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| 1 | Regulation of TH17 cell differentiation by innate immune signals显示文摘在抗原刺激之上,天真的 T 助手房间区分进不同的系达到专业化性质和受动器功能。T H 17 房间, CD4 + 受动器 T 房间的一个最近识别的系,对真菌和细胞外的细菌在有免疫力的防卫起一个关键作用,而且贡献许多自体免疫的条件的致病。T H 17 房间被在 T 房间表明小径和 transcriptional 管理者的一个复杂网络安排。当 T 房间内在的小径的参与广泛地被描述了时,我们开始就正在欣赏怎么 T H 17 房间开发被外来的小径塑造,特别天生的有免疫力的信号。树枝状的房间(DC ) ,到天生的桥牌的最重要的房间类型和适应免疫,驱动器 T 由提供 antigenic, costimulatory 和 cytokine 的 H 17 房间区别发信号。这被 DC 被天生、煽动性的信号的识别经由模式识别受体, cytokine 受体和接着激活细胞内部的发信号网络的另外的 immunomodulatory 受体调停。特别地, p38α地图 kinase 作为一条批评小径出现了编程序 DC 依赖的 T 由在 DC 集成多重有启发性的信号的 H 17 房间区别。这里,我们在导出 DC 的天生的有免疫力的信号由驾驶 T H 17 房间区别。 | Gonghua Huang Yanyan Wang Hongbo Chi | 2012 | Cellular & Molecular Immunology2012，9，4： | 24 |
| 2 | Brown adipose tissue transplantation improves whole-body energy metabolism显示文摘 | Qingsheng Chi Dehua Wang Zhaoyun Zhang Chenzhong Li Yiming Li Yaoming Xue John R Speakma Wanzhu Jin Xiaomeng Liu Zongji Zhen Xiaoming Zhu Minghui Meng Lan Li Yanyan Shen | 2013 | Cell Research2013，23，6： | 11 |
| 3 | Rb Protein is Essential to the Senescence-Associated Heterochromatic Foci Formation Induced by HMGA2 in Primary WI38 Cells显示文摘细胞的老朽是提供一个障碍给肿瘤的转变的房间周期拘捕的一张不可逆的表格。Rb (Retinoblastoma ) 小径的正直为为衰老的状态的稳定性提供一个分子的基础的联系老朽的 heterochromatin foci (SAHF ) 的形成是必要的。令人惊讶地,尽管高活动性组 A2 蛋白质(HMGA2 ) 能支持 tumorigenesis 并且在肿瘤房间禁止 Rb 功能, HMGA2 的高级表示是足够的在主要房间导致 SAHF 形成。决定 Rb 蛋白质是否在导致 HMGA2 的 SAHF 形成是必要的因此变得重要。在这研究,我们由 HMGA2,典型衰老的标记在被看见的宫外的表示建立了细胞的老朽和 SAHF 汇编 WI38 房间模型,包括 p53, p21 和 p16 的著名 upregulation,并且提高了 SA -- 和 E2F 目标基因的 downregulation 染色的牛乳糖。我们然后证明 Rb 小径禁止者 E7 蛋白质能部分在 WI38 房间在 HMGA2 表示以后废除 SAHF 形成的能力,显示 Rb 是为导致 HMGA2 的 SAHF 形成的一个关键因素。然而, Rb 弄空完全没救 HMGA2 导致的房间生长拘捕,建议 Rb 不是为在 WI38 房间的导致 HMGA2 的老朽的一条独占的小径。 | Xi Shi Baoqing Tian Lingxia Liu Yanyan Gao Chi Ma Namusamba Mwichie Wenlong Ma Liping Han Baiqu Huang Jun Lu Yu Zhang | 2013 | Journal of Genetics and Genomics2013，40，8： | 4 |
| 4 | LKB1 orchestrates dendritic cell metabolic quiescence and anti-tumor immunity显示文摘Den dritic cells(DCs)play a pivotal role in priming adaptive immunity.However,the in volveme nt of DCs in con trolling excessive and deleterious T cell responses remains poorly defined.Moreover,the metabolic dependenee and regulation of DC function are unclear.Here we show that LKB1 signaling in DCs functions as a brake to restrain excessive tumor-promoting regulatory T cell(Treg)and Th17 cell responses,thereby promoting protective anti-tumor immunity and maintaining proper immune homeostasis.LKB1 deficiency results in dysregulated metabolism and mTOR activation of DCs.Loss of LKB1 also leads to aberrant DC maturation and production of cytokines and immunoregulatory molecules.Blocking mTOR signaling in LKB1-deficient DCs partially rectifies the abno rmal phe no types of DC activation and Treg expansio n,whereas unc on trolled Th17 resp on ses depend upon IL-6-STAT3 signaling.By coordi nating metabolic and immune quiesce nee of DCs,LKB1 acts as a crucial signali ng hub in DCs to enforce protective anti-tumor immunity and normal immune homeostasis. | Yanyan Wang Xingrong Du Jun Wei Lingyun Long Haiyan Tan Cliff Guy Yogesh Dhungana Chenxi Qian Geoffrey Neale Yang-Xin Fu Jiyang Yu Junmin Peng Hongbo Chi | 2019 | Cell Research2019，29，5： | 3 |
| 5 | Enhanced Multi-phosphopeptide Enrichment and Nano LC-ESI-qTOF-MS Detection Strategy Using Click OEG-CD Matrix显示文摘 | ZHAO Yanyan WANG Liheng GUO Zhimou CHI Xiaofei MA Xiaochi QI Yan FANG Shinong LI Xiuling LIANG Xinmiao | 2015 | Chemical Research in Chinese Universities2015，31，1： | 1 |
| 6 | Existence and features of the myodural bridge in gentoo penguins:a morphological study显示文摘Recent studies have evidenced that the anatomical structure now known as the myodural bridge(MDB)connects the suboccipital musculature to the cervical spinal dura mater(SDM).In humans,the MDB passes through both the posterior atlanto-occipital and the posterior atlanto-axial interspaces.The existence of the MDB in various mammals,including flying birds(Rock pigeons and Gallus domesticus)has been previously validated.Gentoo penguins are the world's fastest diving birds.The present study was therefore carried out to investigate the existence and characteristics of the MDB in Gentoo penguin,a non-flying,marine bird that can dive.For this study,six Gentoo penguin specimens were dissected to observe the existence and composition of their MDB. | Cheng Chen Yu Shengbo Chi Yanyan Tan Guangyuan Yan Baocheng Zheng Nan Sui Hongjin | 2021 | 解剖学杂志2021，44，S01： | 1 |
| 7 | Effects of alcohols on bacterial cellulose production by Acetobacter xylinum 186显示文摘 | Lu Zhigang Zhang Yanyan Chi Yujie | 2011 | World Microbiol Biotechnol2011，，27： | 1 |
| 8 | Structural mechanism of phospholipids translocation by MlaFEDB complex显示文摘In Gram-negative bacteria,phospholipids are major components of the inner membrane and the inner leaflet of the outer membrane,playing an essential role in forming the unique dual-membrane barrier to exclude the entry of most antibiotics.Understanding the mechanisms of phospholipid translocation between the inner and outer membrane represents one of the major challenges surrounding bacterial phospholipid homeostasis.The conserved MlaFEDB complex in the inner membrane functions as an ABC transporter to drive the translocation of phospholipids between the inner membrane and the periplasmic protein MlaC.However,the mechanism of phospholipid translocation remains elusive.Here we determined three cryo-EM structures of MlaFEDB from Escherichia coli in its nucleotide-free and ATP-bound conformations,and performed extensive functional studies to verify and extend our findings from structural analyses.Our work reveals unique structural features of the entire MlaFEDB complex,six wellresolved phospholipids in three distinct cavities,and large-scale conformational changes upon ATP binding.Together,these findings define the cycle of structural rearrangement of MlaFEDB in action,and suggest that MlaFEDB uses an extrusion mechanism to extract and release phospholipids through the central translocation cavity. | Ximin Chi Qiongxuan Fan Yuanyuan Zhang Ke Liang Li Wan Qiang Zhou Yanyan Li | 2020 | Cell Research2020，30，12： | 0 |
| 9 | PVA-assisted hydrated vanadium pentoxide/reduced graphene oxide films for excellent Li^(+)and Zn^(2+)storage properties显示文摘Low-cost,high safety and environment-friendly aqueous energy storage systems(ESSs)are huge potential for grid-level energy storage,but the(de)intercalation of metal ions in the electrode materials(e.g.vanadium oxides)to obtain superior long-term cycling stability is a significant challenge.Herein,we demonstrate that polyvinyl alcohol(PVA)-assisted hydrated vanadium pentoxide/reduced graphene oxide(V_(2)O_(5)·n H_(2)O/r GO/PVA,denoted as the VGP)films enable long cycle stability and high capacity for the Li^(+)and Zn^(2+)storages in both the VGP//Li Cl(aq)//VGP and the VGP//Zn SO4(aq)//Zn cells.The binderfree VGP films are synthesized by a one-step hydrothermal method combination with the filtration.The extensive hydrogen bonds are formed among PVA,GO and H_(2)O,and they act as structural pillars and connect the adjacent layers as glue,which contributes to the ultrahigh specific capacitance and ultralong cyclic performance of Li^(+)and Zn^(2+)storage properties.As for Li^(+)storage,the binder-free VGP4 film(4mg PVA)electrode achieves the highest specific capacitance up to 1381 F g^(-1)at 1.0 A g^(-1)in the three-electrode system and 962 F g^(-1)at 1.0 A g^(-1)in the symmetric two-electrode system.It also behaves the outstanding cyclic performance with the capacitance retention of 96.5%after 15000 cycles in the three-electrode system and 99.7%after 25000 cycles in the symmetric two-electrode system.As for Zn^(2+)storage,the binder-free VGP4 film electrode exhibits the high specific capacity of 184 m A h g^(-1)at 0.5A g^(-1)in the VGP4//Zn SO4(aq)//Zn cell and the superb cycle performance of 98.5%after 25000 cycles.This work not only provides a new strategy for the construction of vanadium oxides composites and demonstrates the potential application of PVA-assisted binder-free film with excellent electrochemical properties,but also extends to construct other potential electrode materials for metal ion storage cells. | Tao Hu Jingjing Sun Yifu Zhang Yanyan Liu Hanmei Jiang Xueying Dong Jiqi Zheng Changgong Meng Chi Huang | 2021 | Journal of Materials Science & Technology2021，，24： | 0 |
| 10 | Inhibitory effects of scorpion venom heat-resistant protein on neurotoxicity of exogenous amyloid beta peptide 1-40显示文摘BACKGROUND: Studies have shown that scorpion venom heat-resistant protein (SVHRP) exhibitsprotective effects on primary cultured hippocampal neurons.OBJECTIVE: To determine the effects of SVHRP on astrocyte activity and synaptic density in thehippocampus induced by amyloid β peptide 1-40 (Aβ_(1-40)) neurotoxicity.DESIGN, TIME AND SETTING: The randomized, controlled, animal experiment was performed atthe Central Laboratory, the Laboratory of Human Anatomy, and the Laboratory of Physiology, inDalian Medical University between March 2006 and June 2008.MATERIALS: Aβ_(1-40) was provided by Biosource, USA; SVHRP was a patented biological product ofDalian Medical University (No. ZL01 1 06166.9).METHODS: A total of 27 healthy, 2-month-old, male SD rats were randomly assigned to 3 groups:control, Aβ, and SVHRP, with 9 rats in each group. Alzheimer's disease was simulated with 10 μgAβ_(1-40) bilaterally injected into the hippocampus of the Aβ and SVHRP groups. The control group wasinjected with 2 μL 0.05% trifluoroacetic acid. One day following model establishment, the SVHRPgroup received an intraperitoneal injection of 2 μg/100 g SVHRP, while the control group and Aβgroup received 0.5 mL/100 g tri-distilled water, once per day, for 10 consecutive days.MAIN OUTCOME MEASURES: At 16 days following model establishment, synaptophysin (p38)expression in CA1 CA4 regions of the rat hippocampus was determined by immunohistochemistry.Glial fibrillary acidic protein (GFAP) expression surrounding the hippocampal Aβ_(1-40) injected areawas also detected. At 11 days following model establishment, escape latency, swimming time, anddistance to target quadrant were measured using the Morris water maze.RESULTS: Compared with the control group, the Aβ group exhibited notably reduced p38expression (P < 0.05) and notably increased GFAP expression in the rat hippocampus (P < 0.05).Water maze results demonstrated that escape latency was prolonged (P < 0.05), and swimming timeand distance to the target quadrant were shortened in the Aβ group. Compared with the Aβ group,the SVHRP group exhibited notably increased p38 expression (P < 0.05) and notably decreasedGFAP expression in the rat hippocampus (P < 0.05). Water maze results demonstrated that escapelatency was significantly reduced (P < 0.05), and swimming time and distance to the target quadrantwere significantly prolonged.CONCLUSION: SVHRP inhibited exogenous Aβ_(1-40)-induced astrocyte activation and synapticdensity decline in the rat hippocampus. Place navigation and spatial searching results showed thatSVHRP blocked Aβ_(1-40)-induced impaired learning and memory. | Shengbo Yu Jin Gong Haibin Gao Yanyan Chi Yan Peng Hongjin Sui Jie Zhao Wanqin Zhang | 2009 | Neural Regeneration Research2009，4，12： | 0 |
| 11 | High-efficiency thermally activated delayed fluorescence materials via a shamrock-shaped design strategy to enable OLEDs with external quantum efficiency over 38%显示文摘To achieve highly-efficient organic light-emitting diodes(OLEDs),great efforts have been devoted into constructing thermally activated delayed fluorescence(TADF)with high horizontal dipole ratios(Θ//).Here,we proposed a design strategy by integrating a rigid electron-accepting oxygen-bridged boron core with triple electron-donating groups,which exhibited a“shamrock-shape”,namely BO-3DMAC and BO-3DPAC.Benefiting from the rigid and large-planar skeletons brought by shamrock-shaped design,BO-3DMAC and BO-3DPAC exhibit highΘ//of 84%/70%and 93%/94%in neat/doped films,respectively,and finally furnish excellent external quantum efficiencies(EQEs)of up to 28.3%and 38.7%in 20 wt%doped OLEDs with sky-blue emission,as well as adequate EQEs of up to 21.0%and 16.7%in nondoped OLEDs.This work unveils a promising strategy to establish high-Θ//TADF emitters by constructing large-planar molecular structures using shamrock-shaped design. | Gaoyu Li Junrong Pu Zhan Yang Huangjun Deng Yanyan Liu Zhu Mao Juan Zhao Shi-Jian Su Zhenguo Chi | 2023 | Aggregate2023，4，6： | 0 |
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