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| 1 | The enhanced X-ray Timing and Polarimetry mission—eXTP显示文摘In this paper we present the enhanced X-ray Timing and Polarimetry mission—eXTP. eXTP is a space science mission designed to study fundamental physics under extreme conditions of density, gravity and magnetism. The mission aims at determining the equation of state of matter at supra-nuclear density, measuring effects of QED, and understanding the dynamics of matter in strong-field gravity. In addition to investigating fundamental physics, eXTP will be a very powerful observatory for astrophysics that will provide observations of unprecedented quality on a variety of galactic and extragalactic objects. In particular, its wide field monitoring capabilities will be highly instrumental to detect the electro-magnetic counterparts of gravitational wave sources.The paper provides a detailed description of:(1) the technological and technical aspects, and the expected performance of the instruments of the scientific payload;(2) the elements and functions of the mission, from the spacecraft to the ground segment. | ShuangNan Zhang Andrea Santangelo Marco Feroci YuPeng Xu FangJun Lu Yong Chen Hua Feng Shu Zhang Sφren Brandt Margarita Hernanz Luca Baldini Enrico Bozzo Riccardo Campana Alessandra De Rosa YongWei Dong Yuri Evangelista Vladimir Karas Norbert Meidinger Aline Meuris Kirpal Nandra Teng Pan Giovanni Pareschi Piotr Orleanski QiuShi Huang Stephane Schanne Giorgia Sironi Daniele Spiga Jiri Svoboda Gianpiero Tagliaferri Christoph Tenzer Andrea Vacchi Silvia Zane Dave Walton ZhanShan Wang Berend Winter Xin Wu Jean J.M.in't Zand Mahdi Ahangarianabhari Giovanni Ambrosi Filippo Ambrosino Marco Barbera Stefano Basso Jörg Bayer Ronaldo Bellazzini Pierluigi Bellutti Bruna Bertucci Giuseppe Bertuccio Giacomo Borghi XueLei Cao Franck Cadoux Francesco Ceraudo TianXiang Chen Yu Peng Chen Jerome Chevenez Marta Civitani Wei Cui WeiWei Cui Thomas Dauser Ettore Del Monte Sergio Di Cosimo Sebastian Diebold Victor Doroshenko Michal Dovciak YuanYuan Du Lorenzo Ducci QingMei Fan Yannick Favre Fabio Fuschino JoséLuis Ga'lvez Min Gao MingYu Ge Olivier Gevin Marco Grassi QuanYing Gu YuDong Gu DaWei Han Bin Hong Wei Hu Long Ji ShuMei Jia WeiChun Jiang Thomas Kennedy Ingo Kreykenbohm Irfan Kuvvetli Claudio Labanti Luca Latronico Gang Li MaoShun Li Xian Li Wei Li ZhengWei Li Olivier Limousin HongWei Liu XiaoJing Liu Bo Lu Tao Luo Daniele Macera Piero Malcovati Adrian Martindale Malgorzata Michalska Bin Meng Massimo Minuti Alfredo Morbidini Fabio Muleri Stephane Paltani Emanuele Perinati Antonino Picciotto Claudio Piemonte JinLu Qu Alexandre Rachevski Irina Rashevskaya Jerome Rodriguez Thomas Schanz ZhengXiang Shen LiZhi Sheng JiangBo Song LiMing Song Carmelo Sgro Liang Sun Ying Tan Phil Uttley Bo Wang DianLong Wang GuoFeng Wang Juan Wang LangPing Wang YuSa Wang Anna L.Watts XiangYang Wen Jörn Wilms ShaoLin Xiong JiaWei Yang Sheng Yang YanJi Yang Nian Yu WenDa Zhang Gianluigi Zampa Nicola Zampa Andrzej A.Zdziarski AiMei Zhang ChengMo Zhang Fan Zhang Long Zhang Tong Zhang Yi Zhang XiaoLi Zhang ZiLiang Zhang BaoSheng Zhao ShiJie Zheng Yu Peng Zhou Nicola Zorzi J.Frans Zwart | 2019 | Science China(Physics,Mechanics & Astronomy)2019，62，2： | 11 |
| 2 | Micro‐RNA profiling reveals a role for miR‐29 in human and murine liver fibrosis显示文摘 | Christoph Roderburg Gerd‐Willem Urban Kira Bettermann Mihael Vucur Henning Zimmermann Sabine Schmidt J?rn Janssen Christiane Koppe Percy Knolle Mirco Castoldi Frank Tacke Christian Trautwein Tom Luedde | 2011 | Hepatology2011，，1： | 3 |
| 3 | Extracorporeal membrane oxygenation for acute respiratory distress syndrome in burn patients:a case series and literature update显示文摘Background:Acute respiratory distress syndrome(ARDS)has a reported incidence of 34–43%in ventilated burn patients and is associated with a mortality of 59%in the severe form.The use and experience with extracorporeal membrane oxygenation(ECMO)in burn patients developing ARDS are still limited.We present our results and discuss the significance of ECMO in treating burn patients.Methods:A retrospective analysis of burn patients treated with ECMO for ARDS between January 2017 and January 2019 was performed.Demographic,clinical,and outcome data were collected and analyzed.Results:Eight burn patients were treated at our institution with ECMO in the designated time period.Of these,all but one patient had inhalation injury,burn percentage of TBSA was 37±23%,ABSI score was 8.4±2,and R-Bauxscore was 98±21.Seven patients developed severe ARDS and one patient moderate ARDS according to the Berlin classification with a PaO_(2)/FiO_(2) ratio upon initiation of ECMO therapy of 62±22 mmHg.ECMO duration was 388±283 h.Three patients died from severe sepsis while five patients survived to hospital discharge.Conclusions:ECMO is a viable therapy option in burn patients developing severe ARDS and can contribute to survival rates similar to ECMO therapy in non-burn-associated severe ARDS.Consequently,patients with severe respiratory insufficiency with unsuccessful conventional treatment and suspected worsening should be transferred to burn units with the possibility of ECMO treatment to improve outcome. | Mehran Dadras Johannes M.Wagner Christoph Wallner Julika Huber Dirk Buchwald Justus Strauch Kamran Harati Nicolai Kapalschinski Björn Behr Marcus Lehnhardt | 2019 | Burns & Trauma2019，7，1： | 2 |
| 4 | 环境变化背景下北极生物的多样性、分布及其适应性显示文摘生物个体是对气候变化和紫外线B(UV-B)辐射变化产生反应的基础,而且这种反应会在各种时间尺度上发生。北极地区的动物、植物以及微生物种类的多样性从表面上看是低的,而且从北方针叶林到极地荒漠逐渐减少,但其原始物种却很丰富。与这种物种多样性随纬向梯度减少的趋势相反,一些空间分布范围很广的单一优势物神的优势度则呈增长趋势。全球气候变暖可能会减少该地区的物种多样性,并限制到这些物种的分布范围,尤其是在该地区生物分布的北部边缘,一些极地特有的动物和植物种类会面临着灭绝的危险。最有可能侵入苔原地带的物种是那些目前生存在极地外缘的北方地区生物。许多植物都具有自身的特征使它们能够在以下环境中生存;短暂的无冰雪覆盖的生长季节,低的太阳高度角,永久冻结地带及低的土壤温度,贫乏的养分获取条件以及极少的物理扰动。以上这些特征有些可能会限制当地物种对气候变暖的反应,但其最主要的因素是这些物种与那些潜在的入侵物种相比缺乏竞争能力。北极地区陆生动物拥有许多适应特性,这使它们能够适应北极地区剧烈的温度变化。许多动物通过冬眠或迁移来逃避极地地区的恶劣天气和资源短缺。北极地区动物生存的生物环境则相对简单:几乎没有天敌、竞争者、疾病、寄生生物,但同时食物资源也很短缺。极地陆生动物可能对由气候变化带来的温暖而干旱的夏季非常不适应,这种变化将会影响到动物的迁移路线、途中栖息地,并会改变冬季积雪的状况和冻融的循环过程。气候变化还会改变动物繁殖和发育的季节,并会引来新的竞争者、捕食者、寄生生物以及疾病等。极地微生物也能很好地适应该地区的气候:一些微生物甚至在-39℃的低温下还能进行代谢活动。蓝藻细菌和藻类生物有着很广泛的适应策略,这能够使它们避免(至少可以减少)紫外线的伤害。微生物能够忍受许多环境条件,而且其生长周期很短,这些特点将使它们能很快适应新的生存环境。与此形成对比的是,极地植物和动物很可能通过改变其分布范围而不是积极的生物进化来适应环境的变暧。 | Terry V.Callaghan Lars Olof Bjrn Yuri Chernov Terry Chapin Torben R.Christensen Brian Huntley Rolf A.Ims Margareta Johansson Dyanna Jolly Sven Jonasson Nadya Matveyeva Nicolai Panikov Walter Oechel Gus Shaver Josef Elster Heikki Henttonen Kari Laine Kari Taulavuori Erja Taulavuori Christoph Zckler 何永涛 | 2004 | AMBIO-人类环境杂志2004，33，B11： | 2 |
| 5 | Differential Effects of Atropine and Isoproterenol on Inducibility of Atrioventricular Nodal Reentrant Tachycardia显示文摘 | Christoph Stellbrink Bj?rn Diem Patrick Schauerte Kathrin Brehmer Henry Schuett Peter Hanrath | 2001 | Journal of Interventional Cardiac Electrophysiology2001，，4： | 1 |
| 6 | Intestinal, adipose, and liver inflammation in diet-induced obese mice显示文摘 | Hong Li Christopher Lelliott Pernilla H?kansson Karolina Ploj Anna Tuneld Martina Verolin-Johansson Lambertus Benthem Bj?rn Carlsson Leonard Storlien Erik Micha?lsson | 2008 | Metabolism2008，，12： | 1 |
| 7 | FOXP3+ regulatory T cells in autoimmune hepatitis are fully functional and not reduced in frequency显示文摘 | Moritz Peiseler Marcial Sebode Bj?rn Franke Frederike Wortmann Dorothee Schwinge Alexander Quaas Udo Baron Sven Olek Christiane Wiegard Ansgar W. Lohse Christina Weiler-Normann Christoph Schramm Johannes Herkel | 2012 | Journal of Hepatology2012，，1： | 1 |
| 8 | Are there really high-tech clusters? The geographic concentration of German manufacturing industries and its determinants显示文摘 | Bj?rn Alecke Christoph Alsleben Frank Scharr Gerhard Untiedt | 2006 | The Annals of Regional Science2006，，1： | 1 |
| 9 | Large-sized hepotocellular carcinoma (HCC): a neoadjuvant treatment protocol with repetitive transarterial chemoembolization (TACE) before percutaneous MR-guided laser-induced thermotherapy (LITT)显示文摘 | Stephan Zangos Katrin Eichler J?rn O. Balzer Ralf Straub Renate Hammerstingl Christopher Herzog Thomas Lehnert Mathias Heller Axel Thalhammer Martin G. Mack Thomas J. Vogl | 2007 | European Radiology2007，，2： | 1 |
| 10 | Proximal Humeral Fractures in Children and Adolescents显示文摘 | Christian Bahrs Sebastian Zipplies Bj?rn Gunnar Ochs J?rg Rether Justus Oehm Christoph Eingartner Bernd Rolauffs Kuno Weise | 2009 | Journal of Pediatric Orthopaedics2009，，3： | 1 |
| 11 | Percutaneous interventional reconstruction of the iliac arteries: primary and long-term success rate in selected TASC C and D lesions显示文摘 | J?rn O. Balzer Verena Gastinger Ralf Ritter Christopher Herzog Martin G. Mack Thomas Schmitz-Rixen Thomas J. Vogl | 2006 | European Radiology2006，，1： | 1 |
| 12 | Large-sized hepotocellular carcinoma (HCC): a neoadjuvant treatment protocol with repetitive transarterial chemoembolization (TACE) before percutaneous MR-guided laser-induced thermotherapy (LITT)显示文摘 | Stephan Zangos Katrin Eichler J?rn O. Balzer Ralf Straub Renate Hammerstingl Christopher Herzog Thomas Lehnert Mathias Heller Axel Thalhammer Martin G. Mack Thomas J. Vogl | 2007 | European Radiology2007，，2： | 1 |
| 13 | Neoadjuvant targeted therapy in a primary metastasized renal cell cancer patient leads to down-staging of inferior vena cava thrombus (IVC) enabling a cardiopulmonary bypass-free tumor nephrectomy: a case report显示文摘 | Inga Peters Michael Winkler Bj?rn Jüttner Omke E. Teebken T. R. Herrmann Christoph Klot Mario Kramer Angela Reichelt Mahmoud Abbas Markus A. Kuczyk Axel S. Merseburger | 2014 | World Journal of Urology2014，，： | 1 |
| 14 | 在物种水平上生物对气候和紫外线B辐射预期变化的响应显示文摘控制实验表明,不同物种对每个环境因子变化变量产生的响应也存在着差异。植物往往对营养元素的变化反应最为强烈,尤其是氮素的增加。夏季增温实验表明,木本植物对温度的升高表现出了积极的响应,而地衣、苔藓类植物的丰富度却因增温而降低。物种对增温的响应主要受水分有效性和雪覆盖程度控制。在气候保持湿润的情况下,伴随着夏季温度的升高,许多无脊椎动物种群的数量都有所增加。实验表明,CO_2浓度和紫外线B(UV-B)辐射的增加对植物和动物影响较小,但是,一些微生物和真菌却对紫外线B辐射的增加非常敏感,甚至可能会因此产生一些诱导突变而引起流行传染病的爆发。苔原土壤的加温、CO_2浓度的升高以及矿物质营养的改善一般都会增加微生物的活动。在温带气候中,藻类往往比蓝藻细菌更占优势。冬季结冰-解冻过程的增加会导致冻壳的形成,从而会大大降低许多陆生动物的冬季存活率,改变这些动物群体的动态过程。厚的积雪会使驯鹿等植食性动物很难采食到雪下的草类植物,同时也不利于其逃避食肉动物的追捕。而无雪期的提前到来则可能会加速植物的生长。物种对气候变化的响应最初可能出现在亚种这一水平上:一个具有很高遗传/群系多样性的北极植物或动物物种,演化历史已经使其具有一种适应不同环境条件的能力,这将使它们能够很快适应未来的环境变化。本土知识(IK)、航空照片和卫星图像表明一些物种的分布已经发生了变化:北极植被更加趋向灌木化,而且生长也更加旺盛;北极驯鹿的分布范围最近也发生了变化一些原来在树线以南区域活动的害虫和鸟类也在北极被发现。与此相对应,大多数在北极地区进行繁殖鸟类的数量却都在下降。根据一些模型的预测,随着气候的变暖,苔原带鸟类的数量将会大幅度地下降。据物种-气候响应模型预测,由于受到气候变暖的影响,北极地区现有物种在未来的潜在分布范围都将大大缩小和向北退缩,而一些无脊椎动物和微生物则很可能会迅速向北扩展到北极地区。 | Terry V.Callaghan Lars Olof Bjrn Yuri Chernov Terry Chapin Torben R.Christensen Brian Huntley Rolf A.Ims Margareta Johansson Dyanna Jolly Sven Jonasson Nadya Matveyeva Nicolai Panikov Walter Oechel Gus Shaver Josef Elster Ingilbjrg S.Jónsdóttir Kari Laine Kari Taulavuori Erja Taulavuori Christoph Zckler 闫魏 | 2004 | AMBIO-人类环境杂志2004，33，B11： | 1 |
| 15 | Methyl-donor supplementation in obese mice prevents the progression of NAFLD, activates AMPK and decreases acyl-carnitine levels显示文摘 | Christoph Dahlhoff Stefanie Worsch Manuela Sailer Bj?rn A. Hummel Jarlei Fiamoncini Kirsten Uebel Rima Obeid Christian Scherling Jürgen Geisel Bernhard L. Bader Hannelore Daniel | 2014 | Molecular Metabolism2014，，： | 1 |
| 16 | Two Cases of serotonin syndrome with venlafaxine and caleineurin inhibitors 显示文摘 | Christopher RN Elias K Kathy C | 2011 | Psychosomatics2011，52，3： | 1 |
| 17 | Body masses, functional responses and predator–prey stability显示文摘 | Gregor Kalinkat Florian D. Schneider Christoph Digel Christian Guill Bj?rn C. Rall Ulrich Brose | 2013 | Ecol Lett2013，，9： | 1 |
| 18 | 依据清创术后细菌培养结果确定开放骨折创面关闭时机显示文摘背景:目前,对开放骨折创面缝合关闭的时机尚没有客观的标准。许多学者对于开放骨折创面缝合关闭最佳时机提出了各种各样的建议,但均依据主观评判的参数。本研究的目的是应用前瞻性方法,在四肢开放骨折清创和冲洗木后,依据创面细菌培养结果来指导创面的缝合关闭时机。方法:本组对422例急诊开放骨折患者,进行了创面清创冲洗、骨折固定和开放创面处理。清创术后创面采样进行厌氧菌和有氧菌培养。清创术后48h,患者再次手术。如果初次细菌培养结果为阳性,则再次进行冲洗和清创术,之后再次留取菌培样本。创面不关闭直到细菌培养结果为阴性为止,否则重复进行冲洗和清创术。结果:在422例开放骨折中,有346例获得了长期随访。全组创面深部感染率为4|3%。GustiloⅡ型开放骨折创面深部感染率为4%,GustiloⅢ型开放骨折为5.7%。在GustiloⅢ型开放骨折中,依骨折类型不同,感染率出现变化,GustiloⅢA型开放骨折为1.8%,GustiloⅢB型开放骨折为10.6%,GustiloⅢC型开放骨折为20%。需要反复清创的骨折患者,伴有糖尿病患者以及体重指数增加的患者,感染率均出现上升。研究数据表明,开放骨折在菌培阳性条件下关闭创面(违反本研究原则)并未显著增加深部感染风险(p=0.0501)。结论:采用本文提出的标准处理方法,与历史对照方法相比,开放骨折深部感染率降到很低。但取得这样结果是以增加冲洗和清创术次数为代价。可信水平:治疗性研究Ⅳ级。关于证据等级的完整描述详见投稿须知。 | Christopher J. Lenarz, MD J. Tracy Watson, MD Berton R. Moed, MD Heidi Israel, PhD, RN J. Daniel Mullen MSPH, BA, BS James B. MacDonald, BS 叶伟胜(译) | 2011 | 中华骨科杂志2011，31，3： | 0 |
| 19 | 佛山世纪莲体育馆显示文摘佛山世纪莲体育馆是佛山市政府为举办2006年第十二届厂东省运动会而建。
体育中心坐落在小山岗上宛如出水芙蓉,在公园里绽放。它是河畔公园的新地标,更是新佛山南部的城市风景线。 | 福尔克温.玛格 Marek Nowak Christoph Helbich Mario Rojas Toledo Michael Knig Sven Greiser Sebastian Hilke Mark Jackschat Michael Haase Stefan Menke Franz Lensing Bjrn Füchtenkord Silke Flaβncker Ebi Tang(cand.arch.) Jennifer Kielas Schlaich Bergermann und Partner Stuttgart Christian Gahl | 2010 | 建筑技艺2010，，2： | 0 |
| 20 | A Reinforcement Learning approach for the continuous electricity market ofGermany: Trading from the perspective of a wind park operator显示文摘With the rising extension of renewable energies, the intraday electricity markets have recorded a growingpopularity amongst traders as well as electric utilities to cope with the induced volatility of the energysupply. Through their short trading horizon and continuous nature, the intraday markets offer the abilityto adjust trading decisions from the day-ahead market or reduce trading risk in a short-term notice. Producersof renewable energies utilize the intraday market to lower their forecast risk, by modifying their providedcapacities based on current forecasts. However, the market dynamics are complex due to the fact that thepower grids have to remain stable and electricity is only partly storable. Consequently, robust and intelligenttrading strategies are required that are capable to operate in the intraday market. In this work, we proposea novel autonomous trading approach based on Deep Reinforcement Learning (DRL) algorithms as a possiblesolution. For this purpose, we model the intraday trade as a Markov Decision Process (MDP) and employ theProximal Policy Optimization (PPO) algorithm as our DRL approach. A simulation framework is introducedthat enables the trading of the continuous intraday price in a resolution of one minute steps. We test ourframework in a case study from the perspective of a wind park operator. We include next to general tradeinformation both price and wind forecasts. On a test scenario of German intraday trading results from 2018,we are able to outperform multiple baselines with at least 45.24% improvement, showing the advantage of theDRL algorithm. However, we also discuss limitations and enhancements of the DRL agent, in order to increasethe performance in future works. | Malte Lehna Björn Hoppmann Christoph Scholz RenéHeinrich | 2022 | Energy and AI2022，8，2： | 0 |
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