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| 1 | 胆固醇酯转移蛋白基因的蛋白质截断型变异体与冠状动脉性心脏病风险的关系显示文摘随机对照试验结果表明,抑制胆固醇酯转运蛋白(cholesteryl ester transfer protein,CETP)的疗法并不能降低冠状动脉性心脏病(coronary heart disease,CHD)的发生风险。研究失败的可能原因包括靶目标无效、靶目标外小分子的不良反应和随机对照设计因素影响等。在编码药物靶点的基因中具有天然存在的遗传变异,以此为基础,人类研究可以深入了解针对基因产物的治疗的潜在功效和安全性。 | Nomura A Won HH Khera AV Takeuchi F Ito K McCarthy S Emdin CA Klarin D Natarajan P Zekavat SM Gupta N Peloso GM Borecki IB Teslovich TM Asselta R Duga S Merlini PA Correa A Kessler T Wilson JG Bown MJ Hall AS Braund PS Carey DJ Murray MF Kirchner HL Leader JB Lavage DR Manus JN Hartze DN Samani NJ Schunkert H Marrugat J Elosua R McPherson R Farrall M Watkins H Juang JJ Hsiung CA Lin SY Wang JS Tada H Kawashiri MA Inazu A Yamagishi M Katsuya T Nakashima E Nakatochi M Yamamoto K Yokota M Momozawa Y Rotter JI Lander ES Rader DJ Danesh J Ardissino D Gabriel S Willer CJ Abecasis GR Saleheen D Kubo M Kato N Ida Chen YD Dewey FE Kathiresan S 刘莉 叶鹏 | 2017 | 中华高血压杂志2017，25，9： | 2 |
| 2 | Macrophage mannose receptor I and SlOOA9 were identified as serum diagnostic biomarkers for color- ectal cancer through a label-free quantitative proteomic analysis 显示文摘 | Fan NJ Chen HM Song W | 2015 | Cancer Biomarkers2015，16，2： | 1 |
| 3 | Role of SODD in regulatioa of tumomecrosis factor responsea显示文摘 | Takada H Chen NJ Mirtsos C | 2003 | Mol Cell Biol2003，23，11： | 1 |
| 4 | Enhanced secretion of IFN-gamma by activated Th1 cells occurs via reverse signaling through TNF-related activation-induced cytokine显示文摘 | Chen NJ Huang MW Hsieh SL | | 0，，01： | 1 |
| 5 | Flower morphologic anatomyand embryological characteristics in Chrysanthemum multicaule(Asteraceae)显示文摘 | Deng YM Chen SM Teng NJ | 2010 | Scientia Horticulturae2010，124，： | 1 |
| 6 | Isolation and characterization of size-sieved stem cells from human bone marrow显示文摘 | Hung SC Chen NJ Hsieh SL | 2002 | Stem cells(Dayton Ohio)2002，20，3： | 1 |
| 7 | Beyond tumor necrosis factor receptor: TRADD signaling in toll - like receptors 显示文摘 | Chen NJ Chio II Lin WJ | 2008 | Proc Natl Acad Sci2008，105，12： | 1 |
| 8 | Treatment of metastatic Ewing' s sarcoma/primitive neuroectodermal tumor of bone: Evaluation of increasing the dose intensity of chemotherapy-a report from the children' s oncology group 显示文摘 | Miser JS Goldsby RE Chen Z Krailo MD Tarbell NJ Link MP | 2007 | Pediatr Blood Cancer2007，49，7： | 1 |
| 9 | C5L2 is critical for the biological activities of the anaphylatoxins C5a and C3a显示文摘 | Chen NJ Mirtsos C Suh D | 2007 | Nature2007，446，7132： | 1 |
| 10 | Pharmacogenetic analysis of UGT1A1, UGT1A6, UGT1A7 and thymidylate synthase in a phase Ⅱ study of capecitabine plus irinotecan in patients with metastatic colorectal cancer显示文摘 | Carlini LE Meropol NJ Chen Y-M | 2004 | Proc Amer Soc Clin Oncol2004，23，： | 1 |
| 11 | Efficacy of sildenafil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating premature ejaculation 显示文摘 | Chen J Mabjeesh NJ Matzkin H | 2003 | Urology2003，61，1： | 1 |
| 12 | Protein measurement with folin-phenol reagent显示文摘 | Lowry OH Rosenbrough NJ Chen AL | 1951 | J Biol1951，193，： | 1 |
| 13 | Facial nerve regenera- tion in the silicone chamber: The influence of nerve growth factor显示文摘 | Chen YS Wang LB Coker NJ | 1989 | Exp Neural1989，103，1： | 1 |
| 14 | Teriflunomide ( leflunomide ) promotes cytostatic, antioxidant, and apoptotic effects in transfored prostate epithelialcells:evidence supporting a role for teriflunomide in prostate cancer chemoprevention 显示文摘 | Hai NJ Chen P Bushiman LR | 2010 | Neoplasia2010，12，6： | 1 |
| 15 | Fusion between a novel Kruppel-like zinc finger gene and the retinoic acid receptor-alpha locus due to a variant t(11;17) translocation associated with acute promyelocytic leukaemia显示文摘 | Chen Z Brand NJ Chen A | 1993 | EMBO J1993，12，3： | 1 |
| 16 | Heat treatment and fruit ripening显示文摘 | Paull RE Chen NJ | 2000 | Postharvest Biology and Technology2000，21，1： | 1 |
| 17 | 针对周围型肺病变的机器人支气管镜检查显示文摘背景:周围型肺病变(PPL)的诊断一直是临床难题。尽管引导性支气管镜检查已广泛应用,但PPL的诊断阳性率并未明显提高。已经研发的机器人辅助支气管镜有望提高PPL的诊断阳性率。目前,评估机器人支气管镜系统在真人受试者中的性能的数据有限。 | Chen AC Pastis NJ Jr Mahajan AK 肖云 肖奎 朱芷若 | 2021 | 中华结核和呼吸杂志2021，44，4： | 1 |
| 18 | Activiation of the growth arrest and DNA damage inducible gene Gadd153 by nephrotoxic cysteine conjugates and dithiothreitol显示文摘 | Chen Q Yu K Holbrook NJ | 1993 | J Biol Chem1993，267，： | 1 |
| 19 | Efficacy of sildenafil as adjuvant therapy to selective serotonin reuptake inhibitor in alleviating premature ejeculation显示文摘 | Chen J Maljeesh NJ Matzkin H | 2003 | Urology2003，61，： | 1 |
| 20 | Isolation and charateri-zation of size-sieved stem cells from human bone marrow 显示文摘 | Huang SC Chen NJ Hsieh SL | 2002 | Stem Cells2002，20，： | 1 |
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