and storage, and thermoelectric conversion, which have attracted considerable interests in the regime of clean energy. | Jinyan Xiong Chao Han Zhen Li Shixue Dou | 2015 | Science Bulletin2015，60，24： | 6 |
| 5 | 可恢复功能装配式梁柱中柱节点抗震性能研究(英文)显示文摘目的:提出一种震后功能可快速恢复的装配式中柱节点,并建立其设计理论;考察装配式中柱节点的抗震性能及震后修复性能,并提出设计建议。创新点:提出一种可快速恢复震后功能的装配式中柱节点;2.提出装配式中柱节点设计理论,并通过数值手段对其合理性进行校核;3.试验研究考察基础试件的抗震性能及震后修复性能。方法:1.通过理论分析手段建立装配式中柱节点设计理论;2.利用数值模拟手段通过4组8个算例来验证节点设计理论,并对节点抗震性能进行数值研究;3.对基础试件进行低周往复荷载试验研究及修复试验研究,进一步验证设计理论的合理性,并考察节点的抗震性能及震后修复性能。结论:1.提出的设计理论可准确地预测装配式中柱节点的屈服荷载;2.设计合理的装配式中柱节点具有良好的承载性能及滞回特性,可满足结构震后功能修复要求;3.翼缘连接盖板厚度和材性、中间螺栓间距和梁段间隙参数对节点抗震性能影响较大,需合理设置。 | Ai-lin ZHANG Ying-xia WU Zi-qin JIANG Xu-qiao ZHANG Chao DOU | 2017 | Journal of Zhejiang University-Science A(Applied Physics & Engineering)2017，18，12： | 6 |
| 6 | COVID-19 Cases Spread Through the K350 Train-Jilin and Heilongjiang Provinces,China,January 2021显示文摘As of 16∶00 on January 13,2021,95 positive cases of coronavirus disease 2019(COVID-19)were reported in Suihua City of Heilongjiang Province and an additional 35 cases have been linked across 7 cities in 3 provinces:Qiqihar City(7 cases),Mudanjiang City(4 cases),Harbin City(3 cases),and Yichun City(1 case)of Heilongjiang Province;Changchun City(9 cases)and Tonghua City(6 cases)of Jilin Province;and Weihai City of Shandong Province(1 case). | Lei Zhou Laishun Yao Peter Hao Chao Li Qinglong Zhao Huiling Dong Jinhua Dou Shengnan Wang George F.Gao Qun Li Biao Huang | 2021 | China CDC weekly2021，3，8： | 5 |
| 7 | Can ChatGPT Boost Artistic Creation:The Need of Imaginative Intelligence for Parallel Art显示文摘CHATGPT,one of the leading Large Language Models(LLMs),has acquired linguistic capabilities such as text comprehension and logical reasoning,enabling it to engage in natural conversations with humans. | Chao Guo Yue Lu Yong Dou Fei-Yue Wang | 2023 | IEEE/CAA Journal of Automatica Sinica2023，10，4： | 4 |
| 8 | Excellent strength-ductility synergy properties of gradient nano-grained structural CrCoNi medium-entropy alloy显示文摘Tailoring heterogeneities could bring out excellent strength-ductility synergy properties.A gradient nanograined(GNG)structure,i.e.grain size range from nanometer(~50 nm)at topest surface layer to micrometer(~1.3μm)at center layer,was successfully introduced into CrCoNi medium-entropy alloy(MEA)by means of high energy shot peening in this work.Experimental results demonstrated that this GNG CrCoNi MEA shows excellent strength and ductility combination properties,exhibiting high yield strength and ultimate tensile strength of~1215 MPa and~1524 MPa,respectively,while remaining a good ductility of~23.0%.The extraordinary hetero-deformation induced(HDI)hardening origins from heterogeneous structure,i.e.GNG structure,which contributes to the majority strength enhancement.Dynamical reinforced heterogeneous structure during tension process results in the enhanced HDI hardening effect,which facilitates excellent ductility and strain hardening capacity at high-level strength.Our work provide not only a feasible and effective way to strengthen the CrCoNi MEA,and other low stacking faults energy(SFE)materials,but also an useful insight to understanding HDI hardening in heterogeneous structure. | Wenjie Lu Xian Luo Dou Ning Miao Wang Chao Yang Miaoquan Li Yanqing Yang Pengtao Li Bin Huang | 2022 | Journal of Materials Science & Technology2022，，17： | 2 |
| 9 | Numerical simulation of preparation of ultrafine cerium oxides using jet-flow pyrolysis显示文摘Ultrafine rare-earth oxides(REOs) are widely applied in all fields of daily life,but the conventional preparation methods are limited by a long procedure,low efficiency and severe environmental pollution.Our team has independently developed a jet pyrolysis reactor for the preparation of ultrafine cerium oxides,and this process has theoretical significance and practical application values.In this study,gas-solid pyrolysis reactions inside the jet-flow pyrolysis reactor were numerically simulated.We performed a coupling computation of the combustion,phase transformation and gas-solid reaction on Fluent and userdefined functions.We characterized the flows of different phases as well as the compositions and distributive laws of the reactants/products in the reactor.The gas-phase inlet velocity and dynamic pressure/additional pressure were related by a quadratic function.The velocity at the throat inlet changed the most,and the outlet velocity was very stable.The CeO2 concentrations were obviously stratified.This study enriches theories of jet-flow pyrolysis and theoretically underlies the optimization and popularization of self-developed pyrolysis reactors. | Chao Lv Ting-An Zhang Zhi-He Dou Qiu-Yue Zhao | 2019 | Rare Metals2019，38，12： | 2 |
| 10 | Programmed death 1, ligand 1 and 2 correlated genes and their association with mutation, immune infiltration and clinical outcomes of hepatocellular carcinoma显示文摘BACKGROUND The exact regulation network of programmed death 1(PD-1), programmed death ligand 1(PD-L1), and programmed death ligand 2(PD-L2) signaling in immune escape is largely unknown. We aimed to describe the gene expression profiles related to PD-1 as well as its ligands PD-L1 and PD-L2, thus deciphering their possible biological processes in hepatocellular carcinoma(HCC).AIM To find the possible mechanism of function of PD-1, PD-L1, and PD-L2 in HCC.METHODS Based on the expression data of HCC from The Cancer Genome Atlas, the PD-1/PD-L1/PD-L2 related genes were screened by weighted correlation network analysis method and the biological processes of certain genes were enriched. Relation of PD1/PD-L1/PD-L2 with immune infiltration and checkpoints was investigated by co-expression analysis. The roles of PD-1/PD-L1/PD-L2 in determination of clinical outcome were also analyzed.RESULTS Mutations of calcium voltage-gated channel subunit alpha1 E, catenin beta 1, ryanodine receptor 2, tumor suppressor protein p53, and Titin altered PD-1/PDL1/PD-L2 expression profiles in HCC. PD-1, PD-L1, and PD-L2 related genes were mainly enriched in biological procedures of T cell activation, cell adhesion, and other important lymphocyte effects. In addition, PD-1/PD-L1/PD-L2 was related with immune infiltration of CD8 T cells, cytotoxic lymphocytes,fibroblasts, and myeloid dendritic cells. Immune checkpoints of CTLA4, CD27, CD80, CD86, and CD28 were significantly related to the PD-1/PD-L1/PD-L2 axis. Clinically, PD-1 and PD-L2 expression was correlated with recurrence(P = 0.005 for both), but there was no significant correlation between their expression and HCC patient survival.CONCLUSION Mutations of key genes influence PD-1, PD-L1, and PD-L2 expression. PD-1, PDL1, and PD-L2 related genes participate in T cell activation, cell adhesion, and other important lymphocyte effects. The finding that PD-1/PD-L1/PD-L2 is related to immune infiltration and other immune checkpoints would expand our understanding of promising anti-PD-1 immunotherapy. | Qiu-Ju Sheng Wen-Yue Tian Xiao-Guang Dou Chong Zhang Yan-Wei Li Chao Han Yao-Xin Fan Ping-Ping Lai Yang Ding | 2020 | World Journal of Gastrointestinal Oncology2020，12，11： | 2 |
| 11 | Effects of carbon on electrochemical performance of red phosphorus(P) and carbon composite as anode for sodium ion batteries显示文摘Red phosphorus/graphite(P/G) and red phosphorus/carbon nanotube(P/CNT) composites were prepared by ball milling red phosphorus with CNTs and graphite, respectively. The electrochemical results show superior electrochemical performances of the P/G and P/CNT composites compared with that of the reference sample milled with Super-P carbon. After 70 cycles, the P/G and P/CNT composites remained771.6 and 431.7 mA h g^(-1), with 68 % and 50 % capacity retention, respectively. With increasing the milling time(20 h), CNTs were cut into short pieces and then broken into carbon rings and sheets which were well mixed with red phosphorus. The morphology of the P/CNT composite can buffer the large volume changes from alloying and de-alloying during cycling, resulting in the enhanced cycling stability. | Zhi-Jia Zhang Wei-Jie Li Shu-Lei Chou Chao Han Hua-Kun Liu Shi-Xue Dou | 2021 | Journal of Materials Science & Technology2021，，9： | 2 |
| 12 | Realization of warm white light emitting in single phase Gd(P_(x)V_(1−x))O_(4):y at% Sm^(3+),1 at% Bi^(3+) phosphor显示文摘A series of single phase,warm white light emitting phosphors,Gd(P_(x)V_(1−x))O_(4):y at%Sm^(3+),with 1 at%Bi^(3+) doping concentration were synthesized by high temperature solid state method in this work.The experimental results indicate broadband cyan emission of Bi^(3+)and characteristic orange-red emission of Sm^(3+)can be effectively tuned by changing the ratios of PO^(3−)_(4)/VO^(3−)_(4) in Gd(P_(x)V_(1−x))O_(4):1 at%Sm^(3+),1 at%Bi^(3+),and the energy transfer process among VO^(3−)_(4),Sm^(3+),Bi^(3+) also can be adjusted.Based on this,warm white light emitting can be realized by further optimizing the doping concentration of Sm^(3+) in the phosphors.At 423 K,the PL intensity of Gd(P_(0.7)V_(0.3))O_(4):2 at%Sm^(3+),1 at%Bi^(3+) remains~84.3%of the initial value at 293 K,while the measured quantum efficiency is 67.8%.EL spectrum analysis results of the fabricated white light emitting diode(wLED)based on a 310 nm UV-chip and Gd(P_(0.7)V_(0.3))O4:2 at%Sm^(3+),1 at%Bi^(3+)phosphors imply low correlated color temperature(3132 K)and appropriate color-rending index(R_(a)=82.7).These results demonstrate that Gd(P_(0.7)V_(0.3))O4:2 at%Sm^(3+),1 at%Bi^(3+)is a good candidate for manufacturing UV-activated warm white light emitting diodes. | Chao Dou Yanzhen Yin Fei Zheng Zhen Wang Shijia Sun Chen Hu Yang Che Bing Teng Degao Zhong | 2022 | Journal of Rare Earths2022，40，4： | 2 |
| 13 | Local conformation transitions of linear DNA induced by cisplatin显示文摘Cisplatin is the most successful anti-tumor drug,and its pharmacological property is generally considered to derive from the modification of DNA molecules.Structural modifications of short DNA induced by cisplatin have already been investigated.However,the conformation transitions induced by cisplatin are not clear.In the present letter,we have studied the effect of low-concentration cisplatin on DNA conformation by using AFM imaging.We observed formations of micro-rod structures of linear DNA induced by cisplatin.A method is presented to quantitatively analyze the occurrence of micro-rod structures.We found that the formation of micro-rod structures depends on the DNA sequence.Based on the results,we proposed a physical mechanism to explain the local conformation transitions of DNA molecules under the influence of cisplatin. | Chao Ji Lingyun Zhang Shuoxing Dou Pengye Wang | 2014 | Chinese Science Bulletin2014，59，25： | 1 |
| 14 | Therapeutic potential and mechanism of Chinese herbal medicines in treating fibrotic liver disease显示文摘Liver fibrosis is a pathological condition characterized by replacement of normal liver tissue with scar tissue,and also the leading cause of liver-related death worldwide.During the treatment of liver fibrosis,in addition to antiviral therapy or removal of inducers,there remains a lack of specific and effective treatment strategies.For thousands of years,Chinese herbal medicines(CHMs)have been widely used to treat liver fibrosis in clinical setting.CHMs are effective for liver fibrosis,though its mechanisms of action are unclear.In recent years,many studies have attempted to determine the possible mechanisms of action of CHMs in treating liver fibrosis.There have been substantial improvements in the experimental investigation of CHMs which have greatly promoted the understanding of anti-liver fibrosis mechanisms.In this review,the role of CHMs in the treatment of liver fibrosis is described,based on studies over the past decade,which has addressed the various mechanisms and signaling pathways that mediate therapeutic efficacy.Among them,inhibition of stellate cell activation is identified as the most common mechanism.This article provides insights into the research direction of CHMs,in order to expand its clinical application range and improve its effectiveness. | LI Yanwei LU Yunrui NIAN Mozuo SHENG Qiuju ZHANG Chong HAN Chao DOU Xiaoguang DING Yang | 2023 | Chinese Journal of Natural Medicines2023，21，9： | 1 |
| 15 | Out-of-plane strength design of spatially trussed arches with a rectangular lattice section显示文摘 | Yan-Lin Guo Si-Yuan Zhao Chao Dou Yong-Lin Pi | 2013 | Journal of Constructional Steel Research2013，，： | 1 |
| 16 | Elastic out-of-plane buckling load of circular steel tubular truss arches incorporating shearing effects显示文摘 | Chao Dou Yan-Lin Guo Si-Yuan Zhao Yong-Lin Pi Mark Andrew Bradford | 2013 | Engineering Structures2013，，： | 1 |
| 17 | Synthesis of aqueous CdTe quantum dots embedded silica nanoparticles and their applications as fluorescence probes显示文摘 | Wang Chao Ma Qiang Dou Wenchao | 2009 | Talanta2009，77，： | 1 |
| 18 | Elastic out-of-plane buckling load of circular steel tubular truss arches incorporating shearing effects显示文摘 | Chao Dou Yan-Lin Guo Si-Yuan Zhao Yong-Lin Pi Mark Andrew Bradford | 2013 | Engineering Structures2013，，： | 1 |
| 19 | Gelcasting of aluminum nitride ceramics using hydantion epoxy resin as gelling agent显示文摘 | Chao Jiang Xueping Gan Dou Zhang Rui Xie Kechao Zhou | 2013 | Ceramics International2013，，： | 1 |
| 20 | Development of a Novel Enzymatic Cycling Assay for Total Homocysteine 显示文摘 | Chao Dou Dongyuan Xia Liqing Zhang | 2005 | Clin Chem2005，51，： | 1 |
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