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| 1 | Serotonin type 3 receptor subunit gene polymorphisms associated with psychosomatic symptoms in irritable bowel syndrome:A multicenter retrospective study显示文摘BACKGROUND Single-nucleotide polymorphisms(SNPs)of the serotonin type 3 receptor subunit(HTR3)genes have been associated with psychosomatic symptoms,but it is not clear whether these associations exist in irritable bowel syndrome(IBS).AIM To assess the association of HTR3 polymorphisms with depressive,anxiety,and somatization symptoms in individuals with IBS.METHODS In this retrospective study,623 participants with IBS were recruited from five specialty centers in Germany,Sweden,the United States,the United Kingdom,and Ireland.Depressive,anxiety,and somatization symptoms and sociodemographic characteristics were collected.Four functional SNPs—HTR3A c.-42C>T,HTR3B c.386A>C,HTR3C c.489C>A,and HTR3E c.*76G>A—were genotyped and analyzed using the dominant and recessive models.We also performed separate analyses for sex and IBS subtypes.SNP scores were calculated as the number of minor alleles of the SNPs above.The impact of HTR3C c.489C>A was tested by radioligand-binding and calcium influx assays.RESULTS Depressive and anxiety symptoms significantly worsened with increasing numbers of minor HTR3C c.489C>A alleles in the dominant model(F_(depressive)=7.475,P_(depressive)=0.006;F_(anxiety)=6.535,P_(anxiety)=0.011).A higher SNP score(range 0-6)was linked to a worsened depressive symptoms score(F=7.710,P-linear trend=0.006)in IBS.The potential relevance of the HTR3C SNP was corroborated,showing changes in the expression level of 5-HT3AC variant receptors.CONCLUSION We have provided the first evidence that HTR3C c.489C>A is involved in depressive and anxiety symptoms in individuals with IBS.The SNP score indicated that an increasing number of minor alleles is linked to the worsening of depressive symptoms in IBS. | Sabrina Berens Yuanjun Dong Nikola Fritz Jutta Walstab Mauro D'Amato Tenghao Zheng Verena Wahl Felix Boekstegers Justo Lorenzo Bermejo Cristina Martinez Stefanie Schmitteckert Egbert Clevers Felicitas Engel Annika Gauss Wolfgang Herzog Robin Spiller Miriam Goebel-Stengel Hubert Mönnikes Viola Andresen Frieling Thomas Jutta Keller Christian Pehl Christoph Stein-Thöringer Gerard Clarke Timothy G Dinan Eamonn M Quigley Gregory Sayuk Magnus Simrén Jonas Tesarz Gudrun Rappold Lukas van Oudenhove Rainer Schaefert Beate Niesler | 2022 | World Journal of Gastroenterology2022，28，21： | 2 |
| 2 | Using simula- tion to inteIpret a discrete time survival model in a complex biological system: fertility and lameness in dairy cows显示文摘 | Christopher D H Jonathan N H Martin J G | 2014 | Plos 0ne2014，9，8： | 1 |
| 3 | Intraoperative magnetic resonance imaging combined with neuronavigation:a new concept显示文摘 | Christopher N Oliver G Helmut K | 2001 | Neurosurgery2001，48，5： | 1 |
| 4 | Risk as feelings显示文摘 | boewenstein G F Elke U W Christopher K H Welch N | 2001 | Psychological Bulletin2001，127，2： | 1 |
| 5 | Intraoperative magnetic resonance imaging combined with neuronavigation: a new concept 显示文摘 | Christopher N Oliver G Helmut K | 2001 | Neurosurgery2001，48，5： | 1 |
| 6 | Intraoperative magnetic resonance imaging combined with neuronavigation: a new concept 显示文摘 | Christopher N Oliver G Helmut K | 2001 | Neurosurgery2001，48，5： | 1 |
| 7 | Burden of valvular heart diseases: a population-based study显示文摘 | Vuyisile T Nkomo Julius M Gardin Thomas N Skelton John S Gottdiener Christopher G Scott Maurice Enriquez-Sarano | 2006 | The Lancet . 2006 (9540)2006，，： | 1 |
| 8 | Polynomial systems : A lowerbound for the Hilbert numbers显示文摘 | Christopher C J Lloyd N G | 1995 | Proc R Soc Lond Ser A1995，450，1938： | 1 |
| 9 | Lack of clinical AIDS in SIV-infected sooty mangabeys with significant CD4^sup +^ T cell loss is associated with double-negative T cells显示文摘 | Milush Jeffrey M Mir Kiran D Sundaravaradan Vasudha Gordon Shari N Engram Jessica Cano Christopher A Reeves Jacqueline F Anton Elizabeth O’Neill Eduardo Butler Eboneé Hancock Kathy Cole Kelly S Brenchley Jason M Else James G Silvestri Guido | 2011 | Journal of Clinical Investigation2011，，3： | 1 |
| 10 | Oxygen isotope evolution of Phanerozoic seawater显示文摘 | Ján Veizer Peter Bruckschen Frank Pawellek Andreas Diener Olaf G Podlaha Giles A.F Carden Torsten Jasper Christoph Korte Harald Strauss Karem Azmy Davin Ala | 1997 | Palaeogeography, Palaeoclimatology, Palaeoecology1997，，1： | 1 |
| 11 | Swalpamycin,a new macrolide antibiotic显示文摘 | CHRISTOPHER M M F JULIA N G SUGATA C | 1987 | The Jour-nal of Aantibiotics1987，11，10： | 1 |
| 12 | Intraoperative magnetic resonance imaging combined with neuronavigation: a new concept显示文摘 | Christopher N Oliver G Helmut K | 2001 | Neurosurgery2001，48，5： | 1 |
| 13 | The draft genome of the transgenic tropical fruit tree papaya ( Carica pap aya Linnaeus ) 显示文摘 | MING R HOU S B FENG Y YU Q DIONNE-LAPORTE A SAW J H SENIN P WANG W LY B V LEWIS K L T SALZBERG S L FENG L GONES M R SKELTON R L MURRAYJ E CHEN C QIAN W SHEN J DU P EUSTICE M TONG E TANG H LYONS E PAULL R E MICHAEL T P WALL K RICE D W ALBERT H WANG M L ZHU Y J SCHATZ M NAGARAJAN N ACOB R A GUAN P BLAS A WAI C M ACKERMAN C M REN Y LIU C WANG J M WANG J P NA J SHAKIROV E V HAAS B THIMMAPURAM J NELSON D WANG X BOWERS J E GSCHWEND A R DELCHER A L SINGH R SUZUKI J Y TRIPATHI S NEUPANE K WEI H IRIKURA B PAIDI M JIANG N ZHANG W PRESTING G WINDSOR A NAVAJAS-PEREZ R TORRES M J FELTUS A PORTER B LI Y BURROUGHS A M LUO M C LIU L CHRISTOPHER D A MOUNT S M MOORE P H SUGIMURA T JIANG J SCHULER M A FRIEDMAN V MITCHELL-OLDS T SHIPPEN D E PAMPHILIS C W PALMER J D FREELING M PATERSON A H GONSALVES D WANG L ALAM M | 2008 | Nature2008，452，： | 1 |
| 14 | Use of protein:creatinine ratio measurements on random urine samples for prediction of significant proteinuria: A systematic review显示文摘 | Christopher P P Ronald G N James C B | 2005 | Clinical Chemistry2005，51，9： | 1 |
| 15 | Long-term outcome of skull base surgery with microvascular Reconstruction for malignant disease显示文摘 | Reza N Yasmin I Christopher G | 2006 | Plast Reconstr Surg2006，118，5： | 1 |
| 16 | Rapid total destruction of chlorophenols by activated hydrogen peroxide显示文摘 | Sayam S G Matthew S Christopher A N | 2002 | Science2002，296，： | 1 |
| 17 | Production of liquid alkanes by aqueous-phase pro- cessing of biomass-derived carbohydrates 显示文摘 | G W HUBER J N CHHEDA J B CHRISTOPHER | 2005 | Science2005，308，5727： | 1 |
| 18 | Strontium isotope stratigraphy: potential resolution and event correlation显示文摘 | Ján Veizer Dieter Buhl Andreas Diener Stefan Ebneth Olaf G Podlaha Peter Bruckschen Torsten Jasper Christoph Korte Michael Schaaf Davin Ala Karem Azmy | 1997 | Palaeogeography Palaeoclimatology Palaeoecology1997，，1： | 1 |
| 19 | Zika virus in Gabon(Central Africa)-2007:a new threat from Aedes albopictus?显示文摘 | Grard G Mélanie C Illich Manfred M DieudonnéN Statiana MO Davy J Didier F Christophe P Eric Maurice L | 2014 | PLoS Negl Trop Dis2014，8，2： | 1 |
| 20 | Surface kinetics model for SiLK chemical mechanical polishing显示文摘 | Christopher L B Dipto G T William N G | 2002 | J Electrochem Soc2002，149，： | 1 |
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