|
|
|
题名
|
作者
|
年代
|
出处
|
被引量
|
| 1 | PTEN-L is a novel protein phosphatase for ubiquitin dephosphorylation to inhibit PINK1-Parkin-mediated mitophagy显示文摘Mitophagy 是为损坏线粒体的特定的消除的选择 autophagy 的一种重要类型。(PINK1 )导致 PTEN 的通常认为的 kinase 蛋白质 1 催化 ubiquitin (Ub ) 的 phosphorylation 在 PINK1-Parkin-mediated mitophagy 的发作起一个关键作用。(PTEN-L ) 磷酸酶和 tensin 相当或相同的事物(PTEN ) 长是 PTEN 的最新识别的 isoform,与到它的 N 终点的 173 氨基酸的增加。这里,我们报导 PTEN-L 是经由它对 phosphorylated ubiquitin 的蛋白质磷酸酶活动的 mitophagy 的一个新奇否定管理者。我们发现 PTEN-L 在外部 mitochondrial 膜(OMM ) 本地化,而 PTEN-L 的删除支持, PTEN-L 的 overexpression 禁止, mitophagy 由各种各样的损坏线粒体的代理人导致了。机械学地, PTEN-L 能够有效地阻止 Parkin mitochondrial translocation,减少 Parkin phosphorylation,维持它的关上的不活跃的符合构造,并且禁止它的 E3 ligase 活动。更重要地, PTEN-L 在 vivo 减少 phosphorylated ubiquitin (pSer65-Ub ) 的水平,并且在 vitro,磷酸酶试金经由它的蛋白质磷酸酶活动证实那 PTEN-L dephosphorylates pSer65-Ub,独立于它的类脂化合物磷酸酶功能。一起拿,我们的调查结果为 ubiquitin 作为蛋白质磷酸酶表明 PTEN-L 的新奇功能,它抵抗在 mitophagy 正式就职和 mitophagy 的最终的抑制导致前馈控制机制的阻塞的调停 PINK1 的 ubiquitin phosphorylation。因此,理解 PTEN-L 的这新奇功能在控制 mitophagy 的分子的难题提供一关键错过片,在包括象 Parkinsons 那样的 neurodegenerative 混乱的许多重要人的疾病的一个批评过程疾病。 | Liming Wang Yik-Lam Cho Yancheng Tang Jigang Wang Jung-Eun Park Yajun Wu Chunxin Wang Yan Tong Ritu Chawla Jianbin Zhang Yin Shi Shuo Deng Guang Lu Yihua Wu Hayden Weng-Siong Tan Pornteera Pawijit Grace Gui-Yin Lim Hui-Ying Chan Jingzi Zhang Lei Fang Hanry Yu Yih-Cherng Liou Mallilankaraman Karthik Boon-Huat Bay Kah-Leong Lim Siu-Kwan Sze Celestial T. Yap Han-Ming Shen | 2018 | Cell Research2018，28，8： | 25 |
| 2 | Fluoride evaporation and crystallization behavior of CaF_2–CaO–Al_2O_3–(TiO_2) slag for electroslag remelting of Ti-containing steels显示文摘To elucidate the behavior of slag films in an electroslag remelting process, the fluoride evaporation and crystallization of CaF_2–CaO–Al_2O_3–(TiO_2) slags were studied using the single hot thermocouple technique. The crystallization mechanism of TiO_2-bearing slag was identified based on kinetic analysis. The fluoride evaporation and incubation time of crystallization in TiO_2-free slag are found to considerably decrease with decreasing isothermal temperature down to 1503 K. Fish-bone and flower-like CaO crystals precipitate in TiO_2-free slag melt, which is accompanied by CaF_2 evaporation from slag melt above 1503 K. Below 1503 K, only near-spherical CaF_2 crystals form with an incubation time of less than 1 s, and the crystallization is completed within 1 s. The addition of 8.1wt% TiO_2 largely prevents the fluoride evaporation from slag melt and promotes the slag crystallization. TiO_2 addition leads to the precipitation of needle-like perovskite(CaTiO_3) crystals instead of CaO crystals in the slag. The crystallization of perovskite(CaTiO_3) occurs by bulk nucleation and diffusion-controlled one-dimensional growth. | Cheng-bin Shi Jung-wook Cho Ding-li Zheng Jing Li | 2016 | International Journal of Minerals,Metallurgy and Materials2016，23，6： | 6 |
| 3 | Effect of TiO_2 on the viscosity and structure of low-fluoride slag used for electroslag remelting of Ti-containing steels显示文摘The viscosity of CaF_2–CaO–Al_2O_3–MgO–(TiO_2) slag was measured using a rotating crucible viscometer. Raman spectroscopy analysis was performed to correlate the viscosity to slag structure. The viscosity of the slag was found to decrease with increasing TiO_2 content in the slag from 0 to 9.73wt%. The activation energy decreased from 95.16 kJ /mol to 79.40 kJ /mol with increasing TiO_2 content in the slag. The introduction of TiO_2 into the slag played a destructive role in Al–O–Al structural units and Q^4 units by forming simpler structural units of Q^2 and Ti_2O_6^(4-) chain. The amount of Al–O–Al significantly decreased with increasing TiO_2 content. The relative fraction of Q^4 units in the [AlO_4]^(5-)-tetrahedral units shows a decreasing trend, whereas the relative fraction of Q^2 units and Ti_2O_6^(4-) chain increases with increasing TiO_2 content accordingly. Consequently, the polymerization degree of the slag decreases with increasing TiO_2 content. The variation in slag structure is consistent with the change in measured viscosity. | Cheng-bin Shi Ding-li Zheng Seung-ho Shin Jing Li Jung-wook Cho | 2017 | International Journal of Minerals,Metallurgy and Materials2017，24，1： | 5 |
| 4 | The Impacts of Simulated Microgravity on Rat Brain Depended on Durations and Regions显示文摘Objective To explore the dynamic impacts of simulated microgravity(SM) on different vital brain regions of rats. Methods Microgravity was simulated for 7 and 21 days, respectively, using the tail-suspension rat model. Histomorphology, oxidative stress, inflammatory cytokines and the expression of some key proteins were determined in hippocampus, cerebral cortex and striatum. Results 21-day SM decreased brain derived neurotrophic factor and induced neuron atrophy in the cerebral cortex. Strong oxidative stress was triggered at day 7 and the oxidative status returned to physiological level at day 21. Inflammatory cytokines were gradually suppressed and in striatum, the suppression was regulated partially through c-Jun/c-Fos. Conclusion The results revealed that the significant impacts of SM on rat brain tissue depended on durations and regions, which might help to understand the health risk and to prevent brain damage for astronauts in space travel. | CHEN Bo ZHANG Yu Shi LI George CHO Jun-Lae DENG Yu Lin LI Yu Juan | 2019 | Biomedical and Environmental Sciences2019，32，7： | 4 |
| 5 | Icariin Augments Bone Formation and Reverses the Phenotypes of Osteoprotegerin-Deficient Mice through the Activation of Wnt/ β -Catenin-BMP Signaling显示文摘 | Xiao-Feng Li Hao Xu Yong-Jian Zhao De-Zhi Tang Guo-Hua Xu Jonathan Holz Jing Wang Shao-Dan Cheng Qi Shi Yong-Jun Wang Stephen Cho Wing Sze | 2013 | Evidence-Based Complementary and Alternative Medicine2013，，： | 2 |
| 6 | Engineered multifunctional nanocarriers for cancer diagnosis and therapeutics显示文摘 | Shi DL Bedford NM Cho HS | | 0，，18： | 1 |
| 7 | Comprehensive proteome analysis of lettuce latex using multidimensional protein-identification technology显示文摘 | Won Kyong Cho Xiong-Yan Chen Nazim Mohamad Uddin Yeonggil Rim Juyeon Moon Jin-Hee Jung Chunlin Shi Hyosub Chu Suwha Kim Seon-Won Kim Zee-Yong Park Jae-Yean Kim | 2009 | Phytochemistry2009，，5： | 1 |
| 8 | Fluorescent Polystyrene-Fe3O4 Composite Nanospheres for in Vivo Imaging and Hyperthermia显示文摘 | Shi D Cho H S Chen Y | 2009 | Adv Mater2009，21，21： | 1 |
| 9 | Prevalence of antiseptic - resistance genes in staphylococci isolated from orthokeratology lens and spectacle wearers in Hong Kong 显示文摘 | Shi GS Boost M Cho P | 2015 | Invest Ophthalmol Vis Sci2015，56，5： | 1 |
| 10 | Coniugation of quantum dots and Fe3O4 on carbon nanotubes for medical diagnosis and treatment 显示文摘 | Shi D L Cho H S Chris H | 2009 | Applied Physics Letters2009，95，22： | 1 |
| 11 | Laser clad Ni-base alloy added nano-and micron-size Ce02 composites显示文摘 | Shi Hong Zhang Ming Xi Li Tong Yul Cho | 2008 | Optics & Laser Technology2008，40，： | 1 |
| 12 | The genome of the cucumber显示文摘 | HUANG S LI R ZHANG Z LI L GU X FAN W LUCAS W J WANG X XIE B NI P REN Y ZHU H LI J LIN K JIN W FEI Z LI G STAUB J KILIAN A VAN DER VOSSEN EA WUY GUO J HE J JIA Z REN Y TIAN G LU Y RUAN J QIANW WANG M HUANG Q LI B XUAN Z CAO J ASAN WUZ ZHANG J CAI Q BAI Y ZHAO B HAN Y LI Y LI X WANG S SHI Q LIU S CHO WK KIM JY XU Y HELLER-USZYNSKA K MIAO H CHENG Z ZHANG S WU J YANG Y KANG H LI M LIANG H REN X SHI Z WEN M JIAN M YANG H ZHANG G YANG Z CHEN R LIU S LI J MA L LIU H ZHOU Y ZHAO J FANG X LI G FANG L LI Y LIUD ZHENG H ZHANG Y QIN N LI Z YANG G YANG S BOLUND L KRISTIANSEN K ZHENG H LI S ZHANG X YANG H WANG J SUN R ZHANG B JIANG S WANG J DUY LI S | 2009 | Cucumis Sativus L NatureGenetics2009，41，： | 1 |
| 13 | An anti-apoptosic protein human surviving is a direct inhibitor of caspase-3 and -7 显示文摘 | Shi S Sung BJ Cho Y S | 2001 | Biochemistry2001，40，4： | 1 |
| 14 | The erythropoietin receptor is a downstream effector of Klotho-induced cytoprotection显示文摘 | Hu MC Shi M Cho H J | 2013 | Kidney Int2013，84，3： | 1 |
| 15 | Klotho has dual protective effects on cisplatin-induced acute kidney injury显示文摘 | Panesso MC Shi M Cho HJ | 2014 | Kidney Int2014，85，4： | 1 |
| 16 | Functional silica nanoparticle-me- diated neuronal membrane sealing following traumatic spinal cord In- jury显示文摘 | Cho Y Shi RY Ivanisevic A | 2010 | J Neurosci Res2010，88，7： | 1 |
| 17 | Chitosan produces potent neuroprotection and physiological recovery following traumatic spinal cord injury 显示文摘 | Cho Y Shi R Borgens RB | 2010 | J Exp Biol2010，213，9： | 1 |
| 18 | Effects of closed kinetic chain exercises on proprioception and functional scores of the knee after anterior cruciate ligament reconstruction 显示文摘 | Cho SHI Bae CH Gak HB | 2013 | J Phys Ther Sci2013，25，10： | 1 |
| 19 | Enhanced thermal stability of carbon nanotubes by plasma surface modification in AI203 composites 显示文摘 | Hoonsung Cho Donglu Shi Yan Guo | 2008 | Applied Physics Letters2008，104，： | 1 |
| 20 | In vivo imaging and drug storage by quantum-dot-conjugated carbon nanotubes 显示文摘 | Yan Guo Donglu Shi Hoonsung Cho | 2008 | Advanced Functional Materials2008，18，： | 1 |
您所在的机构暂未开通此部分的功能，请联系管理员