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| 1 | Endoscopic and radiographic features of gastrointestinal involvement in vasculitis显示文摘Vasculitis is an inflammation of vessel walls,followed by alteration of the blood flow and damage to the dependent organ.Vasculitis can cause local or diffuse pathologic changes in the gastrointestinal (GI) tract.The variety of GI lesions includes ulcer,submucosal edema,hemorrhage,paralytic ileus,mesenteric ischemia,bowel obstruction,and life-threatening perforation.The endoscopic and radiographic features of GI involvement in vasculitisare reviewed with the emphasis on small-vessel vasculitis by presenting our typicalcases,including Churg-Strauss syndrome,HenochSch nlein purpura,systemic lupus erythematosus,and Beh et's disease.Important endoscopic features are ischemic enterocolitis and ulcer.Characteristic computed tomographic findings include bowel wall thickening with the target sign and engorgement of mesenteric vessels with comb sign.Knowledge of endoscopic and radiographic GI manifestations can help make an early diagnosis and establish treatment strategy. | Akira Hokama Kazuto Kishimoto Yasushi Ihama Chiharu Kobashigawa Manabu Nakamoto Tetsuo Hirata Nagisa Kinjo Futoshi Higa Masao Tateyama Fukunori Kinjo Kunitoshi Iseki Seiya Kato Jiro Fujita | 2012 | World Journal of Gastrointestinal Endoscopy2012，4，3： | 9 |
| 2 | 胃肠的淀粉样变性病的内视镜、组织病理学说的特征显示文摘 Amyloidosis is a rare disorder, characterized by the extracellular deposition of an abnormal fibrillar protein, which disrupts tissue structure and function. Amyloidosis can be acquired or hereditary, and systemic or localized to a single organ, such as the gastrointestinal (GI) tract. Clinical manifestations may vary from asymptomatic to fatal forms. Primary amyloidosis (monoclonal immunoglobulin light chains, AL) is the most common form of amyloidosis. AL amyloidosis has been associated with plasma cell dyscrasias, such as, mul- tiple myeloma. Secondary amyloidosis is caused by the deposition of fragments of the circulating acute-phase reactant, serum amyloid A protein (SAA). Common causes of AA amyloidosis are chronic inflammatory dis-orders. Although GI symptoms are usually nonspecific, histopathological patterns of amyloid deposition are associated with clinical and endoscopic features. Amyloid deposition in the muscularis mucosae, submucosa, and muscularis propria has been dominant in AL amyloidosis, leading to polypoid protrusions and thickening of the valvulae conniventes, whereas granular amyloid deposition mainly in the propria mucosae has been related to AA amyloidosis, resulting in the fine granular appearance, mucosal friability, and erosions. As a result, AL amyloidosis usually presents with constipation, mechanical obstruction, or chronic intestinal pseudoobstruction while AA amyloidosis presents with diarrhea and malabsorption Amyloidotic GI symptoms are mostly refractory and have a negative impact on quality of life and survival. Diagnosing GI amyloidosis requires high suspicion of evaluating endoscopists. Because of the absence of specific treatments for reducing the abundance of the amyloidogenic precursor protein, we should be aware of certain associations between patterns of amyloid deposition and clinical and endoscopic features. | Akira Hokama Kazuto Kishimoto Manabu Nakamoto Chiharu Kobashigawa Tetsuo Hirata Nagisa Kinjo Fukunori Kinjo Seiya Kato Jiro Fujita | 2011 | World Journal of Gastrointestinal Endoscopy2011，3，8： | 6 |
| 3 | PPAR-γ ligands inhibit the expression of inflammatory cytokines and attenuate autoimmune myocarditis显示文摘 | 袁祖贻 刘艳 刘豫 张继军 Chiharu Kishimoto 王燕妮 马爱群 刘治全 | 2004 | Chinese Medical Journal2004，，8： | 6 |
| 4 | Simeprevir with Peginterferon/Ribavirin for Treatment-Na?ve Hepatitis C Genotype 1 Patients in Japan: CONCERTO-1, a Phase III Trial显示文摘 | Norio Hayashi Namiki Izumi Hiromitsu Kumada Takeshi Okanoue Hirohito Tsubouchi Hiroshi Yatsuhashi Mai Kato Rito Ki Yuji Komada Chiharu Seto Shoichiro Goto | 2014 | Journal of Hepatology2014，，： | 3 |
| 5 | Protective effect of urinary trypsin inhibitor on myocardial mitochondria during hemorrhagic shock and reperfusion显示文摘 | Takashi Masuda Kiyotaka Sato Chiharu Noda Kazuko M. Ikeda Atsuhiko Matsunaga Misao N. Ogura Kazuhiko Shimizu Hiroshi Nagasawa Narihisa Matsuyama Tohru Izumi | 2003 | Critical Care Medicine2003，，7： | 2 |
| 6 | An Intravoxel Incoherent Motion Diffusion-Weighted Imaging Study of Prostate Cancer显示文摘 | Hiroshi Shinmoto Chiharu Tamura Shigeyoshi Soga Eisuke Shiomi Nobuyuki Yoshihara Tatsumi Kaji Robert V. Mulkern | 2012 | American Journal of Roentgenology2012，，： | 2 |
| 7 | Application of real-time RT-PCR quantification to evaluate differential expression of Arabidopsis Aux/IAA genes显示文摘The molecular techniques including Northern blot, dot blot, in situ hybridization, etc. have been successfully used to estimate semi-quantitatively mRNA levels in plant samples. In this study, we employed a real-time reverse transcription-PCR (RT-PCR) assay using SYBR Green I fluorescence methodology to evaluate accurate quantitation and sequence specific detection of Aux/IAA mRNA levels in Arabidopsis. Results obtained indicate a linear dynamic range of 102-106 Aux/IAA mRNA copies with standard deviations of generally less than 15%. As a model experiment, the outcome of analysis of expression patterns of five Aux/IAA genes in Arabidopsis under various chemical and temperature treatments is presented. The method presented here provides a sensitive and rapid technique to evaluate plant Aux/IAA mRNA expression levels in nanogram order. | LIU Jinyuan Chiharu Oura Evalour T.Aspuria Yutaka Oono Hirofumi Uchimiya | 2001 | Chinese Science Bulletin2001，46，19： | 2 |
| 8 | Detection of active bleeding from gastric antral vascular ectasia by capsule endoscopy显示文摘Gastric antral vascular ectasia(GAVE) has been recognized as one of the important causes of occult and obscure gastrointestinal bleeding.The diagnosis is typically made based on the characteristic endoscopic features,including longitudinal row of flat,reddish stripes radiating from the pylorus into the antrum that resemble the stripes on a watermelon.These appearances,however,can easily be misinterpreted as moderate to severe gastritis.Although it is believed that capsule endoscopy(CE) is not helpful for the study of the stomach with its large lumen,GAVE can be more likely to be detected at CE rather than conventional endoscopy.CE can be regarded as 'physiologic' endoscopy,without the need for gastric inflation and subsequent compression of the vasculature.The blood flow of the ecstatic vessels may be diminished in an inflated stomach.Therefore,GAVE may be prominent in CE.We herein describe a case of active bleeding from GAVE detected by CE and would like to emphasize a possibility that CE can improve diagnostic yields for GAVE. | Tetsuya Ohira Akira Hokama Nagisa Kinjo Manabu Nakamoto Chiharu Kobashigawa Yuya Kise Satoshi Yamashiro Fukunori Kinjo Yukio Kuniyoshi Jiro Fujita | 2013 | World Journal of Gastrointestinal Endoscopy2013，5，3： | 2 |
| 9 | Antimicrobial effect of fluoroquinolones for the eradication of nontyperble haemophilus influrnzae isolates within biofilms显示文摘 | Chiharu Kaji Kiwao Watanabe Michael | 2008 | Tohoku J Exp Med2008，214，： | 1 |
| 10 | An encoder-less ultrasonic stepping motor using openloop control system显示文摘 | Chiharu Kusakabe Yoshiro Tomikawa Takehiro Takano | 1992 | Japanese Journal of Applied Physics1992，31，1： | 1 |
| 11 | Optimization ofMn^ Ag] _xCut N Anti-Perovskite Compound Pabricalioti for Kesist-anoe Standard 显示文摘 | Takchiko 0 E Chiharu U Motoyoshi H | 2013 | IEEE Transactions on Instrumentation andMeasurement2013，62，6： | 1 |
| 12 | Once-daily simeprevir with peginterferon and ribavirin for treatment-experienced HCV genotype 1-infected patients in Japan: the CONCERTO-2 and CONCERTO-3 studies显示文摘 | Namiki Izumi Norio Hayashi Hiromitsu Kumada Takeshi Okanoue Hirohito Tsubouchi Hiroshi Yatsuhashi Mai Kato Rito Ki Yuji Komada Chiharu Seto Shoichiro Goto | 2014 | Journal of Gastroenterology2014，，5： | 1 |
| 13 | An Encoder-less Ultrasonic Stepping Motor Using Open-loop Control System显示文摘 | Chiharu Kusakabe Yoshiro Tomikawa Takehiro Takano etal | 1992 | Japanese Journal of Applied Physics1992，31，1： | 1 |
| 14 | Poor nutritional status is associated with low physical activity in patients undergoing peritoneal dialysis 显示文摘 | Aldko W Koji H Chiharu H | 2015 | Int J Cardiol2015，187，： | 1 |
| 15 | Effects of salt concentration on the reaction rate of glc with amino acids,peptides,and proteins显示文摘 | Keiko Yamaguchi Y N Katsumi Nakajima Chiharu Nagatsuka | 2009 | Bioscience Biotechnology and Biochemistry2009，73，11： | 1 |
| 16 | Thermal oxidation temperature dependence of 4H-SiC MOS interface 显示文摘 | Hirofumi Kurimoto Kaoru Shibata Chiharu Kimura | 2006 | Applied Surface Science2006，253，： | 1 |
| 17 | Cloning and function of rabbit peroxisome proliferator-activated receptor δ/β in mature osteoclasts显示文摘 | Chiharu Kimura Yokio Fujisawa | 2000 | J Biol Chem2000，11，： | 1 |
| 18 | Blends of Poly(L-lactic acid) with Poly(ω-pentadecalactone) Synthesized by Enzyme -catalyzed Polymerlzation显示文摘 | NAKANE Koji TAMAKI Chiharu | 2008 | Journal of Applied Polymer Science2008，108，： | 1 |
| 19 | Raptor, a Binding Partner of Target of Rapamycin (TOR), Mediates TOR Action显示文摘 | Kenta Hara Yoshiko Maruki Xiaomeng Long Ken-ichi Yoshino Noriko Oshiro Sujuti Hidayat Chiharu Tokunaga Joseph Avruch Kazuyoshi Yonezawa | 2002 | Cell2002，，2： | 1 |
| 20 | Poor nutritional sta- tus is associated with low physical activity in pa- tients undergoing peritoneal dialysis 显示文摘 | Akiko W Koji H Chiharu H | 2015 | Int J Cardi- ol2015，187，： | 1 |
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