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| 1 | Thymosin Alpha-1 Inhibits Complete Freund’s Adjuvant-Induced Pain and Production of Microglia-Mediated Pro-inflammatory Cytokines in Spinal Cord显示文摘Activation of inflammatory responses regulates the transmission of pain pathways through an integrated network in the peripheral and central nervous systems.The immunopotentiator thymosin alpha-1(Tal)has recently been reported to have anti-inflammatory and neuroprotective functions in rodents.However,how Tα1 affects inflammatory pain remains unclear.In the present study,intraperitoneal injection of Tal attenuated complete Freund's adjuvant(CFA)-induced pain hypersensitivity,and decreased the up-regulation of pro-inflammatory cytokines(TNF-α,IL-1β,and IL-6)in inflamed skin and the spinal cord.We found that CFA-induced peripheral inflammation evoked strong microglial activation,but the effect was reversed by Tα1.Notably,Tα1 reversed the CFA-induced up-regulation of vesicular glutamate transporter(VGLUT)and down-regulated the vesicular γ-aminobutyric acid transporter(VGAT)in the spinal cord.Taken together,these results suggest that Tα1 plays a therapeutic role in inflammatory pain and in the modulation of microgliainduced pro-inflammatory cytokine production in addition to mediation of VGLUT and VGAT expression in the spinal cord. | Yunlong Xu Yanjun Jiang Lin Wang Jiahua Huang Junmao Wen Hang Lv Xiaoli Wu Chaofan Wan Chuanxin Yu Wenjie Zhang Jiaying Zhao Yinqi Zhou Yongjun Chen | 2019 | Neuroscience Bulletin2019，35，4： | 4 |
| 2 | Near-infrared chemiluminescent carbon nanogels for oncology imaging and therapy显示文摘Carbon nanogels(CNGs)with dual ability of reactive oxygen species(ROS)imaging and photodynamic therapy have been designed with selfassembled chemiluminescent carbonized polymer dots(CPDs).With efficient deep-red/near-infrared chemiluminescence(CL)emission and distinctive photodynamic capacity,the H2O2-driven chemiluminescent CNGs are further designed by assembling the polymeric conjugate and CL donors,enabling an in vitro and in vivo ROS bioimaging capability in animal inflammation models and a high-performance therapy for xenograft tumors.Mechanistically,ROS generated in inflammatory sites or tumor microenvironment can trigger the chemically initiated electron exchange luminescence in the chemical reaction of peroxalate and H2O2,enabling in vivo CL imaging.Meanwhile,part of the excited-state electrons will transfer to the ambient H2O or dissolved oxygen and in turn lead to the type I and type II photochemical ROS production of hydroxyl radicals or singlet oxygen,endowing the apoptosis of tumor cells and thus enabling cancer therapy.These results open up a new avenue for the design of multifunctional nanomaterials for bioimaging and antienoplastic agents. | Chenglong Shen Tianci Jiang Qing Lou Wenbo Zhao Chaofan Lv Guangsong Zheng Hangrui Liu Pengfei Li Lingling Dai Kaikai Liu Jinhao Zang Feng Wang Lin Dong Songnan Qu Zhe Cheng Chongxin Shan | 2022 | SmartMat2022，3，2： | 1 |
| 3 | Pressure-induced photoluminescence enhancement and ambient retention in confined carbon dots显示文摘Piezochromic luminescent materials have shown great potential in advanced optoelectronic applications.However,most of luminescent materials usually undergo emission quenching under external stimuli.Herein,we demonstrate for the first time that the photoluminescence of carbon dots(CDs)confined within sodium hydroxide can be enhanced when high pressure is applied.They exhibit a 1.6-fold fluorescence enhancement compared with pristine CDs.Importantly,the enhanced fluorescence intensity can be retained after the release of pressure to ambient conditions.A combination of experimental analysis and theoretical simulations indicates that such an enhanced emission is mainly attributed to the strong confinement resulting from the sodium hydroxide matrix,which can separate the CDs spatially and restrict the nonradiative pathway.These results provide a rational strategy for manipulating the optical properties of CDs with enhanced and retainable photoluminescence(PL)performance,thus opening up a venue for designing luminescent CDs-based materials. | Qing Lou Xigui Yang Kaikai Liu Zhongzheng Ding Jinxu Qin Yizhe Li Chaofan Lv Yuan Shang Yuewen Zhang Zhuangfei Zhang Jinhao Zang Lin Dong Chong-Xin Shan | 2022 | Nano Research2022，15，3： | 1 |
| 4 | Highly sensitive humidity sensors based on hexagonal boron nitride nanosheets for contactless sensing显示文摘Humidity sensors with high sensitivity,rapid response,and facile fabrication process for contactless sensing applications have received considerable attention in recent years.Herein,humidity sensors based on hexagonal boron nitride(h-BN)nanosheets that are synthesized by a facile ultrasonic process have been fabricated,which display an ultrahigh sensitivity of 28,384%at 85%relative humidity(RH),rapid response/recovery time(3.0/5.5 s),and long-term stability in a wide humidity detection range(11%-85%RH),superior to most of the reported humidity sensors.The high sensitivity can be ascribed to the massive hydrophilic functional groups absorbed on the h-BN nanosheet surface.Benefiting from the high humidity sensing performances,contactless Morse code messaging and human writing and speech recognition have been demonstrated.This work demonstrates the great potential of the high-performance h-BN nanosheet-based humidity sensors for future contactless sensing devices. | Hang Liu Jinxu Qin Xigui Yang Chaofan Lv Wentao Huang Fukui Li Chuang Zhang Yanran Wu Lin Dong Chongxin Shan | 2023 | Nano Research2023，16，7： | 0 |
| 5 | Ultrasensitive broadband position-sensitive detector based on graphitic carbon nitride显示文摘As a typical two-dimensional material,graphitic carbon nitride(g-CN)has attracted great interest because of its distinctive electronic,optical,and catalytic properties.However,the absence of a feasible route toward large-area and high-quality films hinders its development in optoelectronics.Herein,high-quality g-CN films have been grown on Si substrate via a vapor-phase transport-assisted condensation method.The g-CN/Si heterojunction shows an obvious response to ultraviolet–visible-near infrared photons with a responsivity of 133 A·W−1,which is two orders of magnitude higher than the best value ever reported for g-CN photodetectors.A position-sensitive detector(PSD)has been developed using the lateral photovoltaic effect of the g-CN/Si heterojunction.The PSD shows a wide response spectrum ranging from 300 to 1,100 nm,and a position sensitivity and rise/decay time of 395 mV·mm−1 and 3.1/50μs,respectively.Moreover,the application of the g-CN/Si heterojunction photodetector in trajectory tracking and acoustic detection has been realized for the first time.This work unveils the potential of g-CN for large-area photodetectors,and prospects for their applications in trajectory tracking and acoustic detection. | Xuexia Chen Xun Yang Qing Lou Yongzhi Tian Zhiyu Liu Chaofan Lv Yancheng Chen Lin Dong Chong-Xin Shan | 2023 | Nano Research2023，16，1： | 0 |
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