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| 1 | A community-derived classification for extant lycophytes and ferns显示文摘发展史长通知了蕨类植物分类。当我们推断进化的树的能力改善了,针对认出生来的组的分类变得逐渐地预兆、稳定。这里,我们为 lycophytes 和蕨纲植物提供一个现代、全面分类,在下面,利用一条基于社区的途径类水平。我们 monophyly 用作主要标准让 taxa,而且目的识别保存两个广泛地被接受的存在 taxa 和界限并且与我们蕨类植物发展史的理解一致。总共,这个分类对待一在 337 个类, 51 个家庭, 14 目,和二个班估计了 11 916 种类。这个分类没在 lycophyte 和蕨纲植物上作为最后的词被打算分类,而是当前的假设的概括陈述,源于最好的可得到的数据并且在问题由熟悉植物的那些大多数塑造了。我们希望它将在蕨类植物上为最近的文学的那些想要的参考用作一个资源发展史和分类,为指导未来调查的一个框架,和推进讲话的刺激。 | Eric Schuettpelz Harald Schneider Alan R. Smith Peter Hovenkamp Jefferson Prado Germinal Rouhan Alexandre Salino Michael Sundue Thafs Elias Almeida Barbara Parris Emily B. Sessa Ashley R. Field Andre Luis de Gasper Carl J. Rothfels Michael D. Windham Marcus Lehnert Benjamin Dauphin Atsushi Ebihara Samuli Lehtonen Pedro Bond Schwartsburd Jordan Metzgar Li-Bing Zhang Li-Yaung Kuo Patrick J. Brownsey Masahiro Kato Marcelo Daniel Arana Francine C. Assis Michael S. Barker David S. Barrington Ho-Ming Chang Yi-Han Chang Yi-Shan Chao Cheng-Wei Chen De-Kui Chen Wen-Liang Chiou Vinicius Antonio de Oliveira Dittrich Yi-Fan Duan Jean-Yves Dubuisson Donald R. Farrar Susan Fawcett Jose Maria Gabriel y Galan Luiz Armando de Araujo Goes-Neto Jason R. Grant Amanda L. Grusz Christopher Haufler Warren Hauk Hai He Sabine Hennequin Regina Yoshie Hirai Layne Huiet Michael Kessler Petra Korall Paulo H. Labiak Anders Larsson Blanca Leen Chun-Xiang Li Fay-Wei Li Melanie Link-Perez Hong-Mei Liu Ngan Thi Lu Esteban I. Meza-Torres Xin-Yuan Miao Robbin Moran Claudine Massi Mynssens Nathalie Nagalingum Benjamin Ollgaard Alison M. Paul Jovani B. de S. Pereira Leon R. Perrie Monica Ponce Tom A. Ranker Christian Schulz Wataru Shinohara Alexander Shmakov Erin M. Sigel Filipe Soares de Souza Lana da Silva Sylvestre Weston Testo Luz Amparo Triana-Moreno Chie Tsutsumi Hanna Tuomisto IvAn A. Valdespino Alejandra Vasco Raquel Stauffer Viveros Alan Weakley Ran Wei Stina Weststrand Paul G. Wolf George Yatskievych Xiao-Gang Xu Yue-Hong Yan Liang Zhang Xian-Chun Zhang Xin-Mao Zhou | 2016 | Journal of Systematics and Evolution2016，54，6： | 44 |
| 2 | Precise nanomedicine for intelligent therapy of cancer显示文摘Precise nanomedicine has been extensively explored for efficient cancer imaging and targeted cancer therapy, as evidenced by a few breakthroughs in their preclinical and clinical explorations. Here, we demonstrate the recent advances of intelligent cancer nanomedicine, and discuss the comprehensive understanding of their structure-function relationship for smart and efficient cancer nanomedicine including various imaging and therapeutic applications, as well as nanotoxicity. In particular, a few emerging strategies that have advanced cancer nanomedicine are also highlighted as the emerging focus such as tumor imprisonment, supramolecular chemotherapy, and DNA nanorobot. The challenge and outlook of some scientific and engineering issues are also discussed in future development. We wish to highlight these new progress of precise nanomedicine with the ultimate goal to inspire more successful explorations of intelligent nanoparticles for future clinical translations. | Huabing Chen Zhanjun Gu Hongwei An Chunying Chen Jie Chen Ran Cui Siqin Chen Weihai Chen Xuesi Chen Xiaoyuan Chen Zhuo Chen Baoquan Ding Qian Dong Qin Fan Ting Fu Dayong Hou Qiao Jiang Hengte Ke Xiqun Jiang Gang Liu Suping Li Tianyu Li Zhuang Liu Guangjun Nie Muhammad Ovais Daiwen Pang Nasha Qiu Youqing Shen Huayu Tian Chao Wang Hao Wang Ziqi Wang Huaping Xu Jiang-Fei Xu Xiangliang Yang Shuang Zhu Xianchuang Zheng Xianzheng Zhang Yanbing Zhao Weihong Tan Xi Zhang Yuliang Zhao | 2018 | Science China Chemistry2018，61，12： | 19 |
| 3 | Electrolyte materials for intermediate-temperature solid oxide fuel cells显示文摘Solid oxide fuel cells(SOFCs)directly convert chemical energy that is stored in a wide range of fuels into direct current electricity,with high efficiency and low emissions,via a series of electrochemical reactions at elevated operating temperatures(generally 400-1000℃).During such an energy conversion process,the properties of electrolyte materials determine the working principle and operating temperature of the SOFC.When considering the cost and stability,lowering the operating temperature is critical,and this has become one of the developing trends in SOFC research.The key point for realizing a reduction in operating temperature is to maintain low ohmic resistance of the electrolyte and low polarization resistance of the electrodes.In practice,the mechanical and chemical stability of the electrolyte is also a big concern.According to their differences in ion conduction mechanisms,there are three main types of electrolyte material available,namely,oxygen ion-conducting,proton-conducting,and dual ion-conducting electrolytes.In this review,we give a comprehensive summary of the recent advances in the development of these three types of electrolyte material for intermediate-temperature SOFCs.Both conductivity and stability are emphasized.In conclusion,the current challenges and future development prospects are discussed. | Huangang Shi Chao Su Ran Ran Jiafeng Cao Zongping Shao | 2020 | Progress in Natural Science:Materials International2020，30，6： | 12 |
| 4 | Effects of dietary yeast nucleotides on growth, non-specific immunity intestine growth and intestinal microbiota of juvenile hybrid tilapia Oreochromis niloticus ♀ × Oreochromis aureus ♂显示文摘This study investigated the effect of dietary supplementation of yeast nucleotides on the growth, nonspecific immunity, intestine growth and intestinal microbiota of juvenile hybrid tilapia. Tilapia(initial average weight of 8.02 g) was fed test diets supplemented with a yeast-originated nucleotide mixture(0,0.15, 0.30, 0.60, and 1.20 g/100 g diet) for 8 weeks. Fish fed the diet with 0.60% nucleotide had significantly higher weight gain than the control group(P < 0.05). Feed efficiency was improved in the fish fed 0.60 and 1.20% nucleotide compared with that in the control group. The optimal doses of nucleotides supplementation for growth and feed efficiency of fish were determined as 0.63 and 0.81%, respectively.Intestinal growth was improved in the 0.30 and 0.60% groups, as indicated by significant increase in intestine length. The fish fed 0.60 and 1.20% nucleotide showed higher super oxide dismutase(SOD)activity and lower malondialdehyde(MDA) level in the liver than the control fish, indicating enhancement of the anti-oxidant status. Serum lysozyme activity was significantly increased in the 0.15 and 0.3%nucleotide supplementation groups, suggesting an enhancement effect on the non-specific immune response. Lastly, dietary nucleotides supplementation exerted moderate influence on the intestinal microbiota of hybrid tilapia. A reduction in the cumulative abundance of putative butyrate-producing species was observed in the intestinal microbiota of fish fed diets with 0.60% nucleotide compared with the control, implying an interaction between dietary nucleotides and butyrate production. Briefly, dietary supplementation with 0.60% nucleotide improve the growth performance, immune activity and intestine growth in tilapia. | Li Xu Chao Ran Suxu He Jianli Zhang Jun Hu Yalin Yang Zhenyu Du Yanou Yang Zhigang Zhou | 2015 | Animal Nutrition2015，，3： | 12 |
| 5 | Antibiotic growth promoter olaquindox increases pathogen susceptibility in fish by inducing gut microbiota dysbiosis显示文摘Low dose antibiotics have been used as growth promoters in livestock and fish. The use of antibiotics has been associated with reduced pathogen infections in livestock. In contrast, antibiotic growth promoter has been suspected of leading to disease outbreaks in aquaculture. However, this phenomenon is circumstantial and has not been confirmed in experimental conditions. In this study,we showed that antibiotic olaquindox increased the susceptibility of zebrafish to A. hydrophila infection. Olaquindox led to profound alterations in the intestinal microbiota of zebrafish, with a drastic bloom of Enterobacter and diminishing of Cetobacterium. Moreover, the innate immune responses of zebrafish were compromised by olaquindox(P<0.05). Transfer of microbiota to GF zebrafish indicated that while the immuo-suppression effect of olaquindox is a combined effect mediated by both OLA-altered micro biota and direct action of the antibiotic(P<0.05), the increased pathogen susceptibility was driven by the OLA-altered microbiota and was not dependent on direct antibiotic effect. Taken together, these data indicate that low level of OLA induced gut microbiota dysbiosis in zebrafish, which led to increased pathogen susceptibility. | suxu he quanmin wang shuning li chao ran xiaoze guo zhen zhang zhigang zhou | 2017 | Science China(Life Sciences)2017，60，11： | 10 |
| 6 | Excision repair cross complementation group 1 polymorphisms and lung cancer risk: a meta-analysis显示文摘背景几研究评估了在在多样的人口,但是与冲突在各个分享相对小的样品的 results.By 的酶和肺癌症风险学习的编码切除修理十字互补组 1 的多型性( ERCC1 )之间的协会,由严密 methods.Methods Embase 执行证据的元分析是可能的,奥维德, Medline 和中国国家知识基础结构被寻找。另外的研究在原来的研究或评论文章从参考书被识别。满足包括标准的文章系统地被考察,并且报导数据用我们从七合格研究与肺癌症和 4332 控制发现了 3810 个案例的 meta-analysis.Results 的统计技术被聚集。T19007C 多型性没在肺癌症风险上显示出重要效果(C 等位基因对 T 等位基因:机会比率(或)=0.91, 95% 信心间隔(CI )=0.80-1.04;CC 对 TT:OR=0.76, 95% CI=0.56-1.02;CC 对(CT+TT ) :OR=0.96, 95% CI=-0.84-1.10 ) 。同样,当成层时,为肺癌症风险上的 T19007C 多型性没有重要主要效果由种族(汉语或白种人) 的分析。没有重要协会在 C8092A 多型性(3060 个病人和 2729 控制) 和肺癌症的风险之间被发现(等位基因对 C 等位基因:OR=1.03, 95% CI=0.95-1.11;AA 对 CC:OR=1.08, 95% CI=-0.88-1.33;AA 对(AC+CC ) :OR=1.08, 95% CI=-0.88-1.31 ) 我们几乎没在白种人或汉中国人民发现在 ERCC 1 的 T1900C 或 C8092A 多型性和肺癌症的风险之间的一个协会的小证据的 .Conclusion。 | CAO Chao ZHANG Yan-mei WANG Ran SUN Shi-fang CHEN Zhong-bo MA Hong-ying YU Yi-ming DING Qun-li SHU Li-hua DENG Zai-chun | 2011 | Chinese Medical Journal2011，，14： | 9 |
| 7 | Bacillus cereus X5 Enhanced Bio-Organic Fertilizers Effectively Control Root-Knot Nematodes(Meloidogyne sp.)显示文摘The efficacy of Bacillus cereus X5 as a potential biological control agent against root-knot nematodes was evaluated in vitro by examining second-stage juvenile mortality and egg hatching rate under addition of culture filtrate and in planta by application of bio-organic fertilizers enhanced with B. cereus X5, B. thuringiensis BTG, or Trichoderma harzianum SQR-T037 alone or together in greenhouse and field experiments. The biofumigation of the root-knot nematode-infested soil with organic materials (chicken manure, pig manure and rice straw) alone or in combination with B. cereus X5 was also conducted in greenhouse experiments. In laboratory, the filtrate of B. cereus X5 more effectively reduced egg hatching rates during the incubation period for 14 d and more effectively killed the second-stage juvenile during the incubation period of 24 h than that of B. thuringiensis BTG. The highest dry shoot weights for greenhouse tomatoes and field muskmelons were found in both the treatment consisting of the bio-organic fertilizer enhanced with the three biocontrol agents and the treatment consisting of the bio-organic fertilizer enhanced only with B. cereus X5. The two bio-organic fertilizers achieved better nematicidal effects than those enhanced only with B. thuringiensis BTG or T. harzianum SQR-T037. B. cereus X5 also enhanced effect of biofumigation, which resulted in increased plant biomass and reduced nematode counts in the roots and rhizosphere soil. Therefore, these results suggested that biological control of root-knot nematodes both in greenhouses and fields could be effectively achieved by using B. cereus X5 and agricultural wastes. | XIAO Tong-Jian CHEN Fang GAO Chao ZHAO Qing-Yun SHEN Qi-Rong RAN Wei | 2013 | Pedosphere2013，23，2： | 7 |
| 8 | Building biological foundries for next-generation synthetic biology显示文摘Synthetic biology is an interdisciplinary field that takes top-down approaches to understand and engineer biological systems through design-build-test cycles. A number of advances in this relatively young field have greatly accelerated such engineering cycles. Specifically, various innovative tools were developed for in silico biosystems design, DNA de novo synthesis and assembly, construct verification, as well as metabolite analysis, which have laid a solid foundation for building biological foundries for rapid prototyping of improved or novel biosystems. This review summarizes the state-of-the-art technologies for synthetic biology and discusses the challenges to establish such biological foundries. | CHAO Ran YUAN YongBo ZHAO HuiMin | 2015 | Science China(Life Sciences)2015，58，7： | 7 |
| 9 | Subaquatic volcanic eruptions in continental facies and their influence on high quality source rocks shown by the volcanic rocks of a faulted depression in Northeast China显示文摘This paper reports the analysis on cores and rock slices,data on seismic and logging activities,characteristics of core samples,and the paleogeographic background of the Yingcheng Formation of the Xujiaweizi faulted depression in the Songliao Basin.The results show that some of the volcanic rocks were formed during subaquatic eruptions.These subaqueous volcanic rocks are further characterized by the interbedded black mudstone and tuffite,the presence of double-layer perlite enclosing aphyric or sparsely phyric rhyolite,the presence of a bentonite layer,and the coefficient of oxidation(Fe2O3/FeO).The types of rocks are volcanic breccia,lava breccias,perlite,rhyolite,tuff and sedimentary tuff.The subaquatic eruptions are distributed mainly in Wangjiatun,Shengping,Xuxi,Xuzhong,and Xudong.The XS-1 area is the most typical.The organic abundance of overburden mud rocks within the volcanic rocks of the Yingcheng Formation indicates that these rocks represent high-quality source rocks.The analysis also shows that continental subaquatic volcanic eruptions provide a rich supply of minerals and energies for the lake basin and increase the organic matter content in the water.Moreover,the water differentiation provides a good reducing environment for the conservation of organic matter,and is beneficial for the formation of high-quality source rocks.Finally,we propose a hypothesis to describe the mode of subaquatic eruptions and the formation of high-quality source rocks. | SHAN XuanLong LI JiYan CHEN ShuMin RAN QingChang CHEN GuiBiao LIU Chao | 2013 | Science China Earth Sciences2013，56，11： | 6 |
| 10 | Reservoir Characteristics and Preservation Conditions of Longmaxi Shale in the Upper Yangtze Block, South China显示文摘The Upper Ordovician-Lower Silurian Longmaxi Shale in the Upper Yangtze block represents one of the most important shale gas plays in China. The shale composition,porosity,organic thermal maturity,and methane sorption were investigated at the Qilongcun section in the Dingshan area,southeastern Sichuan Basin. The results show that the Upper Ordovician-Lower Silurian Longmaxi Shale contains:(1) sapropelic I organic matter;(2) a 40-m thick bedded sequence where total organic carbon(TOC) content is > 2%;(3) a 30-m thick layer at the base of the Longmaxi Shale with a brittle mineral content higher than 50%; and(4) a mean methane adsorption capacity of 1.80 cm^3/g(7 MPa pressure). A positive correlation between TOC and sorbed gas indicates that organic matter content exerts an important control on methane storage capacity. Based on the analysis of the shale reservoir characteristics,the lower member of the Longmaxi Shale can thus be considered a favorable stratum for shale gas exploration and exploitation. It has similar reservoir characteristics with the Longmaxi Shale in the Jiaoshiba area tested with a high-yield industrial gas flow. However,based on tectonic analysis,differences in the level of industrial gas flow between the low-yield study area and the high-yield Jiaoshiba area may result from different tectonic preservation conditions. Evidence from these studies indicates the shale gas potential of the Longmaxi Shale is constrained by the reservoir and preservation conditions. | RAN Bo LIU Shugen Luba JANSA SUN Wei YANG Di WANG Shiyu YE Yuehao Christopher XIAO ZHANHG Jian ZHAI Cangbo LUO Chao ZHANG Changjun | 2016 | Acta Geologica Sinica(English Edition)2016，90，6： | 6 |
| 11 | Hydriding Pd cocatalysts: An approach to giant enhancement on photocatalytic CO2 reduction into CH4显示文摘进高增值 CH 4 的公司 2 的 Photocatalytic 减小是精力和环境危机的一个有希望的解决方案。与 cocatalysts 集成半导体能为 photocatalytic 公司 2 减小改进这些活动;然而,大多数金属 cocatalysts 主要生产公司和 H 2 。此处,我们为显著地提高公司 2 的 photocatalytic 减小进 CH 4 报导一条 cocatalyst hydridation 途径。进 PdH 0.43 的 Hydriding Pd cocatalysts 在表演改进起了一个双作用。是由我们的同位素的标记实验揭示了, PdH 0.43 氢化物 cocatalysts 减少了 H 2 进化,它压制了 H 2 生产并且便于 CO 中介的变换进最后的产品:CH 4 。同时, hydridation 支持了在 cocatalysts 上套住的电子,改进充电分离。这条途径在 Pd 上从 3.2% ~ 63.6% 在 CH 4 生产增加了 photocatalytic 选择 { 100 } 并且从 15.6% ~ 73.4% 在 Pd 上 { 111 } 。结果提供卓见进 photocatalytic 机制研究并且为向 photocatalytic 公司 2 变换设计材料介绍新机会。 | Yuzhen Zhu Chao Gao Song Bai Shuangming Chen Ran Long Li Song Zhengquan Li Yujie Xiong | 2017 | Nano Research2017，10，10： | 5 |
| 12 | Association of serum gamma-glutamyl transferase with treatment outcome in chronic hepatitis B patients显示文摘AIM:To investigate the association of serum gammaglutamyl transferase(GGT) levels with chronic hepatitis B infection and hepatitis B e antigen(HBe Ag) seroconversion.METHODS:A retrospective study was performed on clinical data collected from patients who had been positive for hepatitis B surface antigen for > 6 mo and who were antiviral-treatment na?ve(n = 215) attending the Hepatitis Clinic at Nanjing Drum Tower Hospital between August 2010 and December 2013. Healthy individuals without liver disease(n = 83) were included as controls. Patients were categorized into four groups based on disease status as recommended by the European Association for the Study of the Liver:immune tolerance(IT; n = 47),HBe Ag-positive hepatitis(EPH; n = 93),HBe Ag-negative hepatitis(ENH;n = 20),and inactive carrier(IC; n = 55). Prediction of complete response(CR) based on serum GGT was also examined in EPH patients(n = 33) treated for 48 wk with nucleos(t)ide analogue(NA) therapy,including lamivudine plus adefovir combination therapy(n = 20) or entecavir monotherapy(n = 13). CR was defined as a serum hepatitis B virus DNA level < 500 copies/m L and HBe Ag seroconversion by 48 wk of treatment. RESULTS:Serum GGT levels were significantly increased in EPH and ENH patients relative to the IT,IC,and healthy control groups(P < 0.01 for all). However,no significant difference in serum GGT levels was found between the EPH and ENH groups. Baseline serum GGT levels were significantly higher in patients who achieved CR(7/33; 21.2%) compared to patients in the non-CR group(26/33; 78.8%; P = 0.011). In addition,the decline in serum GGT was greater in CR patients compared to non-CR patients after 24 wk and 48 wk of treatment(P = 0.012 and P = 0.008,respectively). The receiver operating characteristic curve yielded a sensitivity of 85.71% and a specificity of 61.54% at a threshold value of 0.89 times the upper limit of normal for baseline serum GGT in the prediction of CR following NA therapy. CONCLUSION:Serum GGT is significantly elevated in EPH and ENH patients and is a potential biomarker for the prediction of HBe Ag seroconversion following NA therapy. | Rui Huang Chen-Chen Yang Yong Liu Juan Xia Ran Su Ya-Li Xiong Gui-Yang Wang Zhen-Hua Sun Xiao-Min Yan Shan Lu Chao Wu | 2015 | World Journal of Gastroenterology2015，21，34： | 4 |
| 13 | DDX3X regulates cell survival and cell cycle during mouse early embryonic development显示文摘DDX3X is a highly conserved DEAD-box RNA helicase that participates in RNA transcription,RNA splicing,and mRNA transport,translation,and nucleo-cytoplasmic transport.It is highly expressed in metaphaseⅡ(MⅡ)oocytes and is the predominant DDX3 variant in the ovary and embryo.However,whether it is important in mouse early embryo development remains unknown.In this study,we investigated the function of DDX3X in early embryogenesis by cytoplasmic microinjection with its siRNA in zygotes or single blastomeres of 2-cell embryos.Our results showed that knockdown of Ddx3x in zygote cytoplasm led to dramatically diminished blastocyst formation,reduced cell numbers,and an increase in the number of apoptotic cells in blastocysts.Meanwhile,there was an accumulation of p53 in RNAi blastocysts.In addition,the ratio of cell cycle arrest during 2-cell to 4-cell transition increased following microinjection of Ddx3x siRNA into single blastomeres of 2-cell embryos compared with control.These results suggest that Ddx3x is an essential gene associated with cell survival and cell cycle control in mouse early embryos,and thus plays key roles in normal embryo development. | Qian Li Pan Zhang Chao Zhang Ying Wang Ru Wan Ye Yang Xuejiang Guo Ran Huo Min Lin Zuomin Zhou Jiahao Sha | 2014 | The Journal of Biomedical Research2014，28，4： | 4 |
| 14 | Effects of Mn and Cr contents on microstructures and mechanical properties of low temperature bainitic steel显示文摘The effects of Mn and Cr contents on bainitic transformation kinetics,microstructures and mechanical properties of high-carbon low alloy steels after austempered at 230,300 and 350 ℃ were determined by dilatometry,optical microscopy,scanning electron microscopy,X-ray diffraction and tensile tests. The results showed that Mn and Cr can extend bainitic incubation period and completion time,and with the increase of Mn and Cr content,the bainitic ferrite plate thickness decreased and the volume fraction of retained austenite increased. TRIP( transformation induced plasticity) effect was observed during tensile testing which improved the overall mechanical property. The increase of Mn concentration can improve the strength to a certain extent,but reduce the ductility. The increase of Cr concentration can improve the ductility of bainitic steels which transformed at a low temperature. The low temperature bainitic steel austempered at 230 ℃ exhibited excellent mechanical properties with ultimate tensile strength of( 2146 ± 11) MPa and total elongation of( 12. 95 ± 0. 15) %. | Hui Guo Peng Zhou Ai-min Zhao Chao Zhi Ran Ding Jia-xing Wang | 2017 | Journal of Iron and Steel Research(International)2017，24，3： | 3 |
| 15 | Synthesis of 3-Phenyl-6-formyl-3, 4-dihydro-2H-1, 3-benzoxazine显示文摘A novel benzoxazine monomer containing aldehyde group, 3-phenyl-6-formyl-3, 4-dihydro-2H-1, 3-benzoxazine (Ald-B), was synthesized via the Mannich condensation of formaldehyde, p-hydroxybenzaldehyde and aniline. Its structure was characterized by Fourier transform infrared spectroscopy (FTIR), proton nuclear magnetic resonance (1HNMR). The side reaction in the synthesis is discussed. | Qi Chao RAN Qiao TIAN Yi GU | 2006 | Chinese Chemical Letters2006，17，10： | 3 |
| 16 | The direct and gut microbiota-mediated effects of dietary bile acids on the improvement of gut barriers in largemouth bass(Micropterus salmoides)显示文摘Fish gut barrier damage under intensive culture model is a significant concern for aquaculture industry.This study aimed to investigate the effects of bile acids(BAs)on gut barriers in Micropterus salmoides.A germ-free(GF)zebrafish model was employed to elucidate the effects of the direct stimulation of BAs and the indirect regulations mediated by the gut microbiota on gut barrier functions.Four diets were formulated with BAs supplemented at 0,150,300 and 450 mg/kg,and these 4 diets were defined as control,BA150,BA300 and BA450,respectively.After 5 weeks of feeding experiment,the survival rate of fish fed with BA300 diet was increased(P<0.05).Histological analysis revealed an improvement of gut structural integrity in the BA150 and BA300 groups.Compared with the control group,the expression of genes related to chemical barrier(mucin,lysozyme and complement 1)and physical barrier(occludin and claudin-4)was increased in the BA150 and BA300 groups(P<0.05),and the expression of genes related to immunological barrier(interleukin[IL]-6,tumor growth factorβ,IL-10,macrophage galactosetype lectin and immunoglobulin M[Ig M])was significantly increased in the BA300 group(P<0.05),but the expression of genes related to chemical barrier(hepcidin)and immunological barrier(IL-1β,tumor necrosis factor-a,IL-6 and arginase)was significantly decreased in the BA450 group(P<0.05).Gut microbiota composition analysis revealed that the abundance of Firmicutes was augmented prominently in the BA150 and BA300 groups(P<0.05),while that of Actinobacteriota and Proteobacteria showed a downward trend in the BA150 and BA300 groups(P>0.05).The results of the gut microbiota transferring experiment demonstrated an upregulation of gut barrier-related genes,including immunoglobulin Z/T(Ig Z/T),IL-6,IL-1βand IL-10,by the gut microbiota transferred from the BA300 group compared with the control(P<0.05).Feeding the BA300 diet directly to GF zebrafish resulted in enhanced expression of Ig M,Ig Z/T,lysozyme,occludin-2,IL-6 and IL-10(P<0.05).In conclusion,BAs can improve the gut barriers of fish through both direct and indirect effects mediated by the gut microbiota. | Rui Xia Qingshuang Zhang Dongmei Xia Qiang Hao Qianwen Ding Chao Ran Yalin Yang Aizhi Cao Zhen Zhang Zhigang Zhou | 2023 | Animal Nutrition2023，，3： | 2 |
| 17 | Integrated single-cell RNA sequencing analysis reveals distinct cellular and transcriptional modules associated with survival in lung cancer显示文摘Lung adenocarcinoma(LUAD)and squamous carcinoma(LUSC)are two major subtypes of non-small cell lung cancer with distinct pathologic features and treatment paradigms.The heterogeneity can be attributed to genetic,transcriptional,and epigenetic parameters.Here,we established a multi-omics atlas,integrating 52 single-cell RNA sequencing and 2342 public bulk RNA sequencing.We investigated their differences in genetic amplification,cellular compositions,and expression modules.We revealed that LUAD and LUSC contained amplifications occurring selectively in subclusters of AT2 and basal cells,and had distinct cellular composition modules associated with poor survival of lung cancer.Malignant and stage-specific gene analyses further uncovered critical transcription factors and genes in tumor progression.Moreover,we identified subclusters with proliferating and differentiating properties in AT2 and basal cells.Overexpression assays of ten genes,including sub-cluster markers AQP5 and KPNA2,further indicated their functional roles,providing potential targets for early diagnosis and treatment in lung cancer. | Li Zhang Yiming Zhang Chengdi Wang Ying Yang Yinyun Ni Zhoufeng Wang Tingting Song Menglin Yao Zhiqiang Liu Ningning Chao Yongfeng Yang Jun Shao Zhidan Li Ran Zhou Li Chen Dan Zhang Yuancun Zhao Wei Liu Yupeng Li Ping He Jing-wen Lin Yuan Wang Kang Zhang Lu Chen Weimin Li | 2022 | Signal Transduction and Targeted Therapy2022，7，2： | 2 |
| 18 | Effect of Trace O Element on High-temperature Wettability Between Ni_3Al Melt and Y_2O_3 Ceramic显示文摘Effect of trace O element on the high-temperature wettability between Ni_3Al scrap melt and Y_2O_3 ceramic at 1873 K is investigated. With the increase in O content in Ni_3Al scrap melt from 6 to 21 ppm, the equilibrium contact angle decreases from 93.3° to 88.9°. The initial surface tension and adhesive work of molten Ni_3Al scrap drop from 3153.5 to 807.4 mN m^(-1) and from 2974.6 to 882.2 mN m^(-1), respectively. The average spreading rate increases from 0.03° s^(-1) to 0.17° s^(-1). The whole wetting processes are divided into four periods. The main driving force for spreading in period(1) is the adsorption and diffusion of active atoms around the interface. Trace O content in Ni_3Al scrap has a significant impact on interfacial reactions which mostly take place in the second stage, and can accelerate the spreading process on Y_2O_3 substrate. The reaction products during wetting process are Y_3Al_5O_(12), YAlO_3 and Al_2O_3. | Peng Bai Hua-Rui Zhang Bei-Bei Wan Chao Ran Hu Zhang | 2018 | Acta Metallurgica Sinica(English Letters)2018，31，5： | 2 |
| 19 | Interactions between commensal bacteria and viral infection:insights for viral disease control in farmed animals显示文摘Viral diseases cause serious economic loss in farmed animals industry.However,the efficacy of remedies for viral infection in farmed animals is limited,and treatment strategies are generally lacking for aquatic animals.Interactions of commensal microbiota and viral infection have been studied in recent years,demonstrating a third player in the interaction between hosts and viruses.Here,we discuss recent developments in the research of interactions between commensal bacteria and viral infection,including both promotion and inhibition effect of commensal bacteria on viral pathogenesis,as well as the impact of viral infection on commensal microbiota.The antiviral effect of commensal bacteria is mostly achieved through priming or regulation of the host immune responses,involving differential microbial components and host signaling pathways,and gives rise to various antiviral probiotics.Moreover,we summarize studies related to the interaction between commensal bacteria and viral infection in farmed animals,including pigs,chickens,fish and invertebrate species.Further studies in this area will deepen our understanding of antiviral immunity of farmed animals in the context of commensal microbiota,and promote the development of novel strategies for treatment of viral diseases in farmed animals. | Chao Ran Yu Li Xufa Ma Yadong Xie Mingxu Xie Yuting Zhang Wei Zhou Yalin Yang Zhen Zhang Li Zhou Kaijian Wei Zhigang Zhou | 2021 | Science China(Life Sciences)2021，64，9： | 2 |
| 20 | Role of circadian gene Clock during differentiation of mouse pluripotent stem cells显示文摘生理节奏的钟控制的生物节奏在胚胎的干细胞(转换字符) 是不在的。然而,他们开始在 pluripotent 转换字符的区别期间发展到下游的房间。相反地,当他们是进导致的 pluripotent 干细胞(iPSCs ) 的 reprogrammed 时,在成年体的房间的生物节奏消失。这些研究显示在转换字符的生物节奏的发展可能仔细与转换字符的维护和区别被联系。核心生理节奏的基因钟为生物节奏的规定是必要的。它在转换字符的生物节奏的发展的角色完全是未知的。这里,我们使用了 CRISPR/CAS9-mediated 基因编辑技术,完全在鼠标转换字符击倒钟表达式。由染色的 AP, teratoma 形成,量的即时 PCR 和 Immunofluorescent,我们没在 pluripotent 状态下面在形态学和 pluripotent 能力发现钟猛烈 mESCs 和野类型 mESCs 之间的任何差别。简言之,这些数据显示钟没影响维持 pluripotent 状态。然而,他们展出了减少的增长并且增加了 apoptosis。而且,生物节奏没能在自发的区别以后在钟猛烈 mESCs 发展,它显示在以前在老鼠模型描述了的很外部的纸巾没有赔偿因素(DeBruyne 等, 2007b ) 。在自发的区别以后,钟蛋白质的损失由于钟基因 silencing 导致了 mESCs 的自发的区别,显示来自 pluripotent 状态,或它的区分的能力的一个出口。我们的调查结果显示生理节奏的基因钟可以是的核心在由调整 mESCs 增长, apoptosis 和活动的正常 mESCs 区别期间必要。 | Chao Lu Yang Yang Ran Zhao Bingxuan Hua Chen Xu Zuoqin Yan Ning sun Ruizhe Qian | 2016 | Protein & Cell2016，7，11： | 2 |
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