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| 1 | Erianin,a novel dibenzyl compound in Dendrobium extract,inhibits lung cancer cell growth and migration via calcium/calmodulin-dependent ferroptosis显示文摘Ferroptosis,a novel form of programmed cell death,is characterized by iron-dependent lipid peroxidation and has been shown to be involved in multiple diseases,including cancer.Stimulating ferroptosis in cancer cells may be a potential strategy for cancer therapy.Therefore,ferroptosis-inducing drugs are attracting more attention for cancer treatment.Here,we showed that erianin,a natural product isolated from Dendrobium chrysotoxum Lindl,exerted its anticancer activity by inducing cell death and inhibiting cell migration in lung cancer cells.Subsequently,we demonstrated for the first time that erianin induced ferroptotic cell death in lung cancer cells,which was accompanied by ROS accumulation,lipid peroxidation,and GSH depletion.The ferroptosis inhibitors Fer-1 and Lip-1 but not Z-VAD-FMK,CQ,or necrostatin-1 rescued erianin-induced cell death,indicating that ferroptosis contributed to erianin-induced cell death.Furthermore,we demonstrated that Ca^(2+)/CaM signaling was a critical mediator of erianin-induced ferroptosis and that blockade of this signaling significantly rescued cell death induced by erianin treatment by suppressing ferroptosis.Taken together,our data suggest that the natural product erianin exerts its anticancer effects by inducing Ca^(2+)/CaMdependent ferroptosis and inhibiting cell migration,and erianin will hopefully serve as a prospective compound for lung cancer treatment. | Peng Chen Qibiao Wu Jiao Feng Lili Yan Yitian Sun Shuiping Liu Yu Xiang Mingming Zhang Ting Pan Xiaying Chen Ting Duan Lijuan Zhai Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Xuemeng Han Yicong Li Liuxi Chen Ying Liu Xingxing Huang Ting Jin Wenzheng Zhang Hong Luo Xiaohui Chen Yongqiang Li Qiujie Li Guohua Li Qin Zhang Lvjia Zhuo Zuyi Yang Huifen Tang Tian Xie Xiaoping Ouyang Xinbing Sui | 2020 | Signal Transduction and Targeted Therapy2020，5，1： | 42 |
| 2 | Baicalin induces ferroptosis in bladder cancer cells by downregulating FTH1显示文摘Ferroptosis is a non-apoptotic regulated cell death caused by iron accumulation and subsequent lipid peroxidation.Currently,the therapeutic role of ferroptosis on cancer is gaining increasing interest.Baicalin an active component in Scutellaria baicalensis Georgi with anticancer potential various cancer types;however,the effects of baicalein on bladder cancer and the underlying molecular mechanisms remain largely unknown.In the study,we investigated the effect of baicalin on bladder cancer cells5637 and KU-19-19.As a result,we show baicalin exerted its anticancer activity by inducing apoptosis and cell death in bladder cancer cells.Subsequently,we for the first time demonstrate baicalin-induced ferroptotic cell death in vitro and in vivo,accompanied by reactive oxygen species(ROS) accumulation and intracellular chelate iron enrichment.The ferroptosis inhibitor deferoxamine but not necrostatin-1,chloroquine(CQ),N-acetyl-L-cysteine,L-glutathione reduced,or carbobenzoxy-valyl-alanyl-aspartyl-[O-methyl]-fluoromethylketone(Z-VAD-FMK) rescued baicalin-induced cell death,indicating ferroptosis contributed to baicalin-induced cell death.Mechanistically,we show that ferritin heavy chain1(FTH1) was a key determinant for baicalin-induced ferroptosis.Overexpression of FTH1 abrogated the anticancer effects of baicalin in both 5637 and KU19-19 cells.Taken together,our data for the first time suggest that the natural product baicalin exerts its anticancer activity by inducing FTH1-dependent ferroptosis,which will hopefully provide a prospective compound for bladder cancer treatment. | Na Kong Xiaying Chen Jiao Feng Ting Duan Shuiping Liu Xueni Sun Peng Chen Ting Pan Lili Yan Ting Jin Yu Xiang Quan Gao Chengyong Wen Weirui Ma Wencheng Liu Mingming Zhang Zuyi Yang Wengang Wang Ruonan Zhang Bi Chen Tian Xie Xinbing Sui Wei Tao | 2021 | Acta Pharmaceutica Sinica B2021，11，12： | 23 |
| 3 | Atorvastatin attenuates involvement of RhoA/Rho-kinase pathway and NF-κB activation in hypoxic pulmonary hypertensive rats显示文摘 | Zhang Yan Dai Li Wu Shangjie Chen Ping Zhao Shuiping | 2014 | Chinese Medical Journal2014，，5： | 12 |
| 4 | Preparation, characterization, pharmacokinetics and anticancer effects of PEGylated β-elemene liposomes显示文摘Objective:This study aimed to develop a new polyethylene glycol(PEG)ylatedβ-elemene liposome(PEG-Lipo-β-E)and evaluate its characterization,pharmacokinetics,antitumor effects and safety in vitro and in vivo.Methods:The liposomes were prepared by ethanol injection and high-pressure micro-jet homogenization.Characterization of the liposomes was conducted,and drug content,entrapment efficiency(EE),in vitro release and stability were studied by ultra-fast liquid chromatography(UFLC)and a liquid surface method.Blood was drawn from rats to establish the pharmacokinetic parameters.The anticancer effect was evaluated in a KU-19-19 bladder cancer xenograft model.Histological analyses were performed to evaluate safety.Results:The PEG-Lipo-β-E showed good stability and was characterized as 83.31±0.181 nm in size,0.279±0.004 in polydispersity index(PDI),-21.4±1.06 mV in zeta potential,6.65±0.02 in pH,5.024±0.107 mg/mL inβ-elemene(β-E)content,and 95.53±1.712%in average EE.The Fourier transform infrared spectroscopy(FTIR)and differential scanning calorimetry(DSC)indicated the formation of PEG-Lipo-β-E.Compared to elemene injection,PEG-Lipo-β-E demonstrated a 1.75-fold decrease in clearance,a 1.62-fold increase in half-life,and a 1.76-fold increase in area under the concentration-time curves(AUCs)from 0 hour to 1.5 hours(P<0.05).PEG-Lipo-β-E also showed an enhanced anticancer effect in vivo.Histological analyses showed that there was no evidence of toxicity to the heart,kidney,liver,lung or spleen.Conclusions:The present study demonstrates PEG-Lipo-β-E as a new formulation with ease of preparation,high EE,good stability,improved bioavailability and antitumor effects. | Bingtao Zhai Qibiao Wu Wengang Wang Mingming Zhang Xuemeng Han Qiujie Li Peng Chen Xiaying Chen Xingxing Huang Guohua Li Qin Zhang Ruonan Zhang Yu Xiang Shuiping Liu Ting Duan Jianshu Lou Tian Xie Xinbing Sui | 2020 | Cancer Biology & Medicine2020，17，1： | 6 |
| 5 | An ATF24 peptide-functionalized β-elemene-nanostructured lipid carrier combined with cisplatin for bladder cancer treatment显示文摘Objective:In this study,we aimed to develop an amino-terminal fragment(ATF)peptide-targeted liposome carryingβ-elemene(ATF24-PEG-Lipo-β-E)for targeted delivery into urokinase plasminogen activator receptor-overexpressing bladder cancer cells combined with cisplatin(DDP)for bladder cancer treatment.Methods:The liposomes were prepared by ethanol injection and high-pressure microjet homogenization.The liposomes were characterized,and the drug content,entrapment efficiency,andin vitro release were studied.The targeting efficiency was investigated using confocal microscopy,ultra-fast liquid chromatography,and an orthotopic bladder cancer model.The effects of ATF24-PEG-Lipo-β-E combined with DDP on cell viability and proliferation were evaluated by a Cell Counting Kit-8(CCK-8)assay,a colony formation assay,and cell apoptosis and cell cycle analyses.The anticancer effects were evaluated in a KU-19-19 bladder cancer xenograft model.Results:ATF24-PEG-Lipo-β-E had small and uniform sizes(~79 nm),high drug loading capacity(~5.24 mg/mL),high entrapment efficiency(98.37±0.95%),and exhibited sustained drug release behavior.ATF24-PEG-Lipo-β-E had better targeting efficiency and higher cytotoxicity than polyethylene glycol(PEG)ylatedβ-elemene liposomes(PEG-Lipo-β-E).DDP,combined with ATF24-PEG-Lipo-β-E,exerted a synergistic effect on cellular apoptosis and cell arrest at the G2/M phase,and these effects were dependent on the caspase-dependent pathway and Cdc25C/Cdc2/cyclin B1 pathways.Furthermore,thein vivo antitumor activity showed that the targeted liposomes effectively inhibited the growth of tumors,using the combined strategy.Conclusions:The present study provided an effective strategy for the targeted delivery ofβ-elemene(β-E)to bladder cancer,and a combined strategy for bladder cancer treatment. | Bingtao Zhai Peng Chen Wengang Wang Shuiping Liu Jiao Feng Ting Duan Yu Xiang Ruonan Zhang Mingming Zhang Xuemeng Han Xiaying Chen Qiujie Li Guohua Li Ying Liu Xingxing Huang Wenzheng Zhang Ting Pan Lili Yan Ting Jin Tian Xie Xinbing Sui | 2020 | Cancer Biology & Medicine2020，17，3： | 5 |
| 6 | PCDH17 increases the sensitivity of colorectal cancer to 5-fluorouracil treatment by inducing apoptosis and autophagic cell death显示文摘5-Fluorouracil(5-FU)is known as a first-line chemotherapeutic agent against colorectal cancer(CRC),but drug resistance occurs frequently and significantly limits its clinical success.Our previous study showed that the protocadherin 17(PCDH17)gene was frequently methylated and functioned as a tumor suppressor in CRC.However,the relationship between PCDH17 and 5-FU resistance in CRC remains unclear.Here,we revealed that PCDH17 was more highly expressed in 5-FU-sensitive CRC tissues than in 5-FU-resistant CRC tissues,and high expression of PCDH17 was correlated with high BECN1 expression.Moreover,this expression profile contributed to superior prognosis and increased survival in CRC patients.Restoring PCDH17 expression augmented the 5-FU sensitivity of CRC in vitro and in vivo by promoting apoptosis and autophagic cell death.Furthermore,autophagy played a dominant role in PCDH17-induced cell death,as an autophagy inhibitor blocked cell death to a greater extent than the pancaspase inhibitor Z-VAD-FMK.PCDH17 inhibition by siRNA decreased the autophagy response and 5-FU sensitivity.Mechanistically,we showed that c-Jun NH2-terminal kinase(JNK)activation was a key determinant in PCDH17-induced autophagy.The compound SP600125,an inhibitor of JNK,suppressed autophagy and 5-FU-induced cell death in PCDH17-reexpressing CRC cells.Taken together,our findings suggest for the first time that PCDH17 increases the sensitivity of CRC to 5-FU treatment by inducing apoptosis and JNK-dependent autophagic cell death.PCDH17 may be a potential prognostic marker for predicting 5-FU sensitivity in CRC patients. | Shuiping Liu Haoming Lin Da Wang Qiang Li Hong Luo Guoxiong Li Xiaohui Chen Yongqiang Li Peng Chen Bingtao Zhai Wengang Wang Ruonan Zhang Bi Chen Mingming Zhang Xuemeng Han Qiujie Li Liuxi Chen Ying Liu Xiaying Chen Guohua Li Yu Xiang Ting Duan Jiao Feng Jianshu Lou Xingxing Huang Qin Zhang Ting Pan Lili Yan Ting Jin Wenzheng Zhang Lvjia Zhuo Yitian Sun Tian Xie Xinbing Sui | 2019 | Signal Transduction and Targeted Therapy2019，4，1： | 4 |
| 7 | Pyrolysis behaviour and combustion kinetics of waste printed circuit boards显示文摘The effective recycling of waste printed circuit boards(WPCBs)can conserve resources and reduce environmental pollution.This study explores the pyrolysis and combustion characteristics of WPCBs in various atmospheres through thermogravimetric and Gaussian fitting analyses.Furthermore,this study analyses the pyrolysis products and combustion processes of WPCBs through thermogravimetric and Fourier transform infrared analyses(TG-FTIR)and thermogravimetry-mass spectrometry(TG-MS).Results show that the pyrolysis and combustion processes of WPCBs do not constitute a single reaction,but rather an overlap of multiple reactions.The pyrolysis and combustion process of WPCBs is divided into multiple reactions by Gaussian peak fitting.The kinetic parameters of each reaction are obtained by the Coats-Redfern method.In an argon atmosphere,pyrolysis consists of the overlap of the preliminary pyrolysis of epoxy resin,pyrolysis of small organic molecules,and pyrolysis of brominated flame retardants.The thermal decomposition process in the O_(2) atmosphere is mainly divided into two reactions:brominated flame retardant combustion and epoxy combustion.This study provided the theoretical basis for pollution control,process optimization,and reactor design of WPCBs pyrolysis. | Kang Yan Chongwei Liu Liping Liu Min Xiong Jiongtong Chen Zhongtang Zhang Shuiping Zhong Zhifeng Xu Jindi Huang | 2022 | International Journal of Minerals,Metallurgy and Materials2022，29，9： | 2 |
| 8 | One-nanometer-thick platinum-based nanowires with controllable surface structures显示文摘Pt-based ultrathin nanowires (NWs) are considered as one of the most intriguing catalysts for fuel cells.However,the delicate controllability of surface structure of ultrathin NWs to regulate their catalytic performances is still a challenge.Here,two kinds of one-nanometer-thick Pt-based NWs with smooth surfaces (S-NWs) and rough surfaces (R-NWs) are demonstrated,in which the combined use of hexadecyltrimethylammonium bromide and oleylamine plays an essential role,as they could form soft-templates to direct the growth of NWs.Due to its high-density of low-coordinated sites on the surface,Pt-based R-NWs exhibit higher oxygen reduction reaction (ORR) activities but lower stabilities than corresponding S-NWs.Notably,Pt0.78Ni0.22 R-NWs possess the highest mass activity (1.07 A-mgpt^-1) and specific activity (1.02 mA·cm^-2) among all Pt-based NWs.After 10,000 sweeping cycles,the mass activity still exhibits 5.7-fold enhancement compared to the corresponding commercial Pt/C.This work presents a new approach to delicately control the surface structure of ultrathin Pt-based NWs as advanced ORR catalysts. | Xiaokun Fan Shuiping Luo Xixia Zhao Xiaotong Wu Zhishan Luo Min Tang Wen Chen Xing Song Zewei Quan | 2019 | Nano Research2019，12，7： | 2 |
| 9 | Study on β-cyclodextrin grafting with chitosan and slow release of its inclusion complex with radioactive iodine 显示文摘 | Chen Shuiping Wang Yuting | 2001 | Journal of Applied Polymer Science2001，84，： | 1 |
| 10 | Preparation of High Antimicrobial Activity Thiourea Chitosan-Ag^+ Complex 显示文摘 | Chen Shuiping Wu Guozhong Zeng Hongyan | 2005 | Carbohydr Polym2005，0，1： | 1 |
| 11 | Ag3 PO4/Biz WO6 hi- erarchical heterostructures with enhanced visible light photocatalyt- ic activity for the degradation of phenol显示文摘 | Fu Guokai Xu Guanan Chen Shuiping | 2013 | Catalysis Communica- tions2013，40，： | 1 |
| 12 | Prepmtion of high antimicrobial activity thiourea chitosan-Ag- complex显示文摘 | CHEN Shuiping WU Guozhong ZENG Hongyan | 2005 | Carbohydrate Polymers2005，60，： | 1 |
| 13 | PKM2: a crucial neuroprotective target against oxidative stress显示文摘Recently,Yao et al.[1]firstly reported that glycolytic enzyme pyru-vate kinase M isoform 2(PKM2)represents a crucial antioxidant intermediate by driving glutathione(GSH)biosynthesis,thereby pro-tecting neurons from oxidative damage and conferring neuroprotec-tive efcts.In general,the activity of PKM2 is largely dependent on its different allosteric states.As a tetramer,PKM2 is enzymarically active in ATP generation,whereas it serves as a transcription fac-tor coactivator in tetrameric form.Interestingly,astrocytic dopamine D2 receptor(DRD2)activation is able to promote PKM2 dimeriza-tion via enhancing the interaction berweenβ-arrestin2 and PKM2,which binds with and acts as a transcription coactivator of nuclear factor(erythroid derived)-like 2(Nrf2),hence increasing GSH lev-els.Moreover,like DRD2,pyridoxine,also named as vitamin B6,is further discovered to exert pharmacologically neuroprotective effect through the PKM2-Nrf2--GSH pathway,which is required for alle-viating dopaminergic neuron loss and damage in Parkinson's disease(PD)mouse model. | Qionglin Zhou Mingzhu Tang Lu He Shuiping Chen | 2020 | Acta Biochimica et Biophysica Sinica2020，52，12： | 1 |
| 14 | Preparation of high antimicrobial activity thiourea ehitosan - Ag ^+ complex 显示文摘 | CHEN SHUIPING WU GUOZHONG ZENG HONGYAN | 2005 | 60( 1 ) :33 - 382005，60，1： | 1 |
| 15 | Preparation of high antimicrobial activity thiourea chitosan-Ag*complex显示文摘 | CHEN Shuiping WU Guozhong ZENG Hongyan | 2005 | Carbohydrate Polymers2005，60，： | 1 |
| 16 | Finding the k shortest paths in a time-schedule network with constraints on arcs显示文摘 | Wen Jin Shuiping Chen Hai Jiang | 2013 | Computers & Operations Research2013，40，12： | 1 |
| 17 | Variable selection approach for zero-inflated count data via adaptive lasso显示文摘 | Ping Zeng Yongyue Wei Yang Zhao Jin Liu Liya Liu Ruyang Zhang Jianwei Gou Shuiping Huang Feng Chen | 2014 | Journal of Applied Statistics2014，，4： | 1 |
| 18 | 显示文摘 | Chen Shuiping Wua Guozhong | 2005 | Carbohydrate Polymers2005，60，： | 1 |
| 19 | Sensitive detection of native proteins using extractive electrospray ionization mass spectrometry显示文摘 | Chen Huanwen Yang Shuiping Li Ming | 2010 | Angewandte Chemie International Edition2010，49，： | 1 |
| 20 | Granulocyte Colony-stimulating Factor-primed Bone Marrow: An Excellent Stem-cell Source for Transplantation in Acute Myelocytic Leukemia and Chronic Myelocytic Leukemia显示文摘 | Yuhang Li Min Jiang Chen Xu Jianlin Chen Botao Li Jun Wang Jiangwei Hu Hongmei Ning Hu Chen Shuiping Chen Liangding Hu | 2015 | Chinese Medical Journal2015，，1： | 1 |
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